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The map label for this gene is ribBA [H]

Identifier: 158424726

GI number: 158424726

Start: 3551918

End: 3553225

Strand: Direct

Name: ribBA [H]

Synonym: AZC_3102

Alternate gene names: 158424726

Gene position: 3551918-3553225 (Clockwise)

Preceding gene: 158424723

Following gene: 158424727

Centisome position: 66.15

GC content: 67.74

Gene sequence:

>1308_bases
ATGAAGCTCGCCGAATGGCTCCAGACCGCTGGCGTGACGCGCAGCGCATTTGCCAAGCAGGTGGGCCTGTCGCCCGCCAG
CGTCACCGCCTTGTGCAACGACGACGGCGCCTGGCTCTCCCGCGAGAGTGCCCAGCGCATCGCCGAGGCCACCGGCCATC
AGGTGACGCCCAATGACTTCCTGGGGCTGCCGGCCCCGCGCATCCGAGGTTTACCCGTGATCGATACCGTGCAGTCCCGC
GTCCAGCTCGCCATCGAAGCCATCGCCCGCGGCGACATCGTCGTCGTGACCGACGATGACGACCGCGAGAACGAAGGCGA
CCTCATCCTCGCCGCCTCGCTCGCGACCCCGCAGAAGCTGGCCTTCCTCATCCGCCACACCTCCGGCATCGTCTGCACGC
CGCTGCCGCCCTCCGAGGCCAAGCGTCTGCGCCTCGACCCGATGGTGTCCAACAACGATGCACCGCTCGGCACCGCCTTC
ACCGTCTCCATCGACGTGAAGCACGGCACCACCACGGGCATCTCGGCCGAGGAGCGCACCAACACCGTGCGCGCGCTCGC
CAATCCCAACATGGGCGCGGCCGATTTCGTTCGGCCGGGCCACATCTTCCCGCTCATCGCGAAGGAAGGCGGCGTGCTCA
TGCGCTCCGGTCACACCGAGGCGGCGGTGGACCTGTGCCGCCTCGCCGGCGTTCCGCCGGTGGGCGTGATCGCCGAACTG
GTGAATGACGACGGCACCGTGAAGCGCGGGCCGCAGGTCAATGCCTTCGCCGACGAGCACGGGCTGCTGCGCATCTCCGT
GGCCGACCTCATCGCCTATCGCCAGGCTCGCGAGAAGCTGGTGACGCGTACTGCCGAATTCCCGGTGCCGACGCTGGCCG
GCGAGATGCAGGGCTATTCCTACATCACCCCGTTCGATCAGGTGAACCATCTGGCGCTCGTTCATGGCCGCATCGGCGAC
GGCGAGAACGTGCTGGTGCGTCTGCATCGCGCTGATCCGGTGGCCGATGCCTTCACCGGCGCCAAGGGCCTGCAAAAGGC
GCTGGAGCGCATCCGGCAGGAAGGCCGAGGCATTCTGGTCTATCTGCGCGACGGCACGGTCGGCGTGCCACCCACCGCGA
TGGGCTCGGAGAAGACCTCGAGCGAGATGGAGCGAGACCAGCACTGGCGGGAAGTCGGCCTCGGCGCACAGATCCTGCGC
GATCTCGGCGTCACCTCCATCCGCCTGCTCGCTTCCAAGACCCGCACCTATGTGGGCCTATCGGGCTTCGGCATCGAGAT
CAAGGAAACCGAGCCTCTCGAGGGCTGA

Upstream 100 bases:

>100_bases
AAAGGCGCTATAAATGCAGGGAAAATTCGTGCATTTTAGTATCACTGAAATTTCCAACGCTTTCATTGCGGCCGAAATTC
GGGTCTGCTAAACATCCCCC

Downstream 100 bases:

>100_bases
TCCAGCCTTCTTCAGAACCACTGGAATCGCAACGCCGGATGCCCCGCATCCGGCGTTTTCTTTTGGCGCCGAGCGCGTAC
CCCAAGGCCAAGCTCAAGTA

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKLAEWLQTAGVTRSAFAKQVGLSPASVTALCNDDGAWLSRESAQRIAEATGHQVTPNDFLGLPAPRIRGLPVIDTVQSR
VQLAIEAIARGDIVVVTDDDDRENEGDLILAASLATPQKLAFLIRHTSGIVCTPLPPSEAKRLRLDPMVSNNDAPLGTAF
TVSIDVKHGTTTGISAEERTNTVRALANPNMGAADFVRPGHIFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
VNDDGTVKRGPQVNAFADEHGLLRISVADLIAYRQAREKLVTRTAEFPVPTLAGEMQGYSYITPFDQVNHLALVHGRIGD
GENVLVRLHRADPVADAFTGAKGLQKALERIRQEGRGILVYLRDGTVGVPPTAMGSEKTSSEMERDQHWREVGLGAQILR
DLGVTSIRLLASKTRTYVGLSGFGIEIKETEPLEG

Sequences:

>Translated_435_residues
MKLAEWLQTAGVTRSAFAKQVGLSPASVTALCNDDGAWLSRESAQRIAEATGHQVTPNDFLGLPAPRIRGLPVIDTVQSR
VQLAIEAIARGDIVVVTDDDDRENEGDLILAASLATPQKLAFLIRHTSGIVCTPLPPSEAKRLRLDPMVSNNDAPLGTAF
TVSIDVKHGTTTGISAEERTNTVRALANPNMGAADFVRPGHIFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
VNDDGTVKRGPQVNAFADEHGLLRISVADLIAYRQAREKLVTRTAEFPVPTLAGEMQGYSYITPFDQVNHLALVHGRIGD
GENVLVRLHRADPVADAFTGAKGLQKALERIRQEGRGILVYLRDGTVGVPPTAMGSEKTSSEMERDQHWREVGLGAQILR
DLGVTSIRLLASKTRTYVGLSGFGIEIKETEPLEG
>Mature_435_residues
MKLAEWLQTAGVTRSAFAKQVGLSPASVTALCNDDGAWLSRESAQRIAEATGHQVTPNDFLGLPAPRIRGLPVIDTVQSR
VQLAIEAIARGDIVVVTDDDDRENEGDLILAASLATPQKLAFLIRHTSGIVCTPLPPSEAKRLRLDPMVSNNDAPLGTAF
TVSIDVKHGTTTGISAEERTNTVRALANPNMGAADFVRPGHIFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
VNDDGTVKRGPQVNAFADEHGLLRISVADLIAYRQAREKLVTRTAEFPVPTLAGEMQGYSYITPFDQVNHLALVHGRIGD
GENVLVRLHRADPVADAFTGAKGLQKALERIRQEGRGILVYLRDGTVGVPPTAMGSEKTSSEMERDQHWREVGLGAQILR
DLGVTSIRLLASKTRTYVGLSGFGIEIKETEPLEG

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=49.5, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=202, Percent_Identity=49.009900990099, Blast_Score=188, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46637; Mature: 46637

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAEWLQTAGVTRSAFAKQVGLSPASVTALCNDDGAWLSRESAQRIAEATGHQVTPNDF
CCHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
LGLPAPRIRGLPVIDTVQSRVQLAIEAIARGDIVVVTDDDDRENEGDLILAASLATPQKL
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHH
AFLIRHTSGIVCTPLPPSEAKRLRLDPMVSNNDAPLGTAFTVSIDVKHGTTTGISAEERT
HHHHCCCCCEEECCCCCCHHHEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHH
NTVRALANPNMGAADFVRPGHIFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
HHEEEECCCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHH
VNDDGTVKRGPQVNAFADEHGLLRISVADLIAYRQAREKLVTRTAEFPVPTLAGEMQGYS
HCCCCCCCCCCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCE
YITPFDQVNHLALVHGRIGDGENVLVRLHRADPVADAFTGAKGLQKALERIRQEGRGILV
EECCHHHCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHCHHHHHHHHHHHHHCCCEEEE
YLRDGTVGVPPTAMGSEKTSSEMERDQHWREVGLGAQILRDLGVTSIRLLASKTRTYVGL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCEEEEE
SGFGIEIKETEPLEG
ECCCEEEECCCCCCC
>Mature Secondary Structure
MKLAEWLQTAGVTRSAFAKQVGLSPASVTALCNDDGAWLSRESAQRIAEATGHQVTPNDF
CCHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
LGLPAPRIRGLPVIDTVQSRVQLAIEAIARGDIVVVTDDDDRENEGDLILAASLATPQKL
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHH
AFLIRHTSGIVCTPLPPSEAKRLRLDPMVSNNDAPLGTAFTVSIDVKHGTTTGISAEERT
HHHHCCCCCEEECCCCCCHHHEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHH
NTVRALANPNMGAADFVRPGHIFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
HHEEEECCCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHH
VNDDGTVKRGPQVNAFADEHGLLRISVADLIAYRQAREKLVTRTAEFPVPTLAGEMQGYS
HCCCCCCCCCCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCE
YITPFDQVNHLALVHGRIGDGENVLVRLHRADPVADAFTGAKGLQKALERIRQEGRGILV
EECCHHHCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHCHHHHHHHHHHHHHCCCEEEE
YLRDGTVGVPPTAMGSEKTSSEMERDQHWREVGLGAQILRDLGVTSIRLLASKTRTYVGL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCEEEEE
SGFGIEIKETEPLEG
ECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA