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The map label for this gene is ydgK [H]

Identifier: 158423957

GI number: 158423957

Start: 2657630

End: 2658901

Strand: Direct

Name: ydgK [H]

Synonym: AZC_2333

Alternate gene names: 158423957

Gene position: 2657630-2658901 (Clockwise)

Preceding gene: 158423955

Following gene: 158423959

Centisome position: 49.49

GC content: 66.67

Gene sequence:

>1272_bases
TTGAGTAAATGTATGACCAGATCTGATCCGGGCGTCGCATCGGCGGCGGCCCAGAAGCCCAGCTTTGTCGAATTCGTCGC
CCTCGTCGCGCTGATGATGGGCGTCACCGCCTTCTCCATCGACAACCTGCTCCCGGCCTTCGAGCCGATCCGCGTCGATC
TGAAGGTGCCCCGCGCCGGCGATCTCCAGCTCATCGTCACCGCCTACATGATCGGCTTCGCGCTGATGCAGCTGGTGTTC
GGCACCATCTCGGACGTCATCGGCCGCAAGCCCGCCCTCATCATCGGTCTCGCCATCTATGCGGTGGGCTGCGGCCTGGC
CATGGTCACGGACAACTTCACGGTCCTGCTGGTGGCCCGCGCAATCCAGGGCATGGGCACGGCGGCGGCCCGCGTGCTCT
CTGTCGCCATCGTGCGCGACCGCTTCAAGGGCCGCGACATGGCCCGCGTCATGTCGCTGTGCATGATGGTGTTCCTCGTC
GTGCCCGTGGTGGCGCCGACGCTCGGCAGCGCCATCCTGCTGGTGGGCACGTGGCACCTCATCTTCCTCGCCATGCTGGC
GCTCGGCGTGATTCTGGCGGTCTGGTTCGGCCTGCGCATGCCGGAGACCCTGCATCCGGAAAATCGCGTGCCCTTCTCCG
TCGCCTCCATCGTGCGCGGGCTGAAGGTCACGGTCACGACGCGGCGGGCCTTCGGCTATGCCACCGGCATGGGGCTGATG
ATGGGCGCGCTGATGTCCTTCGTCGCCTCGGCCCCGCAGATCTTCGACACCGAGGTCTATCACCTCGGCAGTGCCTTCCC
CCTCGCCTTCTCGTCCGTCGCGGCGGTGATGTCGGCGGCGTCCTTCCTCAATTCCCGGCTCGTGGGGCGCATCGGCATGC
GCCACCTCTCGCACGCCGCCATCATCGGCTTCACGCTGGTGGGCGGGCTGCAGGTGGCATTCGCCCTCGCCTATGACGGC
AAGCCGCCCTTCCTGCTCTTCTGCACGCTGATCGCGCTCAACCAGGCGCTGTTCGCGCTCACCGTGCCGAACTTCAACTC
CATGGCCATGGAGCCGCTCGGCGCAATTGCCGGCACCGCCTCGTCCTTCATCGGCTTCTACACGACGCTGTTCGGGGCCA
TCATGGGCATGGTGGTCGGCCAGTCGGTGGCGGGCTCGGTGCTGCCGCTGGCGCTCGGCTATTTCTGCCTCGGCTTCCTC
GCCATCCTCTCCACCTTCTGGGCCGAGAAGGGAAAGCTCTTCGGCGGCCAGATGGGCGCGCAGCCGCATTGA

Upstream 100 bases:

>100_bases
CAATCATCCCCGCCCGCCCTGCCCGCACAGGGACGCGCTTTTTGTCGCGGCATCGCTTAAAAGGGCTGGCCCTGCGCGGC
TGGCGTCGCGCGGCCCCACC

Downstream 100 bases:

>100_bases
CCCGTATCGGCGGGGCGCACCCGCCCCGCCGAACCCGTCAGTTGCCGGTTTCTTTGGCGCAGGCAGCGATGGTGGCCGAC
AGCTTCACCCGGCCCGCATT

Product: drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSKCMTRSDPGVASAAAQKPSFVEFVALVALMMGVTAFSIDNLLPAFEPIRVDLKVPRAGDLQLIVTAYMIGFALMQLVF
GTISDVIGRKPALIIGLAIYAVGCGLAMVTDNFTVLLVARAIQGMGTAAARVLSVAIVRDRFKGRDMARVMSLCMMVFLV
VPVVAPTLGSAILLVGTWHLIFLAMLALGVILAVWFGLRMPETLHPENRVPFSVASIVRGLKVTVTTRRAFGYATGMGLM
MGALMSFVASAPQIFDTEVYHLGSAFPLAFSSVAAVMSAASFLNSRLVGRIGMRHLSHAAIIGFTLVGGLQVAFALAYDG
KPPFLLFCTLIALNQALFALTVPNFNSMAMEPLGAIAGTASSFIGFYTTLFGAIMGMVVGQSVAGSVLPLALGYFCLGFL
AILSTFWAEKGKLFGGQMGAQPH

Sequences:

>Translated_423_residues
MSKCMTRSDPGVASAAAQKPSFVEFVALVALMMGVTAFSIDNLLPAFEPIRVDLKVPRAGDLQLIVTAYMIGFALMQLVF
GTISDVIGRKPALIIGLAIYAVGCGLAMVTDNFTVLLVARAIQGMGTAAARVLSVAIVRDRFKGRDMARVMSLCMMVFLV
VPVVAPTLGSAILLVGTWHLIFLAMLALGVILAVWFGLRMPETLHPENRVPFSVASIVRGLKVTVTTRRAFGYATGMGLM
MGALMSFVASAPQIFDTEVYHLGSAFPLAFSSVAAVMSAASFLNSRLVGRIGMRHLSHAAIIGFTLVGGLQVAFALAYDG
KPPFLLFCTLIALNQALFALTVPNFNSMAMEPLGAIAGTASSFIGFYTTLFGAIMGMVVGQSVAGSVLPLALGYFCLGFL
AILSTFWAEKGKLFGGQMGAQPH
>Mature_422_residues
SKCMTRSDPGVASAAAQKPSFVEFVALVALMMGVTAFSIDNLLPAFEPIRVDLKVPRAGDLQLIVTAYMIGFALMQLVFG
TISDVIGRKPALIIGLAIYAVGCGLAMVTDNFTVLLVARAIQGMGTAAARVLSVAIVRDRFKGRDMARVMSLCMMVFLVV
PVVAPTLGSAILLVGTWHLIFLAMLALGVILAVWFGLRMPETLHPENRVPFSVASIVRGLKVTVTTRRAFGYATGMGLMM
GALMSFVASAPQIFDTEVYHLGSAFPLAFSSVAAVMSAASFLNSRLVGRIGMRHLSHAAIIGFTLVGGLQVAFALAYDGK
PPFLLFCTLIALNQALFALTVPNFNSMAMEPLGAIAGTASSFIGFYTTLFGAIMGMVVGQSVAGSVLPLALGYFCLGFLA
ILSTFWAEKGKLFGGQMGAQPH

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=387, Percent_Identity=27.906976744186, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI48994889, Length=152, Percent_Identity=37.5, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790794, Length=190, Percent_Identity=32.6315789473684, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790146, Length=151, Percent_Identity=33.112582781457, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082312, Length=160, Percent_Identity=33.125, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787065, Length=235, Percent_Identity=25.9574468085106, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081983, Length=226, Percent_Identity=25.6637168141593, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44700; Mature: 44569

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKCMTRSDPGVASAAAQKPSFVEFVALVALMMGVTAFSIDNLLPAFEPIRVDLKVPRAG
CCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
DLQLIVTAYMIGFALMQLVFGTISDVIGRKPALIIGLAIYAVGCGLAMVTDNFTVLLVAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHH
AIQGMGTAAARVLSVAIVRDRFKGRDMARVMSLCMMVFLVVPVVAPTLGSAILLVGTWHL
HHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFLAMLALGVILAVWFGLRMPETLHPENRVPFSVASIVRGLKVTVTTRRAFGYATGMGLM
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHH
MGALMSFVASAPQIFDTEVYHLGSAFPLAFSSVAAVMSAASFLNSRLVGRIGMRHLSHAA
HHHHHHHHHCCCHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGFTLVGGLQVAFALAYDGKPPFLLFCTLIALNQALFALTVPNFNSMAMEPLGAIAGTA
HHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHH
SSFIGFYTTLFGAIMGMVVGQSVAGSVLPLALGYFCLGFLAILSTFWAEKGKLFGGQMGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
QPH
CCC
>Mature Secondary Structure 
SKCMTRSDPGVASAAAQKPSFVEFVALVALMMGVTAFSIDNLLPAFEPIRVDLKVPRAG
CCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]