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The map label for this gene is ygeZ [C]

Identifier: 158423590

GI number: 158423590

Start: 2268306

End: 2269775

Strand: Reverse

Name: ygeZ [C]

Synonym: AZC_1966

Alternate gene names: 158423590

Gene position: 2269775-2268306 (Counterclockwise)

Preceding gene: 158423591

Following gene: 158423589

Centisome position: 42.27

GC content: 66.19

Gene sequence:

>1470_bases
ATGTCTGATTTCGCGTTCGATACGGTCATCCACGGCGGCACCATCGTCACCGCCACCGACACCTACAAGGCGGACATCGG
CATCCGCGACGGACGCATCGCCGCCGTCGCGGAAAGCCTTGCGGGCGGCACCAAGCGGATCGATGCCACGGGCCGGCTGG
TGATGCCGGGCGGCATTGAGGGCCATGCGCACATCGCGCAGGAAAGCTCCACCAAGATCATGACCGCCGATGATTATTAC
ACCGGCTCGGTCTCGGCGGCCTTCGGCGGCAACTCCTCCTTCATCCCCTTCGCCGCCCAGCATCGCGGCCAGTCGCTGGA
CGATGTGGTCGCGATCTATGACGAGCGGGCGGCGCCAAATTCCGTCATCGATTATTCCTACCACCTCATCGTCTCCGATC
CCTCCCCCGAGGTGCTGGAGGAGCAGCTTCCGCGGGCCTTTGCGCGGGGCATCACCTCTTTCAAGGTCTTCATGACCTAC
GACCTGCTGAACCTCGGCGATGGCGGCATGCTGGACGTGCTCACCGTCGCCAAGACCCATGGCGCGCTCACCATGGTCCA
TGCCGAGAATAACGACATGGTGAAGTGGATGAACAAGCGCCTCGCCGCCAAGGGACTGACGGCGCCGAAGTATCACGCCA
TCTCCCGGCCGGAGCTGGCCGAGGAGGAGGCCATCAACCGCGCGGTGACGCTGGCTAAGCTCGTGGATGCCCCCCTGTTC
GTGGTGCATGTGTCGACGGAAGCGGGCGCGGCCATCATCCGCCGGGAGACGCAAGCGGGCGTGAAGCTCTTCGCCGAAAC
CTGCCCCCAGTATCTCGCCCTCACCCGCGAGGACCTCGACCGGCCGGGCATGGAAGGCGCCAAGTTCATGTGCTCGCCCC
CGGTGCGCGATGCGCAGACGCAGGAGGCCCTGTGGCGGCACATTCAGGCGGGCACCTTCATGAGCGTGTCATCCGACCAC
GCCCCCTATCGCTATGACGAGACCGGCAAGCTCTTCAACGGCGCGGACGTGCCCTATCCGAAGATCGCCAACGGCATGCC
CGGCATCGCCATGCGGCTGCCCTGGCTGTTCTCGGAAGGCGTCGTGAAGGGCCGCATCAGCGCCAACCAGTTCGTGGCCC
TCACCTCCACCAACGCGGCCAAGGTGTTCGGCATGGCGCGGAAGGGTTCCATCGCCCCCGGCTTCGATGCCGACATCGCC
ATCTGGGATCCCAACGAGACCCGCGTGGTGTCACTGGACGACCAGCACGACAATATGGACTACACCCCCTTCGAGGGCCT
CACCGTCACCGGCTGGCCGCGCACGGTGCTGAACCGGGGCGAACTGGTGGTGGAGGAGCGTGAACTCGTCGCCACGCGCG
GCCGCGGCCGCTTCGTCGCCCGCGATACGGTGGACCTCACCGGCCGTCCCGGCTATCGCGCCCCCGAACTCGATCCCGCG
CGCAATTTCGGCGCGGACATCGCCCCCTGA

Upstream 100 bases:

>100_bases
CTGGCATCAGGCGCGCCCGAGCTGAACGGCCAATCGTCCAGTTCGCACCGCCCCTTCCGTCCCGCCCCTCGCGGCAACGC
CCCTGCCCAAGGTTTCTCCC

Downstream 100 bases:

>100_bases
GGATCGCGCCATGACCGCCAAAGGCCCCATCCTCGTCATCAATCCCAACAGCGATGTCGCCGTCACCGAGGCGCTGTCGC
GAGCGGTCGAGCCCTTCCGG

Product: dihydropyrimidinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSDFAFDTVIHGGTIVTATDTYKADIGIRDGRIAAVAESLAGGTKRIDATGRLVMPGGIEGHAHIAQESSTKIMTADDYY
TGSVSAAFGGNSSFIPFAAQHRGQSLDDVVAIYDERAAPNSVIDYSYHLIVSDPSPEVLEEQLPRAFARGITSFKVFMTY
DLLNLGDGGMLDVLTVAKTHGALTMVHAENNDMVKWMNKRLAAKGLTAPKYHAISRPELAEEEAINRAVTLAKLVDAPLF
VVHVSTEAGAAIIRRETQAGVKLFAETCPQYLALTREDLDRPGMEGAKFMCSPPVRDAQTQEALWRHIQAGTFMSVSSDH
APYRYDETGKLFNGADVPYPKIANGMPGIAMRLPWLFSEGVVKGRISANQFVALTSTNAAKVFGMARKGSIAPGFDADIA
IWDPNETRVVSLDDQHDNMDYTPFEGLTVTGWPRTVLNRGELVVEERELVATRGRGRFVARDTVDLTGRPGYRAPELDPA
RNFGADIAP

Sequences:

>Translated_489_residues
MSDFAFDTVIHGGTIVTATDTYKADIGIRDGRIAAVAESLAGGTKRIDATGRLVMPGGIEGHAHIAQESSTKIMTADDYY
TGSVSAAFGGNSSFIPFAAQHRGQSLDDVVAIYDERAAPNSVIDYSYHLIVSDPSPEVLEEQLPRAFARGITSFKVFMTY
DLLNLGDGGMLDVLTVAKTHGALTMVHAENNDMVKWMNKRLAAKGLTAPKYHAISRPELAEEEAINRAVTLAKLVDAPLF
VVHVSTEAGAAIIRRETQAGVKLFAETCPQYLALTREDLDRPGMEGAKFMCSPPVRDAQTQEALWRHIQAGTFMSVSSDH
APYRYDETGKLFNGADVPYPKIANGMPGIAMRLPWLFSEGVVKGRISANQFVALTSTNAAKVFGMARKGSIAPGFDADIA
IWDPNETRVVSLDDQHDNMDYTPFEGLTVTGWPRTVLNRGELVVEERELVATRGRGRFVARDTVDLTGRPGYRAPELDPA
RNFGADIAP
>Mature_488_residues
SDFAFDTVIHGGTIVTATDTYKADIGIRDGRIAAVAESLAGGTKRIDATGRLVMPGGIEGHAHIAQESSTKIMTADDYYT
GSVSAAFGGNSSFIPFAAQHRGQSLDDVVAIYDERAAPNSVIDYSYHLIVSDPSPEVLEEQLPRAFARGITSFKVFMTYD
LLNLGDGGMLDVLTVAKTHGALTMVHAENNDMVKWMNKRLAAKGLTAPKYHAISRPELAEEEAINRAVTLAKLVDAPLFV
VHVSTEAGAAIIRRETQAGVKLFAETCPQYLALTREDLDRPGMEGAKFMCSPPVRDAQTQEALWRHIQAGTFMSVSSDHA
PYRYDETGKLFNGADVPYPKIANGMPGIAMRLPWLFSEGVVKGRISANQFVALTSTNAAKVFGMARKGSIAPGFDADIAI
WDPNETRVVSLDDQHDNMDYTPFEGLTVTGWPRTVLNRGELVVEERELVATRGRGRFVARDTVDLTGRPGYRAPELDPAR
NFGADIAP

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503051, Length=459, Percent_Identity=33.7690631808279, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI62422571, Length=459, Percent_Identity=33.7690631808279, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI4503377, Length=459, Percent_Identity=33.9869281045752, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI190194363, Length=461, Percent_Identity=34.4902386117137, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI4503375, Length=463, Percent_Identity=33.6933045356371, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI4503379, Length=457, Percent_Identity=32.1663019693654, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=33.9168490153173, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI18105007, Length=442, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87082175, Length=459, Percent_Identity=35.7298474945534, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786722, Length=475, Percent_Identity=26.7368421052632, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17539558, Length=458, Percent_Identity=34.2794759825328, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71989490, Length=460, Percent_Identity=34.1304347826087, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI86575075, Length=430, Percent_Identity=27.4418604651163, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193204318, Length=410, Percent_Identity=24.390243902439, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=406, Percent_Identity=24.384236453202, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137462, Length=457, Percent_Identity=34.7921225382932, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI221377917, Length=469, Percent_Identity=35.8208955223881, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24644287, Length=315, Percent_Identity=34.9206349206349, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24644289, Length=231, Percent_Identity=35.9307359307359, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24642586, Length=409, Percent_Identity=23.7163814180929, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18859883, Length=244, Percent_Identity=27.4590163934426, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 53068; Mature: 52936

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFAFDTVIHGGTIVTATDTYKADIGIRDGRIAAVAESLAGGTKRIDATGRLVMPGGIE
CCCCCCHHEECCCEEEEEECCEEEECCCCCCHHHHHHHHHCCCCEEECCCCCEEECCCCC
GHAHIAQESSTKIMTADDYYTGSVSAAFGGNSSFIPFAAQHRGQSLDDVVAIYDERAAPN
CCEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCC
SVIDYSYHLIVSDPSPEVLEEQLPRAFARGITSFKVFMTYDLLNLGDGGMLDVLTVAKTH
CEEEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCEEHEEEHCCC
GALTMVHAENNDMVKWMNKRLAAKGLTAPKYHAISRPELAEEEAINRAVTLAKLVDAPLF
CEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
VVHVSTEAGAAIIRRETQAGVKLFAETCPQYLALTREDLDRPGMEGAKFMCSPPVRDAQT
EEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHH
QEALWRHIQAGTFMSVSSDHAPYRYDETGKLFNGADVPYPKIANGMPGIAMRLPWLFSEG
HHHHHHHHHCCCEEEECCCCCCEEECCCCCEECCCCCCCCHHHCCCCCHHEECCHHHHCC
VVKGRISANQFVALTSTNAAKVFGMARKGSIAPGFDADIAIWDPNETRVVSLDDQHDNMD
CEEEECCCCEEEEEECCCCHHEEEECCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCC
YTPFEGLTVTGWPRTVLNRGELVVEERELVATRGRGRFVARDTVDLTGRPGYRAPELDPA
CCCCCCEEECCCCHHHHCCCCEEEECHHHHEECCCCEEEEECCEEECCCCCCCCCCCCCH
RNFGADIAP
HHCCCCCCC
>Mature Secondary Structure 
SDFAFDTVIHGGTIVTATDTYKADIGIRDGRIAAVAESLAGGTKRIDATGRLVMPGGIE
CCCCCHHEECCCEEEEEECCEEEECCCCCCHHHHHHHHHCCCCEEECCCCCEEECCCCC
GHAHIAQESSTKIMTADDYYTGSVSAAFGGNSSFIPFAAQHRGQSLDDVVAIYDERAAPN
CCEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCC
SVIDYSYHLIVSDPSPEVLEEQLPRAFARGITSFKVFMTYDLLNLGDGGMLDVLTVAKTH
CEEEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCEEHEEEHCCC
GALTMVHAENNDMVKWMNKRLAAKGLTAPKYHAISRPELAEEEAINRAVTLAKLVDAPLF
CEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
VVHVSTEAGAAIIRRETQAGVKLFAETCPQYLALTREDLDRPGMEGAKFMCSPPVRDAQT
EEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHH
QEALWRHIQAGTFMSVSSDHAPYRYDETGKLFNGADVPYPKIANGMPGIAMRLPWLFSEG
HHHHHHHHHCCCEEEECCCCCCEEECCCCCEECCCCCCCCHHHCCCCCHHEECCHHHHCC
VVKGRISANQFVALTSTNAAKVFGMARKGSIAPGFDADIAIWDPNETRVVSLDDQHDNMD
CEEEECCCCEEEEEECCCCHHEEEECCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCC
YTPFEGLTVTGWPRTVLNRGELVVEERELVATRGRGRFVARDTVDLTGRPGYRAPELDPA
CCCCCCEEECCCCHHHHCCCCEEEECHHHHEECCCCEEEEECCEEECCCCCCCCCCCCCH
RNFGADIAP
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]