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The map label for this gene is gyaR [H]

Identifier: 158424243

GI number: 158424243

Start: 2952841

End: 2953794

Strand: Direct

Name: gyaR [H]

Synonym: AZC_2619

Alternate gene names: 158424243

Gene position: 2952841-2953794 (Clockwise)

Preceding gene: 158424242

Following gene: 158424245

Centisome position: 54.99

GC content: 70.55

Gene sequence:

>954_bases
GTGAGCCGAGACCTCTCCATGAAGCCCGACCTGCTCCAGCTCTGCCCGCTGATGCCGTCCCTCGAGGCGGATCTGGCGGA
GCGCTTCACGGTGCACCGCCTGCACGAGGCGGCGGATGCCGAGGCCTTTCTCGCCACCCACGGTTCGGCCATCAAGGCGG
TCGCCACAGGCGGCCACATCGGCCTGCCGCCGGCGGTGGGCGCGCGGCTGCCGGCCCTTGAGATCGTCGCCATCAACGGG
GTCGGCTACGACAAGGTGGACCTCGCCGAAGCCAGGCGCCGGGGCTATCGCGTCGCCAACACGCCCGACGTGCTCACGGA
GGACGTGGCGGACCTTGCCATCGGCCTCACCATCGCCGCACTGCGCCAGCTGGTGCGGGGCGATGGGCATGTGCGCGCCG
GCCAATGGCCGAAAGGCGACCTGCCGCTCGGCCGCAAGATGTCGCGCAAGAAGTTCGGCATCGTCGGTCTCGGCCGCATC
GGCCGTGCCATCGCCAAGCGCCTTCAGGCCTTCGACGGCGAGATCGGTTATGCCTCCCGCAGCCCGCAGGATGTGCCCTA
TCGGGCGTTCGAGAGCCCGGCGGCACTCGCCGCCTGGTGCGATGTGCTCATCATCGCCGCCGCCGCCTCGGCGGAGACGC
GACACCTCATCAACGGGCCGGTTCTGGAGGCCCTCGGGCCGAAGGGCGTGCTGGTGAACGTGGCGCGCGGCTCTCTGGTG
GACGAGAAGGCCCTGCTCCACGCCGTCCAGCACGGCCAGATCGCCGGTGCCGCGCTCGACGTGTTCGAGAACGAGCCCCA
CGTGCCGGAAGGCTTCCATGGCCTTCCCAACGTGGTGCTGACCCCGCACATGGCGAGCGCCACGCATGAGACGCGTGCCG
ACATGGCCGCCCTCGTGATCGCCAATCTCGATGCCCACTTCGCCGGGCGGGCGCTGCCGACGCCGGTGGTGTGA

Upstream 100 bases:

>100_bases
TCATGCACAAGGGCCGCATCTGGGAGGAAGGCCCCTCCCAGGAGCTGTTCGCCAATCCCCAGACGCCGGAACTGCGCCAG
TTCGTGAAGGCGGACGTGAA

Downstream 100 bases:

>100_bases
AAGCCGGGGCGCGGTTGGCCGCGCCCCGGCCAAGGCCTCAGGGCAAGTTGACGATCTCGACCCAGTTGGGGTTCTTGCCA
AGTTCCTGCCGACCAATGGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSRDLSMKPDLLQLCPLMPSLEADLAERFTVHRLHEAADAEAFLATHGSAIKAVATGGHIGLPPAVGARLPALEIVAING
VGYDKVDLAEARRRGYRVANTPDVLTEDVADLAIGLTIAALRQLVRGDGHVRAGQWPKGDLPLGRKMSRKKFGIVGLGRI
GRAIAKRLQAFDGEIGYASRSPQDVPYRAFESPAALAAWCDVLIIAAAASAETRHLINGPVLEALGPKGVLVNVARGSLV
DEKALLHAVQHGQIAGAALDVFENEPHVPEGFHGLPNVVLTPHMASATHETRADMAALVIANLDAHFAGRALPTPVV

Sequences:

>Translated_317_residues
MSRDLSMKPDLLQLCPLMPSLEADLAERFTVHRLHEAADAEAFLATHGSAIKAVATGGHIGLPPAVGARLPALEIVAING
VGYDKVDLAEARRRGYRVANTPDVLTEDVADLAIGLTIAALRQLVRGDGHVRAGQWPKGDLPLGRKMSRKKFGIVGLGRI
GRAIAKRLQAFDGEIGYASRSPQDVPYRAFESPAALAAWCDVLIIAAAASAETRHLINGPVLEALGPKGVLVNVARGSLV
DEKALLHAVQHGQIAGAALDVFENEPHVPEGFHGLPNVVLTPHMASATHETRADMAALVIANLDAHFAGRALPTPVV
>Mature_316_residues
SRDLSMKPDLLQLCPLMPSLEADLAERFTVHRLHEAADAEAFLATHGSAIKAVATGGHIGLPPAVGARLPALEIVAINGV
GYDKVDLAEARRRGYRVANTPDVLTEDVADLAIGLTIAALRQLVRGDGHVRAGQWPKGDLPLGRKMSRKKFGIVGLGRIG
RAIAKRLQAFDGEIGYASRSPQDVPYRAFESPAALAAWCDVLIIAAAASAETRHLINGPVLEALGPKGVLVNVARGSLVD
EKALLHAVQHGQIAGAALDVFENEPHVPEGFHGLPNVVLTPHMASATHETRADMAALVIANLDAHFAGRALPTPVV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=36.1111111111111, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI23308577, Length=253, Percent_Identity=34.3873517786561, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4557497, Length=240, Percent_Identity=30.8333333333333, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI61743967, Length=240, Percent_Identity=30.8333333333333, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI145580578, Length=255, Percent_Identity=29.4117647058824, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4557499, Length=255, Percent_Identity=29.4117647058824, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI145580575, Length=255, Percent_Identity=29.4117647058824, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI87082289, Length=315, Percent_Identity=33.6507936507937, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787645, Length=266, Percent_Identity=26.6917293233083, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789279, Length=232, Percent_Identity=29.7413793103448, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081824, Length=164, Percent_Identity=35.3658536585366, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=245, Percent_Identity=30.2040816326531, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=246, Percent_Identity=25.609756097561, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=238, Percent_Identity=34.453781512605, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=247, Percent_Identity=28.7449392712551, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=235, Percent_Identity=29.3617021276596, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=286, Percent_Identity=27.6223776223776, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=37.2093023255814, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28571528, Length=249, Percent_Identity=36.9477911646586, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45552429, Length=276, Percent_Identity=34.0579710144928, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24585514, Length=276, Percent_Identity=34.0579710144928, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI28574282, Length=276, Percent_Identity=34.0579710144928, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI45551003, Length=276, Percent_Identity=34.0579710144928, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574284, Length=276, Percent_Identity=34.0579710144928, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=35.4330708661417, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24646446, Length=231, Percent_Identity=32.9004329004329, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646448, Length=231, Percent_Identity=32.9004329004329, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646452, Length=231, Percent_Identity=32.9004329004329, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646450, Length=231, Percent_Identity=32.9004329004329, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62472511, Length=231, Percent_Identity=32.9004329004329, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921140, Length=235, Percent_Identity=29.7872340425532, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33472; Mature: 33341

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDLSMKPDLLQLCPLMPSLEADLAERFTVHRLHEAADAEAFLATHGSAIKAVATGGHI
CCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEEECCCCC
GLPPAVGARLPALEIVAINGVGYDKVDLAEARRRGYRVANTPDVLTEDVADLAIGLTIAA
CCCCHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LRQLVRGDGHVRAGQWPKGDLPLGRKMSRKKFGIVGLGRIGRAIAKRLQAFDGEIGYASR
HHHHHCCCCCEECCCCCCCCCCCCCHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCCC
SPQDVPYRAFESPAALAAWCDVLIIAAAASAETRHLINGPVLEALGPKGVLVNVARGSLV
CCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCEEEEECCCCCH
DEKALLHAVQHGQIAGAALDVFENEPHVPEGFHGLPNVVLTPHMASATHETRADMAALVI
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHH
ANLDAHFAGRALPTPVV
HCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
SRDLSMKPDLLQLCPLMPSLEADLAERFTVHRLHEAADAEAFLATHGSAIKAVATGGHI
CCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEEECCCCC
GLPPAVGARLPALEIVAINGVGYDKVDLAEARRRGYRVANTPDVLTEDVADLAIGLTIAA
CCCCHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LRQLVRGDGHVRAGQWPKGDLPLGRKMSRKKFGIVGLGRIGRAIAKRLQAFDGEIGYASR
HHHHHCCCCCEECCCCCCCCCCCCCHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCCC
SPQDVPYRAFESPAALAAWCDVLIIAAAASAETRHLINGPVLEALGPKGVLVNVARGSLV
CCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCEEEEECCCCCH
DEKALLHAVQHGQIAGAALDVFENEPHVPEGFHGLPNVVLTPHMASATHETRADMAALVI
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHH
ANLDAHFAGRALPTPVV
HCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA