Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 158425253

GI number: 158425253

Start: 4166072

End: 4167544

Strand: Direct

Name: zwf [H]

Synonym: AZC_3629

Alternate gene names: 158425253

Gene position: 4166072-4167544 (Clockwise)

Preceding gene: 158425252

Following gene: 158425254

Centisome position: 77.58

GC content: 67.41

Gene sequence:

>1473_bases
ATGGTTGCTCGCGTCATAACCGTGGATCCGTTTGACATCGTGGTGTTCGGCGCCACTGGGGATCTGGCGAAACGCAAGCT
GCTGCCGGCCCTCTATGAGCGCGACCTCGCCGGGCAGATCCCGCCCGACGCGCGCATCATCGGCGTCTCCCGTCGTCCCA
TGTCGCGGGGCGAGTTCCAGGAACTGGCCCGCGATTCGGTGGAGGATCGCGACGGCATCGACACCATCGAGGCCCAGCGC
CTCGCCCGCTTCCTCGACCGCGTGGACTACGTGGCGGTAGATGCGGTCTCCGACGAAGGCTGGACCGACCTGAAGGCGCG
CCTCTCCGAAGGCGGCGACCGGGTGCGCGTGTTCTATCTCGCGGTGGGGCCGGACCTCTTCGACGACATCTGCAGCCGCA
TCGGCGCCCATGGCCTCGTCACGCCCCAGAGCCGCGTGGTGGTGGAAAAGCCGGTGGGCAAGAATCTCGCCTCGGCCCGC
AAGGTCAATGAGGCGGTGGGCCGGGTCTTCCCGGAAGACTCGATCTTCCGCATCGACCACTATCTCGGCAAGGAGACGGT
GCAGAACCTGATGGCGCTGCGCTTCGCCAATGCCCTGTTCGAGCCGGTGTGGAACAACGCCCATATCGACCATGTGCAGA
TCACGGTAGCCGAGAGCATCGGCACCGCCGGACGCGCGGGCTATTACGACACCGCCGGCGCCCTGCGCGACATGGTGCAG
AACCACATCCTCCAGCTGCTCTGCCTTGTGGCCATGGAGCCGCCCGTCTCCATGGATGCGGACGCGGTGCGCGACGAGAA
GCTGAAGGTGCTGAAGGCCCTCGTGCCCATCGACGAGCGCAGCGCCCCGCATCTCACCGTGCGCGGCCAGTATCGCTCCG
GCGCCTCGGCCGGTGGAGCGGTGCCGGGCTATCTCGAAGAACTCGGATCGCCCGAGAGCGACACCGAGACCTTCGTCGCC
CTGCGCGCGGAAATCGCCAACTGGCGCTGGGCCGGCGTGCCCTTCTATCTGCGCACCGGCAAGCGCCTGCCCTCCCGCGT
CTCGGAAATCGTCGTTGCCTTCCGGCCCATTCCGCATTCCGTCTTCGACGGGCAGGCGGGGCCGATCATGGCGAACCGCC
TCGTCATCCGCCTCCAGCCGGACGAGGGCGTGAAGCTGTGGCTGATGATCAAGGATCCCGGCCCGGGCGGCATGCGCCTC
CAGCACGTGCCGCTCGACATGAGCTTCGCCGAGGCCTTCGGCGTGCGCAATCCGGACGCCTACGAGCGGCTGCTGATGGA
TGTGGTGCGCGGCAACCAGACCCTGTTCATGCGCCGCGACGAAGTGGAAGCGGCGTGGAAATGGATCGATCCGATCCTTG
AGGCCTGGCGCAATTCCCACGAGCCGCCCAAGCCCTATACGGCCGGCACCTGGGGGCCCTCCGCCTCCATCGCGCTGATC
GAGCGCGACGGCCGCACCTGGATGGACGACTGA

Upstream 100 bases:

>100_bases
TAACGTTCCCGCCCGATGGTCGCATCATCGACGCGAAGGATTTGCTAGAAGGGTCCTTTGACGACGGTGTTCGGCCTTGG
GCCGGGTCTGGAGAGTTGAG

Downstream 100 bases:

>100_bases
CGCCTGCCGCGTGACCCCGGCTCCGGCCGGGGACCGCCCTGCCCTTCCGGCCCCGCACTGGAGCCCGCCATGACCGAAAC
CGCACCGGGCGAGCTGCTGC

Product: glucose-6-phosphate dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MVARVITVDPFDIVVFGATGDLAKRKLLPALYERDLAGQIPPDARIIGVSRRPMSRGEFQELARDSVEDRDGIDTIEAQR
LARFLDRVDYVAVDAVSDEGWTDLKARLSEGGDRVRVFYLAVGPDLFDDICSRIGAHGLVTPQSRVVVEKPVGKNLASAR
KVNEAVGRVFPEDSIFRIDHYLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSMDADAVRDEKLKVLKALVPIDERSAPHLTVRGQYRSGASAGGAVPGYLEELGSPESDTETFVA
LRAEIANWRWAGVPFYLRTGKRLPSRVSEIVVAFRPIPHSVFDGQAGPIMANRLVIRLQPDEGVKLWLMIKDPGPGGMRL
QHVPLDMSFAEAFGVRNPDAYERLLMDVVRGNQTLFMRRDEVEAAWKWIDPILEAWRNSHEPPKPYTAGTWGPSASIALI
ERDGRTWMDD

