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The map label for this gene is pccB [H]

Identifier: 158423399

GI number: 158423399

Start: 2030195

End: 2031727

Strand: Reverse

Name: pccB [H]

Synonym: AZC_1775

Alternate gene names: 158423399

Gene position: 2031727-2030195 (Counterclockwise)

Preceding gene: 158423401

Following gene: 158423398

Centisome position: 37.84

GC content: 64.77

Gene sequence:

>1533_bases
ATGAAGGAAATCCTGGAAGAGCTCGAGAACCGCCGGGTCGTCGCCCGGCTGGGAGGCGGCGAGAAGCGCATCCAGGCGCA
GCACGGGCGCGGCAAGCTCACCGCGCGCGAGCGCATCGAGCTCCTGCTGGATCACGGCTCCTTCGAGGAGTTCGACACCT
TCGTGCAGCATCGCTGCGGCGATTTCGGCATGGAGAACCAGAAGATCCCCGGCGACGGCGTCGTCACGGGCTGGGGCACG
GTCAACGGCCGGCAGGTCTTCGTCTTCGCCAAGGACTTCACCGTCTTCGGCGGCTCCCTCTCGGAAGCCCATGCGCAGAA
GATCACCAAGATCCAGGATCTGGCGCTGAAGACCCGCGCCCCCATCATCGGCCTGTTCGATGCCGGCGGCGCCCGCATCC
AGGAAGGCGTGGCGGCACTCGGCGGCTATGGCGAGGTGTTCAAGCGCAATGTGACCGCCTCGGGTGTCATCCCGCAGATC
TCCCTCATCATGGGCCCGTGCGCGGGCGGCGACGTCTATTCGCCGGCCATGACCGACTTCATCTTCATGGTCCGCGATAC
GAGCTACATGTTCGTCACCGGCCCGGACGTGGTGAAGACGGTGACGAACGAGACCGTCACCTCGGAGGAGTTGGGCGGCG
CCAAGGTGCACACCACCAAGTCCTCGGTGGCGGACGGCGCCTATGAGAACGACGTAGAGATGCTGCTCCAGACCCGTCGT
CTCATCGATTTCCTGCCGCTGAACAATCAGGTGGGCGTGCCCGAATGGCCGTCCTTCGATGCGCCCGACCGCGTCGAGGA
GAGCCTCGACACCCTGATCCCGGACAATCCGAACAAGCCTTACGACATCAAGGAACTGATCCTGAAGGTGGCGGACGAGG
CGGATTTCTTCGAGATCCAGGCCGCCTACGCCAAGAACATCGTCACCGGCTTCGGCCGCATTGAGGGCCGCACGGTGGGC
TTCGTCGCCAACCAGCCCATGGTGCTCGCTGGCGTGCTCGACGCGGATGCGTCGCGAAAAGCCGCGCGCTTCGTGCGCTT
CTGCGATGCGTTCGAGATCCCGATCGTCACCTTCGTGGACGTGCCCGGCTTCCTGCCCGGCACGGCGCAGGAATATGGCG
GCCTCATCAAGCACGGCGCCAAGCTGCTGTTCGCCTATTCGCAGGCCACCGTACCGCTCGTCACCATCATCACCCGCAAG
GCCTTCGGCGGCGCATATGACGTGATGGCCTCCAAGCACGTGGGCGGCGACGTGAACTATGCCTGGCCCACCGCCCAGAT
CGCGGTGATGGGCGCCAAGGGCGCGGTTGAGATCATCTTCCGGTCCGACATGGACGATCCGGAGAAGATCGCCGAGCAGA
CCCGCAAATATGAGCAGCGCTTCCTCTCGCCCTTCGTGGCGGCGGAGCGCGGCTATATCGACGAGGTCATCAAGCCCCAT
TCCACGCGCCGGCGCATCGCCCGCGCGCTCGCCATGCTGCGCTCCAAGAAAGTGGAGCAGCCGCTGAAGAAGCACGACAA
TCTGCCGCTTTAG

Upstream 100 bases:

>100_bases
CAGTGGAGTATTCTTTGCGCCTGAAACCCTGAGTGGTCTTTCCCTCTCGGGTTCCCCATCGCTAGAGTGAGGACCGCAGG
GAAACCGGCGGGGGTATCAG

Downstream 100 bases:

>100_bases
GCCATAGCCGGGACAACGCCCCGCCTGCCCCCTCCCTGCCCTCCCCCGCAAGCGGGAGAGGGTTCCCCCGCCCGGACGAA
GCTGTCGCGATGGCGAGACC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKEILEELENRRVVARLGGGEKRIQAQHGRGKLTARERIELLLDHGSFEEFDTFVQHRCGDFGMENQKIPGDGVVTGWGT
VNGRQVFVFAKDFTVFGGSLSEAHAQKITKIQDLALKTRAPIIGLFDAGGARIQEGVAALGGYGEVFKRNVTASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTSEELGGAKVHTTKSSVADGAYENDVEMLLQTRR
LIDFLPLNNQVGVPEWPSFDAPDRVEESLDTLIPDNPNKPYDIKELILKVADEADFFEIQAAYAKNIVTGFGRIEGRTVG
FVANQPMVLAGVLDADASRKAARFVRFCDAFEIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTIITRK
AFGGAYDVMASKHVGGDVNYAWPTAQIAVMGAKGAVEIIFRSDMDDPEKIAEQTRKYEQRFLSPFVAAERGYIDEVIKPH
STRRRIARALAMLRSKKVEQPLKKHDNLPL

Sequences:

>Translated_510_residues
MKEILEELENRRVVARLGGGEKRIQAQHGRGKLTARERIELLLDHGSFEEFDTFVQHRCGDFGMENQKIPGDGVVTGWGT
VNGRQVFVFAKDFTVFGGSLSEAHAQKITKIQDLALKTRAPIIGLFDAGGARIQEGVAALGGYGEVFKRNVTASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTSEELGGAKVHTTKSSVADGAYENDVEMLLQTRR
LIDFLPLNNQVGVPEWPSFDAPDRVEESLDTLIPDNPNKPYDIKELILKVADEADFFEIQAAYAKNIVTGFGRIEGRTVG
FVANQPMVLAGVLDADASRKAARFVRFCDAFEIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTIITRK
AFGGAYDVMASKHVGGDVNYAWPTAQIAVMGAKGAVEIIFRSDMDDPEKIAEQTRKYEQRFLSPFVAAERGYIDEVIKPH
STRRRIARALAMLRSKKVEQPLKKHDNLPL
>Mature_510_residues
MKEILEELENRRVVARLGGGEKRIQAQHGRGKLTARERIELLLDHGSFEEFDTFVQHRCGDFGMENQKIPGDGVVTGWGT
VNGRQVFVFAKDFTVFGGSLSEAHAQKITKIQDLALKTRAPIIGLFDAGGARIQEGVAALGGYGEVFKRNVTASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTSEELGGAKVHTTKSSVADGAYENDVEMLLQTRR
LIDFLPLNNQVGVPEWPSFDAPDRVEESLDTLIPDNPNKPYDIKELILKVADEADFFEIQAAYAKNIVTGFGRIEGRTVG
FVANQPMVLAGVLDADASRKAARFVRFCDAFEIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTIITRK
AFGGAYDVMASKHVGGDVNYAWPTAQIAVMGAKGAVEIIFRSDMDDPEKIAEQTRKYEQRFLSPFVAAERGYIDEVIKPH
STRRRIARALAMLRSKKVEQPLKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=63.7080867850099, Blast_Score=667, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=61.4800759013283, Blast_Score=656, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=524, Percent_Identity=32.0610687022901, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI310133460, Length=126, Percent_Identity=38.0952380952381, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786382, Length=178, Percent_Identity=30.8988764044944, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=60.6299212598425, Blast_Score=654, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=60.6299212598425, Blast_Score=654, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=518, Percent_Identity=32.2393822393822, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71997163, Length=328, Percent_Identity=23.4756097560976, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24586065, Length=528, Percent_Identity=32.0075757575758, Blast_Score=251, Evalue=9e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55979; Mature: 55979

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEILEELENRRVVARLGGGEKRIQAQHGRGKLTARERIELLLDHGSFEEFDTFVQHRCG
CHHHHHHHHCCEEEEEECCCHHHEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
DFGMENQKIPGDGVVTGWGTVNGRQVFVFAKDFTVFGGSLSEAHAQKITKIQDLALKTRA
CCCCCCCCCCCCCEEEECCCCCCCEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHHCC
PIIGLFDAGGARIQEGVAALGGYGEVFKRNVTASGVIPQISLIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPDVVKTVTNETVTSEELGGAKVHTTKSSVADGAYENDVEMLLQTRR
EEEEECCCEEEEECCHHHHHHHCCCCCHHHCCCCEEEECHHHHCCCCCHHHHHHHHHHHH
LIDFLPLNNQVGVPEWPSFDAPDRVEESLDTLIPDNPNKPYDIKELILKVADEADFFEIQ
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHH
AAYAKNIVTGFGRIEGRTVGFVANQPMVLAGVLDADASRKAARFVRFCDAFEIPIVTFVD
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTIITRKAFGGAYDVMASKHVGGDVNY
CCCCCCCCHHHHCHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AWPTAQIAVMGAKGAVEIIFRSDMDDPEKIAEQTRKYEQRFLSPFVAAERGYIDEVIKPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
STRRRIARALAMLRSKKVEQPLKKHDNLPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKEILEELENRRVVARLGGGEKRIQAQHGRGKLTARERIELLLDHGSFEEFDTFVQHRCG
CHHHHHHHHCCEEEEEECCCHHHEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
DFGMENQKIPGDGVVTGWGTVNGRQVFVFAKDFTVFGGSLSEAHAQKITKIQDLALKTRA
CCCCCCCCCCCCCEEEECCCCCCCEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHHCC
PIIGLFDAGGARIQEGVAALGGYGEVFKRNVTASGVIPQISLIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPDVVKTVTNETVTSEELGGAKVHTTKSSVADGAYENDVEMLLQTRR
EEEEECCCEEEEECCHHHHHHHCCCCCHHHCCCCEEEECHHHHCCCCCHHHHHHHHHHHH
LIDFLPLNNQVGVPEWPSFDAPDRVEESLDTLIPDNPNKPYDIKELILKVADEADFFEIQ
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHH
AAYAKNIVTGFGRIEGRTVGFVANQPMVLAGVLDADASRKAARFVRFCDAFEIPIVTFVD
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTIITRKAFGGAYDVMASKHVGGDVNY
CCCCCCCCHHHHCHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AWPTAQIAVMGAKGAVEIIFRSDMDDPEKIAEQTRKYEQRFLSPFVAAERGYIDEVIKPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
STRRRIARALAMLRSKKVEQPLKKHDNLPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]