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The map label for this gene is hldD [H]

Identifier: 158423877

GI number: 158423877

Start: 2575848

End: 2576858

Strand: Direct

Name: hldD [H]

Synonym: AZC_2253

Alternate gene names: 158423877

Gene position: 2575848-2576858 (Clockwise)

Preceding gene: 158423876

Following gene: 158423878

Centisome position: 47.97

GC content: 66.67

Gene sequence:

>1011_bases
ATGTCCCATTCTGCCGCCGGTGCCCGCGATACCATTCTCGTGACCGGAGGTGCCGGCTTCATCGGCTCCAACATGGCCCG
CGCTTTCGCCGAAGATGGCCGCCGCGTGGTGGTCGCCGACTGGCTGGAGGATGGCCCGAAGTGGCGGAACATCGCCGACA
TCGCCCTCGATGACGTGATCCGCCCCGAGGCCATCACGTCGTTCGTGGAGCGCGAGTCGGGCCGGCTCGCCGGCATCATC
CACATGGGCGCCATCTCGGCCACCACGGAGCGGGACGGGGACAAGATCGTCGCCCGCAACATCCGCCCAACGCTCGATCT
GTGGGACCAATGCGCCCGCAAGGGCCTGCCCTTCATCTATGCCTCCTCCGGCGCCACCTATGGCGACGGCACGCGCGGCT
TTGCCGATGACGAAAGCCCGGCGGCGCTTGGGCAGCTGGCGCCGCTCAATGCCTATGGCTGGTCGAAGCTGATGGCGGAC
CGGCGCTTCATCGCCGATGTGCGCGCCGGCCGGCCCCGCCCGCCGCAATGGGCGGGCCTGCGCTTCTTCAACGTCTATGG
GCCCGGCGAGGCGCACAAGGGCGACATGCGCTCGGTCATTCACAAGATCTACCCCACCGCCGCCAAGGGCGAGGCGGTGA
CCCTCTTCAAGTCGCATCATCCGGGCTACACGGACGGTGGTCAGTTGCGCGACTTCATCTATGTGAAGGATTGCGTGAGT
GTCGCCCTCTGGCTCATTGAAAATCCGCACGTTTCCGGAATTTTCAACGTGGGCACGGGGGCCGCGCGCTCGTTCGCGGA
TCTCGCCCGCGCGGTGTTCTCCGCCGCTGGCCAGCCCGAGCGCATCACCTATATCGACATGCCGGAGGCGCTCCAGGGTG
CCTACCAGTATTTCACGCAGGCGGATGTCTCGAAGCTCCGGGCAGCCGGCTACGCCAAGCCCTTCACCAGCCTTGAGGAT
GGCGTCGCCGATTATGTGACGCGCCATCTGCGTGGCGCCAACGCGGCCTGA

Upstream 100 bases:

>100_bases
GCGGGCCATCAGCCTGCTGCGGCTCGGCCATGCCGACGCCATGGACAAGATGTGAGGGCGGAGGGATAAGAGGCGCGTTT
CAAACGAGGCCGAGTTCCCG

Downstream 100 bases:

>100_bases
GCGGGGAAGAAAATGCTCGCCGAAACCCAGCTCGCGCCCATCGCCGTCATCGGCGACGTGATGGTGGACCGCTACATCAC
CGGCTCCGTCTCGCGCATCT

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSHSAAGARDTILVTGGAGFIGSNMARAFAEDGRRVVVADWLEDGPKWRNIADIALDDVIRPEAITSFVERESGRLAGII
HMGAISATTERDGDKIVARNIRPTLDLWDQCARKGLPFIYASSGATYGDGTRGFADDESPAALGQLAPLNAYGWSKLMAD
RRFIADVRAGRPRPPQWAGLRFFNVYGPGEAHKGDMRSVIHKIYPTAAKGEAVTLFKSHHPGYTDGGQLRDFIYVKDCVS
VALWLIENPHVSGIFNVGTGAARSFADLARAVFSAAGQPERITYIDMPEALQGAYQYFTQADVSKLRAAGYAKPFTSLED
GVADYVTRHLRGANAA

Sequences:

>Translated_336_residues
MSHSAAGARDTILVTGGAGFIGSNMARAFAEDGRRVVVADWLEDGPKWRNIADIALDDVIRPEAITSFVERESGRLAGII
HMGAISATTERDGDKIVARNIRPTLDLWDQCARKGLPFIYASSGATYGDGTRGFADDESPAALGQLAPLNAYGWSKLMAD
RRFIADVRAGRPRPPQWAGLRFFNVYGPGEAHKGDMRSVIHKIYPTAAKGEAVTLFKSHHPGYTDGGQLRDFIYVKDCVS
VALWLIENPHVSGIFNVGTGAARSFADLARAVFSAAGQPERITYIDMPEALQGAYQYFTQADVSKLRAAGYAKPFTSLED
GVADYVTRHLRGANAA
>Mature_335_residues
SHSAAGARDTILVTGGAGFIGSNMARAFAEDGRRVVVADWLEDGPKWRNIADIALDDVIRPEAITSFVERESGRLAGIIH
MGAISATTERDGDKIVARNIRPTLDLWDQCARKGLPFIYASSGATYGDGTRGFADDESPAALGQLAPLNAYGWSKLMADR
RFIADVRAGRPRPPQWAGLRFFNVYGPGEAHKGDMRSVIHKIYPTAAKGEAVTLFKSHHPGYTDGGQLRDFIYVKDCVSV
ALWLIENPHVSGIFNVGTGAARSFADLARAVFSAAGQPERITYIDMPEALQGAYQYFTQADVSKLRAAGYAKPFTSLEDG
VADYVTRHLRGANAA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=319, Percent_Identity=42.0062695924765, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786974, Length=298, Percent_Identity=27.8523489932886, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36353; Mature: 36222

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSAAGARDTILVTGGAGFIGSNMARAFAEDGRRVVVADWLEDGPKWRNIADIALDDVI
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCCHHHHHHHHHC
RPEAITSFVERESGRLAGIIHMGAISATTERDGDKIVARNIRPTLDLWDQCARKGLPFIY
CHHHHHHHHHHCCCCEEEEEEECCEECCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
ASSGATYGDGTRGFADDESPAALGQLAPLNAYGWSKLMADRRFIADVRAGRPRPPQWAGL
ECCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
RFFNVYGPGEAHKGDMRSVIHKIYPTAAKGEAVTLFKSHHPGYTDGGQLRDFIYVKDCVS
EEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
VALWLIENPHVSGIFNVGTGAARSFADLARAVFSAAGQPERITYIDMPEALQGAYQYFTQ
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
ADVSKLRAAGYAKPFTSLEDGVADYVTRHLRGANAA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SHSAAGARDTILVTGGAGFIGSNMARAFAEDGRRVVVADWLEDGPKWRNIADIALDDVI
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCCHHHHHHHHHC
RPEAITSFVERESGRLAGIIHMGAISATTERDGDKIVARNIRPTLDLWDQCARKGLPFIY
CHHHHHHHHHHCCCCEEEEEEECCEECCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
ASSGATYGDGTRGFADDESPAALGQLAPLNAYGWSKLMADRRFIADVRAGRPRPPQWAGL
ECCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
RFFNVYGPGEAHKGDMRSVIHKIYPTAAKGEAVTLFKSHHPGYTDGGQLRDFIYVKDCVS
EEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
VALWLIENPHVSGIFNVGTGAARSFADLARAVFSAAGQPERITYIDMPEALQGAYQYFTQ
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
ADVSKLRAAGYAKPFTSLEDGVADYVTRHLRGANAA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA