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The map label for this gene is uxuB [H]

Identifier: 158424971

GI number: 158424971

Start: 3874901

End: 3876376

Strand: Direct

Name: uxuB [H]

Synonym: AZC_3347

Alternate gene names: 158424971

Gene position: 3874901-3876376 (Clockwise)

Preceding gene: 158424970

Following gene: 158424972

Centisome position: 72.16

GC content: 71.75

Gene sequence:

>1476_bases
ATGCGCCTCTCGCTTGCCAATCTGAGCCGTCTTCCGGCCGATATCCGCCGCCCCGCCTATGACGTCGCCGCCGCGCAGGT
GGGCGTCGTCCATCTCGGCGTCGGTGCCTTCCACCGCGCCCATCAGGCCGTCTATCTGGACGACTGCCTGGCCCGGGGCG
CTGCCGGCTGGGCGGTGTGCGGCGCCAGCCTGCGCTCTCCCGACACGTCGGAGGCGCTCGATCCGCAGGACGGCCTCTAT
ACGCTCGCCGTGCGTTCCGGCACGGGCGACGATTTGCGCGTCATCGGCTCCCTGCGCCGCCTGCTGGTGGCCCCGCGCGA
TCCGTCCACTCTCCTCGCGGCCATGTGCGATCCCAACGTGCGCATCGTCACCCTGACCGTGACCGAGAAGGGCTATTGCC
ACGACCCGGCCACCGGCACGCTGGACGAGGCCCATCCCGACATCATCGCGGACCTTGCCAATCCCGCCGTGCCCCGCAGC
GCGCCCGGCTTCCTCGTGGAAGCGCTCGCCCGGCGGCGGGCGGCCGGTGTTGCGCCCTTCACCGTGCTCTGCTGCGACAA
TCTCCCCGCCAATGGCGAGACGGTCGCCCGCGTGGTGGCCCGCTTCGCTGCCTTGCGCGATCCGGACCTCGGCCGCTGGG
TCGAGGCGGAGGTCGCCTTCCCCTGCACCATGGTGGACCGCATCGTGCCCGCCACCACCGATGCCGACCGGGCCATGGTG
GCCGGGCGCCTCGGCATGGAGGATGCCTGGCCGGTGATGGCCGAGCCCTTCACCCAGTGGGTGGTGGAGGATCGCTTTCC
CGCCGGCCGGCCGCCGTTGGAAGACGTCGGCGCGGAACTGGTCGCCGACGTGCGCCCCTATGAGCTGATGAAGCTCCGCC
TGCTCAACGGCAGCCACTCCACCCTCGCCTATCTCGGCTATCTGGCGGGCAAGGAAACCATCGCCGAGACCATGGCCGAA
CCCGCCTTCCAGCGGCTCGTGGCGCGGCTTCAGGACGAGGAAGTCACCTCGACCGTCCCGGCCCCGCCCGGTGCCGATCT
CGGCGCCTACAAGCGGGCCCTGCGGGAGCGCTTCGCCAATCCGGCACTCAAGCATCGCACGTGGCAGATCGCCATGGACG
GCTCGCAGAAGCTGCCCCAGCGCCTGCTCTCCCCCATCCGCGACCGGCTCGCCGCCGGGGCGCCCATCGGCTTCCTCGCC
CTCGGGGTGGCGGGCTGGATGCGCTATGTCTCGGGCACGGATGAGAAAGGCAGCGCCATCGACGTGCGCGACCCCCTCGC
CGCCCGCTTCAAGGCGGTAGCGGAAACGGCGGGACCGGACGCCGACCGGCTGGCGGAGGGCCTTCTGGCGGTGCGCGAGG
TGTTCGGCGCCGATCTGCCAACCGATCCGCGCTTCACCGGCGCGGTCAAGGCGGCGCTCGGCCGTCTCTATGCGGAAGGG
GCTGCCGCCAGCGTCGACGCCGCCACGCGGGGTTGA

Upstream 100 bases:

>100_bases
GGCCCGCGCCAAGTCCGAGCACGCCCACTGAGCTGAAGCGGGGCGCGCGGGAAGCCGCGCGCCCCGTTCTCGTTCCAACG
CCCCTTCAAGAAGGCCGAAG

Downstream 100 bases:

>100_bases
CGCTGCGGCGAAGGACCGCGACGTTCGGGCACGCACGCAGAAGGCGGAGATTCCCATTCCGCTTCTCTGAAAGGAAGCCC
ATGAGCCCCCATCGCCTGCT

Product: mannitol dehydrogenase

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MRLSLANLSRLPADIRRPAYDVAAAQVGVVHLGVGAFHRAHQAVYLDDCLARGAAGWAVCGASLRSPDTSEALDPQDGLY
TLAVRSGTGDDLRVIGSLRRLLVAPRDPSTLLAAMCDPNVRIVTLTVTEKGYCHDPATGTLDEAHPDIIADLANPAVPRS
APGFLVEALARRRAAGVAPFTVLCCDNLPANGETVARVVARFAALRDPDLGRWVEAEVAFPCTMVDRIVPATTDADRAMV
AGRLGMEDAWPVMAEPFTQWVVEDRFPAGRPPLEDVGAELVADVRPYELMKLRLLNGSHSTLAYLGYLAGKETIAETMAE
PAFQRLVARLQDEEVTSTVPAPPGADLGAYKRALRERFANPALKHRTWQIAMDGSQKLPQRLLSPIRDRLAAGAPIGFLA
LGVAGWMRYVSGTDEKGSAIDVRDPLAARFKAVAETAGPDADRLAEGLLAVREVFGADLPTDPRFTGAVKAALGRLYAEG
AAASVDAATRG

Sequences:

>Translated_491_residues
MRLSLANLSRLPADIRRPAYDVAAAQVGVVHLGVGAFHRAHQAVYLDDCLARGAAGWAVCGASLRSPDTSEALDPQDGLY
TLAVRSGTGDDLRVIGSLRRLLVAPRDPSTLLAAMCDPNVRIVTLTVTEKGYCHDPATGTLDEAHPDIIADLANPAVPRS
APGFLVEALARRRAAGVAPFTVLCCDNLPANGETVARVVARFAALRDPDLGRWVEAEVAFPCTMVDRIVPATTDADRAMV
AGRLGMEDAWPVMAEPFTQWVVEDRFPAGRPPLEDVGAELVADVRPYELMKLRLLNGSHSTLAYLGYLAGKETIAETMAE
PAFQRLVARLQDEEVTSTVPAPPGADLGAYKRALRERFANPALKHRTWQIAMDGSQKLPQRLLSPIRDRLAAGAPIGFLA
LGVAGWMRYVSGTDEKGSAIDVRDPLAARFKAVAETAGPDADRLAEGLLAVREVFGADLPTDPRFTGAVKAALGRLYAEG
AAASVDAATRG
>Mature_491_residues
MRLSLANLSRLPADIRRPAYDVAAAQVGVVHLGVGAFHRAHQAVYLDDCLARGAAGWAVCGASLRSPDTSEALDPQDGLY
TLAVRSGTGDDLRVIGSLRRLLVAPRDPSTLLAAMCDPNVRIVTLTVTEKGYCHDPATGTLDEAHPDIIADLANPAVPRS
APGFLVEALARRRAAGVAPFTVLCCDNLPANGETVARVVARFAALRDPDLGRWVEAEVAFPCTMVDRIVPATTDADRAMV
AGRLGMEDAWPVMAEPFTQWVVEDRFPAGRPPLEDVGAELVADVRPYELMKLRLLNGSHSTLAYLGYLAGKETIAETMAE
PAFQRLVARLQDEEVTSTVPAPPGADLGAYKRALRERFANPALKHRTWQIAMDGSQKLPQRLLSPIRDRLAAGAPIGFLA
LGVAGWMRYVSGTDEKGSAIDVRDPLAARFKAVAETAGPDADRLAEGLLAVREVFGADLPTDPRFTGAVKAALGRLYAEG
AAASVDAATRG

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=484, Percent_Identity=49.1735537190083, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1788497, Length=473, Percent_Identity=48.6257928118393, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1787823, Length=477, Percent_Identity=47.5890985324948, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI48994885, Length=378, Percent_Identity=26.4550264550265, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790028, Length=310, Percent_Identity=28.3870967741935, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=488, Percent_Identity=39.344262295082, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320765, Length=488, Percent_Identity=39.344262295082, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 52317; Mature: 52317

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSLANLSRLPADIRRPAYDVAAAQVGVVHLGVGAFHRAHQAVYLDDCLARGAAGWAVC
CCCCHHHHHHCCHHHHCCHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCCCHHHH
GASLRSPDTSEALDPQDGLYTLAVRSGTGDDLRVIGSLRRLLVAPRDPSTLLAAMCDPNV
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
RIVTLTVTEKGYCHDPATGTLDEAHPDIIADLANPAVPRSAPGFLVEALARRRAAGVAPF
EEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLCCDNLPANGETVARVVARFAALRDPDLGRWVEAEVAFPCTMVDRIVPATTDADRAMV
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCHHHHHHHCCCCCCCHHHHH
AGRLGMEDAWPVMAEPFTQWVVEDRFPAGRPPLEDVGAELVADVRPYELMKLRLLNGSHS
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHEEEEECCCCH
TLAYLGYLAGKETIAETMAEPAFQRLVARLQDEEVTSTVPAPPGADLGAYKRALRERFAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHCC
PALKHRTWQIAMDGSQKLPQRLLSPIRDRLAAGAPIGFLALGVAGWMRYVSGTDEKGSAI
HHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEE
DVRDPLAARFKAVAETAGPDADRLAEGLLAVREVFGADLPTDPRFTGAVKAALGRLYAEG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
AAASVDAATRG
CCCCCCCCCCC
>Mature Secondary Structure
MRLSLANLSRLPADIRRPAYDVAAAQVGVVHLGVGAFHRAHQAVYLDDCLARGAAGWAVC
CCCCHHHHHHCCHHHHCCHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCCCHHHH
GASLRSPDTSEALDPQDGLYTLAVRSGTGDDLRVIGSLRRLLVAPRDPSTLLAAMCDPNV
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
RIVTLTVTEKGYCHDPATGTLDEAHPDIIADLANPAVPRSAPGFLVEALARRRAAGVAPF
EEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLCCDNLPANGETVARVVARFAALRDPDLGRWVEAEVAFPCTMVDRIVPATTDADRAMV
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCHHHHHHHCCCCCCCHHHHH
AGRLGMEDAWPVMAEPFTQWVVEDRFPAGRPPLEDVGAELVADVRPYELMKLRLLNGSHS
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHEEEEECCCCH
TLAYLGYLAGKETIAETMAEPAFQRLVARLQDEEVTSTVPAPPGADLGAYKRALRERFAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHCC
PALKHRTWQIAMDGSQKLPQRLLSPIRDRLAAGAPIGFLALGVAGWMRYVSGTDEKGSAI
HHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEE
DVRDPLAARFKAVAETAGPDADRLAEGLLAVREVFGADLPTDPRFTGAVKAALGRLYAEG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
AAASVDAATRG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]