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The map label for this gene is mepA [H]

Identifier: 158424868

GI number: 158424868

Start: 3740669

End: 3742087

Strand: Reverse

Name: mepA [H]

Synonym: AZC_3244

Alternate gene names: 158424868

Gene position: 3742087-3740669 (Counterclockwise)

Preceding gene: 158424869

Following gene: 158424867

Centisome position: 69.69

GC content: 70.75

Gene sequence:

>1419_bases
ATGAGCGGAACGGGCGAGGATGGCGTGCGCTTCGCCGCGCCCCTCGATCTTGCCGATCCGCGCCTTGAGCGTCTCATCGT
CCGCCTCGCCGTTCCTTCGGTGGCGGGGCTGTCGATCACGGCCCTGCATCACGTCGCCAATGCGGCGTTCGTCGGCCTGC
TGAGCGGGCAGGCGCTGGCGGCGGTCAGCATCGCCGTGCCGATCTTCGCCCTCGTGGCCGCCATCGGCCATGGGCTCGGC
ATCGGCGGTGCTGCCAGCATCGGGCGCCTGCTGGGAGCGGGGGACGCGCTCGACGCGGGCCGCGCCGCGAGCGCGACGCT
CGCCCTGTGCGTGCTGTTGGGGGGCGCGGCCGGCATCGGACTGTTCTGGGGCGCCGGCGGCGTGCTGGCGCTCTTCAGCC
CGGGGCCGGACCTCGCGCCCATCGCAGCAACCTATCTCCGGCTGCTTGCGGTCTCGTGCCCCTTGCTTCTGGCGCAGATC
GCATGCGACTTCATCGCCATCGCGGAAGGCAACAGCCGGTTCAGCATGTGGACGCTGCTCGGCGCGTTCGCACTCAATAT
CGTGCTCGATCCGCTGCTCATCTTCGGCTTCGGCCTCGGCGTCGAAGGTGCGGCACTCGCCACCATTCTGTCCCAGCTGG
CCGCTCTCGCGGCCTACGGTCTCTATTTCGGCCGCCGCTGGGGCCGGGTGCGTCTCGGCGTCGGCGGGTTGGGCCTCAAG
GCACGATTGCTGCGCCCGATCCTCGCGGTGGGCGTACCGGCCGGGCTGAGCAGCGCGCTGTCCGCTCTGGCCTTCGCCGT
TGTGTACGCCATGGCCGGGATCCATGGCGGCGATGAGGCCGTGGCGGGGGTCAGCATCGCCTTCCGTCTGCTCACGCTCG
GCCTCTTGCCGGTGATCGGCTTCTGCCTCGGGGCACAGCCGGTGCTGAGCTTCGCCGCCGGAGCGGGCGATCGGATCCGC
CTACGGGCGGCCACGCTGTTCATGGCGCGGGTCGCGCTCGGCTTCACGCTTTTCTACGCCGTGTCCATGATGCTGGGGTC
GGCTCCGCTCGTGGGCCTCTTCACGGCCGATGCGCGCGTGGCCGACGTCGCGAGACGCGGGCTCATTCTCTTCCACGCCG
GCTTCGCGCTGACCGGTCTGCATCAGGTTCTGGTGATCCTCCTCCAGGCCATGGAGCGGGCGCGTCTTGCGGCGGTCATC
TCGCTGGCCCCGCAGGGCTATCTGCTGCTGCCGCTGCTTTATGGCGGCGCGGCTTTGTGGGGCATGGACGGCGTGCTCGC
GGCGCCGCCGCTGGCCATGGGCCTCACCGCCCTGGTGTCCGCCGCCCTTCTCCTGCGCGAAGTGCGGCGCCTCCCGACCG
CCCGGTCGCGAAAGTCATCCCCATCACTGGCCGCTGAAGGCGCTGGAGGTTCCGCATGA

Upstream 100 bases:

>100_bases
TGCTGCTGCGGGAGCGCTTCTTCGGCGACCGCCTCTGGCAGCCGGATTTCGATGCCACCGCCCAGCCGGTGCTGCCGGTG
GCGGCCCAGGCCGTACCGGC

Downstream 100 bases:

>100_bases
ACAAGCCGCTCGATCACGAGGCCCTGCCGGCTCAGGGGGGCTGGAGCCGCGAGGTCAATCTGCTGGCGGCGGCGGTGCCG
CCGATCTTCCAGACCTCGCT

Product: efflux transporter inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSGTGEDGVRFAAPLDLADPRLERLIVRLAVPSVAGLSITALHHVANAAFVGLLSGQALAAVSIAVPIFALVAAIGHGLG
IGGAASIGRLLGAGDALDAGRAASATLALCVLLGGAAGIGLFWGAGGVLALFSPGPDLAPIAATYLRLLAVSCPLLLAQI
ACDFIAIAEGNSRFSMWTLLGAFALNIVLDPLLIFGFGLGVEGAALATILSQLAALAAYGLYFGRRWGRVRLGVGGLGLK
ARLLRPILAVGVPAGLSSALSALAFAVVYAMAGIHGGDEAVAGVSIAFRLLTLGLLPVIGFCLGAQPVLSFAAGAGDRIR
LRAATLFMARVALGFTLFYAVSMMLGSAPLVGLFTADARVADVARRGLILFHAGFALTGLHQVLVILLQAMERARLAAVI
SLAPQGYLLLPLLYGGAALWGMDGVLAAPPLAMGLTALVSAALLLREVRRLPTARSRKSSPSLAAEGAGGSA

Sequences:

>Translated_472_residues
MSGTGEDGVRFAAPLDLADPRLERLIVRLAVPSVAGLSITALHHVANAAFVGLLSGQALAAVSIAVPIFALVAAIGHGLG
IGGAASIGRLLGAGDALDAGRAASATLALCVLLGGAAGIGLFWGAGGVLALFSPGPDLAPIAATYLRLLAVSCPLLLAQI
ACDFIAIAEGNSRFSMWTLLGAFALNIVLDPLLIFGFGLGVEGAALATILSQLAALAAYGLYFGRRWGRVRLGVGGLGLK
ARLLRPILAVGVPAGLSSALSALAFAVVYAMAGIHGGDEAVAGVSIAFRLLTLGLLPVIGFCLGAQPVLSFAAGAGDRIR
LRAATLFMARVALGFTLFYAVSMMLGSAPLVGLFTADARVADVARRGLILFHAGFALTGLHQVLVILLQAMERARLAAVI
SLAPQGYLLLPLLYGGAALWGMDGVLAAPPLAMGLTALVSAALLLREVRRLPTARSRKSSPSLAAEGAGGSA
>Mature_471_residues
SGTGEDGVRFAAPLDLADPRLERLIVRLAVPSVAGLSITALHHVANAAFVGLLSGQALAAVSIAVPIFALVAAIGHGLGI
GGAASIGRLLGAGDALDAGRAASATLALCVLLGGAAGIGLFWGAGGVLALFSPGPDLAPIAATYLRLLAVSCPLLLAQIA
CDFIAIAEGNSRFSMWTLLGAFALNIVLDPLLIFGFGLGVEGAALATILSQLAALAAYGLYFGRRWGRVRLGVGGLGLKA
RLLRPILAVGVPAGLSSALSALAFAVVYAMAGIHGGDEAVAGVSIAFRLLTLGLLPVIGFCLGAQPVLSFAAGAGDRIRL
RAATLFMARVALGFTLFYAVSMMLGSAPLVGLFTADARVADVARRGLILFHAGFALTGLHQVLVILLQAMERARLAAVIS
LAPQGYLLLPLLYGGAALWGMDGVLAAPPLAMGLTALVSAALLLREVRRLPTARSRKSSPSLAAEGAGGSA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47594; Mature: 47463

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTGEDGVRFAAPLDLADPRLERLIVRLAVPSVAGLSITALHHVANAAFVGLLSGQALA
CCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
AVSIAVPIFALVAAIGHGLGIGGAASIGRLLGAGDALDAGRAASATLALCVLLGGAAGIG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHH
LFWGAGGVLALFSPGPDLAPIAATYLRLLAVSCPLLLAQIACDFIAIAEGNSRFSMWTLL
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHH
GAFALNIVLDPLLIFGFGLGVEGAALATILSQLAALAAYGLYFGRRWGRVRLGVGGLGLK
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHH
ARLLRPILAVGVPAGLSSALSALAFAVVYAMAGIHGGDEAVAGVSIAFRLLTLGLLPVIG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FCLGAQPVLSFAAGAGDRIRLRAATLFMARVALGFTLFYAVSMMLGSAPLVGLFTADARV
HHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHH
ADVARRGLILFHAGFALTGLHQVLVILLQAMERARLAAVISLAPQGYLLLPLLYGGAALW
HHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCHHHH
GMDGVLAAPPLAMGLTALVSAALLLREVRRLPTARSRKSSPSLAAEGAGGSA
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
SGTGEDGVRFAAPLDLADPRLERLIVRLAVPSVAGLSITALHHVANAAFVGLLSGQALA
CCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
AVSIAVPIFALVAAIGHGLGIGGAASIGRLLGAGDALDAGRAASATLALCVLLGGAAGIG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHH
LFWGAGGVLALFSPGPDLAPIAATYLRLLAVSCPLLLAQIACDFIAIAEGNSRFSMWTLL
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHH
GAFALNIVLDPLLIFGFGLGVEGAALATILSQLAALAAYGLYFGRRWGRVRLGVGGLGLK
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHH
ARLLRPILAVGVPAGLSSALSALAFAVVYAMAGIHGGDEAVAGVSIAFRLLTLGLLPVIG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FCLGAQPVLSFAAGAGDRIRLRAATLFMARVALGFTLFYAVSMMLGSAPLVGLFTADARV
HHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHH
ADVARRGLILFHAGFALTGLHQVLVILLQAMERARLAAVISLAPQGYLLLPLLYGGAALW
HHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCHHHH
GMDGVLAAPPLAMGLTALVSAALLLREVRRLPTARSRKSSPSLAAEGAGGSA
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA