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The map label for this gene is thiE [H]

Identifier: 158425165

GI number: 158425165

Start: 4067155

End: 4067766

Strand: Direct

Name: thiE [H]

Synonym: AZC_3541

Alternate gene names: 158425165

Gene position: 4067155-4067766 (Clockwise)

Preceding gene: 158425164

Following gene: 158425166

Centisome position: 75.74

GC content: 72.06

Gene sequence:

>612_bases
GTGCTGCCCCACCCGCCCCTGCTTCTGATCACCGATCGTCATCAGGCAAGGACCGATCTTTCGGACGTGCTCGAAGCATC
CTTCGGCGCGGGGCTGCGCTGGACCAGCGTGCGGGAGAAGGACCTTGCCCCGGCCGAACAGGTGGACCTCGTACGGCGGC
TTCTGCCCGTCGCCCATGCGCATGGGGCCTGCCTGACCCTCCACGGCACGGCCGCGCTCGCTCTTGAGGCCGGCGCCGAT
GGCGTGCATCTGCCGTCCGGGGCCGATGTGAATGCCGCGCGCGCCCTGCTGGGGCCGGACGCCTTGATCGGGCTCTCAGT
CCACAGCATGGCGGAGGTCACGGCCGCACCGCCGTCCGCCTCCTATCTGGTGGCCGGTCCGGCCTTCGAGACCGCCTCCA
AGCCCGGCTATGGCCCCGCACTCGGGCCAGAGGGGCTGGCGCAGCTCGCGCGCGCCACCGCCCTGCCCCTGCTGGCCCTC
GGCGGCCTCGACCGCCACACGCTGCTCCTCTGCCAGGACAGCGGCCTTGCCGGTGCAGCCGTGATGGGTGGCGTGATGCG
GGCGAACGATCCGGCAGCAGAAGTGCGCGCCCTGCTGGCCGCGATTGGGTAG

Upstream 100 bases:

>100_bases
GCGCGACGTTTCCGATAGCTCCGACGAAGGCGGGGCATGCCTCTGGACGGGCGCGTGCTGCATAAGCACTGTGCCCGCCG
CATCATGACAGGAGCCCGCC

Downstream 100 bases:

>100_bases
TGAAGAAACAGTTACACGTTTGACGCGAATTTATGCTCTTCTTCAGGGATAAATTTTCATCTCTGGACGATTTCCCATGC
GCATTGCGACTTTTAACGTC

Product: thiamine-phosphate pyrophosphorylase

Products: NA

Alternate protein names: TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLPHPPLLLITDRHQARTDLSDVLEASFGAGLRWTSVREKDLAPAEQVDLVRRLLPVAHAHGACLTLHGTAALALEAGAD
GVHLPSGADVNAARALLGPDALIGLSVHSMAEVTAAPPSASYLVAGPAFETASKPGYGPALGPEGLAQLARATALPLLAL
GGLDRHTLLLCQDSGLAGAAVMGGVMRANDPAAEVRALLAAIG

Sequences:

>Translated_203_residues
MLPHPPLLLITDRHQARTDLSDVLEASFGAGLRWTSVREKDLAPAEQVDLVRRLLPVAHAHGACLTLHGTAALALEAGAD
GVHLPSGADVNAARALLGPDALIGLSVHSMAEVTAAPPSASYLVAGPAFETASKPGYGPALGPEGLAQLARATALPLLAL
GGLDRHTLLLCQDSGLAGAAVMGGVMRANDPAAEVRALLAAIG
>Mature_203_residues
MLPHPPLLLITDRHQARTDLSDVLEASFGAGLRWTSVREKDLAPAEQVDLVRRLLPVAHAHGACLTLHGTAALALEAGAD
GVHLPSGADVNAARALLGPDALIGLSVHSMAEVTAAPPSASYLVAGPAFETASKPGYGPALGPEGLAQLARATALPLLAL
GGLDRHTLLLCQDSGLAGAAVMGGVMRANDPAAEVRALLAAIG

Specific function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [H]

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: =2.5.1.3 [H]

Molecular weight: Translated: 20535; Mature: 20535

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPHPPLLLITDRHQARTDLSDVLEASFGAGLRWTSVREKDLAPAEQVDLVRRLLPVAHA
CCCCCCEEEEECCCHHHCCHHHHHHHHHCCCCEECCCCHHCCCCHHHHHHHHHHHHHHHC
HGACLTLHGTAALALEAGADGVHLPSGADVNAARALLGPDALIGLSVHSMAEVTAAPPSA
CCCEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCC
SYLVAGPAFETASKPGYGPALGPEGLAQLARATALPLLALGGLDRHTLLLCQDSGLAGAA
CEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
VMGGVMRANDPAAEVRALLAAIG
HHCCHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLPHPPLLLITDRHQARTDLSDVLEASFGAGLRWTSVREKDLAPAEQVDLVRRLLPVAHA
CCCCCCEEEEECCCHHHCCHHHHHHHHHCCCCEECCCCHHCCCCHHHHHHHHHHHHHHHC
HGACLTLHGTAALALEAGADGVHLPSGADVNAARALLGPDALIGLSVHSMAEVTAAPPSA
CCCEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCC
SYLVAGPAFETASKPGYGPALGPEGLAQLARATALPLLALGGLDRHTLLLCQDSGLAGAA
CEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
VMGGVMRANDPAAEVRALLAAIG
HHCCHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA