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The map label for this gene is ywrD [H]

Identifier: 158424395

GI number: 158424395

Start: 3151004

End: 3152683

Strand: Reverse

Name: ywrD [H]

Synonym: AZC_2771

Alternate gene names: 158424395

Gene position: 3152683-3151004 (Counterclockwise)

Preceding gene: 158424397

Following gene: 158424394

Centisome position: 58.71

GC content: 68.75

Gene sequence:

>1680_bases
TTGCAAGCTTTCCTCCTGACCCCGGGCGCACTAGAGACGAAGCAGACATACGCCCCAGCGCAGAAGAGGCCCACCGTGGA
TCTGTCGTCGCTCGATTATCGCACCTCCTATCCAATGCATCGCCAGCCGGTGCTCGGCCGCAATGTGGTCAGCACCTCGC
AGCCGCTGGCGGCGCAAGCGGGCCTGTCCATGCTGGCGCGCGGCGGCAATGCGGTGGATGCCGCCATCGCCACTGCTATG
GCGCTGGTGGTGGTGGAGCCGTCCGGCAACGGCCTCGGCTCCGACGGCTTCGCCATCCTGTGGGACGGGCAGCAACTGCA
TGGCCTCAACGCCTCCGGCCGCTCTCCCGCCGGCTGGACGCGCGACCGCTTCGCCGGCCGGGCGGTGATGCCCGAGCGCG
GCTGGGACGCGGTGACGGTGCCGGGCGCGGTTTCGGGCTGGATCGCCCTGTGGCGGCGCTTCGGTTCGCTGCCGCTGGAG
GTGATCGCCGAGCCCGCCATCCGCTATGCGCGCGAGGGCTATCCGGTTTCTCCCAGCGTCGCAAAGCTCTGGGCCAATGC
CGAGAAAATCCTGTCCGACCAGCCCGGCTTCGCGGAGGCCTTCCTGCCCGAGGGGCGGGCGCCGAAGGCGGGCGAGGTGT
TCCGCTGCGAGCCCATGGCCCGGAGCCTCGAACTCATCGCCCAGACCGAAGGCGAGGCCTTCTATCGCGGTGAACTCGCC
GACAAGATGATCGCCCATGCCAAGGCCCATGGGGCGGCAATGTCCCTCGACGATCTCGGCGCCCATCAGGCGGACTTCGT
CGAGACCCTGTCGCAGCCCTTCGGCTCCGGCGTGGTGCACGAACTGCCGCCGAACGGGCAGGGCATCGCCACCCTCATCA
CCCTCGGCATTCTGGAAGCGCTCGGCGCGCCGCATGAGGACGTGGACAGCGTTGCCGGCATTCATCTGGGCATCGAGGCC
ACCAAGCTCGCTCTGGCCGACCTGTTCCAGTATGTGGCCGATCCGGCCTACATGAATATCGATCCCGCCTCGCTCCTCGA
TCCCGCCTATCTCGCCGAGCGTGCGAAGCTGATCGACCGCAGCAAGGCGAGCCTGCCCAGCTATGGCGCGCCGCGCCAGG
CCGGCACGGTCTATCTCACGGTGGCGGACGCGAAGGGCATGATGGTGTCCTTCATCCAGTCCAACTACATGGGTTTCGGT
TCGGGGGTGGTCGTGCCGGGCACCGGCATCAGCCTGCAGAACCGCGGCGCTGGCTTCGTGCTGAAGCAGGGCCACGCCAA
TGAGGTGGCGCCGCGCAAGCGCCCGTTCCAGACCATTATCCCCGGCTTCGCCATGGACCATGCGGGCGCGCCGCTCATGT
CCTTCGGCGTCATGGGCGGGCCGATGCAGGCACAGGGCCACACCCAGATGGCGCTCCGGGTGCTGCGGTACAACCAGAAC
CCGCAGGCGGCCGCAGATGCGCCGCGCTGGCGCGTGGTGGCGGGCCGCAAGGTGGCGGTGGAACCGGGTGTGGGTCTCGA
GGTTCTGGAAGGGCTGAAGGTGCTTGGCCACGAGATCGTGGTGGACCCGCCGGAGGCGGTCTTCGCCTTCGGCTCGGCCC
AGCTCATCGTGCGCGGCGACAACGGCTTCTATGCCGCCGGCTGCGACAGCCGCAAGGACAGCCAGGCCGCCGCCTTCTGA

Upstream 100 bases:

>100_bases
CTTAGTCGTCCGATACCGAAGGCCAAGCCCATGGTCGCGAAGACCCTCTCATACCTTTGCGGCATGCGGTTTCCTGCAGC
GCCGGTCAGGTTCTGATGCA

Downstream 100 bases:

>100_bases
TCGACGCCGCCCGGTCCGCCGGGCGGCATGCCATTGAGAGGTTTGGAGGAGGTGATGGCCGACGATCCGTTCCACCTCCA
GCGCTTCCTCGATGCGCAGA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MQAFLLTPGALETKQTYAPAQKRPTVDLSSLDYRTSYPMHRQPVLGRNVVSTSQPLAAQAGLSMLARGGNAVDAAIATAM
ALVVVEPSGNGLGSDGFAILWDGQQLHGLNASGRSPAGWTRDRFAGRAVMPERGWDAVTVPGAVSGWIALWRRFGSLPLE
VIAEPAIRYAREGYPVSPSVAKLWANAEKILSDQPGFAEAFLPEGRAPKAGEVFRCEPMARSLELIAQTEGEAFYRGELA
DKMIAHAKAHGAAMSLDDLGAHQADFVETLSQPFGSGVVHELPPNGQGIATLITLGILEALGAPHEDVDSVAGIHLGIEA
TKLALADLFQYVADPAYMNIDPASLLDPAYLAERAKLIDRSKASLPSYGAPRQAGTVYLTVADAKGMMVSFIQSNYMGFG
SGVVVPGTGISLQNRGAGFVLKQGHANEVAPRKRPFQTIIPGFAMDHAGAPLMSFGVMGGPMQAQGHTQMALRVLRYNQN
PQAAADAPRWRVVAGRKVAVEPGVGLEVLEGLKVLGHEIVVDPPEAVFAFGSAQLIVRGDNGFYAAGCDSRKDSQAAAF

Sequences:

>Translated_559_residues
MQAFLLTPGALETKQTYAPAQKRPTVDLSSLDYRTSYPMHRQPVLGRNVVSTSQPLAAQAGLSMLARGGNAVDAAIATAM
ALVVVEPSGNGLGSDGFAILWDGQQLHGLNASGRSPAGWTRDRFAGRAVMPERGWDAVTVPGAVSGWIALWRRFGSLPLE
VIAEPAIRYAREGYPVSPSVAKLWANAEKILSDQPGFAEAFLPEGRAPKAGEVFRCEPMARSLELIAQTEGEAFYRGELA
DKMIAHAKAHGAAMSLDDLGAHQADFVETLSQPFGSGVVHELPPNGQGIATLITLGILEALGAPHEDVDSVAGIHLGIEA
TKLALADLFQYVADPAYMNIDPASLLDPAYLAERAKLIDRSKASLPSYGAPRQAGTVYLTVADAKGMMVSFIQSNYMGFG
SGVVVPGTGISLQNRGAGFVLKQGHANEVAPRKRPFQTIIPGFAMDHAGAPLMSFGVMGGPMQAQGHTQMALRVLRYNQN
PQAAADAPRWRVVAGRKVAVEPGVGLEVLEGLKVLGHEIVVDPPEAVFAFGSAQLIVRGDNGFYAAGCDSRKDSQAAAF
>Mature_559_residues
MQAFLLTPGALETKQTYAPAQKRPTVDLSSLDYRTSYPMHRQPVLGRNVVSTSQPLAAQAGLSMLARGGNAVDAAIATAM
ALVVVEPSGNGLGSDGFAILWDGQQLHGLNASGRSPAGWTRDRFAGRAVMPERGWDAVTVPGAVSGWIALWRRFGSLPLE
VIAEPAIRYAREGYPVSPSVAKLWANAEKILSDQPGFAEAFLPEGRAPKAGEVFRCEPMARSLELIAQTEGEAFYRGELA
DKMIAHAKAHGAAMSLDDLGAHQADFVETLSQPFGSGVVHELPPNGQGIATLITLGILEALGAPHEDVDSVAGIHLGIEA
TKLALADLFQYVADPAYMNIDPASLLDPAYLAERAKLIDRSKASLPSYGAPRQAGTVYLTVADAKGMMVSFIQSNYMGFG
SGVVVPGTGISLQNRGAGFVLKQGHANEVAPRKRPFQTIIPGFAMDHAGAPLMSFGVMGGPMQAQGHTQMALRVLRYNQN
PQAAADAPRWRVVAGRKVAVEPGVGLEVLEGLKVLGHEIVVDPPEAVFAFGSAQLIVRGDNGFYAAGCDSRKDSQAAAF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=543, Percent_Identity=24.6777163904236, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI73915090, Length=543, Percent_Identity=24.6777163904236, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI73915096, Length=543, Percent_Identity=24.6777163904236, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI73915094, Length=543, Percent_Identity=24.6777163904236, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI113429324, Length=548, Percent_Identity=25.3649635036496, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI113429326, Length=553, Percent_Identity=25.1356238698011, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI109148539, Length=468, Percent_Identity=27.5641025641026, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI153266885, Length=540, Percent_Identity=23.3333333333333, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI153266901, Length=541, Percent_Identity=23.2902033271719, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI153266907, Length=536, Percent_Identity=22.7611940298507, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1789856, Length=530, Percent_Identity=27.7358490566038, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17506189, Length=477, Percent_Identity=25.9958071278826, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI212646519, Length=472, Percent_Identity=24.364406779661, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=472, Percent_Identity=24.5762711864407, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17542894, Length=489, Percent_Identity=25.1533742331288, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193208245, Length=483, Percent_Identity=23.3954451345756, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI193208247, Length=483, Percent_Identity=23.3954451345756, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17564448, Length=392, Percent_Identity=23.9795918367347, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323330, Length=511, Percent_Identity=22.3091976516634, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859893, Length=506, Percent_Identity=26.2845849802372, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161077496, Length=489, Percent_Identity=26.1758691206544, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077878, Length=467, Percent_Identity=25.6959314775161, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077880, Length=467, Percent_Identity=25.6959314775161, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642670, Length=467, Percent_Identity=25.6959314775161, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642666, Length=467, Percent_Identity=25.6959314775161, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551474, Length=467, Percent_Identity=25.6959314775161, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859741, Length=489, Percent_Identity=23.5173824130879, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59096; Mature: 59096

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAFLLTPGALETKQTYAPAQKRPTVDLSSLDYRTSYPMHRQPVLGRNVVSTSQPLAAQA
CCEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
GLSMLARGGNAVDAAIATAMALVVVEPSGNGLGSDGFAILWDGQQLHGLNASGRSPAGWT
HHHHHHCCCCHHHHHHHHEEEEEEECCCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCC
RDRFAGRAVMPERGWDAVTVPGAVSGWIALWRRFGSLPLEVIAEPAIRYAREGYPVSPSV
HHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
AKLWANAEKILSDQPGFAEAFLPEGRAPKAGEVFRCEPMARSLELIAQTEGEAFYRGELA
HHHHHCHHHHHCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCEEEHHHHH
DKMIAHAKAHGAAMSLDDLGAHQADFVETLSQPFGSGVVHELPPNGQGIATLITLGILEA
HHHHHHHHHCCCEECHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHH
LGAPHEDVDSVAGIHLGIEATKLALADLFQYVADPAYMNIDPASLLDPAYLAERAKLIDR
HCCCHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCEECCCHHHHCCHHHHHHHHHHHHH
SKASLPSYGAPRQAGTVYLTVADAKGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGAGFV
HHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEECCCCCEECCCCCCEE
LKQGHANEVAPRKRPFQTIIPGFAMDHAGAPLMSFGVMGGPMQAQGHTQMALRVLRYNQN
EECCCCCCCCCCCCCHHHHCCCHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
PQAAADAPRWRVVAGRKVAVEPGVGLEVLEGLKVLGHEIVVDPPEAVFAFGSAQLIVRGD
CCCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHCCEEEECCHHHHEEECCEEEEEECC
NGFYAAGCDSRKDSQAAAF
CCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MQAFLLTPGALETKQTYAPAQKRPTVDLSSLDYRTSYPMHRQPVLGRNVVSTSQPLAAQA
CCEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
GLSMLARGGNAVDAAIATAMALVVVEPSGNGLGSDGFAILWDGQQLHGLNASGRSPAGWT
HHHHHHCCCCHHHHHHHHEEEEEEECCCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCC
RDRFAGRAVMPERGWDAVTVPGAVSGWIALWRRFGSLPLEVIAEPAIRYAREGYPVSPSV
HHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
AKLWANAEKILSDQPGFAEAFLPEGRAPKAGEVFRCEPMARSLELIAQTEGEAFYRGELA
HHHHHCHHHHHCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCEEEHHHHH
DKMIAHAKAHGAAMSLDDLGAHQADFVETLSQPFGSGVVHELPPNGQGIATLITLGILEA
HHHHHHHHHCCCEECHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHH
LGAPHEDVDSVAGIHLGIEATKLALADLFQYVADPAYMNIDPASLLDPAYLAERAKLIDR
HCCCHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCEECCCHHHHCCHHHHHHHHHHHHH
SKASLPSYGAPRQAGTVYLTVADAKGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGAGFV
HHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEECCCCCEECCCCCCEE
LKQGHANEVAPRKRPFQTIIPGFAMDHAGAPLMSFGVMGGPMQAQGHTQMALRVLRYNQN
EECCCCCCCCCCCCCHHHHCCCHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
PQAAADAPRWRVVAGRKVAVEPGVGLEVLEGLKVLGHEIVVDPPEAVFAFGSAQLIVRGD
CCCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHCCEEEECCHHHHEEECCEEEEEECC
NGFYAAGCDSRKDSQAAAF
CCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]