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The map label for this gene is proC [H]

Identifier: 158425603

GI number: 158425603

Start: 4546432

End: 4547268

Strand: Reverse

Name: proC [H]

Synonym: AZC_3979

Alternate gene names: 158425603

Gene position: 4547268-4546432 (Counterclockwise)

Preceding gene: 158425604

Following gene: 158425602

Centisome position: 84.68

GC content: 72.16

Gene sequence:

>837_bases
ATGTCTCTCGAAGTTCTGAAGCAGTTGGACGGCCCGATCGTCCTCGTGGGCGCGGGCAAGATGGGCGGCGCGCTGCTGGA
AGGCTGGCTGGGGCTCGGCATCGAACCCGCCCGCCTCGTGGTGCTCGATCCCAACCTCAATCCCGAGGCCGCCAAGGCGC
TGGCCGACAAGGGCGTTTCCGCCAATCCCGCCTATGACGCCATCCCCCACGCCGCCGTCCTTATCCTGGCGGTGAAGCCG
CAGGTGGCGCCGGCCGTCATTGCCAGCATCCGCGGCATCGTCGGGCCGAAGAGCGTGGTGGTCTCCATCATGGCGGGACG
CACCATCGGCTTCATGCAGGAAGCGCTGCCGCGGGGCGCCGCCATCGTGCGCACCATTCCCAACACGCCGGCCGCCATCG
GCAAGGGCATCACGGTCGCCGTGGCGAATGCCGCGGTCTCGCCGGAGGCCCGCGCCGCCACCTCCGCCTTGCTCGGCACC
GTCGGCCCCGTGGAATGGGTTGAGAGCGAGAGCCTGATCGACGCGGCCACCGCCGTCTCCGGCTCCGGCCCCGCCTACGT
CTTCCTGCTGGCCGAGGCGCTGGCCAAGGCCGGCGCCGCCGCCGGCCTGCCGGCGGATCTGGCGGACCGGCTCGCCCGTG
CCACCGTTTCGGGCGCCGGCGCGCTCCTGGAGCAGTCCGGCATCGATCCCGCCATTCTGCGCCAGAATGTCACCTCGCCG
GGCGGCACGACGGCAGCGGCGCTCGCCGTGCTCATGGATGAGGCCAAGGGCTTCGGCCCGCTGCTGACGCAGGCCGTGGC
CGAGGCGACCCACCGCTCGCGCGAACTCGCGGGCTGA

Upstream 100 bases:

>100_bases
CCGCGCTTTTCGAGACGGCCGGAGAAGCTTAAGACAGCGGAACCTGTTTCGCGGGGCGCGCCGCCGGTCCGGCGGGCGCC
TCCACTTCCAAGGTGTTCCG

Downstream 100 bases:

>100_bases
ACCGCGCCGGTTCGCCTCTTGCTGATGGCGGAGGCGGGGCTTGTGGCGGCAGGTCCGCGCCCCCACGTCTGACGGGCGTG
GGGGAGTTCAGCCGGTGAAG

Product: delta 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSLEVLKQLDGPIVLVGAGKMGGALLEGWLGLGIEPARLVVLDPNLNPEAAKALADKGVSANPAYDAIPHAAVLILAVKP
QVAPAVIASIRGIVGPKSVVVSIMAGRTIGFMQEALPRGAAIVRTIPNTPAAIGKGITVAVANAAVSPEARAATSALLGT
VGPVEWVESESLIDAATAVSGSGPAYVFLLAEALAKAGAAAGLPADLADRLARATVSGAGALLEQSGIDPAILRQNVTSP
GGTTAAALAVLMDEAKGFGPLLTQAVAEATHRSRELAG

Sequences:

>Translated_278_residues
MSLEVLKQLDGPIVLVGAGKMGGALLEGWLGLGIEPARLVVLDPNLNPEAAKALADKGVSANPAYDAIPHAAVLILAVKP
QVAPAVIASIRGIVGPKSVVVSIMAGRTIGFMQEALPRGAAIVRTIPNTPAAIGKGITVAVANAAVSPEARAATSALLGT
VGPVEWVESESLIDAATAVSGSGPAYVFLLAEALAKAGAAAGLPADLADRLARATVSGAGALLEQSGIDPAILRQNVTSP
GGTTAAALAVLMDEAKGFGPLLTQAVAEATHRSRELAG
>Mature_277_residues
SLEVLKQLDGPIVLVGAGKMGGALLEGWLGLGIEPARLVVLDPNLNPEAAKALADKGVSANPAYDAIPHAAVLILAVKPQ
VAPAVIASIRGIVGPKSVVVSIMAGRTIGFMQEALPRGAAIVRTIPNTPAAIGKGITVAVANAAVSPEARAATSALLGTV
GPVEWVESESLIDAATAVSGSGPAYVFLLAEALAKAGAAAGLPADLADRLARATVSGAGALLEQSGIDPAILRQNVTSPG
GTTAAALAVLMDEAKGFGPLLTQAVAEATHRSRELAG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=37.4074074074074, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=37.4074074074074, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=36.6666666666667, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=33.2075471698113, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=34.5588235294118, Blast_Score=134, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=34.8314606741573, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=30.0353356890459, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=287, Percent_Identity=29.9651567944251, Blast_Score=116, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21358587, Length=272, Percent_Identity=37.8676470588235, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=43.3526011560694, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24648116, Length=282, Percent_Identity=32.2695035460993, Blast_Score=121, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27594; Mature: 27463

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEVLKQLDGPIVLVGAGKMGGALLEGWLGLGIEPARLVVLDPNLNPEAAKALADKGVS
CCHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCC
ANPAYDAIPHAAVLILAVKPQVAPAVIASIRGIVGPKSVVVSIMAGRTIGFMQEALPRGA
CCCCHHHCCHHEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCCC
AIVRTIPNTPAAIGKGITVAVANAAVSPEARAATSALLGTVGPVEWVESESLIDAATAVS
EEEEECCCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCC
GSGPAYVFLLAEALAKAGAAAGLPADLADRLARATVSGAGALLEQSGIDPAILRQNVTSP
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
GGTTAAALAVLMDEAKGFGPLLTQAVAEATHRSRELAG
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLEVLKQLDGPIVLVGAGKMGGALLEGWLGLGIEPARLVVLDPNLNPEAAKALADKGVS
CHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCC
ANPAYDAIPHAAVLILAVKPQVAPAVIASIRGIVGPKSVVVSIMAGRTIGFMQEALPRGA
CCCCHHHCCHHEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCCC
AIVRTIPNTPAAIGKGITVAVANAAVSPEARAATSALLGTVGPVEWVESESLIDAATAVS
EEEEECCCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCC
GSGPAYVFLLAEALAKAGAAAGLPADLADRLARATVSGAGALLEQSGIDPAILRQNVTSP
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
GGTTAAALAVLMDEAKGFGPLLTQAVAEATHRSRELAG
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]