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The map label for this gene is guaA [H]

Identifier: 158425329

GI number: 158425329

Start: 4250073

End: 4251620

Strand: Direct

Name: guaA [H]

Synonym: AZC_3705

Alternate gene names: 158425329

Gene position: 4250073-4251620 (Clockwise)

Preceding gene: 158425327

Following gene: 158425335

Centisome position: 79.15

GC content: 67.38

Gene sequence:

>1548_bases
ATGCACGACACCGTCCTCATCATCGATTTCGGCAGCCAGGTCACGCAGCTGATCGCGCGCCGGGTGCGCGAGGAAGGCGT
CTATTCGGAAGTCGTGCCCTTCCAGAAGGCCGCCGAGGCCATGGATCGGCTGAAGCCCCGCGCCGTCATCCTCTCCGGCG
GCCCGGCTTCCGTGATCGAGGGCGAGAGCCCGCGCGCCCCGCAGGCGGTGTTCGAGGCCGGCATTCCGGTGCTCGGCATC
TGCTATGGCGAGCAGGCCATGGCCGACCAGCTCGGCGGCAAGGTGGAAGCCGGGCACCATCGCGAATTCGGCCGCGCCGA
GGTGGAAGTGGTGAAGCCCGCCGCCCTGTTCGAGGGCGTGTGGCAGGAAGGCCAGCGCTATCTCGTCTGGATGAGCCATG
GCGACCGCGTCACCCAGCTGCCCGCCGGCTTCGAGGTGATCGCCCAGTCCGAGAACGCGCCGTTTGCCGCCATCGCGGAC
GAGAGCCGCAAGTTCTACGGCGTGCAGTTCCACCCCGAGGTGGTACACACGCCGCAAGGCGCCCAGCTGCTGCGCAATTT
CGTGCGCAAGGTGGCCGGCCTCCAGGGCGATTGGACCATGGGCGCCTTCCGCGAGGAATCCATCCGGAAGATCCGCGCCC
AGGTGGGCGACAAGCGCGTGCTCTGCGGCCTCTCCGGCGGCGTCGATTCCGCCGTGGCGGCGGTGCTCATCCACGAGGCC
ATCGGCGACCAGCTGACCTGCGTGTTCGTGGACCACGGCCTGATGCGCCTCGGCGAGGCCGAGCAGGTGGTCTCGCTCTT
CCGCAACACCTACAACATCCCGCTGGTGCACGTGGATGCGTCCGAGCTGTTCCTGAAGGAACTGGACGGCGTTTCGGACC
CCGAGAAGAAGCGCAAGACCATCGGCAAGCTCTTCATCGACGTGTTCGAGGCCGAGGCCAAGAAGATCGGTGGCGCCGAT
TTCCTCGCCCAGGGTACGCTCTATCCGGACGTGATCGAGAGCGTCTCCTTCACCGGCGGCCCCTCCGTCACCATCAAGTC
GCACCACAATGTGGGCGGTCTTCCTGAGCGTATGAACATGAAGCTCGTCGAGCCGCTGCGCGAGCTGTTCAAGGACGAGG
TGCGCGCGCTCGGCCGCGAGCTCGGCCTGCCGGAGAGCTTCGTCGGCCGGCACCCCTTCCCCGGCCCTGGCCTTGCCATC
CGCTGCCCCGGCGAGATCACCCCCGAAAAGCTGGAAATCCTGCGCCAGGCGGACGCCATCTATCTGGAAGAGATCCGCGC
CGCCGGCCTCTATGACGTGATCTGGCAGGCCTTTGCCGTGCTGCTGCCGGTGCGCACCGTGGGCGTGATGGGCGACGGCC
GCACCTACGACCACGTGCTGGCCCTGCGAGCCGTCACCTCCATCGACGGCATGACGGCCGACTTCTACCCCTTCCAGATG
GACTTCCTCGGCCGCGCCGCCACCCGCATCATCAACGAGGTGCGCGGCATCAACCGCGTGGTCTACGACGTGACCTCGAA
GCCCCCGGGCACGATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
AGCGGCGCGCAGACCTGATGCGATACCGCCCGGCTTTTGTCGCCAGAACTTTCCCGCTAAAGGAAGCGCTCGAACGCCCC
CTTGCGCCGGAAAGCCCCTC

Downstream 100 bases:

