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The map label for this gene is uvrC [H]

Identifier: 158425590

GI number: 158425590

Start: 4533560

End: 4535716

Strand: Direct

Name: uvrC [H]

Synonym: AZC_3966

Alternate gene names: 158425590

Gene position: 4533560-4535716 (Clockwise)

Preceding gene: 158425579

Following gene: 158425591

Centisome position: 84.43

GC content: 69.31

Gene sequence:

>2157_bases
ATGACGAGCCGCCCCCCGAACGACCTGCCCGACACGCCGGACGACGCCGACCTCCTGCCCGAGACCGAGGACGAAGCCTC
CCTGCCCCTCGCGGAGGAGAGCGACGAGGCCGAGCCCGCCGAGGGTCCCCTGGCCACGGGCCGCGCCGTCATCGCCCGCG
CAGCCAAGCACGCGCCGACAGGACCGGGCGTCTATCGGATGCTGGGGGCGGACGGCACGGTGCTCTATGTGGGCAAGGCC
AAGAGCATCAAGAAGCGCATCCTCAGCTACACGCGCCTCGTCGGCCACACCAACCGCATCGCCCGCATGATCGCGGCCAC
CGCCAGCATGGAGTTCGTCTCCACCGCGACGGAGCCCGAGGCGCTGCTGCTGGAAGCAAACCTCATCAAGCAGCTGAAGC
CGCGCTTCAACGTGCTGCTGCGGGACGACAAGTCCTTTCCTTATATCCTCATCACCGCCGACCATCCGGCGCCGCAGATC
CTCAAGCATCGCGGCGCCCGCTCGCGGCCGGGCGATTATTACGGGCCGTTCGCCAGCGTCTGGGCGGTGGACCGCACCAT
CAACGCGCTCCAGCGCGCCTTCCTCCTGCGCTCCTGCTCGGACAGCTATTACGAGAACCGCTCACGCCCCTGCCTGCTCT
ACCAGATCAAGCGCTGCTCCGGCCCCTGCACCGGTGAGGTGAGCACCACCGATTATGCCGAACTGGTGCGCGAGGCCCGC
GCCTTCCTCGCCGGGCGCTCGCGCGCCATCAAGGAGGAACTGGCGAAGGAGATGGAAGCGGCGGCGGAGGAGCTGGAATT
CGAGCGCGCCGCCCGCCTGCGCGACCGTCTCGCGGCGCTGTCCGCCGTGCAGGGCAGCCAGGGCATCAACCCCCGCTCGG
TAGAAGAGGCGGACGTCTTCGCCTGCCACCAGCAGGGCGGGGCCACCTGCATCGAGGTCTTCTTCTTCCGCACCGGCCAG
AACTGGGGCAACCGCGCCTATTATCCCCGCGCCGACCGCTCGCTGGACGAGAAGGACGTGCTCGGCCCCTTCCTCTCGCA
ATTCTATGAGGACAAGCCCTGCCCGCGCCTCATCCTCTTGAGCCACGAGGTGGAGGAGCAGGATCTCATCGCCGAGGCCC
TGTCGCAGAAGGCGGGCTACAAGGTGGAGATCAGCGCGCCCAAGCGGGGCGAGAAGCGCGATCTTGTGGACCACGCGCTC
CAGAATGCCCGCGAGGCGCTGGGCCGCAAGCTCGCGGAGACGGCGACGCAGGGCAAGCTGCTGGACGGCGTCGCCGCCGC
CTTCAAGCTGGAGAAGCCGCCCCAGCGCATCGAAGTCTATGACAACTCCCACATCATGGGCACCAATGCGGTGGGCGGCA
TGATCGTCGCGGGGCCGGAAGGCTTCCGCAAAAGCCAGTACCGCAAGTTCAACATCAAGTCCGCCGACCTCGTGCCCGGC
GACGATTACGGCATGATGCGCGAGGTGCTGCGCCGCCGCTTCTCCCGCCTGCTGCGGGAAGCCCCGCGCGGTGGGGCGGC
GCCTGCGGTGGCCCCGCTGGCGCCAGCTCCGACGGATTTGCCCGCTCCGCCTCCCGCCCCCACCGCCGCCGCGCAGGAGA
CCTGGCGCACGCGCGGCGAGCCCGGCGAAATCCCGGTCGATCCAGCCCCTCTCCCGCCCACCCCGGCCGAGGTGCAGGAG
GCCGCCGACGAGGCCTCGCCTTGGCCTGACCTCGTGCTGATCGACGGCGGCCTCGGCCAGCTCAATGCGGCGCGCGCGGT
GATGGACGAGCTCGGCATCACCGACGTGCCGATGGTGGGCATCGCCAAGGGCCTCGACCGCGAGGCGGGGCGCGAGCAGT
TCTTCATCCCCGGCCAGCAGCCGTTCCGCATGGAGCCCCGCGATCCGGTGCTCTATTTCATCCAGCGCCTGCGGGACGAA
GCCCACCGTTTCGCCATCGGCTCGCACCGGGCGCGGCGGAAGAAGGACATTTCGGATGCCGGCCTTCAGGCCATCCCCGG
CGTCGGCCCGACCCGCAAGCGCGCGCTGCTGAGGCACTTCGGTACCCTCAAGGCCATCGAACGGGCCTCGCTCGCCGATC
TTGAGCAGGTTCCGGGCGTAAATGCCTCGACGGCACGGGCCATCTACGAGTATTTCCATGATCGCATCGGCGCGTGA

