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The map label for this gene is cya [H]

Identifier: 158425589

GI number: 158425589

Start: 4531294

End: 4533513

Strand: Reverse

Name: cya [H]

Synonym: AZC_3965

Alternate gene names: 158425589

Gene position: 4533513-4531294 (Counterclockwise)

Preceding gene: 158425596

Following gene: 158425588

Centisome position: 84.43

GC content: 68.56

Gene sequence:

>2220_bases
TTGCATCCCCCAATCCATGGACAAGGCGTAAAAAACTACTACCAATCAGCCCGGTACCTGCCGGGGGGCTTCATGTTCGG
TTTCCTGTCCATCCGCTCCAAGGTTCTGGCCATGCTGCTCATCTGCGGCATCGGCTGTCTGGTGGCGGCGAGCCTTGTCG
CCATGCGCAGCGGAACCACGACGCTGAAGTCCAGCATCTTCGACCAGCTCACCACCCTGCGCACCGCCAAGGCGGCGCAG
GTGGTCAACTGGTTCCAGGACGTCTCGGACGACTTTAGCGACATCTCGCAGGATGCCTCGACCATTGCCGGCATACAGGC
CTTCTCGGCCGCCTACCTGCGGGCCGGCGTCGGCGCGTCCGCGACGCCCACGCCGGAGCTCGATGCCTATTACAAGGACA
AGTTCCTGCCCTCGTTCGCCATGCTCGTGGATGCGCCGCTGGTGCCGCGCGGCTTTCTGCCGGCGAGCCCGGCCGCCCTG
CGGCTTCAGGCCGCCTATGTGACGCGCAACGCCAATCCGGTGGGCACGGAGGGCGTGTCGCGGGAGGATACCGGCCAGCC
GGCGGACTCCGGCCTTGCCGCCTATGACGATGCGGTGGCGCGCTTCCAGCCCTTCTTCCGCCGGGCCGTGGAAACTCACG
CGCTGGAAGACATCCTGCTGGTGGACACCCGGAGCGGCACCATCGTCTATACGGTGGCCAAGCGGACCGATCTCGGCGCC
AGCCTGAAGAGCGGGTCCCTCTCCACCTCCGGCGCCGCCCGCGCCTTCAGCCGCGTGATCGAGGGCGGCGGGGTGCCCGG
CCATACGGTGCTGGAGGACTTCTCCGCTTATATTCCCGCGGGCCTGCGCCCCTCCGCCTTCATCGCGGCGCCGGTCTTTT
CGGACGGCAATCTCGTGGGCGTTGTCATCGGCGTGCTGTCGGTCAAGCAGATCAACGCGCTCATGACCAACGACCGGCAT
TGGGAAGAGGCCGGGCTGGGACGCACGGGCGAGGTCTATCTCGTCGGCGTCAACGAGCTGCTGATGCGCTCGCCCTCGCG
CTTCCTGATCCAGGACCCGGCGGCCTATTTCAAGGCGCTGGAGGCCACCGGCGTGAGTTCGGAGACGCTCGCGCGCATCA
GGCATTTCGACTCGCCCATCATGGCCCAGAAGGTCAGCACGGAGGCGACGCGCGAGGGCCAGAAGGGACGCTCCGACACC
CAGATCGTGGCCGATTACCGGGGCGTCTCCACCCTGAGCTCCTGGGGGCCGGTGGCGGTGCAGGGCCTGCACTGGATCGT
GGTCGCCCAGCAGGACGAGGCGGAGGCGCTGGCGCCAGTGGACGGCCTGCGCCACTCCATCCTGGTGGTGGCGGCGCTGG
CGGCGGTCATCCTCACCGCCATCTCGGTGGCGCTCGCCAGCGTATTCACCCGCCCCATCCAGGCGGTGCTCGCCGGCGTC
AACACGCTGGCGGCGGGCGACGAGAGCGTGCGCATTCCGGTGAAGGGGCGCGATGAATTCGCCGACCTCGCCCGCGCCTT
CAACGCCATGGCCAACGAGATCGCCGAGCGCTCCGCCCGCATCGAGCAGAAGACGGTCGAGTACGAGCAACTGCTGCGCA
ATTTCTATCCCGACCTCATCGCCGACCGCATCCGCAATGGCGAGGGCGCCTTCTCCGAGCATGTGCGCAACGTCTGCGTG
GTGGTCCTCATCATCGAGGGTTTCGAGGGGCTGGTGCGGGGCGGCAGCGGCGAGACGCTGGAGCGCGTCAATGCCGTGGT
GGGCGATCTGGACGAGCTGTGCACCGCCGGCGGGCTGGAGAAGATCCGCACCATCGGCGAAACCTATATGGCCGCCTGCG
GCCTCTCGACGCCGCGCCTCGACGCCGCCCAGCGGGGCCTTGCCTTCGTGGAGCAGGTGAGCGGTGCGCTCGACCGCCTG
TCGCGGGTCTATGAGGTCGAACTCTCGGTCCGCGCCGGCGTCGCGCTCGGCGACGTGGAGGTGGGCATCGTCGGCCGCCA
CCGCATGCTTTACGACGTGTGGGGCGCCACCATGCTGGAAGCCCGGCGCATCGTCTTCGACGCCGAGCCGGGCACCGTGC
GGGTGACGGAGGCGGTCTTCCAGCAGTTGAGCGTGCGCGAGGGCTTCGAGCCCAAGGCGGAGATCACGCTGTTCGATGAC
ACGCCGGTCGCCACGTGGCAGCGCCCGGCCGCGCCTGCGCCCGCCGCCGAGAGCCGGTGA

Upstream 100 bases:

>100_bases
GAGGTCGGCGTCGTCCGGCGTGTCGGGCAGGTCGTTCGGGGGGCGGCTCGTCATGGGCGGAAGGTAGGGATTCGCCGGGC
CGAGGGCCAGAGGCCAGCCT

Downstream 100 bases:

>100_bases
GGCGGCGATGCTCAGCGCGCAGATCGCCCAAGAGGTGCCGTGGACGATCCTGATCGTCCTCGGCTTTCCGCTCCTCACGG
TTCTTCTCATCGAGCTGACG

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MHPPIHGQGVKNYYQSARYLPGGFMFGFLSIRSKVLAMLLICGIGCLVAASLVAMRSGTTTLKSSIFDQLTTLRTAKAAQ
VVNWFQDVSDDFSDISQDASTIAGIQAFSAAYLRAGVGASATPTPELDAYYKDKFLPSFAMLVDAPLVPRGFLPASPAAL
RLQAAYVTRNANPVGTEGVSREDTGQPADSGLAAYDDAVARFQPFFRRAVETHALEDILLVDTRSGTIVYTVAKRTDLGA
SLKSGSLSTSGAARAFSRVIEGGGVPGHTVLEDFSAYIPAGLRPSAFIAAPVFSDGNLVGVVIGVLSVKQINALMTNDRH
WEEAGLGRTGEVYLVGVNELLMRSPSRFLIQDPAAYFKALEATGVSSETLARIRHFDSPIMAQKVSTEATREGQKGRSDT
QIVADYRGVSTLSSWGPVAVQGLHWIVVAQQDEAEALAPVDGLRHSILVVAALAAVILTAISVALASVFTRPIQAVLAGV
NTLAAGDESVRIPVKGRDEFADLARAFNAMANEIAERSARIEQKTVEYEQLLRNFYPDLIADRIRNGEGAFSEHVRNVCV
VVLIIEGFEGLVRGGSGETLERVNAVVGDLDELCTAGGLEKIRTIGETYMAACGLSTPRLDAAQRGLAFVEQVSGALDRL
SRVYEVELSVRAGVALGDVEVGIVGRHRMLYDVWGATMLEARRIVFDAEPGTVRVTEAVFQQLSVREGFEPKAEITLFDD
TPVATWQRPAAPAPAAESR

Sequences:

>Translated_739_residues
MHPPIHGQGVKNYYQSARYLPGGFMFGFLSIRSKVLAMLLICGIGCLVAASLVAMRSGTTTLKSSIFDQLTTLRTAKAAQ
VVNWFQDVSDDFSDISQDASTIAGIQAFSAAYLRAGVGASATPTPELDAYYKDKFLPSFAMLVDAPLVPRGFLPASPAAL
RLQAAYVTRNANPVGTEGVSREDTGQPADSGLAAYDDAVARFQPFFRRAVETHALEDILLVDTRSGTIVYTVAKRTDLGA
SLKSGSLSTSGAARAFSRVIEGGGVPGHTVLEDFSAYIPAGLRPSAFIAAPVFSDGNLVGVVIGVLSVKQINALMTNDRH
WEEAGLGRTGEVYLVGVNELLMRSPSRFLIQDPAAYFKALEATGVSSETLARIRHFDSPIMAQKVSTEATREGQKGRSDT
QIVADYRGVSTLSSWGPVAVQGLHWIVVAQQDEAEALAPVDGLRHSILVVAALAAVILTAISVALASVFTRPIQAVLAGV
NTLAAGDESVRIPVKGRDEFADLARAFNAMANEIAERSARIEQKTVEYEQLLRNFYPDLIADRIRNGEGAFSEHVRNVCV
VVLIIEGFEGLVRGGSGETLERVNAVVGDLDELCTAGGLEKIRTIGETYMAACGLSTPRLDAAQRGLAFVEQVSGALDRL
SRVYEVELSVRAGVALGDVEVGIVGRHRMLYDVWGATMLEARRIVFDAEPGTVRVTEAVFQQLSVREGFEPKAEITLFDD
TPVATWQRPAAPAPAAESR
>Mature_739_residues
MHPPIHGQGVKNYYQSARYLPGGFMFGFLSIRSKVLAMLLICGIGCLVAASLVAMRSGTTTLKSSIFDQLTTLRTAKAAQ
VVNWFQDVSDDFSDISQDASTIAGIQAFSAAYLRAGVGASATPTPELDAYYKDKFLPSFAMLVDAPLVPRGFLPASPAAL
RLQAAYVTRNANPVGTEGVSREDTGQPADSGLAAYDDAVARFQPFFRRAVETHALEDILLVDTRSGTIVYTVAKRTDLGA
SLKSGSLSTSGAARAFSRVIEGGGVPGHTVLEDFSAYIPAGLRPSAFIAAPVFSDGNLVGVVIGVLSVKQINALMTNDRH
WEEAGLGRTGEVYLVGVNELLMRSPSRFLIQDPAAYFKALEATGVSSETLARIRHFDSPIMAQKVSTEATREGQKGRSDT
QIVADYRGVSTLSSWGPVAVQGLHWIVVAQQDEAEALAPVDGLRHSILVVAALAAVILTAISVALASVFTRPIQAVLAGV
NTLAAGDESVRIPVKGRDEFADLARAFNAMANEIAERSARIEQKTVEYEQLLRNFYPDLIADRIRNGEGAFSEHVRNVCV
VVLIIEGFEGLVRGGSGETLERVNAVVGDLDELCTAGGLEKIRTIGETYMAACGLSTPRLDAAQRGLAFVEQVSGALDRL
SRVYEVELSVRAGVALGDVEVGIVGRHRMLYDVWGATMLEARRIVFDAEPGTVRVTEAVFQQLSVREGFEPKAEITLFDD
TPVATWQRPAAPAPAAESR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI24497587, Length=206, Percent_Identity=30.0970873786408, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI31083193, Length=211, Percent_Identity=26.0663507109005, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI50959205, Length=202, Percent_Identity=27.7227722772277, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI115387102, Length=209, Percent_Identity=28.7081339712919, Blast_Score=72, Evalue=3e-12,
Organism=Homo sapiens, GI4557255, Length=190, Percent_Identity=31.0526315789474, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI4557257, Length=190, Percent_Identity=27.8947368421053, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI10181096, Length=274, Percent_Identity=26.2773722627737, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI34486092, Length=192, Percent_Identity=28.125, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI10947061, Length=274, Percent_Identity=26.2773722627737, Blast_Score=67, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71995893, Length=264, Percent_Identity=22.7272727272727, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71995895, Length=264, Percent_Identity=22.7272727272727, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71995899, Length=264, Percent_Identity=22.7272727272727, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI62473752, Length=224, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17137448, Length=224, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24642014, Length=210, Percent_Identity=28.0952380952381, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR018297 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 79098; Mature: 79098

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPPIHGQGVKNYYQSARYLPGGFMFGFLSIRSKVLAMLLICGIGCLVAASLVAMRSGTT
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TLKSSIFDQLTTLRTAKAAQVVNWFQDVSDDFSDISQDASTIAGIQAFSAAYLRAGVGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ATPTPELDAYYKDKFLPSFAMLVDAPLVPRGFLPASPAALRLQAAYVTRNANPVGTEGVS
CCCCCCCHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCHHHEEEEHEEECCCCCCCCCCCC
REDTGQPADSGLAAYDDAVARFQPFFRRAVETHALEDILLVDTRSGTIVYTVAKRTDLGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCCC
SLKSGSLSTSGAARAFSRVIEGGGVPGHTVLEDFSAYIPAGLRPSAFIAAPVFSDGNLVG
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHH
VVIGVLSVKQINALMTNDRHWEEAGLGRTGEVYLVGVNELLMRSPSRFLIQDPAAYFKAL
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEHHHHHHCCCCCCEEECHHHHHHHH
EATGVSSETLARIRHFDSPIMAQKVSTEATREGQKGRSDTQIVADYRGVSTLSSWGPVAV
HHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHCCCCCEE
QGLHWIVVAQQDEAEALAPVDGLRHSILVVAALAAVILTAISVALASVFTRPIQAVLAGV
CCEEEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTLAAGDESVRIPVKGRDEFADLARAFNAMANEIAERSARIEQKTVEYEQLLRNFYPDLI
HHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ADRIRNGEGAFSEHVRNVCVVVLIIEGFEGLVRGGSGETLERVNAVVGDLDELCTAGGLE
HHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCHH
KIRTIGETYMAACGLSTPRLDAAQRGLAFVEQVSGALDRLSRVYEVELSVRAGVALGDVE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEECCEE
VGIVGRHRMLYDVWGATMLEARRIVFDAEPGTVRVTEAVFQQLSVREGFEPKAEITLFDD
EEEECCHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHHHHHHHCCCCCCCEEEEECC
TPVATWQRPAAPAPAAESR
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHPPIHGQGVKNYYQSARYLPGGFMFGFLSIRSKVLAMLLICGIGCLVAASLVAMRSGTT
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TLKSSIFDQLTTLRTAKAAQVVNWFQDVSDDFSDISQDASTIAGIQAFSAAYLRAGVGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ATPTPELDAYYKDKFLPSFAMLVDAPLVPRGFLPASPAALRLQAAYVTRNANPVGTEGVS
CCCCCCCHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCHHHEEEEHEEECCCCCCCCCCCC
REDTGQPADSGLAAYDDAVARFQPFFRRAVETHALEDILLVDTRSGTIVYTVAKRTDLGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCCC
SLKSGSLSTSGAARAFSRVIEGGGVPGHTVLEDFSAYIPAGLRPSAFIAAPVFSDGNLVG
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHH
VVIGVLSVKQINALMTNDRHWEEAGLGRTGEVYLVGVNELLMRSPSRFLIQDPAAYFKAL
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEHHHHHHCCCCCCEEECHHHHHHHH
EATGVSSETLARIRHFDSPIMAQKVSTEATREGQKGRSDTQIVADYRGVSTLSSWGPVAV
HHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHCCCCCEE
QGLHWIVVAQQDEAEALAPVDGLRHSILVVAALAAVILTAISVALASVFTRPIQAVLAGV
CCEEEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTLAAGDESVRIPVKGRDEFADLARAFNAMANEIAERSARIEQKTVEYEQLLRNFYPDLI
HHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ADRIRNGEGAFSEHVRNVCVVVLIIEGFEGLVRGGSGETLERVNAVVGDLDELCTAGGLE
HHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCHH
KIRTIGETYMAACGLSTPRLDAAQRGLAFVEQVSGALDRLSRVYEVELSVRAGVALGDVE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEECCEE
VGIVGRHRMLYDVWGATMLEARRIVFDAEPGTVRVTEAVFQQLSVREGFEPKAEITLFDD
EEEECCHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHHHHHHHCCCCCCCEEEEECC
TPVATWQRPAAPAPAAESR
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]