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The map label for this gene is lysR [C]

Identifier: 158424896

GI number: 158424896

Start: 3778392

End: 3779285

Strand: Reverse

Name: lysR [C]

Synonym: AZC_3272

Alternate gene names: 158424896

Gene position: 3779285-3778392 (Counterclockwise)

Preceding gene: 158424898

Following gene: 158424894

Centisome position: 70.38

GC content: 64.43

Gene sequence:

>894_bases
GTGCCACGGGATAATGTAAACGATCTGCTGGTGTTCCTCGCGGTCGCCCGTGAGCGCAGCTTCACGCGGGCCGCTGCGAA
GATGGGAGTCTCGCAGTCGGCGCTGAGCCACACCATCCGCCAGTTGGAGGCGCGGCTCGGCGTGCGGCTTCTGACCCGCA
CCACGCGCGCGGTCTCCCCCACGGAAGCGGGCGAGCGCCTGCTGGCGGGCATCGGCCCGCATTTCGACGAGATCGAAGCG
CAGGTCGATGCGCTCAATGACCTGAGGGACAAGCCGGCGGGCACCATCCGCATCTCCGCGCCGGACTTTGCCATCTCCAG
CGTTCTGTGGCCGAAGCTGAAGGCCTTTCTGCCGCAGTTTCCGGACATCAAGGTGGAACTGCTCCAGGAGAATGGCCTCA
CCGATATCGTCACCGAGCGTTATGACGCGGGCGTGCGCATGGGAGATCAGCTTGCCAAGGACATGATCTCTGCGCGTATC
GGACCGGACTTCCGCTTCGCGGTGGTCGGCTCCAAATCCTACTTTGCTTCGCGTCCCGAGCCCGCCACGCCACAGGATCT
GGTGCAGCACAGCTGTATCAATTACCGGTTTCCGACGTCCGGGGGGCTCTGGGCCTGGGACTTTGAGGAAGAGGGGCGCG
AGTTCAAGATCCGCGTCGAGGGCCAGCTGGTGTTCAACAACATCTTTAATGCGCTGGACGCGGCTGTCGCCGGCTTCGGC
CTCGCTTATGTGCCCGAGGAACTCGCCATTCCCCATCTGGCCAAGGGCCGACTCGTGCGCGTGCTGGAGCGCTGGAGCCC
CTATTGGGACGGCTACTACCTCTATTATCCGAGCCGCCGCCAGTCCTCTCCGGCTTTCGTGGCGCTGGTCGAGGCCCTGC
GCCATCGCGGATAG

Upstream 100 bases:

>100_bases
CGGAAGTGGCGGCGCGTGCGGTATCAGATGGGAAAGGGCGTTTCACGCGCGGGAGGCATCACGTCCCGCCGCTGCGCGCC
CGGAGGGCCGGAGGTTCGAG

Downstream 100 bases:

>100_bases
GACAGGGGCCGTGCCCACCATGGCCGCCCGCGGACCGGCCATGGTGGGATGGGCTCAGACCCGAAGCAGGGTCTTGATGG
CCCGCCGCTCGTCCATGGCG

Product: regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MPRDNVNDLLVFLAVARERSFTRAAAKMGVSQSALSHTIRQLEARLGVRLLTRTTRAVSPTEAGERLLAGIGPHFDEIEA
QVDALNDLRDKPAGTIRISAPDFAISSVLWPKLKAFLPQFPDIKVELLQENGLTDIVTERYDAGVRMGDQLAKDMISARI
GPDFRFAVVGSKSYFASRPEPATPQDLVQHSCINYRFPTSGGLWAWDFEEEGREFKIRVEGQLVFNNIFNALDAAVAGFG
LAYVPEELAIPHLAKGRLVRVLERWSPYWDGYYLYYPSRRQSSPAFVALVEALRHRG

Sequences:

>Translated_297_residues
MPRDNVNDLLVFLAVARERSFTRAAAKMGVSQSALSHTIRQLEARLGVRLLTRTTRAVSPTEAGERLLAGIGPHFDEIEA
QVDALNDLRDKPAGTIRISAPDFAISSVLWPKLKAFLPQFPDIKVELLQENGLTDIVTERYDAGVRMGDQLAKDMISARI
GPDFRFAVVGSKSYFASRPEPATPQDLVQHSCINYRFPTSGGLWAWDFEEEGREFKIRVEGQLVFNNIFNALDAAVAGFG
LAYVPEELAIPHLAKGRLVRVLERWSPYWDGYYLYYPSRRQSSPAFVALVEALRHRG
>Mature_296_residues
PRDNVNDLLVFLAVARERSFTRAAAKMGVSQSALSHTIRQLEARLGVRLLTRTTRAVSPTEAGERLLAGIGPHFDEIEAQ
VDALNDLRDKPAGTIRISAPDFAISSVLWPKLKAFLPQFPDIKVELLQENGLTDIVTERYDAGVRMGDQLAKDMISARIG
PDFRFAVVGSKSYFASRPEPATPQDLVQHSCINYRFPTSGGLWAWDFEEEGREFKIRVEGQLVFNNIFNALDAAVAGFGL
AYVPEELAIPHLAKGRLVRVLERWSPYWDGYYLYYPSRRQSSPAFVALVEALRHRG

Specific function: May have a role in the regulation of oprD expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787589, Length=297, Percent_Identity=46.4646464646465, Blast_Score=297, Evalue=6e-82,
Organism=Escherichia coli, GI1787128, Length=292, Percent_Identity=40.7534246575342, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1786401, Length=271, Percent_Identity=28.0442804428044, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789639, Length=258, Percent_Identity=29.4573643410853, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081978, Length=291, Percent_Identity=29.8969072164948, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI145693193, Length=287, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789440, Length=270, Percent_Identity=24.8148148148148, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789173, Length=254, Percent_Identity=28.3464566929134, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786448, Length=288, Percent_Identity=27.4305555555556, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788748, Length=124, Percent_Identity=37.9032258064516, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI157672245, Length=137, Percent_Identity=35.7664233576642, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790011, Length=271, Percent_Identity=23.9852398523985, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI145693105, Length=257, Percent_Identity=24.5136186770428, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787879, Length=297, Percent_Identity=26.2626262626263, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788706, Length=256, Percent_Identity=23.4375, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=129, Percent_Identity=32.5581395348837, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33248; Mature: 33117

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRDNVNDLLVFLAVARERSFTRAAAKMGVSQSALSHTIRQLEARLGVRLLTRTTRAVSP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TEAGERLLAGIGPHFDEIEAQVDALNDLRDKPAGTIRISAPDFAISSVLWPKLKAFLPQF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
PDIKVELLQENGLTDIVTERYDAGVRMGDQLAKDMISARIGPDFRFAVVGSKSYFASRPE
CCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHCCCCC
PATPQDLVQHSCINYRFPTSGGLWAWDFEEEGREFKIRVEGQLVFNNIFNALDAAVAGFG
CCCHHHHHHHHHHCEECCCCCCEEEECHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCC
LAYVPEELAIPHLAKGRLVRVLERWSPYWDGYYLYYPSRRQSSPAFVALVEALRHRG
HHHCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRDNVNDLLVFLAVARERSFTRAAAKMGVSQSALSHTIRQLEARLGVRLLTRTTRAVSP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TEAGERLLAGIGPHFDEIEAQVDALNDLRDKPAGTIRISAPDFAISSVLWPKLKAFLPQF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
PDIKVELLQENGLTDIVTERYDAGVRMGDQLAKDMISARIGPDFRFAVVGSKSYFASRPE
CCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHCCCCC
PATPQDLVQHSCINYRFPTSGGLWAWDFEEEGREFKIRVEGQLVFNNIFNALDAAVAGFG
CCCHHHHHHHHHHCEECCCCCCEEEECHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCC
LAYVPEELAIPHLAKGRLVRVLERWSPYWDGYYLYYPSRRQSSPAFVALVEALRHRG
HHHCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 1427017 [H]