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The map label for this gene is fabF [H]

Identifier: 158424030

GI number: 158424030

Start: 2733021

End: 2734301

Strand: Direct

Name: fabF [H]

Synonym: AZC_2406

Alternate gene names: 158424030

Gene position: 2733021-2734301 (Clockwise)

Preceding gene: 158424029

Following gene: 158424031

Centisome position: 50.9

GC content: 67.53

Gene sequence:

>1281_bases
ATGGCGCAGACCTATAACGACAAGTTCGGCCGCCCCATCGTGGTCGTGACCGGCATCGGCATCGTCACCTCCCTCGGGCA
GGGCAAGGCCGAAAACTGGAAGAAGCTGACGGCCGGCGAGTCGGGCATCCACCGCATCACGCGCTTCCCCGTTGAGGGCA
TGCGCACGACCATTGCGGGCACGGTGGACTTCCTGTTCGACGAGCGCGTCGCCGCCCCGAACCTGTCCGAGAAGCTCGCG
ACGCTCGCCGCAGAGGAAGCCATTTCCGAGGCCGGCATCGGCGGCAATGGCGATTTCCCCGGTCCCCTGTTCGCGGCCGT
TCCGCCGGTCGAGATCGAGTGGCCCGAGCGCCGGCAGCTGGCGGAAGTCGTGACCCACCGCCCGATGGTCTACCACGACC
TCCTCGGCGCAGCCGCCACCGGCAAGTTCCGTCCCTGGCACGAGCGTTTCCTGTTCGGCTCTGTGGCCGATGCGCTTGCC
GACCGTTTTGGGACGCGGGGCCAACCGATCTCCCTGTCCACGGCCTGCGCGTCGGGCGCCACCGCCATCCAGCTCGCCGT
CGAGGCGATCCGGCGCGGCGAGTGCGATGTTGCGCTCTCCCTCGGCACGGACGGCTCGGTGCATCCCGAAGCGCTCATCC
GCTTCTCGCTGCTCTCGGCCCTTACCACCGCCAATGACAATCCCGCCGAGGCCTCCAAGCCCTTCGCCAAGAACCGGGAC
GGCTTCGTCATGGCCGAGGGCGCAGCGGCGCTGGTGCTGGAGAGCTACGAGCACGCCAAGGCGCGCGGCGCCAGGATCCT
CGGCGTGCTGGAAGGCGCCGGCGAGATGGCCGACAATTTCCATCGCACCCGCTCCAGCCCGGATGCCAAGCCCATCATCG
GCTGCATCAACCGGGCACTTTCGGATGCCGGCGTCACCATCGCGGATGTGGGCTACATCAACGCCCACGGCACCTCGACC
CCCGAGAACGACCGCATGGAGCATGTGGGCTTCTCGGCGGTGTTCGGCGAGCAGCTGAAGAACGTGCCCATCTCGTCCAA
CAAGTCGATGATCGGCCACACGCTCACTGCCGCCGGCGCCATCGAGGCGGCCTTCTCGCTGCTGACCATCCAGAACAGCC
GTATCCCGCCGACCATCAACTACCACGTGCCCGATCCGGCCATTCCGCTGGACGTGGTGCCGAATGTCGCCCGTGACGCC
GAGGTGAAGCGGGTGATCTCGTCGTCCTTCGGCTTCGGCGGCCAGAACGTGTGTCTGGTCATTGCGGGTGAGCCCGCGTG
A

Upstream 100 bases:

>100_bases
CCGGGCGGCTTCGTTTCAAGGGTGAAAAATCGCTCCGGCGCATTAGGTTTGGGCCAAGTTCCGCCCGCCGCGCGCGGGCC
GCTCAGATCAGGAGGCGCCC

Downstream 100 bases:

>100_bases
GCGAACCGAAGAAACGCGTTCTCGTCACCGGCGGCGGGCGGGGCCTCGGCTCCGCCATCGTCCGTGCGCTCGCCGCACAG
GGCTTCGCGGTGACCTTCAC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAQTYNDKFGRPIVVVTGIGIVTSLGQGKAENWKKLTAGESGIHRITRFPVEGMRTTIAGTVDFLFDERVAAPNLSEKLA
TLAAEEAISEAGIGGNGDFPGPLFAAVPPVEIEWPERRQLAEVVTHRPMVYHDLLGAAATGKFRPWHERFLFGSVADALA
DRFGTRGQPISLSTACASGATAIQLAVEAIRRGECDVALSLGTDGSVHPEALIRFSLLSALTTANDNPAEASKPFAKNRD
GFVMAEGAAALVLESYEHAKARGARILGVLEGAGEMADNFHRTRSSPDAKPIIGCINRALSDAGVTIADVGYINAHGTST
PENDRMEHVGFSAVFGEQLKNVPISSNKSMIGHTLTAAGAIEAAFSLLTIQNSRIPPTINYHVPDPAIPLDVVPNVARDA
EVKRVISSSFGFGGQNVCLVIAGEPA

Sequences:

>Translated_426_residues
MAQTYNDKFGRPIVVVTGIGIVTSLGQGKAENWKKLTAGESGIHRITRFPVEGMRTTIAGTVDFLFDERVAAPNLSEKLA
TLAAEEAISEAGIGGNGDFPGPLFAAVPPVEIEWPERRQLAEVVTHRPMVYHDLLGAAATGKFRPWHERFLFGSVADALA
DRFGTRGQPISLSTACASGATAIQLAVEAIRRGECDVALSLGTDGSVHPEALIRFSLLSALTTANDNPAEASKPFAKNRD
GFVMAEGAAALVLESYEHAKARGARILGVLEGAGEMADNFHRTRSSPDAKPIIGCINRALSDAGVTIADVGYINAHGTST
PENDRMEHVGFSAVFGEQLKNVPISSNKSMIGHTLTAAGAIEAAFSLLTIQNSRIPPTINYHVPDPAIPLDVVPNVARDA
EVKRVISSSFGFGGQNVCLVIAGEPA
>Mature_425_residues
AQTYNDKFGRPIVVVTGIGIVTSLGQGKAENWKKLTAGESGIHRITRFPVEGMRTTIAGTVDFLFDERVAAPNLSEKLAT
LAAEEAISEAGIGGNGDFPGPLFAAVPPVEIEWPERRQLAEVVTHRPMVYHDLLGAAATGKFRPWHERFLFGSVADALAD
RFGTRGQPISLSTACASGATAIQLAVEAIRRGECDVALSLGTDGSVHPEALIRFSLLSALTTANDNPAEASKPFAKNRDG
FVMAEGAAALVLESYEHAKARGARILGVLEGAGEMADNFHRTRSSPDAKPIIGCINRALSDAGVTIADVGYINAHGTSTP
ENDRMEHVGFSAVFGEQLKNVPISSNKSMIGHTLTAAGAIEAAFSLLTIQNSRIPPTINYHVPDPAIPLDVVPNVARDAE
VKRVISSSFGFGGQNVCLVIAGEPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=441, Percent_Identity=34.2403628117914, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI223972627, Length=149, Percent_Identity=40.9395973154362, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI41872631, Length=277, Percent_Identity=31.0469314079422, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=35.4761904761905, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=33.0917874396135, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71983541, Length=278, Percent_Identity=35.9712230215827, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=36.7816091954023, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=289, Percent_Identity=29.0657439446367, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=298, Percent_Identity=27.8523489932886, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=29.3064876957494, Blast_Score=149, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24644341, Length=431, Percent_Identity=36.4269141531323, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24581345, Length=276, Percent_Identity=27.8985507246377, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19920632, Length=280, Percent_Identity=28.2142857142857, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=28.2142857142857, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44983; Mature: 44852

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTYNDKFGRPIVVVTGIGIVTSLGQGKAENWKKLTAGESGIHRITRFPVEGMRTTIAG
CCCCCCCCCCCCEEEEECCHHHHHCCCCCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHH
TVDFLFDERVAAPNLSEKLATLAAEEAISEAGIGGNGDFPGPLFAAVPPVEIEWPERRQL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCHHHHH
AEVVTHRPMVYHDLLGAAATGKFRPWHERFLFGSVADALADRFGTRGQPISLSTACASGA
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCH
TAIQLAVEAIRRGECDVALSLGTDGSVHPEALIRFSLLSALTTANDNPAEASKPFAKNRD
HHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFVMAEGAAALVLESYEHAKARGARILGVLEGAGEMADNFHRTRSSPDAKPIIGCINRAL
CEEEECCCCEEHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
SDAGVTIADVGYINAHGTSTPENDRMEHVGFSAVFGEQLKNVPISSNKSMIGHTLTAAGA
HHCCCEEEEECEEECCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IEAAFSLLTIQNSRIPPTINYHVPDPAIPLDVVPNVARDAEVKRVISSSFGFGGQNVCLV
HHHHHHHHEEECCCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEE
IAGEPA
EECCCC
>Mature Secondary Structure 
AQTYNDKFGRPIVVVTGIGIVTSLGQGKAENWKKLTAGESGIHRITRFPVEGMRTTIAG
CCCCCCCCCCCEEEEECCHHHHHCCCCCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHH
TVDFLFDERVAAPNLSEKLATLAAEEAISEAGIGGNGDFPGPLFAAVPPVEIEWPERRQL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCHHHHH
AEVVTHRPMVYHDLLGAAATGKFRPWHERFLFGSVADALADRFGTRGQPISLSTACASGA
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCH
TAIQLAVEAIRRGECDVALSLGTDGSVHPEALIRFSLLSALTTANDNPAEASKPFAKNRD
HHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFVMAEGAAALVLESYEHAKARGARILGVLEGAGEMADNFHRTRSSPDAKPIIGCINRAL
CEEEECCCCEEHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
SDAGVTIADVGYINAHGTSTPENDRMEHVGFSAVFGEQLKNVPISSNKSMIGHTLTAAGA
HHCCCEEEEECEEECCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IEAAFSLLTIQNSRIPPTINYHVPDPAIPLDVVPNVARDAEVKRVISSSFGFGGQNVCLV
HHHHHHHHEEECCCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEE
IAGEPA
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]