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The map label for this gene is bcd [H]

Identifier: 158424457

GI number: 158424457

Start: 3224528

End: 3225700

Strand: Reverse

Name: bcd [H]

Synonym: AZC_2833

Alternate gene names: 158424457

Gene position: 3225700-3224528 (Counterclockwise)

Preceding gene: 158424458

Following gene: 158424456

Centisome position: 60.07

GC content: 66.07

Gene sequence:

>1173_bases
ATGCTTGCCAACGCCCAAACCGGATTCGATTTCCAGCTCGGCGAGACCGCCGATCTGCTGCGCGACAGCGTGCGCGGCTT
CTCGCAGGACCGCATCGCCCCGCGCGCCGACGAGATCGACCGGAGCAACCAGTTTCCCCGCGACCTCTGGCCGGAACTGG
GGGCGCTGGGCCTCCTGGGGCTCACGGTGGAAGAGGAGTATGGCGGTTCGGGCCTCGGCTATCTCGAGCATGTCATCGCC
ATGGAGGAGATCAGCCGCGCCTCGGCCTCCGTCGGTCTCTCCTACGGCGCCCATTCCAACCTGTGCGTGAACCAGATCCG
CCGCAACGGCTCGCAGGAACAGAAGCAGCGCTACCTGCCCAAGCTCATTTCCGGCGAGCATGTGGGCGCGCTCGCCATGT
CCGAGCCGGGCGCGGGGTCGGACGTCGTCTCCATGCGCACCCGCGCGGAGAAGAAGGGCGACCGCTACATCCTCAACGGC
TCCAAGATGTGGATCACCAACGGCCCCATCGCCGAGACTCTGGTGGTCTATGCCAAGACCGATCCCGCGGCCGGCGCGCG
CGGCATCACCGCCTTCCTCATCGAAAAGGGGTTCAAGGGCTTCTCCACGGCTCAGAAGCTGGACAAGCTCGGGATGCGCG
GCTCCGACACCGGCGAACTGGTGTTCGAGGATTGCGAGGTGCCCGAGGAGAACGTGCTGGGGCAGGTGGGGCGCGGCGTG
AACGTGCTCATGTCCGGCCTCGACTACGAGCGCGCCGTGCTGGCGGGCGGCCCCATCGGCATCATGCAGGCCTGCATGGA
CGTGGTGATTCCCTATGTCCATGAGCGCAAGCAGTTCGGCCAGCCCATCGGCACCTTCCAGCTGATGCAGGGCAAGATCG
CCGACATGTACGTCGCGATGAACTCCGTGAAGGCGTATGTCTATGCGGTGGCCAAGGCCTGCGACCGCGGCCTCACCACC
CGCGAGGATGCGGCCGGCGCGATCCTCATCGCCGCCGAAAAGGCCACGTGGATGGCGCTGGAGGCGATCCAGACGCTGGG
CGGCAATGGTTACATCAACGACTATCCCACCGGCCGCCTGCTGCGCGACGCCAAGCTCTATGAGATCGGCGCCGGTACCA
GCGAGATCCGCCGCATGCTGATCGGTCGCGAACTGTTCGAAAAGACCGCCTGA

Upstream 100 bases:

>100_bases
TTCCCGCCCGCCGCTTCCTGTTCTACGATCCCCCAGCAGCCGGACCGCAGAAGTCCGCGCCCATGTCGGACGGCCTTCAG
GGCCAGGGAGAGGACGCCAG

Downstream 100 bases:

>100_bases
GCGGTAGCCGCGCCCGCCGGGGCCTTGCGCACCGGCGGGCGTCCCGTCACATCAGGGCGCTGATCCTCCGGCCGGGGCCG
GGGGCGGCGTCGGGACGGGC

Product: isovaleryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MLANAQTGFDFQLGETADLLRDSVRGFSQDRIAPRADEIDRSNQFPRDLWPELGALGLLGLTVEEEYGGSGLGYLEHVIA
MEEISRASASVGLSYGAHSNLCVNQIRRNGSQEQKQRYLPKLISGEHVGALAMSEPGAGSDVVSMRTRAEKKGDRYILNG
SKMWITNGPIAETLVVYAKTDPAAGARGITAFLIEKGFKGFSTAQKLDKLGMRGSDTGELVFEDCEVPEENVLGQVGRGV
NVLMSGLDYERAVLAGGPIGIMQACMDVVIPYVHERKQFGQPIGTFQLMQGKIADMYVAMNSVKAYVYAVAKACDRGLTT
REDAAGAILIAAEKATWMALEAIQTLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFEKTA

Sequences:

>Translated_390_residues
MLANAQTGFDFQLGETADLLRDSVRGFSQDRIAPRADEIDRSNQFPRDLWPELGALGLLGLTVEEEYGGSGLGYLEHVIA
MEEISRASASVGLSYGAHSNLCVNQIRRNGSQEQKQRYLPKLISGEHVGALAMSEPGAGSDVVSMRTRAEKKGDRYILNG
SKMWITNGPIAETLVVYAKTDPAAGARGITAFLIEKGFKGFSTAQKLDKLGMRGSDTGELVFEDCEVPEENVLGQVGRGV
NVLMSGLDYERAVLAGGPIGIMQACMDVVIPYVHERKQFGQPIGTFQLMQGKIADMYVAMNSVKAYVYAVAKACDRGLTT
REDAAGAILIAAEKATWMALEAIQTLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFEKTA
>Mature_390_residues
MLANAQTGFDFQLGETADLLRDSVRGFSQDRIAPRADEIDRSNQFPRDLWPELGALGLLGLTVEEEYGGSGLGYLEHVIA
MEEISRASASVGLSYGAHSNLCVNQIRRNGSQEQKQRYLPKLISGEHVGALAMSEPGAGSDVVSMRTRAEKKGDRYILNG
SKMWITNGPIAETLVVYAKTDPAAGARGITAFLIEKGFKGFSTAQKLDKLGMRGSDTGELVFEDCEVPEENVLGQVGRGV
NVLMSGLDYERAVLAGGPIGIMQACMDVVIPYVHERKQFGQPIGTFQLMQGKIADMYVAMNSVKAYVYAVAKACDRGLTT
REDAAGAILIAAEKATWMALEAIQTLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFEKTA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=66.1333333333333, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=64.8648648648649, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=41.0666666666667, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=36.7847411444142, Blast_Score=264, Evalue=8e-71,
Organism=Homo sapiens, GI4557231, Length=384, Percent_Identity=35.9375, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI187960098, Length=384, Percent_Identity=35.9375, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=34.7593582887701, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=37.6021798365123, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=37.6470588235294, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=37.6470588235294, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI7656849, Length=366, Percent_Identity=32.2404371584699, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=32.7272727272727, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI7669494, Length=381, Percent_Identity=33.3333333333333, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=26.7605633802817, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=26.7605633802817, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI38505218, Length=319, Percent_Identity=21.9435736677116, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=25.4385964912281, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=29.2105263157895, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=29.9212598425197, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=28.2945736434109, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081702, Length=275, Percent_Identity=25.8181818181818, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=63.1299734748011, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=36.5038560411311, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=36.5535248041775, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=35.0404312668464, Blast_Score=250, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=34.6774193548387, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=35.9173126614987, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71990804, Length=301, Percent_Identity=38.8704318936877, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17533517, Length=364, Percent_Identity=34.0659340659341, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=32.5714285714286, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=31.9148936170213, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=36, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.0952380952381, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.7901907356948, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=286, Percent_Identity=33.2167832167832, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=30.6451612903226, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=28.8702928870293, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=28.1138790035587, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=28.1138790035587, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=62.532981530343, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=41.2698412698413, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=39.6276595744681, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=33.9622641509434, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=35.9375, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI281363737, Length=377, Percent_Identity=35.2785145888594, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=31.758530183727, Blast_Score=191, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 42262; Mature: 42262

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANAQTGFDFQLGETADLLRDSVRGFSQDRIAPRADEIDRSNQFPRDLWPELGALGLLG
CCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHCHHHEE
LTVEEEYGGSGLGYLEHVIAMEEISRASASVGLSYGAHSNLCVNQIRRNGSQEQKQRYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
KLISGEHVGALAMSEPGAGSDVVSMRTRAEKKGDRYILNGSKMWITNGPIAETLVVYAKT
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCEEEEEEEC
DPAAGARGITAFLIEKGFKGFSTAQKLDKLGMRGSDTGELVFEDCEVPEENVLGQVGRGV
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCH
NVLMSGLDYERAVLAGGPIGIMQACMDVVIPYVHERKQFGQPIGTFQLMQGKIADMYVAM
HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHH
NSVKAYVYAVAKACDRGLTTREDAAGAILIAAEKATWMALEAIQTLGGNGYINDYPTGRL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCH
LRDAKLYEIGAGTSEIRRMLIGRELFEKTA
HHCCCEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLANAQTGFDFQLGETADLLRDSVRGFSQDRIAPRADEIDRSNQFPRDLWPELGALGLLG
CCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHCHHHEE
LTVEEEYGGSGLGYLEHVIAMEEISRASASVGLSYGAHSNLCVNQIRRNGSQEQKQRYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
KLISGEHVGALAMSEPGAGSDVVSMRTRAEKKGDRYILNGSKMWITNGPIAETLVVYAKT
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCEEEEEEEC
DPAAGARGITAFLIEKGFKGFSTAQKLDKLGMRGSDTGELVFEDCEVPEENVLGQVGRGV
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCH
NVLMSGLDYERAVLAGGPIGIMQACMDVVIPYVHERKQFGQPIGTFQLMQGKIADMYVAM
HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHH
NSVKAYVYAVAKACDRGLTTREDAAGAILIAAEKATWMALEAIQTLGGNGYINDYPTGRL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCH
LRDAKLYEIGAGTSEIRRMLIGRELFEKTA
HHCCCEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]