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The map label for this gene is livM [H]

Identifier: 158424417

GI number: 158424417

Start: 3172976

End: 3174955

Strand: Reverse

Name: livM [H]

Synonym: AZC_2793

Alternate gene names: 158424417

Gene position: 3174955-3172976 (Counterclockwise)

Preceding gene: 158424418

Following gene: 158424416

Centisome position: 59.13

GC content: 68.84

Gene sequence:

>1980_bases
ATGGGCGGGCCGGCGACCCGCGCGGTGCGCGCCCCCGTTTCCAGAGCCCCACACGCCGTTCCAACGAAAGGTCGAGCCGT
GGATTTCATCGTCGTCCAGGCCCTCACCGGTCTCGCCAGCGCAGCCTCGCTGTTCCTGGTCGCCTCCGGCCTGTCGATCA
TCTTCGGCGTCACGCGCATCGTGAACTTCGCCCATGGCGCCTTCTACATGCTCGGCGCCTACATCGCCTTCACCCTCACC
GAGGCGCTCTCGGGCACGCTCGGCTTCTGGGGCGGCATCGTGCTCGCCGCCCTCATCGTCGCCGTGCTGGGCGCGGCGCT
GGAGATCGTGCTGCTGCGCCGGATCTACCGCGCGCCCGAACTCTTCCAGCTGCTCGCCACCTTCGGCGTGACGCTGATGG
TGCAGGACATCGTCATCCTCATCTGGGGCCCGGAAGACCTGATGGGCCGCCGCGCCCCCGGCTTCCGCGGCGCCGTGGAC
ATCATGGGCCAGATGGTGCCCGCCTATGACCTGCTGCTCATCGGCCTCGGCCCGGCCGTGCTCGGCGTGCTGTGGCTGAT
CTTCCACCGCACCCGCTGGGGTGTGCTGGTGCGCGCGGCGACGCAGGACCGCGACATGGTGGCGGCGCTGGGCGTGAACC
AGAAGTGGCTGTTCACCAGCGTCTTCGCCCTCGGCGTTTTCCTCGCCGGCCTCGGCGGCGCGCTCCAGATCCCGCGCGAC
GCGGTGAGCCATGCCATGGACCTGCGCGTCATCGTGGACGTGTTCGTGGTGGTGGTCATCGGCGGCCTTGGCAGCGTCAC
CGGCGCCTTCGTGGCGGCCATTCTCGTGTCCGAGCTGAACGCCTTCGGCATTCTCATCTTCCCGAAGATCTCGCTGGTGC
TCGTCTTCATCGTGATGGCAGTGGTGCTGGTGATCCGCCCCTACGGCCTGTTCGGCAAGGCGGAAGGGCCGCAGCGCGTG
GCCGCCGGCCTCTCCATCCGGCCGTGGCGTCCGTTCACGCAGGCCGAGCGCCTCGCGGTGGCGGCGGCAGTGCTGGTGGC
GGCGAGCCTGCCGCTGTTCCTCGGCAACTACATGCTGACGGTCGGCTCGGAAATCCTCGTCTTCGTCCTGTTCGCGGCGA
GCCTGCACTTCCTCATGACCGTGGGCGGGCTCTCCTCCTTCGGCCATGCGGCCTATTTCGGCCTTGGCGCCTATGGCGCC
GCCTTCATGGTGAAGCTCGCCGGCGCTTCCATGGTGGTGGCGCTCTTGGTCGGCCCCTTCATGGGCTTGGCGGGGGCGGT
GCTGTTCGGCTGGTTCGCGGTGCGCCTGTCGGGCGTCTATTTCGCCATGCTGACGCTCGCCTTCGCGCAGATCACCTGGT
CCATCGCCTTCCAGTGGGTGGAGGTGACGGGCGGCGATAACGGCATGCTGGGCATCTGGCCGGCGAGCTGGGCGTCGAGC
CCGCAGGGCTTCTTCTGGCTGACGCTCGGTGTGGTGGCCATCGGTGTTGCGGTGCTGCGGATGCTCGTCTTCTCGCCCTT
CGGCTTCGGCCTTCGGGCAGCGCGGGACAGCGCCCTGCGCTCGGAAGCCATCGGCATCGACCGCAAGAACGTCCAGTGGG
CCGCCTTCGTTGTTGCCGGCACCTTCGCGGGCGTGGCCGGCGCCCTGTTCGGCTTCCTCAAGGGCAGCGTCTTCCCCGAG
AACCTCGCCATCCCGACCTCGGTGGACGGGCTCGTGATGGTGCTGCTCGGCGGCATCGAGACCGTCTCGGGCGCCGTGGT
GGGTGCCATCGTCTACAAGGCGCTGGCCATCTGGCTCATGAGCAAGACGGAGCTCTCCAAGCTCGTGCTCGGCGGCGTCA
TCGTGCTGCTGGTGGTGGCCTTTCCGAAAGGCATCGTCGGCTTCCTCGAAGACCTGCGCCACCGCCGGCGTCCGCCGACG
CCGGACGGGGCGGGGCCGAAGCCGGCCGGTTATGTCGCCAAGGTGGAGGCTGCGGAATGA

Upstream 100 bases:

>100_bases
CTGCGTCCGCAGAACTGACGCTGGCGGCGGCGCCCGCCCGGCGCCGCCGTTCCCGCCGCCCCTGTCGCGGGCGGCGCTTC
AGGCCCGGCCGTGCCGCCCT

Downstream 100 bases:

>100_bases
CCACGCTGCTGCAAGTGGAAGGGCTCGCCAAGTCCTATGGCGGTGTTCATGCGGTGCGCGGCGTCTCCTTCAGCCTTAAG
GCGGGACGCATCCTCGCGCT

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MGGPATRAVRAPVSRAPHAVPTKGRAVDFIVVQALTGLASAASLFLVASGLSIIFGVTRIVNFAHGAFYMLGAYIAFTLT
EALSGTLGFWGGIVLAALIVAVLGAALEIVLLRRIYRAPELFQLLATFGVTLMVQDIVILIWGPEDLMGRRAPGFRGAVD
IMGQMVPAYDLLLIGLGPAVLGVLWLIFHRTRWGVLVRAATQDRDMVAALGVNQKWLFTSVFALGVFLAGLGGALQIPRD
AVSHAMDLRVIVDVFVVVVIGGLGSVTGAFVAAILVSELNAFGILIFPKISLVLVFIVMAVVLVIRPYGLFGKAEGPQRV
AAGLSIRPWRPFTQAERLAVAAAVLVAASLPLFLGNYMLTVGSEILVFVLFAASLHFLMTVGGLSSFGHAAYFGLGAYGA
AFMVKLAGASMVVALLVGPFMGLAGAVLFGWFAVRLSGVYFAMLTLAFAQITWSIAFQWVEVTGGDNGMLGIWPASWASS
PQGFFWLTLGVVAIGVAVLRMLVFSPFGFGLRAARDSALRSEAIGIDRKNVQWAAFVVAGTFAGVAGALFGFLKGSVFPE
NLAIPTSVDGLVMVLLGGIETVSGAVVGAIVYKALAIWLMSKTELSKLVLGGVIVLLVVAFPKGIVGFLEDLRHRRRPPT
PDGAGPKPAGYVAKVEAAE

Sequences:

>Translated_659_residues
MGGPATRAVRAPVSRAPHAVPTKGRAVDFIVVQALTGLASAASLFLVASGLSIIFGVTRIVNFAHGAFYMLGAYIAFTLT
EALSGTLGFWGGIVLAALIVAVLGAALEIVLLRRIYRAPELFQLLATFGVTLMVQDIVILIWGPEDLMGRRAPGFRGAVD
IMGQMVPAYDLLLIGLGPAVLGVLWLIFHRTRWGVLVRAATQDRDMVAALGVNQKWLFTSVFALGVFLAGLGGALQIPRD
AVSHAMDLRVIVDVFVVVVIGGLGSVTGAFVAAILVSELNAFGILIFPKISLVLVFIVMAVVLVIRPYGLFGKAEGPQRV
AAGLSIRPWRPFTQAERLAVAAAVLVAASLPLFLGNYMLTVGSEILVFVLFAASLHFLMTVGGLSSFGHAAYFGLGAYGA
AFMVKLAGASMVVALLVGPFMGLAGAVLFGWFAVRLSGVYFAMLTLAFAQITWSIAFQWVEVTGGDNGMLGIWPASWASS
PQGFFWLTLGVVAIGVAVLRMLVFSPFGFGLRAARDSALRSEAIGIDRKNVQWAAFVVAGTFAGVAGALFGFLKGSVFPE
NLAIPTSVDGLVMVLLGGIETVSGAVVGAIVYKALAIWLMSKTELSKLVLGGVIVLLVVAFPKGIVGFLEDLRHRRRPPT
PDGAGPKPAGYVAKVEAAE
>Mature_658_residues
GGPATRAVRAPVSRAPHAVPTKGRAVDFIVVQALTGLASAASLFLVASGLSIIFGVTRIVNFAHGAFYMLGAYIAFTLTE
ALSGTLGFWGGIVLAALIVAVLGAALEIVLLRRIYRAPELFQLLATFGVTLMVQDIVILIWGPEDLMGRRAPGFRGAVDI
MGQMVPAYDLLLIGLGPAVLGVLWLIFHRTRWGVLVRAATQDRDMVAALGVNQKWLFTSVFALGVFLAGLGGALQIPRDA
VSHAMDLRVIVDVFVVVVIGGLGSVTGAFVAAILVSELNAFGILIFPKISLVLVFIVMAVVLVIRPYGLFGKAEGPQRVA
AGLSIRPWRPFTQAERLAVAAAVLVAASLPLFLGNYMLTVGSEILVFVLFAASLHFLMTVGGLSSFGHAAYFGLGAYGAA
FMVKLAGASMVVALLVGPFMGLAGAVLFGWFAVRLSGVYFAMLTLAFAQITWSIAFQWVEVTGGDNGMLGIWPASWASSP
QGFFWLTLGVVAIGVAVLRMLVFSPFGFGLRAARDSALRSEAIGIDRKNVQWAAFVVAGTFAGVAGALFGFLKGSVFPEN
LAIPTSVDGLVMVLLGGIETVSGAVVGAIVYKALAIWLMSKTELSKLVLGGVIVLLVVAFPKGIVGFLEDLRHRRRPPTP
DGAGPKPAGYVAKVEAAE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=322, Percent_Identity=24.223602484472, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789866, Length=306, Percent_Identity=24.5098039215686, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 69258; Mature: 69126

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGPATRAVRAPVSRAPHAVPTKGRAVDFIVVQALTGLASAASLFLVASGLSIIFGVTRI
CCCCCCHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNFAHGAFYMLGAYIAFTLTEALSGTLGFWGGIVLAALIVAVLGAALEIVLLRRIYRAPE
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LFQLLATFGVTLMVQDIVILIWGPEDLMGRRAPGFRGAVDIMGQMVPAYDLLLIGLGPAV
HHHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCCHHH
LGVLWLIFHRTRWGVLVRAATQDRDMVAALGVNQKWLFTSVFALGVFLAGLGGALQIPRD
HHHHHHHHHHHHHHEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
AVSHAMDLRVIVDVFVVVVIGGLGSVTGAFVAAILVSELNAFGILIFPKISLVLVFIVMA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHH
VVLVIRPYGLFGKAEGPQRVAAGLSIRPWRPFTQAERLAVAAAVLVAASLPLFLGNYMLT
HHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGSEILVFVLFAASLHFLMTVGGLSSFGHAAYFGLGAYGAAFMVKLAGASMVVALLVGPF
HHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLAGAVLFGWFAVRLSGVYFAMLTLAFAQITWSIAFQWVEVTGGDNGMLGIWPASWASS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCCCCC
PQGFFWLTLGVVAIGVAVLRMLVFSPFGFGLRAARDSALRSEAIGIDRKNVQWAAFVVAG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TFAGVAGALFGFLKGSVFPENLAIPTSVDGLVMVLLGGIETVSGAVVGAIVYKALAIWLM
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
SKTELSKLVLGGVIVLLVVAFPKGIVGFLEDLRHRRRPPTPDGAGPKPAGYVAKVEAAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
GGPATRAVRAPVSRAPHAVPTKGRAVDFIVVQALTGLASAASLFLVASGLSIIFGVTRI
CCCCCHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNFAHGAFYMLGAYIAFTLTEALSGTLGFWGGIVLAALIVAVLGAALEIVLLRRIYRAPE
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LFQLLATFGVTLMVQDIVILIWGPEDLMGRRAPGFRGAVDIMGQMVPAYDLLLIGLGPAV
HHHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCCHHH
LGVLWLIFHRTRWGVLVRAATQDRDMVAALGVNQKWLFTSVFALGVFLAGLGGALQIPRD
HHHHHHHHHHHHHHEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
AVSHAMDLRVIVDVFVVVVIGGLGSVTGAFVAAILVSELNAFGILIFPKISLVLVFIVMA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHH
VVLVIRPYGLFGKAEGPQRVAAGLSIRPWRPFTQAERLAVAAAVLVAASLPLFLGNYMLT
HHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGSEILVFVLFAASLHFLMTVGGLSSFGHAAYFGLGAYGAAFMVKLAGASMVVALLVGPF
HHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLAGAVLFGWFAVRLSGVYFAMLTLAFAQITWSIAFQWVEVTGGDNGMLGIWPASWASS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCCCCC
PQGFFWLTLGVVAIGVAVLRMLVFSPFGFGLRAARDSALRSEAIGIDRKNVQWAAFVVAG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TFAGVAGALFGFLKGSVFPENLAIPTSVDGLVMVLLGGIETVSGAVVGAIVYKALAIWLM
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
SKTELSKLVLGGVIVLLVVAFPKGIVGFLEDLRHRRRPPTPDGAGPKPAGYVAKVEAAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]