Upstream 100 bases:

>100_bases
CCGGGCTGATTGGTAGTAGTTTTTTACGCCTTGTCCATGGATTGGGGGATGCAAAGGCTGGCCTCTGGCCCTCGGCCCGG
CGAATCCCTACCTTCCGCCC

Downstream 100 bases:

>100_bases
GGCGGCCTCGACCCTGCCTGCTTTCGCGCGCACAGTGGCTGCGATGGACGTAACGGCAGGCCTCGAGATTCGAGGCGCGC
GGCGTCCCGTGGCAGAACGC

Product: excinuclease ABC C subunit

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 718; Mature: 717

Protein sequence:

>718_residues
MTSRPPNDLPDTPDDADLLPETEDEASLPLAEESDEAEPAEGPLATGRAVIARAAKHAPTGPGVYRMLGADGTVLYVGKA
KSIKKRILSYTRLVGHTNRIARMIAATASMEFVSTATEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILITADHPAPQI
LKHRGARSRPGDYYGPFASVWAVDRTINALQRAFLLRSCSDSYYENRSRPCLLYQIKRCSGPCTGEVSTTDYAELVREAR
AFLAGRSRAIKEELAKEMEAAAEELEFERAARLRDRLAALSAVQGSQGINPRSVEEADVFACHQQGGATCIEVFFFRTGQ
NWGNRAYYPRADRSLDEKDVLGPFLSQFYEDKPCPRLILLSHEVEEQDLIAEALSQKAGYKVEISAPKRGEKRDLVDHAL
QNAREALGRKLAETATQGKLLDGVAAAFKLEKPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFNIKSADLVPG
DDYGMMREVLRRRFSRLLREAPRGGAAPAVAPLAPAPTDLPAPPPAPTAAAQETWRTRGEPGEIPVDPAPLPPTPAEVQE
AADEASPWPDLVLIDGGLGQLNAARAVMDELGITDVPMVGIAKGLDREAGREQFFIPGQQPFRMEPRDPVLYFIQRLRDE
AHRFAIGSHRARRKKDISDAGLQAIPGVGPTRKRALLRHFGTLKAIERASLADLEQVPGVNASTARAIYEYFHDRIGA

Sequences:

>Translated_718_residues
MTSRPPNDLPDTPDDADLLPETEDEASLPLAEESDEAEPAEGPLATGRAVIARAAKHAPTGPGVYRMLGADGTVLYVGKA
KSIKKRILSYTRLVGHTNRIARMIAATASMEFVSTATEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILITADHPAPQI
LKHRGARSRPGDYYGPFASVWAVDRTINALQRAFLLRSCSDSYYENRSRPCLLYQIKRCSGPCTGEVSTTDYAELVREAR
AFLAGRSRAIKEELAKEMEAAAEELEFERAARLRDRLAALSAVQGSQGINPRSVEEADVFACHQQGGATCIEVFFFRTGQ
NWGNRAYYPRADRSLDEKDVLGPFLSQFYEDKPCPRLILLSHEVEEQDLIAEALSQKAGYKVEISAPKRGEKRDLVDHAL
QNAREALGRKLAETATQGKLLDGVAAAFKLEKPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFNIKSADLVPG
DDYGMMREVLRRRFSRLLREAPRGGAAPAVAPLAPAPTDLPAPPPAPTAAAQETWRTRGEPGEIPVDPAPLPPTPAEVQE
AADEASPWPDLVLIDGGLGQLNAARAVMDELGITDVPMVGIAKGLDREAGREQFFIPGQQPFRMEPRDPVLYFIQRLRDE
AHRFAIGSHRARRKKDISDAGLQAIPGVGPTRKRALLRHFGTLKAIERASLADLEQVPGVNASTARAIYEYFHDRIGA
>Mature_717_residues
TSRPPNDLPDTPDDADLLPETEDEASLPLAEESDEAEPAEGPLATGRAVIARAAKHAPTGPGVYRMLGADGTVLYVGKAK
SIKKRILSYTRLVGHTNRIARMIAATASMEFVSTATEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILITADHPAPQIL
KHRGARSRPGDYYGPFASVWAVDRTINALQRAFLLRSCSDSYYENRSRPCLLYQIKRCSGPCTGEVSTTDYAELVREARA
FLAGRSRAIKEELAKEMEAAAEELEFERAARLRDRLAALSAVQGSQGINPRSVEEADVFACHQQGGATCIEVFFFRTGQN
WGNRAYYPRADRSLDEKDVLGPFLSQFYEDKPCPRLILLSHEVEEQDLIAEALSQKAGYKVEISAPKRGEKRDLVDHALQ
NAREALGRKLAETATQGKLLDGVAAAFKLEKPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFNIKSADLVPGD
DYGMMREVLRRRFSRLLREAPRGGAAPAVAPLAPAPTDLPAPPPAPTAAAQETWRTRGEPGEIPVDPAPLPPTPAEVQEA
ADEASPWPDLVLIDGGLGQLNAARAVMDELGITDVPMVGIAKGLDREAGREQFFIPGQQPFRMEPRDPVLYFIQRLRDEA
HRFAIGSHRARRKKDISDAGLQAIPGVGPTRKRALLRHFGTLKAIERASLADLEQVPGVNASTARAIYEYFHDRIGA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=451, Percent_Identity=39.4678492239468, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788037, Length=183, Percent_Identity=30.6010928961749, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 78856; Mature: 78725

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRPPNDLPDTPDDADLLPETEDEASLPLAEESDEAEPAEGPLATGRAVIARAAKHAPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GPGVYRMLGADGTVLYVGKAKSIKKRILSYTRLVGHTNRIARMIAATASMEFVSTATEPE
CCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALLLEANLIKQLKPRFNVLLRDDKSFPYILITADHPAPQILKHRGARSRPGDYYGPFASV
HHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHH
WAVDRTINALQRAFLLRSCSDSYYENRSRPCLLYQIKRCSGPCTGEVSTTDYAELVREAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHHH
AFLAGRSRAIKEELAKEMEAAAEELEFERAARLRDRLAALSAVQGSQGINPRSVEEADVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ACHQQGGATCIEVFFFRTGQNWGNRAYYPRADRSLDEKDVLGPFLSQFYEDKPCPRLILL
HHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
SHEVEEQDLIAEALSQKAGYKVEISAPKRGEKRDLVDHALQNAREALGRKLAETATQGKL
CCCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LDGVAAAFKLEKPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFNIKSADLVPG
HHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCEEEECCCCHHHCCCEEECCCCCCCCCC
DDYGMMREVLRRRFSRLLREAPRGGAAPAVAPLAPAPTDLPAPPPAPTAAAQETWRTRGE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
PGEIPVDPAPLPPTPAEVQEAADEASPWPDLVLIDGGLGQLNAARAVMDELGITDVPMVG
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHH
IAKGLDREAGREQFFIPGQQPFRMEPRDPVLYFIQRLRDEAHRFAIGSHRARRKKDISDA
HHHCCCHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
GLQAIPGVGPTRKRALLRHFGTLKAIERASLADLEQVPGVNASTARAIYEYFHDRIGA
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSRPPNDLPDTPDDADLLPETEDEASLPLAEESDEAEPAEGPLATGRAVIARAAKHAPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GPGVYRMLGADGTVLYVGKAKSIKKRILSYTRLVGHTNRIARMIAATASMEFVSTATEPE
CCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALLLEANLIKQLKPRFNVLLRDDKSFPYILITADHPAPQILKHRGARSRPGDYYGPFASV
HHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHH
WAVDRTINALQRAFLLRSCSDSYYENRSRPCLLYQIKRCSGPCTGEVSTTDYAELVREAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHHH
AFLAGRSRAIKEELAKEMEAAAEELEFERAARLRDRLAALSAVQGSQGINPRSVEEADVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ACHQQGGATCIEVFFFRTGQNWGNRAYYPRADRSLDEKDVLGPFLSQFYEDKPCPRLILL
HHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
SHEVEEQDLIAEALSQKAGYKVEISAPKRGEKRDLVDHALQNAREALGRKLAETATQGKL
CCCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LDGVAAAFKLEKPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFNIKSADLVPG
HHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCEEEECCCCHHHCCCEEECCCCCCCCCC
DDYGMMREVLRRRFSRLLREAPRGGAAPAVAPLAPAPTDLPAPPPAPTAAAQETWRTRGE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
PGEIPVDPAPLPPTPAEVQEAADEASPWPDLVLIDGGLGQLNAARAVMDELGITDVPMVG
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHH
IAKGLDREAGREQFFIPGQQPFRMEPRDPVLYFIQRLRDEAHRFAIGSHRARRKKDISDA
HHHCCCHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
GLQAIPGVGPTRKRALLRHFGTLKAIERASLADLEQVPGVNASTARAIYEYFHDRIGA
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA