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The map label for this gene is coaBC [H]

Identifier: 158425537

GI number: 158425537

Start: 4472848

End: 4474050

Strand: Reverse

Name: coaBC [H]

Synonym: AZC_3913

Alternate gene names: 158425537

Gene position: 4474050-4472848 (Counterclockwise)

Preceding gene: 158425538

Following gene: 158425536

Centisome position: 83.32

GC content: 70.49

Gene sequence:

>1203_bases
ATGCTGCACGATCGCCGCATCCTTCTGATCATCGGCGGCGGGATCGCCGCCTATAAGTGCCTCGATCTGATCCGCCGCCT
GAAGGAGCGCGGCGCCAGCGTGCGCGCCATCATGACCTCGGCCGCCCAGCATTTCGTGACGCCCCTTTCGGTCGGCGCAC
TGACCGGCGAGCGGGTGTTCACGGACCTGTTCGACCTCACGGCCGAGCACGACATCGGCCATATCCGCCTCTCGCGGGAG
GCCGATCTCGTGGTGGTTGCCCCCGCCACCGCCGATCTCATGGCCAAGGCGGCCAACGGCCTTGCGGATGATCTCGCTTC
CACCGCGCTGCTCGCCACCGACAAGCCGGTGCTGTTCGCCCCGGCCATGAACCCGCGCATGTGGAGCCATCCGGCCACCC
GGCGCAATCTGGCGCTGCTGAAGGAAGACGGCGCCGCCATCGTCGGCCCCAATGCCGGCGCCATGGCCGAGCGGGGCGAG
TTCGGCGAGGGCCGGATGGCCGAGCCGCTGGAAATCCTCGCCGCCATCGAGGCGCGCTTCGAAACCCACCCGCAACTGCT
CAAGGGACGGCGGCTCCTGGTCACCTCCGGGCCGACGGTCGAGCCCATCGATCCGGTGCGCTATATCGCCAACCGGTCTT
CCGGCAAGCAGGGCCACGCCATCGCGGCGGCGGCGGCGGCGGCCGGGGCGGAGGTGGTGCTGGTCTCCGGCCCGGTGCAG
GTGCCCGATCCCCGCGGCGTCACCGTCATCCATGTGGAGCGGGCGCGGGAGATGCTGGCGGCGGTGGAGGAGCATCTGCC
GGTGGATGCCGCCGTCTTCGCCGCGGCGGTGGCCGACTGGCGTGTGGCCGGCGAGGCGGACCAGAAGATCAAGAAGGGGC
CGCAAGGCACGCCCGATCTCCAGCTCACCGAGAATCCGGACATCCTTGCCACCATCTCGCACCATTCCACCCTGCGGCCC
CGTCTCGTGGTGGGCTTTGCCGCCGAGACGGAGAATGTGGTGCCGAACGCCCGCGACAAGCGCCTGCGCAAGGGCTGCGA
CTGGATCGTCGCCAATGACGTCTCGCCCGCCACCGGCATCATGGGCGGGGATGCCAATACGGTGCATCTCGTCACCGGCG
AGGGCGTGGAGGACTGGCCCTCCGCCAGCAAGGCGGAGGTGGCCCGCCGCCTCGTCGCCCGCATCGCCGGGGCGCTGGCC
TGA

Upstream 100 bases:

>100_bases
ATCCAGCCCTTTGCCGCCGGGTGCGCCTGAACGCGAATTCCGGTAGAGGACTGCCTGTGCCCGATGTGCGCATCGGGCCG
GCGCCGCGAGGGAGACCGCC

Downstream 100 bases:

>100_bases
CGGTGCCGCATTTGCGCCTCACGTGTCTTTAGGGTCACCGAAACCTCCCGGTGGGATGATGCCCGCCGGCCGCAGCGCCT
GCCGCCTTCAAGGACCCCCG

Product: DNA/pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLHDRRILLIIGGGIAAYKCLDLIRRLKERGASVRAIMTSAAQHFVTPLSVGALTGERVFTDLFDLTAEHDIGHIRLSRE
ADLVVVAPATADLMAKAANGLADDLASTALLATDKPVLFAPAMNPRMWSHPATRRNLALLKEDGAAIVGPNAGAMAERGE
FGEGRMAEPLEILAAIEARFETHPQLLKGRRLLVTSGPTVEPIDPVRYIANRSSGKQGHAIAAAAAAAGAEVVLVSGPVQ
VPDPRGVTVIHVERAREMLAAVEEHLPVDAAVFAAAVADWRVAGEADQKIKKGPQGTPDLQLTENPDILATISHHSTLRP
RLVVGFAAETENVVPNARDKRLRKGCDWIVANDVSPATGIMGGDANTVHLVTGEGVEDWPSASKAEVARRLVARIAGALA

Sequences:

>Translated_400_residues
MLHDRRILLIIGGGIAAYKCLDLIRRLKERGASVRAIMTSAAQHFVTPLSVGALTGERVFTDLFDLTAEHDIGHIRLSRE
ADLVVVAPATADLMAKAANGLADDLASTALLATDKPVLFAPAMNPRMWSHPATRRNLALLKEDGAAIVGPNAGAMAERGE
FGEGRMAEPLEILAAIEARFETHPQLLKGRRLLVTSGPTVEPIDPVRYIANRSSGKQGHAIAAAAAAAGAEVVLVSGPVQ
VPDPRGVTVIHVERAREMLAAVEEHLPVDAAVFAAAVADWRVAGEADQKIKKGPQGTPDLQLTENPDILATISHHSTLRP
RLVVGFAAETENVVPNARDKRLRKGCDWIVANDVSPATGIMGGDANTVHLVTGEGVEDWPSASKAEVARRLVARIAGALA
>Mature_400_residues
MLHDRRILLIIGGGIAAYKCLDLIRRLKERGASVRAIMTSAAQHFVTPLSVGALTGERVFTDLFDLTAEHDIGHIRLSRE
ADLVVVAPATADLMAKAANGLADDLASTALLATDKPVLFAPAMNPRMWSHPATRRNLALLKEDGAAIVGPNAGAMAERGE
FGEGRMAEPLEILAAIEARFETHPQLLKGRRLLVTSGPTVEPIDPVRYIANRSSGKQGHAIAAAAAAAGAEVVLVSGPVQ
VPDPRGVTVIHVERAREMLAAVEEHLPVDAAVFAAAVADWRVAGEADQKIKKGPQGTPDLQLTENPDILATISHHSTLRP
RLVVGFAAETENVVPNARDKRLRKGCDWIVANDVSPATGIMGGDANTVHLVTGEGVEDWPSASKAEVARRLVARIAGALA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87082301, Length=397, Percent_Identity=47.6070528967254, Blast_Score=288, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17560194, Length=143, Percent_Identity=35.6643356643357, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=197, Percent_Identity=28.4263959390863, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24657262, Length=192, Percent_Identity=31.25, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42330; Mature: 42330

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHDRRILLIIGGGIAAYKCLDLIRRLKERGASVRAIMTSAAQHFVTPLSVGALTGERVF
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHH
TDLFDLTAEHDIGHIRLSREADLVVVAPATADLMAKAANGLADDLASTALLATDKPVLFA
HHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCHHHHHHHHEEEECCCCEEEE
PAMNPRMWSHPATRRNLALLKEDGAAIVGPNAGAMAERGEFGEGRMAEPLEILAAIEARF
CCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ETHPQLLKGRRLLVTSGPTVEPIDPVRYIANRSSGKQGHAIAAAAAAAGAEVVLVSGPVQ
CCCHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEECCEE
VPDPRGVTVIHVERAREMLAAVEEHLPVDAAVFAAAVADWRVAGEADQKIKKGPQGTPDL
CCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCE
QLTENPDILATISHHSTLRPRLVVGFAAETENVVPNARDKRLRKGCDWIVANDVSPATGI
EEECCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCE
MGGDANTVHLVTGEGVEDWPSASKAEVARRLVARIAGALA
ECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLHDRRILLIIGGGIAAYKCLDLIRRLKERGASVRAIMTSAAQHFVTPLSVGALTGERVF
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHH
TDLFDLTAEHDIGHIRLSREADLVVVAPATADLMAKAANGLADDLASTALLATDKPVLFA
HHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCHHHHHHHHEEEECCCCEEEE
PAMNPRMWSHPATRRNLALLKEDGAAIVGPNAGAMAERGEFGEGRMAEPLEILAAIEARF
CCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ETHPQLLKGRRLLVTSGPTVEPIDPVRYIANRSSGKQGHAIAAAAAAAGAEVVLVSGPVQ
CCCHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEECCEE
VPDPRGVTVIHVERAREMLAAVEEHLPVDAAVFAAAVADWRVAGEADQKIKKGPQGTPDL
CCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCE
QLTENPDILATISHHSTLRPRLVVGFAAETENVVPNARDKRLRKGCDWIVANDVSPATGI
EEECCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCE
MGGDANTVHLVTGEGVEDWPSASKAEVARRLVARIAGALA
ECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA