Click here to switch to the map view.

The map label for this gene is cobH [H]

Identifier: 158425561

GI number: 158425561

Start: 4503324

End: 4503962

Strand: Direct

Name: cobH [H]

Synonym: AZC_3937

Alternate gene names: 158425561

Gene position: 4503324-4503962 (Clockwise)

Preceding gene: 158425560

Following gene: 158425562

Centisome position: 83.86

GC content: 71.05

Gene sequence:

>639_bases
GTGAGCCCCTCGCCTCTCGATTATGAGCGCGACGGCACGGCCATCTACGAACGCTCCTTCGCCATCATCCGCGCCGAGGC
CGACCTTTCCCGCTTCTCGGACGAGGAGGCGGATGTGGCCGTGCGCATGATCCATGCCTGCGGCCTTGTGGAAGCGGCGC
GCGATTTCGTGTTCGGTCCCGGCTTCGTGGCGGCGGCCCGCGCGGCGCTTCAGGCCGGCGCGCCCATCCTGTGCGATGCG
CAGATGGTGGCGCATGGCGTGACCCGCGCCCGGCTGCCCGCGAACAACGAAGTCATCTGCACCCTGCGCGATGAACGGGT
GCCGGCGCTCGCCGCCGAAATCGGCAACACCCGATCCGCCGCCGCGCTGGAACTCTGGCGGGAGCACATGGAGGGCGCCG
TGGTGGCCATCGGCAATGCGCCCACCGCCTTGTTCCATCTGTTCGAGATGCTGGATGCCGGCGCGCCGAAGCCCGCCGCC
ATCCTCGGCATGCCGGTGGGCTTCGTGGGCGCGGCGGAATCGAAGGATGCGCTGGCGGAAAACCCGCGCGGCGTGCCCTT
CGCCATCGTGCGCGGGCGGCTGGGCGGCAGCGCCATCACCGCCGCCGCCGTCAACGCACTCGCGAGGGCCGGGCTGTGA

Upstream 100 bases:

>100_bases
CCCACACGCCCGGCGCGCGCATGGTCGAGACGCTGGCGGCCCTGCCGTCCTCGTCGCTGGAGCCGTTGCTGTTGTCACCC
GCCGTGCTGGAGTCCACCCC

Downstream 100 bases:

>100_bases
ACGCCGCCATCGGACAGCTCATCGGCGTCGGCGTCGGCCCCGGCGATCCCGAACTCATGACGCTCAAGGCCGTGCGCGCG
CTGGAGCAGGCGGACGTGAT

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSPSPLDYERDGTAIYERSFAIIRAEADLSRFSDEEADVAVRMIHACGLVEAARDFVFGPGFVAAARAALQAGAPILCDA
QMVAHGVTRARLPANNEVICTLRDERVPALAAEIGNTRSAAALELWREHMEGAVVAIGNAPTALFHLFEMLDAGAPKPAA
ILGMPVGFVGAAESKDALAENPRGVPFAIVRGRLGGSAITAAAVNALARAGL

Sequences:

>Translated_212_residues
MSPSPLDYERDGTAIYERSFAIIRAEADLSRFSDEEADVAVRMIHACGLVEAARDFVFGPGFVAAARAALQAGAPILCDA
QMVAHGVTRARLPANNEVICTLRDERVPALAAEIGNTRSAAALELWREHMEGAVVAIGNAPTALFHLFEMLDAGAPKPAA
ILGMPVGFVGAAESKDALAENPRGVPFAIVRGRLGGSAITAAAVNALARAGL
>Mature_211_residues
SPSPLDYERDGTAIYERSFAIIRAEADLSRFSDEEADVAVRMIHACGLVEAARDFVFGPGFVAAARAALQAGAPILCDAQ
MVAHGVTRARLPANNEVICTLRDERVPALAAEIGNTRSAAALELWREHMEGAVVAIGNAPTALFHLFEMLDAGAPKPAAI
LGMPVGFVGAAESKDALAENPRGVPFAIVRGRLGGSAITAAAVNALARAGL

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 22073; Mature: 21942

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSPLDYERDGTAIYERSFAIIRAEADLSRFSDEEADVAVRMIHACGLVEAARDFVFGP
CCCCCCCCCCCCCEEEECCEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GFVAAARAALQAGAPILCDAQMVAHGVTRARLPANNEVICTLRDERVPALAAEIGNTRSA
CHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCHH
AALELWREHMEGAVVAIGNAPTALFHLFEMLDAGAPKPAAILGMPVGFVGAAESKDALAE
HHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHC
NPRGVPFAIVRGRLGGSAITAAAVNALARAGL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPSPLDYERDGTAIYERSFAIIRAEADLSRFSDEEADVAVRMIHACGLVEAARDFVFGP
CCCCCCCCCCCCEEEECCEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GFVAAARAALQAGAPILCDAQMVAHGVTRARLPANNEVICTLRDERVPALAAEIGNTRSA
CHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCHH
AALELWREHMEGAVVAIGNAPTALFHLFEMLDAGAPKPAAILGMPVGFVGAAESKDALAE
HHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHC
NPRGVPFAIVRGRLGGSAITAAAVNALARAGL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]