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The map label for this gene is rnd [H]

Identifier: 158425285

GI number: 158425285

Start: 4210071

End: 4211222

Strand: Direct

Name: rnd [H]

Synonym: AZC_3661

Alternate gene names: 158425285

Gene position: 4210071-4211222 (Clockwise)

Preceding gene: 158425284

Following gene: 158425291

Centisome position: 78.4

GC content: 67.36

Gene sequence:

>1152_bases
ATGGACCCGATCACCTCCACGGAGGCCCTGGCAGCCGCCTGCGAGCGCCTCTCCCGCCACGACTTCGTCACTGTCGACAC
CGAGTTCCTGCGTGAGACGACCTTCTGGCCGAAGCTCTGCGTGATTCAGGTGGCCAGCGTCGACGAGGCCATCATCATCG
ATGCCCTCGCGGAAGGGCTGGACCTCGCGCCTTTCTTCGCCCTGATGGGCAATGAGAAGGTGAAGAAGGTGTTCCATGCC
GGCCGGCAGGACATCGAGATCGTCTGGCATCTGGCGGAGATCATCCCCCATCCGGTGTTCGACACCCAAGTGGCGGCCAT
GGTGCTCGGCTATGGCGACAGCATCTCCTATGACCAGCTGGTGCAGCGGATCACCGGCCACGCCATCGACAAGTCCTCCC
GCTTCACCGACTGGTCGCGCCGGCCGCTCTCGCAGGCCCAGCTTACCTATGCGGTCGCCGACGTCACGCACCTGCGCGAT
GTCTACAAGAAGCTGATGGAGGATCTGGAGAGCCGCGGCCGGGCCGACTGGATGGGCGAGGAGATGAACATCCTCACCTC
TCCCAGCACCTATCGCCAAGACCCCGAGACCGCCTACGAGCGGCTGAAATCCCGGGTGCGCAAGCCGCGTGAACTGGCAG
TCCTCGCCGAGGTCGCCGCCTGGCGCGAGCGCGAGGCGCAGGCCCGCGACCTGCCGCGCGGGCGCATCATCAAGGACGAG
GTGATCGGCGAGATCGCCGTTCAGCAGCCGCAGACCGCCGAGAAGCTGGCCGAACTGCGCTCGCTGCCCAAGGGCTTCGA
GCGCTCGCGCTATGGCGAGGCGGTGCTGGAAGCGGTCAAGAAGGGCGTGGCCCGCGATCCCAAGACCCTGCCCCGCATCG
AGCGCGACAAGCCGCTGCCGAACGGCGCTGCCGCCACCGTCGAACTGCTCAAGGTGCTGCTGCGCATGACTGCCGAGCAG
AATGCGGTGGCCGCCAAGGTGATCGCCACCACCGACGACCTCGAGCGGATCGCCGTCGACGACGAGGCTCCCGTCCCCGC
CCTCTCCGGCTGGCGGCGGGAACTGTTCGGTGAACGGGCGCTAGCCCTCAAGGCCGGTCGCCTTGCCCTCGCCGTCGACC
GCGGCAAGGTCATCGCCGTCGAGCGGGATTGA

Upstream 100 bases:

>100_bases
GCGCCACCGAGGCGCGGGACATGTCCTTCCAGGCCGTAAGCTGAGCGGCACATCATTCAGGCTCTTTCGCGGCAAGCTAG
GCTTCTTTATGGTGGCCGCC

Downstream 100 bases:

>100_bases
GTCCCGACGGCCGACCCAGCCATCAGTCGCTCGTGATCATCACCTCGGGAAAGGTGTCGGGCTCTTCCAGATCGAGCCCG
TCCTCTTCCGCCAGCGGAAC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MDPITSTEALAAACERLSRHDFVTVDTEFLRETTFWPKLCVIQVASVDEAIIIDALAEGLDLAPFFALMGNEKVKKVFHA
GRQDIEIVWHLAEIIPHPVFDTQVAAMVLGYGDSISYDQLVQRITGHAIDKSSRFTDWSRRPLSQAQLTYAVADVTHLRD
VYKKLMEDLESRGRADWMGEEMNILTSPSTYRQDPETAYERLKSRVRKPRELAVLAEVAAWREREAQARDLPRGRIIKDE
VIGEIAVQQPQTAEKLAELRSLPKGFERSRYGEAVLEAVKKGVARDPKTLPRIERDKPLPNGAAATVELLKVLLRMTAEQ
NAVAAKVIATTDDLERIAVDDEAPVPALSGWRRELFGERALALKAGRLALAVDRGKVIAVERD

Sequences:

>Translated_383_residues
MDPITSTEALAAACERLSRHDFVTVDTEFLRETTFWPKLCVIQVASVDEAIIIDALAEGLDLAPFFALMGNEKVKKVFHA
GRQDIEIVWHLAEIIPHPVFDTQVAAMVLGYGDSISYDQLVQRITGHAIDKSSRFTDWSRRPLSQAQLTYAVADVTHLRD
VYKKLMEDLESRGRADWMGEEMNILTSPSTYRQDPETAYERLKSRVRKPRELAVLAEVAAWREREAQARDLPRGRIIKDE
VIGEIAVQQPQTAEKLAELRSLPKGFERSRYGEAVLEAVKKGVARDPKTLPRIERDKPLPNGAAATVELLKVLLRMTAEQ
NAVAAKVIATTDDLERIAVDDEAPVPALSGWRRELFGERALALKAGRLALAVDRGKVIAVERD
>Mature_383_residues
MDPITSTEALAAACERLSRHDFVTVDTEFLRETTFWPKLCVIQVASVDEAIIIDALAEGLDLAPFFALMGNEKVKKVFHA
GRQDIEIVWHLAEIIPHPVFDTQVAAMVLGYGDSISYDQLVQRITGHAIDKSSRFTDWSRRPLSQAQLTYAVADVTHLRD
VYKKLMEDLESRGRADWMGEEMNILTSPSTYRQDPETAYERLKSRVRKPRELAVLAEVAAWREREAQARDLPRGRIIKDE
VIGEIAVQQPQTAEKLAELRSLPKGFERSRYGEAVLEAVKKGVARDPKTLPRIERDKPLPNGAAATVELLKVLLRMTAEQ
NAVAAKVIATTDDLERIAVDDEAPVPALSGWRRELFGERALALKAGRLALAVDRGKVIAVERD

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=258, Percent_Identity=24.4186046511628, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI50301240, Length=258, Percent_Identity=24.4186046511628, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788105, Length=371, Percent_Identity=30.188679245283, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17531757, Length=241, Percent_Identity=28.2157676348548, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=265, Percent_Identity=25.2830188679245, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078302, Length=252, Percent_Identity=25.3968253968254, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42869; Mature: 42869

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPITSTEALAAACERLSRHDFVTVDTEFLRETTFWPKLCVIQVASVDEAIIIDALAEGL
CCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCCHHHHEEECCCCHHHHHHHHHCCC
DLAPFFALMGNEKVKKVFHAGRQDIEIVWHLAEIIPHPVFDTQVAAMVLGYGDSISYDQL
CHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHH
VQRITGHAIDKSSRFTDWSRRPLSQAQLTYAVADVTHLRDVYKKLMEDLESRGRADWMGE
HHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EMNILTSPSTYRQDPETAYERLKSRVRKPRELAVLAEVAAWREREAQARDLPRGRIIKDE
CCCEEECCCHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
VIGEIAVQQPQTAEKLAELRSLPKGFERSRYGEAVLEAVKKGVARDPKTLPRIERDKPLP
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NGAAATVELLKVLLRMTAEQNAVAAKVIATTDDLERIAVDDEAPVPALSGWRRELFGERA
CCHHHHHHHHHHHHHHHCCCCHHHHHHEECHHHHHHHCCCCCCCCCHHHHHHHHHHCCHH
LALKAGRLALAVDRGKVIAVERD
HHHCCCCEEEEECCCCEEEEECC
>Mature Secondary Structure
MDPITSTEALAAACERLSRHDFVTVDTEFLRETTFWPKLCVIQVASVDEAIIIDALAEGL
CCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCCHHHHEEECCCCHHHHHHHHHCCC
DLAPFFALMGNEKVKKVFHAGRQDIEIVWHLAEIIPHPVFDTQVAAMVLGYGDSISYDQL
CHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHH
VQRITGHAIDKSSRFTDWSRRPLSQAQLTYAVADVTHLRDVYKKLMEDLESRGRADWMGE
HHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EMNILTSPSTYRQDPETAYERLKSRVRKPRELAVLAEVAAWREREAQARDLPRGRIIKDE
CCCEEECCCHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
VIGEIAVQQPQTAEKLAELRSLPKGFERSRYGEAVLEAVKKGVARDPKTLPRIERDKPLP
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NGAAATVELLKVLLRMTAEQNAVAAKVIATTDDLERIAVDDEAPVPALSGWRRELFGERA
CCHHHHHHHHHHHHHHHCCCCHHHHHHEECHHHHHHHCCCCCCCCCHHHHHHHHHHCCHH
LALKAGRLALAVDRGKVIAVERD
HHHCCCCEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]