>100_bases
TCGAGGATTTATTTTTCGCGATCCGGGTGCGTGCAAGTCGATCGGTGTCGTGACAGCGTCCATTCAGGGCCGTCAGGAGC
TACAGCTTCTGGCGGTCCTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MHDTVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKAAEAMDRLKPRAVILSGGPASVIEGESPRAPQAVFEAGIPVLGI
CYGEQAMADQLGGKVEAGHHREFGRAEVEVVKPAALFEGVWQEGQRYLVWMSHGDRVTQLPAGFEVIAQSENAPFAAIAD
ESRKFYGVQFHPEVVHTPQGAQLLRNFVRKVAGLQGDWTMGAFREESIRKIRAQVGDKRVLCGLSGGVDSAVAAVLIHEA
IGDQLTCVFVDHGLMRLGEAEQVVSLFRNTYNIPLVHVDASELFLKELDGVSDPEKKRKTIGKLFIDVFEAEAKKIGGAD
FLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRALGRELGLPESFVGRHPFPGPGLAI
RCPGEITPEKLEILRQADAIYLEEIRAAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSIDGMTADFYPFQM
DFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_515_residues
MHDTVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKAAEAMDRLKPRAVILSGGPASVIEGESPRAPQAVFEAGIPVLGI
CYGEQAMADQLGGKVEAGHHREFGRAEVEVVKPAALFEGVWQEGQRYLVWMSHGDRVTQLPAGFEVIAQSENAPFAAIAD
ESRKFYGVQFHPEVVHTPQGAQLLRNFVRKVAGLQGDWTMGAFREESIRKIRAQVGDKRVLCGLSGGVDSAVAAVLIHEA
IGDQLTCVFVDHGLMRLGEAEQVVSLFRNTYNIPLVHVDASELFLKELDGVSDPEKKRKTIGKLFIDVFEAEAKKIGGAD
FLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRALGRELGLPESFVGRHPFPGPGLAI
RCPGEITPEKLEILRQADAIYLEEIRAAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSIDGMTADFYPFQM
DFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_515_residues
MHDTVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKAAEAMDRLKPRAVILSGGPASVIEGESPRAPQAVFEAGIPVLGI
CYGEQAMADQLGGKVEAGHHREFGRAEVEVVKPAALFEGVWQEGQRYLVWMSHGDRVTQLPAGFEVIAQSENAPFAAIAD
ESRKFYGVQFHPEVVHTPQGAQLLRNFVRKVAGLQGDWTMGAFREESIRKIRAQVGDKRVLCGLSGGVDSAVAAVLIHEA
IGDQLTCVFVDHGLMRLGEAEQVVSLFRNTYNIPLVHVDASELFLKELDGVSDPEKKRKTIGKLFIDVFEAEAKKIGGAD
FLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRALGRELGLPESFVGRHPFPGPGLAI
RCPGEITPEKLEILRQADAIYLEEIRAAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSIDGMTADFYPFQM
DFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=38.0692167577413, Blast_Score=310, Evalue=3e-84,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=56.9767441860465, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1789760, Length=152, Percent_Identity=32.8947368421053, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787517, Length=186, Percent_Identity=27.4193548387097, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=38.353765323993, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71992717, Length=571, Percent_Identity=38.353765323993, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=38.353765323993, Blast_Score=315, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=53.7284894837476, Blast_Score=552, Evalue=1e-158,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=36.9090909090909, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56548; Mature: 56548

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDTVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKAAEAMDRLKPRAVILSGGPASVIE
CCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCCC
GESPRAPQAVFEAGIPVLGICYGEQAMADQLGGKVEAGHHREFGRAEVEVVKPAALFEGV
CCCCCCCHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHHH
WQEGQRYLVWMSHGDRVTQLPAGFEVIAQSENAPFAAIADESRKFYGVQFHPEVVHTPQG
HHCCCEEEEEEECCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEEEECCCCEECCCH
AQLLRNFVRKVAGLQGDWTMGAFREESIRKIRAQVGDKRVLCGLSGGVDSAVAAVLIHEA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
IGDQLTCVFVDHGLMRLGEAEQVVSLFRNTYNIPLVHVDASELFLKELDGVSDPEKKRKT
HCCCEEEEEECCHHHHCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHH
IGKLFIDVFEAEAKKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNM
HHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCHHCCH
KLVEPLRELFKDEVRALGRELGLPESFVGRHPFPGPGLAIRCPGEITPEKLEILRQADAI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YLEEIRAAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSIDGMTADFYPFQM
HHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
DFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure
MHDTVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKAAEAMDRLKPRAVILSGGPASVIE
CCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCCC
GESPRAPQAVFEAGIPVLGICYGEQAMADQLGGKVEAGHHREFGRAEVEVVKPAALFEGV
CCCCCCCHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHHH
WQEGQRYLVWMSHGDRVTQLPAGFEVIAQSENAPFAAIADESRKFYGVQFHPEVVHTPQG
HHCCCEEEEEEECCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEEEECCCCEECCCH
AQLLRNFVRKVAGLQGDWTMGAFREESIRKIRAQVGDKRVLCGLSGGVDSAVAAVLIHEA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
IGDQLTCVFVDHGLMRLGEAEQVVSLFRNTYNIPLVHVDASELFLKELDGVSDPEKKRKT
HCCCEEEEEECCHHHHCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHH
IGKLFIDVFEAEAKKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNM
HHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCHHCCH
KLVEPLRELFKDEVRALGRELGLPESFVGRHPFPGPGLAIRCPGEITPEKLEILRQADAI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YLEEIRAAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSIDGMTADFYPFQM
HHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
DFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA