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The map label for this gene is fumC [H]

Identifier: 158423525

GI number: 158423525

Start: 2178576

End: 2180030

Strand: Reverse

Name: fumC [H]

Synonym: AZC_1901

Alternate gene names: 158423525

Gene position: 2180030-2178576 (Counterclockwise)

Preceding gene: 158423526

Following gene: 158423524

Centisome position: 40.6

GC content: 65.7

Gene sequence:

>1455_bases
ATGGCGTTGAGCGAAGCCCCCACATTGCGAGCGGTCCCCATCGGGATCGATGCCACCGGCACCCGTCAGGAGTTCGACAG
CATGGGCACGGTCGCGGTGCCGGCCGACCGATATTGGGGGGCTCAGACCGAGCGCTCGCTGCATCATTTCGATATTGGCG
GCGACCGGATGCCCAAGGCCGTCTATCACGCCTATGGTTATGTGAAGAAAGCCTGCGCCCTGGTCAACGCGGCCGCCGGC
CGCCTGCCGGACTGGAAACGCGACGCCATCATCCAGGCGGCGGACGAAACCATCGCCGGCAAGCTCGACGACCATTTCCC
GCTCTATGTCTGGCAGACGGGCTCGGGCACCCAGTCGAACATGAATGTCAATGAGGTGCTGTCCAACCGGGCGATCCAGT
TGCTCGGCGGCACCCTCGGCACCCAGCATCCCGTCGGCCCCAATGACGACGTGAACATGGGCCAGTCGTCGAACGACACC
TTTCCGACCGCCATGCACATCGCGACCATCTTCGCGATCGACGACCAACTGCTCCCGGCTGTGACCCGGCTGGTCGAAAT
CATCGAGAAGAAGGCCGATGGCTGGATGGATGTGGTCAAGATCGGCCGCACCCATCTGGAAGATGCCGTTCCCTTGACGG
TCGGCCAGGAATGGCACGGATGGGCCGGACAGATCCGCGCCTGCATCGCCGCCATCGAGGCGAGCCGCGCCGGGCTCTAC
GAACTGGCGGTGGGCGGCACGGCGGTGGGCACCGGCCTGAACGCGCCGGCCGGCTTCTCCCGCGACGTGGCGGCGAAGAT
CGCAGAACTGACCGGCAAGCCATTCGTCACCGCCCCCAACAAGTTCATGGCCCAGGGCTCGCTGGACGCCATGGTGCGGG
CGTCCGCCGGGCTGCGCGGCCTTGCCATCGCGCTGATGAAGATCGCCAACGACATGCGCTGGCTCGCGTCCGGCCCGCGC
TGCGGCCTCGGCGAGCTGAAGCTGCCGGACAACGAGCCGGGCTCCTCCATCATGCCTGGCAAGGTCAACCCGACCCAGTG
CGAGGCGATGGTGATGATCGCCATCCAGGTGCTCGGCAACGACAGCGCCGTCGCCTTTGGTGGCAGCCAGGGCAATTTCG
AGCTCAACGCCATGCGCCCGCTGCTCATCAACAACGTGCTGCACTCCATCCGCATTCTCGCCGACGGCTGCGACCGCTTT
CGCGAATTCTCGGTCGAGGGCACGGAGATCGAGCGCGAGAAGATCAGCGCCTATGTCGCGGGCAGCGTGATGCTGGTGAC
CGCGTTGTCGCCCGTCATCGGCTACCAGAACGCGGCCCATATCGCGGAAAAGGCGATTGCCGACGGCACAACGCTGAAGG
AGGCCGCGCTCGCCTCCGGCAAGGTGGATGAAGCCCTGTTCGACAAGGTCATCGTGCCGCTGAACATGGTCGGCAAAGGC
CTTGCCGGCGCCTGA

Upstream 100 bases:

>100_bases
CAGAGGCCGCCAGGAGGCCATAAAGACCACGACCCCTCGGACGTCCGACCGCGGGCGGATCATCTGACCCCGCCCCGCAA
CCATCCTCAAGCAAAGGAGC

Downstream 100 bases:

>100_bases
AGGAGACGACGAATATGATCCGTTGCGTCCGCATGTGGACCGGCCCCGATGGCAATTCCCTCTTCGAGGAAGGCACGCTG
GAGATCGGAGCCGGCCAGCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MALSEAPTLRAVPIGIDATGTRQEFDSMGTVAVPADRYWGAQTERSLHHFDIGGDRMPKAVYHAYGYVKKACALVNAAAG
RLPDWKRDAIIQAADETIAGKLDDHFPLYVWQTGSGTQSNMNVNEVLSNRAIQLLGGTLGTQHPVGPNDDVNMGQSSNDT
FPTAMHIATIFAIDDQLLPAVTRLVEIIEKKADGWMDVVKIGRTHLEDAVPLTVGQEWHGWAGQIRACIAAIEASRAGLY
ELAVGGTAVGTGLNAPAGFSRDVAAKIAELTGKPFVTAPNKFMAQGSLDAMVRASAGLRGLAIALMKIANDMRWLASGPR
CGLGELKLPDNEPGSSIMPGKVNPTQCEAMVMIAIQVLGNDSAVAFGGSQGNFELNAMRPLLINNVLHSIRILADGCDRF
REFSVEGTEIEREKISAYVAGSVMLVTALSPVIGYQNAAHIAEKAIADGTTLKEAALASGKVDEALFDKVIVPLNMVGKG
LAGA

Sequences:

>Translated_484_residues
MALSEAPTLRAVPIGIDATGTRQEFDSMGTVAVPADRYWGAQTERSLHHFDIGGDRMPKAVYHAYGYVKKACALVNAAAG
RLPDWKRDAIIQAADETIAGKLDDHFPLYVWQTGSGTQSNMNVNEVLSNRAIQLLGGTLGTQHPVGPNDDVNMGQSSNDT
FPTAMHIATIFAIDDQLLPAVTRLVEIIEKKADGWMDVVKIGRTHLEDAVPLTVGQEWHGWAGQIRACIAAIEASRAGLY
ELAVGGTAVGTGLNAPAGFSRDVAAKIAELTGKPFVTAPNKFMAQGSLDAMVRASAGLRGLAIALMKIANDMRWLASGPR
CGLGELKLPDNEPGSSIMPGKVNPTQCEAMVMIAIQVLGNDSAVAFGGSQGNFELNAMRPLLINNVLHSIRILADGCDRF
REFSVEGTEIEREKISAYVAGSVMLVTALSPVIGYQNAAHIAEKAIADGTTLKEAALASGKVDEALFDKVIVPLNMVGKG
LAGA
>Mature_483_residues
ALSEAPTLRAVPIGIDATGTRQEFDSMGTVAVPADRYWGAQTERSLHHFDIGGDRMPKAVYHAYGYVKKACALVNAAAGR
LPDWKRDAIIQAADETIAGKLDDHFPLYVWQTGSGTQSNMNVNEVLSNRAIQLLGGTLGTQHPVGPNDDVNMGQSSNDTF
PTAMHIATIFAIDDQLLPAVTRLVEIIEKKADGWMDVVKIGRTHLEDAVPLTVGQEWHGWAGQIRACIAAIEASRAGLYE
LAVGGTAVGTGLNAPAGFSRDVAAKIAELTGKPFVTAPNKFMAQGSLDAMVRASAGLRGLAIALMKIANDMRWLASGPRC
GLGELKLPDNEPGSSIMPGKVNPTQCEAMVMIAIQVLGNDSAVAFGGSQGNFELNAMRPLLINNVLHSIRILADGCDRFR
EFSVEGTEIEREKISAYVAGSVMLVTALSPVIGYQNAAHIAEKAIADGTTLKEAALASGKVDEALFDKVIVPLNMVGKGL
AGA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=55.5555555555556, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=46.7532467532467, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1787896, Length=462, Percent_Identity=56.2770562770563, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=37.1490280777538, Blast_Score=306, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=56.8627450980392, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=54.2944785276074, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324993, Length=459, Percent_Identity=52.9411764705882, Blast_Score=488, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=56.7391304347826, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=56.7391304347826, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=55.1948051948052, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=54.880694143167, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=49.5670995670996, Blast_Score=450, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51252; Mature: 51121

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSEAPTLRAVPIGIDATGTRQEFDSMGTVAVPADRYWGAQTERSLHHFDIGGDRMPKA
CCCCCCCCEEEEEECCCCCCCHHHHHCCCCEEECCHHHCCCCHHCCCEEECCCCCCCHHH
VYHAYGYVKKACALVNAAAGRLPDWKRDAIIQAADETIAGKLDDHFPLYVWQTGSGTQSN
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
MNVNEVLSNRAIQLLGGTLGTQHPVGPNDDVNMGQSSNDTFPTAMHIATIFAIDDQLLPA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHH
VTRLVEIIEKKADGWMDVVKIGRTHLEDAVPLTVGQEWHGWAGQIRACIAAIEASRAGLY
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEE
ELAVGGTAVGTGLNAPAGFSRDVAAKIAELTGKPFVTAPNKFMAQGSLDAMVRASAGLRG
EEEECCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHCCCHHHHHHHHCCHHH
LAIALMKIANDMRWLASGPRCGLGELKLPDNEPGSSIMPGKVNPTQCEAMVMIAIQVLGN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
DSAVAFGGSQGNFELNAMRPLLINNVLHSIRILADGCDRFREFSVEGTEIEREKISAYVA
CCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GSVMLVTALSPVIGYQNAAHIAEKAIADGTTLKEAALASGKVDEALFDKVIVPLNMVGKG
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
LAGA
CCCC
>Mature Secondary Structure 
ALSEAPTLRAVPIGIDATGTRQEFDSMGTVAVPADRYWGAQTERSLHHFDIGGDRMPKA
CCCCCCCEEEEEECCCCCCCHHHHHCCCCEEECCHHHCCCCHHCCCEEECCCCCCCHHH
VYHAYGYVKKACALVNAAAGRLPDWKRDAIIQAADETIAGKLDDHFPLYVWQTGSGTQSN
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
MNVNEVLSNRAIQLLGGTLGTQHPVGPNDDVNMGQSSNDTFPTAMHIATIFAIDDQLLPA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHH
VTRLVEIIEKKADGWMDVVKIGRTHLEDAVPLTVGQEWHGWAGQIRACIAAIEASRAGLY
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEE
ELAVGGTAVGTGLNAPAGFSRDVAAKIAELTGKPFVTAPNKFMAQGSLDAMVRASAGLRG
EEEECCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHCCCHHHHHHHHCCHHH
LAIALMKIANDMRWLASGPRCGLGELKLPDNEPGSSIMPGKVNPTQCEAMVMIAIQVLGN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
DSAVAFGGSQGNFELNAMRPLLINNVLHSIRILADGCDRFREFSVEGTEIEREKISAYVA
CCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GSVMLVTALSPVIGYQNAAHIAEKAIADGTTLKEAALASGKVDEALFDKVIVPLNMVGKG
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
LAGA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]