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The map label for this gene is pyrH

Identifier: 158423319

GI number: 158423319

Start: 1941986

End: 1942702

Strand: Direct

Name: pyrH

Synonym: AZC_1695

Alternate gene names: 158423319

Gene position: 1941986-1942702 (Clockwise)

Preceding gene: 158423318

Following gene: 158423320

Centisome position: 36.17

GC content: 70.43

Gene sequence:

>717_bases
ATGCCGGGCCTTCCCTATCCACGCATCCTGGTCAAGGTCTCGGGCGAGGCCTTGATGGGATCGGAACCGTTCGGGCTTCA
TCCCCCGACGGTTGCCCGCATCGCCCGCGAACTCGTAGCCGCGCGTGAGCTCGGCTGCGAGGTGGCGGTGGTCGTGGGCG
GCGGCAACATCCTGCGTGGCGCGCGGGTGGCGGGCGAGGATCTCGACCGCTCCACCGCCGACCACATGGGCATGCTGGCC
ACCGTGATGAACTGCCTGGCGCTGGAAGCGGCGGTGGAGGCGGCGGGCCAGCCCGCACGCACCATGTCCGCTATTCCGAT
GCCGACGGTGTGCGAGCCCTACGCCCGCCAGCCGGCCCAGCGCCACCTGCGGCGCGGCCGCGTCGTGCTTCTGGCCGGCG
GCACCGGCAATCCGTACTTCACCACGGATACGGGCGCCGTGCTGCGCGCGGCGGAGCTCGACTGCGACGCCGTGCTCAAG
GCCACCAATGTGGACGGCGTGTACACCGCCGACCCCAAGACCGACCCGACCGCCACCCGCTACGAGCGTATCACCCACGA
TCAGGCCCTGGCCTATGATCTCAAGGTGATGGATGCGGCGGCCTTCGCCCTTGCCCGCGAGGCGTCGCTGCCTATCATCG
TGTTCTCCATCCGCGATCCGGGCGCCATCGTGGCGGCGGCGCAGGGAGAGGGGCGCGTGACGGTGGTTTCTCCCTGA

Upstream 100 bases:

>100_bases
ATGCCCTCGGCGAGGGCATCGAGAAGGAAGAGAGCGACTTCGCGGCCGAGGTCGCTGCTGCGGCTGGCCAGTCCTGACCG
CCGGCGAAGGCGAAACGGCA

Downstream 100 bases:

>100_bases
GGTTCGATGCGCGGCTGGTGACGGGCTTGAGGCCCGCGCCGGCCGCGTTCGCGTTGCCGCCGGGCGATCGCCGGAGGATC
ATCGTCGGGTGATCTTGGGG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MPGLPYPRILVKVSGEALMGSEPFGLHPPTVARIARELVAARELGCEVAVVVGGGNILRGARVAGEDLDRSTADHMGMLA
TVMNCLALEAAVEAAGQPARTMSAIPMPTVCEPYARQPAQRHLRRGRVVLLAGGTGNPYFTTDTGAVLRAAELDCDAVLK
ATNVDGVYTADPKTDPTATRYERITHDQALAYDLKVMDAAAFALAREASLPIIVFSIRDPGAIVAAAQGEGRVTVVSP

Sequences:

>Translated_238_residues
MPGLPYPRILVKVSGEALMGSEPFGLHPPTVARIARELVAARELGCEVAVVVGGGNILRGARVAGEDLDRSTADHMGMLA
TVMNCLALEAAVEAAGQPARTMSAIPMPTVCEPYARQPAQRHLRRGRVVLLAGGTGNPYFTTDTGAVLRAAELDCDAVLK
ATNVDGVYTADPKTDPTATRYERITHDQALAYDLKVMDAAAFALAREASLPIIVFSIRDPGAIVAAAQGEGRVTVVSP
>Mature_237_residues
PGLPYPRILVKVSGEALMGSEPFGLHPPTVARIARELVAARELGCEVAVVVGGGNILRGARVAGEDLDRSTADHMGMLAT
VMNCLALEAAVEAAGQPARTMSAIPMPTVCEPYARQPAQRHLRRGRVVLLAGGTGNPYFTTDTGAVLRAAELDCDAVLKA
TNVDGVYTADPKTDPTATRYERITHDQALAYDLKVMDAAAFALAREASLPIIVFSIRDPGAIVAAAQGEGRVTVVSP

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=52.5862068965517, Blast_Score=243, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_AZOC5 (A8I467)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524611.1
- ProteinModelPortal:   A8I467
- SMR:   A8I467
- GeneID:   5688105
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1695
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   ACAU438753:AZC_1695-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24971; Mature: 24840

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 163-163 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLPYPRILVKVSGEALMGSEPFGLHPPTVARIARELVAARELGCEVAVVVGGGNILRG
CCCCCCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEECC
ARVAGEDLDRSTADHMGMLATVMNCLALEAAVEAAGQPARTMSAIPMPTVCEPYARQPAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHCCHHH
RHLRRGRVVLLAGGTGNPYFTTDTGAVLRAAELDCDAVLKATNVDGVYTADPKTDPTATR
HHHHCCCEEEEECCCCCCCEECCCCCEEEEECCCHHHHEEECCCCCEEECCCCCCCCHHH
YERITHDQALAYDLKVMDAAAFALAREASLPIIVFSIRDPGAIVAAAQGEGRVTVVSP
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCEEEEECC
>Mature Secondary Structure 
PGLPYPRILVKVSGEALMGSEPFGLHPPTVARIARELVAARELGCEVAVVVGGGNILRG
CCCCCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEECC
ARVAGEDLDRSTADHMGMLATVMNCLALEAAVEAAGQPARTMSAIPMPTVCEPYARQPAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHCCHHH
RHLRRGRVVLLAGGTGNPYFTTDTGAVLRAAELDCDAVLKATNVDGVYTADPKTDPTATR
HHHHCCCEEEEECCCCCCCEECCCCCEEEEECCCHHHHEEECCCCCEEECCCCCCCCHHH
YERITHDQALAYDLKVMDAAAFALAREASLPIIVFSIRDPGAIVAAAQGEGRVTVVSP
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA