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The map label for this gene is groEL

Identifier: 158423936

GI number: 158423936

Start: 2635701

End: 2637329

Strand: Direct

Name: groEL

Synonym: AZC_2312

Alternate gene names: 158423936

Gene position: 2635701-2637329 (Clockwise)

Preceding gene: 158423935

Following gene: 158423937

Centisome position: 49.08

GC content: 65.38

Gene sequence:

>1629_bases
ATGGCTGCCAAGGACGTAAAATTCGCCGGTGATGCCCGCGAGAAGATGCTGCGCGGCGTGGACATCCTCGCCAATGCGGT
AAAGGTCACCCTCGGCCCCAAGGGCCGCAACGTCGTGATCGAGAAGAGCTTCGGCGCCCCGCGCATCACCAAGGACGGCG
TTTCCGTCGCCAAGGAGATCGAGCTCGAGGACAAGTTCGAGAACCTCGGCGCCCAGCTGGTGCGCGAAGTCGCCTCCAAG
ACCAACGACCTCGCCGGTGACGGCACCACCACCGCCACGGTGCTGGCCCAGGCCATCGTCAAGGAAGGTTCCAAGGCGGT
TGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACCTCGCGGTCGACGCCATCGTCAAGGACCTCGCCGCCA
AGGCCAAGAAGGTGACCTCGAACGCCGAGATCGCCCAGGTCGGCACCATCTCCGCCAATGGCGACGCCGATGTCGGCAAG
TTCCTCGCCGAGGCCATGCAGAAGGTCGGCAACGAGGGTGTCATCACCGTCGAGGAAGCCAAGACCGCCGAGACCGAGCT
CGAAGTGGTCGAGGGCATGCAGTTCGACCGCGGCTACCTCTCGCCCTACTTCGTGACCAACGCCGAGAAGATGCGCGTTG
AGTTCGAGGATCCCTACATCCTCATCCACGAGAAGAAGCTCTCCAACCTGCAGGAACTCCTCCCGGTCCTCGAGGCCGTG
GTGCAGTCCGGCAAGCCGCTGGTGATCGTGGCCGAGGACGTCGAGGGCGAGGCTCTGGCTACCCTCGTGGTCAACAAGCT
GCGCGGCGGTCTCAAGGTTGCGGCCGTGAAGGCTCCGGGCTTCGGCGACCGCCGCAAGGCCATGCTGCAGGACATCGCGA
TCCTGACCGGCGGCCAGGCGATCTCGGAAGACCTCGGCATCAAGCTCGAGAACGTGAACCTCTCCATGCTCGGCCGCGCC
AAGAAGGTGGTGATCGAGAAGGAGAACACCACGATCGTCGACGGCAATGGCGAGAAGGCCGACATCGAGGCCCGCGTCGC
CCAGATCAAGGCGCAGATCGAGGAGACCACCTCGGACTACGACCGTGAGAAGCTCCAGGAGCGTCTGGCCAAGCTCGCGG
GCGGCGTCGCGGTGATCCGCGTCGGCGGTGCGACCGAGGTCGAGGTGAAGGAGAAGAAGGACCGCGTTGACGACGCCCTG
CACGCCACCCGCGCTGCGGTGGAAGAAGGCATTGTCCCCGGCGGTGGCGTTGCCCTGCTCCGCGCCATCAAGGTGCTGGA
AGGCCTGAAGGTCGAGAACACCGATCAGAAGACCGGCATCGACATCGTGCGTCGCGCCATCCAGGCTCCGGCCCGCCAGA
TCGTCGCCAACGCTGGCGATGACGGCTCGGTCGTGGTCGGCAAGATCCTCGAGAACGAGACCTACACCTTCGGCTACAAC
GCCCAGACGGGCGAGTATGTGGACATGGTGGCTTCGGGCATCATCGACCCGGCCAAGGTCGTGCGCACGGCTCTCCAGGA
CGCGGCCTCCATCTCGGCTCTGATCATCACCACCGAGGCCCTCGTGGTCGAGCTGCCGAAGAAGGCTGCTGCGGCTCCGG
CCATGCCGGGCGGTGGCATGGACTTCTGA

Upstream 100 bases:

>100_bases
TCCTCGGCGTGGTCGAGGCGTCCGCCTCCGCCAAGAAGGCCGCGTGACGCTTTCCTCGCACGCTTCGTGAACAACGTCAC
AACCTGAAGGAACAGGCACA

Downstream 100 bases:

>100_bases
TCCAGGAGCACCCATTGGCGCCGCCCGGCGTCCTTAAAAGACAATGCCGGCGCAGCCGGCACGGGCGGTGGCATGGACTT
CTGATCCAGGAGCAACCGTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAAKDVKFAGDAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVKEGSKAVAAGMNPMDLKRGIDLAVDAIVKDLAAKAKKVTSNAEIAQVGTISANGDADVGK
FLAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNAEKMRVEFEDPYILIHEKKLSNLQELLPVLEAV
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQAISEDLGIKLENVNLSMLGRA
KKVVIEKENTTIVDGNGEKADIEARVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRAIKVLEGLKVENTDQKTGIDIVRRAIQAPARQIVANAGDDGSVVVGKILENETYTFGYN
AQTGEYVDMVASGIIDPAKVVRTALQDAASISALIITTEALVVELPKKAAAAPAMPGGGMDF

Sequences:

>Translated_542_residues
MAAKDVKFAGDAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVKEGSKAVAAGMNPMDLKRGIDLAVDAIVKDLAAKAKKVTSNAEIAQVGTISANGDADVGK
FLAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNAEKMRVEFEDPYILIHEKKLSNLQELLPVLEAV
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQAISEDLGIKLENVNLSMLGRA
KKVVIEKENTTIVDGNGEKADIEARVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRAIKVLEGLKVENTDQKTGIDIVRRAIQAPARQIVANAGDDGSVVVGKILENETYTFGYN
AQTGEYVDMVASGIIDPAKVVRTALQDAASISALIITTEALVVELPKKAAAAPAMPGGGMDF
>Mature_541_residues
AAKDVKFAGDAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASKT
NDLAGDGTTTATVLAQAIVKEGSKAVAAGMNPMDLKRGIDLAVDAIVKDLAAKAKKVTSNAEIAQVGTISANGDADVGKF
LAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNAEKMRVEFEDPYILIHEKKLSNLQELLPVLEAVV
QSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQAISEDLGIKLENVNLSMLGRAK
KVVIEKENTTIVDGNGEKADIEARVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALH
ATRAAVEEGIVPGGGVALLRAIKVLEGLKVENTDQKTGIDIVRRAIQAPARQIVANAGDDGSVVVGKILENETYTFGYNA
QTGEYVDMVASGIIDPAKVVRTALQDAASISALIITTEALVVELPKKAAAAPAMPGGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=55.5977229601518, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=55.5977229601518, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI5453607, Length=548, Percent_Identity=22.6277372262774, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=68.361581920904, Blast_Score=702, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=54.2533081285444, Blast_Score=579, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=54.0284360189574, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=57.9847908745247, Blast_Score=618, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=57.685009487666, Blast_Score=610, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=57.685009487666, Blast_Score=610, Evalue=1e-175,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=54.6489563567362, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=54.6489563567362, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=54.6489563567362, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI17864606, Length=548, Percent_Identity=46.8978102189781, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=35.9404096834264, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=35.9404096834264, Blast_Score=343, Evalue=2e-94,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_AZOC5 (A8I5R5)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525228.1
- ProteinModelPortal:   A8I5R5
- SMR:   A8I5R5
- GeneID:   5687853
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2312
- HOGENOM:   HBG625289
- OMA:   LEKEQYA
- ProtClustDB:   PRK00013
- BioCyc:   ACAU438753:AZC_2312-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57310; Mature: 57178

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFAGDAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHC
ELEDKFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVKEGSKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHCH
DLAVDAIVKDLAAKAKKVTSNAEIAQVGTISANGDADVGKFLAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNAEKMRVEFEDPYILIHEKKLSNLQELLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQA
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ISEDLGIKLENVNLSMLGRAKKVVIEKENTTIVDGNGEKADIEARVAQIKAQIEETTSDY
HHHHHCEEEECCCHHHHCCCEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAIKVLEGLKVENTDQKTGIDIVRRAIQAPARQIVANAGDDGSVVVGKILENETYTFGYN
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEECCC
AQTGEYVDMVASGIIDPAKVVRTALQDAASISALIITTEALVVELPKKAAAAPAMPGGGM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEEHHHHHHCCCHHHCCCCCCCCCCC
DF
CC
>Mature Secondary Structure 
AAKDVKFAGDAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHC
ELEDKFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVKEGSKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHCH
DLAVDAIVKDLAAKAKKVTSNAEIAQVGTISANGDADVGKFLAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNAEKMRVEFEDPYILIHEKKLSNLQELLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQA
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ISEDLGIKLENVNLSMLGRAKKVVIEKENTTIVDGNGEKADIEARVAQIKAQIEETTSDY
HHHHHCEEEECCCHHHHCCCEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAIKVLEGLKVENTDQKTGIDIVRRAIQAPARQIVANAGDDGSVVVGKILENETYTFGYN
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEECCC
AQTGEYVDMVASGIIDPAKVVRTALQDAASISALIITTEALVVELPKKAAAAPAMPGGGM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEEHHHHHHCCCHHHCCCCCCCCCCC
DF
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA