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The map label for this gene is lysR [H]

Identifier: 158423805

GI number: 158423805

Start: 2498112

End: 2499035

Strand: Reverse

Name: lysR [H]

Synonym: AZC_2181

Alternate gene names: 158423805

Gene position: 2499035-2498112 (Counterclockwise)

Preceding gene: 158423808

Following gene: 158423801

Centisome position: 46.54

GC content: 69.16

Gene sequence:

>924_bases
TTGGACGAATTTATTTCAGTCGCGATCGGAATATCGATGGAACTGCGCACACTCCGCGCCTTCGTGGAGGTGGTCCGGCA
GGGCGGCTTTTCCCAGGCCGCCAAGGCCGTCTTCGCCACCCAGAGCACCATCAGCAAGGCGGTGAAGCAACTGGAGGACG
AGCTGGGCGTCCCCCTGCTCGACCGCGTCGGGCACAAGAGCCGGCTTACGGCCGCGGGCGAGATCGTCTATCGCCGCGCC
GTGACCATGCTGGCCGAGCGGGACGATCTGGTGGCCGAACTCGGGGAGTTGCGCGGCCTCAAGCGCGGCAGCCTGCGCCT
CGGCCTGCCGCCGCTTGGCAGCGATACCCTCTATGCGCCGCTCTTCGCGCTCTACCGGAGCCGCTATCCGGGCATCGACA
TCCAGCTCGTGGAACACGGCAGCGCGCGTCTCGAGGAGATGATCCTCGCCGGCGATCTCGACCTTGCCGGATCGCTCCTG
CCCATCACCGACGAATTCGAGTGGCAGTCGGTGCATGACGAGCCGCTGGTGGCGCTGGTGGCCGACACCCACCCCCTGGC
CGGCGCCGCATCCTGCCGGCTGGCCGATCTTGCCGCCTCGCCCTTCCTCTTCTTCGAGGAAGGCTTCGCGCTCAACAAGG
TACTGCGGGAGGCCTGCCAGAAGCAGGGAATCACCCCCCAGATTGCCGCCCGCAGCGGCCAGATCGACTTCCTCGTGGGG
CTGGCGGCAGCGGGCCTCGGCACGGCCTTCCTGCCCCGCATGATCGCCGAGCAGCGCCACCATCCGGGCGTTGCCCGCGT
GCTGCTGGACGAGCCGGACACCGCCTGGCACATGGCGCTGGTCTGGCGCCGGGGCGGTTATCTGTCCCACGCCGCCCGCG
CCTGGCTCGCGCTCGCCCGCGAGGTCCACGGCGCGCGCAACTGA

Upstream 100 bases:

>100_bases
GAGGGAACGGGGCATGGGAAAACCATGTAAATGCTGGAAGGCGCCGGTTCATCCGACTTGCCTTGCACTTTACGTTGCAA
CGCATCATGCGTAAAATGAA

Downstream 100 bases:

>100_bases
TGGATACCCGCGCCGGCCATCCGGCCAGCGCGGGCGCGAGCCGCCTCAGGCCTTCGCAAGCGCCTGATCGAGATCGGCAA
TGATGTCCGCCACGTCCTCG

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MDEFISVAIGISMELRTLRAFVEVVRQGGFSQAAKAVFATQSTISKAVKQLEDELGVPLLDRVGHKSRLTAAGEIVYRRA
VTMLAERDDLVAELGELRGLKRGSLRLGLPPLGSDTLYAPLFALYRSRYPGIDIQLVEHGSARLEEMILAGDLDLAGSLL
PITDEFEWQSVHDEPLVALVADTHPLAGAASCRLADLAASPFLFFEEGFALNKVLREACQKQGITPQIAARSGQIDFLVG
LAAAGLGTAFLPRMIAEQRHHPGVARVLLDEPDTAWHMALVWRRGGYLSHAARAWLALAREVHGARN

Sequences:

>Translated_307_residues
MDEFISVAIGISMELRTLRAFVEVVRQGGFSQAAKAVFATQSTISKAVKQLEDELGVPLLDRVGHKSRLTAAGEIVYRRA
VTMLAERDDLVAELGELRGLKRGSLRLGLPPLGSDTLYAPLFALYRSRYPGIDIQLVEHGSARLEEMILAGDLDLAGSLL
PITDEFEWQSVHDEPLVALVADTHPLAGAASCRLADLAASPFLFFEEGFALNKVLREACQKQGITPQIAARSGQIDFLVG
LAAAGLGTAFLPRMIAEQRHHPGVARVLLDEPDTAWHMALVWRRGGYLSHAARAWLALAREVHGARN
>Mature_307_residues
MDEFISVAIGISMELRTLRAFVEVVRQGGFSQAAKAVFATQSTISKAVKQLEDELGVPLLDRVGHKSRLTAAGEIVYRRA
VTMLAERDDLVAELGELRGLKRGSLRLGLPPLGSDTLYAPLFALYRSRYPGIDIQLVEHGSARLEEMILAGDLDLAGSLL
PITDEFEWQSVHDEPLVALVADTHPLAGAASCRLADLAASPFLFFEEGFALNKVLREACQKQGITPQIAARSGQIDFLVG
LAAAGLGTAFLPRMIAEQRHHPGVARVLLDEPDTAWHMALVWRRGGYLSHAARAWLALAREVHGARN

Specific function: Positive Regulatory Protein For The Cyn Operon. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=285, Percent_Identity=31.2280701754386, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787879, Length=301, Percent_Identity=30.8970099667774, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788887, Length=297, Percent_Identity=29.2929292929293, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790399, Length=279, Percent_Identity=27.9569892473118, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI145693105, Length=295, Percent_Identity=23.3898305084746, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787530, Length=282, Percent_Identity=26.241134751773, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788481, Length=291, Percent_Identity=26.8041237113402, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790208, Length=265, Percent_Identity=25.6603773584906, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788748, Length=295, Percent_Identity=26.4406779661017, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786401, Length=120, Percent_Identity=38.3333333333333, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789506, Length=293, Percent_Identity=23.5494880546075, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787601, Length=282, Percent_Identity=23.4042553191489, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789639, Length=123, Percent_Identity=35.7723577235772, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787806, Length=283, Percent_Identity=27.9151943462898, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=27.2357723577236, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790262, Length=247, Percent_Identity=22.6720647773279, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI2367136, Length=254, Percent_Identity=22.0472440944882, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI145693193, Length=133, Percent_Identity=28.5714285714286, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33405; Mature: 33405

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEFISVAIGISMELRTLRAFVEVVRQGGFSQAAKAVFATQSTISKAVKQLEDELGVPLL
CCCHHEEHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
DRVGHKSRLTAAGEIVYRRAVTMLAERDDLVAELGELRGLKRGSLRLGLPPLGSDTLYAP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHH
LFALYRSRYPGIDIQLVEHGSARLEEMILAGDLDLAGSLLPITDEFEWQSVHDEPLVALV
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ADTHPLAGAASCRLADLAASPFLFFEEGFALNKVLREACQKQGITPQIAARSGQIDFLVG
ECCCCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHH
LAAAGLGTAFLPRMIAEQRHHPGVARVLLDEPDTAWHMALVWRRGGYLSHAARAWLALAR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
EVHGARN
HHHCCCC
>Mature Secondary Structure
MDEFISVAIGISMELRTLRAFVEVVRQGGFSQAAKAVFATQSTISKAVKQLEDELGVPLL
CCCHHEEHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
DRVGHKSRLTAAGEIVYRRAVTMLAERDDLVAELGELRGLKRGSLRLGLPPLGSDTLYAP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHH
LFALYRSRYPGIDIQLVEHGSARLEEMILAGDLDLAGSLLPITDEFEWQSVHDEPLVALV
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ADTHPLAGAASCRLADLAASPFLFFEEGFALNKVLREACQKQGITPQIAARSGQIDFLVG
ECCCCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHH
LAAAGLGTAFLPRMIAEQRHHPGVARVLLDEPDTAWHMALVWRRGGYLSHAARAWLALAR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
EVHGARN
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]