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The map label for this gene is ilvC

Identifier: 158423998

GI number: 158423998

Start: 2700396

End: 2701415

Strand: Reverse

Name: ilvC

Synonym: AZC_2374

Alternate gene names: 158423998

Gene position: 2701415-2700396 (Counterclockwise)

Preceding gene: 158423999

Following gene: 158423997

Centisome position: 50.31

GC content: 65.0

Gene sequence:

>1020_bases
ATGCGCGTTTATTACGATCGTGATGCCGACCTGAACCTCATCAAGGGCAAGAAGGTTGTCATCGTCGGCTACGGCAGCCA
GGGCCACGCCCATGCGCTCAACCTGCGCGACAGCGGCGTGAAGGATATCGTGGTCGCCCTGCGTCCCGGTTCCGCCAGCG
CCAAGAAGGCCGAGGGCGAGGGCTTCAAGGTCATGACCCCCGCGGAAGCCGCCAAGTGGGGCGACGTGGTGATGATGCTC
ACCCCCGACGAGCTCCAGGCCGACATCTATCGCGAGAGCCTGCACGACAACATGAAGCAGGGCGCCGCGCTGCTGTTCGC
CCACGGCCTCAACGTGCACTTCAACCTCATCGAGCCCCGCAAGGATCTCGACGTGCTCATGATCGCCCCGAAGGGCCCGG
GCCACACGGTGCGCTCCGAGTACCAGCGTGGCGGCGGCGTGCCGACCCTCATCGCCATCGCGCAGGACGCCTCGGGCAAC
GCCCATGACCTCGGCCTCTCCTACGCCTCGGCCAACGGCGGCGGCCGCGCCGGCATCATCGAGACCACCTTCAAGGAAGA
GTGCGAGACCGACCTGTTCGGCGAGCAGGTCGTCCTCTGCGGCGGCCTCGTGGAGCTGATCCGCGCCGGCTTCGAGACGC
TGGTGGAAGCCGGCTACGCGCCGGAGATGGCCTATTTCGAGTGCCTGCACGAAGTGAAGCTGATCGTCGACCTCATCTAT
GAGGGCGGCATCGCCAACATGAACTACTCCATCTCGAACACCGCCGAGTATGGCGAGTATGTCACCGGCCCCCGCATCAT
CACGCCCGAGACCAAGGCCGAGATGAAGCGCGTGCTGACCGACATCCAGACCGGCAAGTTCACCCGCGACTGGATGCTGG
AGAACAAGGTCAACCAGGCCTCGTTCAAGGCCACCCGCGCCCGCCACAACGCCCACCAGATCGAGGCGGTCGGCGAGAAG
CTCCGCGAGATGATGCCCTGGATCAAGGCCAAGGCGCTCGTGGACAAGAGCAAGAACTGA

Upstream 100 bases:

>100_bases
AGGTGGCGCGCACCGGCATCGTCGCCATTTCCCGCGGCCCGGAAGCCATGTGAGCGCCGGCTGCGACCCCTTTCAACCCG
TTTTACCAAGAGGAAAACCC

Downstream 100 bases:

>100_bases
GTTTCAGTCAGGTTCTGGAACAGGGAGCGGGCGCCGGAAGGCGCCCGTTTCTGTTTCAGGGTGCCCATCCGATCCGCTGC
ACGACAGAAGCCTCCTAAAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLRDSGVKDIVVALRPGSASAKKAEGEGFKVMTPAEAAKWGDVVMML
TPDELQADIYRESLHDNMKQGAALLFAHGLNVHFNLIEPRKDLDVLMIAPKGPGHTVRSEYQRGGGVPTLIAIAQDASGN
AHDLGLSYASANGGGRAGIIETTFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLTDIQTGKFTRDWMLENKVNQASFKATRARHNAHQIEAVGEK
LREMMPWIKAKALVDKSKN

Sequences:

>Translated_339_residues
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLRDSGVKDIVVALRPGSASAKKAEGEGFKVMTPAEAAKWGDVVMML
TPDELQADIYRESLHDNMKQGAALLFAHGLNVHFNLIEPRKDLDVLMIAPKGPGHTVRSEYQRGGGVPTLIAIAQDASGN
AHDLGLSYASANGGGRAGIIETTFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLTDIQTGKFTRDWMLENKVNQASFKATRARHNAHQIEAVGEK
LREMMPWIKAKALVDKSKN
>Mature_339_residues
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLRDSGVKDIVVALRPGSASAKKAEGEGFKVMTPAEAAKWGDVVMML
TPDELQADIYRESLHDNMKQGAALLFAHGLNVHFNLIEPRKDLDVLMIAPKGPGHTVRSEYQRGGGVPTLIAIAQDASGN
AHDLGLSYASANGGGRAGIIETTFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLTDIQTGKFTRDWMLENKVNQASFKATRARHNAHQIEAVGEK
LREMMPWIKAKALVDKSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=299, Percent_Identity=40.8026755852843, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323387, Length=265, Percent_Identity=34.3396226415094, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_AZOC5 (A8I679)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525290.1
- ProteinModelPortal:   A8I679
- SMR:   A8I679
- GeneID:   5690176
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2374
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   ACAU438753:AZC_2374-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37153; Mature: 37153

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLRDSGVKDIVVALRPGSASAKKAEGE
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCC
GFKVMTPAEAAKWGDVVMMLTPDELQADIYRESLHDNMKQGAALLFAHGLNVHFNLIEPR
CEEEECCHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEEECCC
KDLDVLMIAPKGPGHTVRSEYQRGGGVPTLIAIAQDASGNAHDLGLSYASANGGGRAGII
CCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCEE
ETTFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLTDIQTGKFTRDWMLENKVNQA
CCCCCCCCEECCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCHH
SFKATRARHNAHQIEAVGEKLREMMPWIKAKALVDKSKN
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLRDSGVKDIVVALRPGSASAKKAEGE
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCC
GFKVMTPAEAAKWGDVVMMLTPDELQADIYRESLHDNMKQGAALLFAHGLNVHFNLIEPR
CEEEECCHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEEECCC
KDLDVLMIAPKGPGHTVRSEYQRGGGVPTLIAIAQDASGNAHDLGLSYASANGGGRAGII
CCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCEE
ETTFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLTDIQTGKFTRDWMLENKVNQA
CCCCCCCCEECCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCHH
SFKATRARHNAHQIEAVGEKLREMMPWIKAKALVDKSKN
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA