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The map label for this gene is fbcH [H]

Identifier: 158425124

GI number: 158425124

Start: 4016881

End: 4018152

Strand: Reverse

Name: fbcH [H]

Synonym: AZC_3500

Alternate gene names: 158425124

Gene position: 4018152-4016881 (Counterclockwise)

Preceding gene: 158425125

Following gene: 158425123

Centisome position: 74.83

GC content: 63.44

Gene sequence:

>1272_bases
ATGGAAGGACATTCCACCTACCAGCCGAAGAGCAGGGTTGCGCGCTGGTTCGAGAGCCGGCTGCCGCTCGTCGGTCTCGT
GCATTCGAGCGCGATTGCCTATCCGGTCCCCAAGAACCTGAACTATTTCTGGACCTTCGGCGCGATCCTCACCCTCATGC
TGGTGGTGCAGATCGTCTCGGGCGTGGTGCTCGCCATGCACTACACCGCCTATGCGCCGGTCTCCTTCGCCCGCGTCGAG
CACATCATGCGCGACGTGAGCTTCGGCTGGATGATCCGCTACATCCACGCCAACGGCGCTTCGATGTTCTTCATCGCGGT
CTACATCCACATGTTCCGCGGCATGTATTACGGCTCCTACAAGGCGCCGCGCGAGGTGCTGTGGATCCTCGGCGTCATCA
TCTACCTGCTGATGATGGCCACGGCCTTCATGGGCTACGTGCTGCCGTGGGGCCAGATGTCCTACTGGGGCGCCACCGTC
ATCACCAACCTGTTCTCGGCCATTCCGCTGGTGGGCGAGACCATCGTGCAGTGGCTGTGGGGTGGGTATTCGGTGGGTGA
TCCGACCCTCAACCGCTTCTTTGCGCTCCACTATCTGCTGCCCTTCATGATCGCCGGCGTCGTCGGCCTGCACATCTGGG
CGCTGCACCATGTGGGCCAGAACAATCCCGACGGCCTCGACGTGAAGAGCGTGGCGAAGGACACCGTGCCGTTCACCCCC
TATGCGACCATCAAGGATGTGTTCGCCATGGTGGTGTTCCTGCTGTTCTTCTCCTGGTTCATCTTCTACGCGCCCAACTA
CATGGGCCACCCGGACAACTACATTCCGGCCAACCCCCTCTCCACCCCGGCGCACATCGTGCCCGAGTGGTACTTCCTGC
CCTTCTACGCCATCCTGCGCTCCATTCCGGACAAGCTCGGCGGTGTGCTGTGCATGTTCGGCGCCATCGCGGTGCTGGCC
TTCCTGCCCTGGCTCGACACCTCGAAGGTGCGCTCGGCCAAGTACCGCCCCCTCTTCCGCCAGTTCTTCTGGATCTTCGC
GGTGGTGGCGGTGGGCCTCGGCTACCTCGGCTCGCAGCCGGCGGAGGGCGGCTACGTGATCGTGTCGCGCATCTTCACCG
CTTATTACTTCATCCATTTCCTCGTCATCCTGCCCGTGCTCGGCCTCGTCGAGCGCCCGAAGCCCCTGCCGGCCTCCATC
GCCGATGCGGTTCTGGCCAAGGGTGGCGCAACGGTCGTCGCCGGAGCCTCGGCTCCGCAGACCAAGGGCTGA

Upstream 100 bases:

>100_bases
CCCGCTGAACCTCGCGGTGCCGCCTTACAACTTCGTTTCCGACAGCAAGATCGTGATCGGCTGACGTGCGCGTCGCCCGT
CCATAACAAGGGTTGGCCCC

Downstream 100 bases:

>100_bases
GCGAGCGGCGGAGACAGAGCCATGAAGAAGACGTTTCTCCTCGGCGCCGTCGCGCTGGCCCTCGCCTTCGCCGCGCCGGC
CCGCGCGGCGGAAGGGGGGC

Product: cytochrome b/c1

Products: Q; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MEGHSTYQPKSRVARWFESRLPLVGLVHSSAIAYPVPKNLNYFWTFGAILTLMLVVQIVSGVVLAMHYTAYAPVSFARVE
HIMRDVSFGWMIRYIHANGASMFFIAVYIHMFRGMYYGSYKAPREVLWILGVIIYLLMMATAFMGYVLPWGQMSYWGATV
ITNLFSAIPLVGETIVQWLWGGYSVGDPTLNRFFALHYLLPFMIAGVVGLHIWALHHVGQNNPDGLDVKSVAKDTVPFTP
YATIKDVFAMVVFLLFFSWFIFYAPNYMGHPDNYIPANPLSTPAHIVPEWYFLPFYAILRSIPDKLGGVLCMFGAIAVLA
FLPWLDTSKVRSAKYRPLFRQFFWIFAVVAVGLGYLGSQPAEGGYVIVSRIFTAYYFIHFLVILPVLGLVERPKPLPASI
ADAVLAKGGATVVAGASAPQTKG

Sequences:

>Translated_423_residues
MEGHSTYQPKSRVARWFESRLPLVGLVHSSAIAYPVPKNLNYFWTFGAILTLMLVVQIVSGVVLAMHYTAYAPVSFARVE
HIMRDVSFGWMIRYIHANGASMFFIAVYIHMFRGMYYGSYKAPREVLWILGVIIYLLMMATAFMGYVLPWGQMSYWGATV
ITNLFSAIPLVGETIVQWLWGGYSVGDPTLNRFFALHYLLPFMIAGVVGLHIWALHHVGQNNPDGLDVKSVAKDTVPFTP
YATIKDVFAMVVFLLFFSWFIFYAPNYMGHPDNYIPANPLSTPAHIVPEWYFLPFYAILRSIPDKLGGVLCMFGAIAVLA
FLPWLDTSKVRSAKYRPLFRQFFWIFAVVAVGLGYLGSQPAEGGYVIVSRIFTAYYFIHFLVILPVLGLVERPKPLPASI
ADAVLAKGGATVVAGASAPQTKG
>Mature_423_residues
MEGHSTYQPKSRVARWFESRLPLVGLVHSSAIAYPVPKNLNYFWTFGAILTLMLVVQIVSGVVLAMHYTAYAPVSFARVE
HIMRDVSFGWMIRYIHANGASMFFIAVYIHMFRGMYYGSYKAPREVLWILGVIIYLLMMATAFMGYVLPWGQMSYWGATV
ITNLFSAIPLVGETIVQWLWGGYSVGDPTLNRFFALHYLLPFMIAGVVGLHIWALHHVGQNNPDGLDVKSVAKDTVPFTP
YATIKDVFAMVVFLLFFSWFIFYAPNYMGHPDNYIPANPLSTPAHIVPEWYFLPFYAILRSIPDKLGGVLCMFGAIAVLA
FLPWLDTSKVRSAKYRPLFRQFFWIFAVVAVGLGYLGSQPAEGGYVIVSRIFTAYYFIHFLVILPVLGLVERPKPLPASI
ADAVLAKGGATVVAGASAPQTKG

Specific function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c [H]

COG id: COG1290

COG function: function code C; Cytochrome b subunit of the bc complex

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI251831119, Length=371, Percent_Identity=49.0566037735849, Blast_Score=360, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6226529, Length=369, Percent_Identity=53.929539295393, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6226532, Length=247, Percent_Identity=52.6315789473684, Blast_Score=265, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6226531, Length=165, Percent_Identity=56.969696969697, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6226530, Length=149, Percent_Identity=48.993288590604, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016175
- InterPro:   IPR005798
- InterPro:   IPR005797
- InterPro:   IPR002326
- InterPro:   IPR021157
- InterPro:   IPR009056
- InterPro:   IPR016174 [H]

Pfam domain/function: PF00032 Cytochrom_B_C; PF00033 Cytochrom_B_N; PF02167 Cytochrom_C1 [H]

EC number: 1.10.2.2

Molecular weight: Translated: 47319; Mature: 47319

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS51002 CYTB_NTER ; PS51003 CYTB_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: QH2; ferricytochrome c

Specific reaction: QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2541921; 12597275 [H]