Sequences:

>Translated_490_residues
MVARVITVDPFDIVVFGATGDLAKRKLLPALYERDLAGQIPPDARIIGVSRRPMSRGEFQELARDSVEDRDGIDTIEAQR
LARFLDRVDYVAVDAVSDEGWTDLKARLSEGGDRVRVFYLAVGPDLFDDICSRIGAHGLVTPQSRVVVEKPVGKNLASAR
KVNEAVGRVFPEDSIFRIDHYLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSMDADAVRDEKLKVLKALVPIDERSAPHLTVRGQYRSGASAGGAVPGYLEELGSPESDTETFVA
LRAEIANWRWAGVPFYLRTGKRLPSRVSEIVVAFRPIPHSVFDGQAGPIMANRLVIRLQPDEGVKLWLMIKDPGPGGMRL
QHVPLDMSFAEAFGVRNPDAYERLLMDVVRGNQTLFMRRDEVEAAWKWIDPILEAWRNSHEPPKPYTAGTWGPSASIALI
ERDGRTWMDD
>Mature_490_residues
MVARVITVDPFDIVVFGATGDLAKRKLLPALYERDLAGQIPPDARIIGVSRRPMSRGEFQELARDSVEDRDGIDTIEAQR
LARFLDRVDYVAVDAVSDEGWTDLKARLSEGGDRVRVFYLAVGPDLFDDICSRIGAHGLVTPQSRVVVEKPVGKNLASAR
KVNEAVGRVFPEDSIFRIDHYLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSMDADAVRDEKLKVLKALVPIDERSAPHLTVRGQYRSGASAGGAVPGYLEELGSPESDTETFVA
LRAEIANWRWAGVPFYLRTGKRLPSRVSEIVVAFRPIPHSVFDGQAGPIMANRLVIRLQPDEGVKLWLMIKDPGPGGMRL
QHVPLDMSFAEAFGVRNPDAYERLLMDVVRGNQTLFMRRDEVEAAWKWIDPILEAWRNSHEPPKPYTAGTWGPSASIALI
ERDGRTWMDD

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=38.3196721311475, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=38.5567010309278, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI52145310, Length=491, Percent_Identity=31.1608961303462, Blast_Score=192, Evalue=7e-49,
Organism=Escherichia coli, GI1788158, Length=484, Percent_Identity=50.4132231404959, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=36.7556468172485, Blast_Score=322, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=37.1369294605809, Blast_Score=292, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24643350, Length=480, Percent_Identity=36.6666666666667, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24643352, Length=480, Percent_Identity=36.6666666666667, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI221513548, Length=498, Percent_Identity=29.9196787148594, Blast_Score=209, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54437; Mature: 54437

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVARVITVDPFDIVVFGATGDLAKRKLLPALYERDLAGQIPPDARIIGVSRRPMSRGEFQ
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHH
ELARDSVEDRDGIDTIEAQRLARFLDRVDYVAVDAVSDEGWTDLKARLSEGGDRVRVFYL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEE
AVGPDLFDDICSRIGAHGLVTPQSRVVVEKPVGKNLASARKVNEAVGRVFPEDSIFRIDH
EECCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEHHHH
YLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHCCCCCCCCCCCHHHHHHHHHH
NHILQLLCLVAMEPPVSMDADAVRDEKLKVLKALVPIDERSAPHLTVRGQYRSGASAGGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCC
VPGYLEELGSPESDTETFVALRAEIANWRWAGVPFYLRTGKRLPSRVSEIVVAFRPIPHS
CCHHHHHCCCCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHCCCCCH
VFDGQAGPIMANRLVIRLQPDEGVKLWLMIKDPGPGGMRLQHVPLDMSFAEAFGVRNPDA
HCCCCCCCEEECEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCHH
YERLLMDVVRGNQTLFMRRDEVEAAWKWIDPILEAWRNSHEPPKPYTAGTWGPSASIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
ERDGRTWMDD
EECCCCCCCC
>Mature Secondary Structure
MVARVITVDPFDIVVFGATGDLAKRKLLPALYERDLAGQIPPDARIIGVSRRPMSRGEFQ
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHH
ELARDSVEDRDGIDTIEAQRLARFLDRVDYVAVDAVSDEGWTDLKARLSEGGDRVRVFYL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEE
AVGPDLFDDICSRIGAHGLVTPQSRVVVEKPVGKNLASARKVNEAVGRVFPEDSIFRIDH
EECCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEHHHH
YLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHCCCCCCCCCCCHHHHHHHHHH
NHILQLLCLVAMEPPVSMDADAVRDEKLKVLKALVPIDERSAPHLTVRGQYRSGASAGGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCC
VPGYLEELGSPESDTETFVALRAEIANWRWAGVPFYLRTGKRLPSRVSEIVVAFRPIPHS
CCHHHHHCCCCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHCCCCCH
VFDGQAGPIMANRLVIRLQPDEGVKLWLMIKDPGPGGMRLQHVPLDMSFAEAFGVRNPDA
HCCCCCCCEEECEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCHH
YERLLMDVVRGNQTLFMRRDEVEAAWKWIDPILEAWRNSHEPPKPYTAGTWGPSASIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
ERDGRTWMDD
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]