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The map label for this gene is nqo3 [H]

Identifier: 158423298

GI number: 158423298

Start: 1914571

End: 1916646

Strand: Direct

Name: nqo3 [H]

Synonym: AZC_1674

Alternate gene names: 158423298

Gene position: 1914571-1916646 (Clockwise)

Preceding gene: 158423297

Following gene: 158423299

Centisome position: 35.65

GC content: 69.08

Gene sequence:

>2076_bases
ATGAGCAAGATCATCGTCGACGGGACAGAGGTTGACGTCCCCGCCGAGTACACGCTGCTCCAGGCGTGTGAGGTGGCGGG
CGTGGAGATTCCGCGCTTCTGCTTCCATGAACGCCTGTCCATCGCCGGCAACTGCCGCATGTGCCTCGTCGAGGTGAAGG
GCGGCCCGCCCAAGCCCACCGCCTCCTGCGCCATGGCGGTGAAGGATCTGCGCCCCGGCCCGAACGGCGAGCCCCCGGTC
GTGCTCACCAAGAGCCCGATGGTGAAGAAGGCCCGCGAAGGGGTGATGGAGTTCCTCCTCATCAACCACCCCCTCGACTG
CCCCATCTGCGACCAGGGCGGCGAGTGCGACCTTCAGGACCAGGCCATGGCCTATGGCGTGGATAGTTCTCGCTTCGCCG
AGAACAAGCGCGCCGTGGAAGACAAGTACATCGGCCCGCTGGTGCGCACCTCCATGAACCGGTGCATCCACTGCACCCGC
TGCGTGCGCTTCTCGACCGAAGTCGCTGGCGTGCCGGACCTCGGCGCCATCGGCCGCGGCGAGGACATGGAGATCACCAC
CTATCTCGAGCACGCCATGCGCTCTGAGATGCAGGGCAATGTGGCGGACCTCTGCCCGGTGGGCGCGTTGACCCACAAGC
CCTACGCCTTCCACGCCCGGCCGTGGGAACTGGCGAAGACCGAGTCCATCGACGTGATGGATGCGGTCGGCTCCAACATC
CGCATCGACACCCGTGGCCGTGAGGTCATGCGCATCCTCCCCCGCGTCCATGAGGGCGTGAACGAGGAGTGGATCTCCGA
CAAGACCCGCTACGTGTGGGATGGCCTGAAGACCCAGCGCCTCGATCGGCCCTACGTGCGCCAGAACGGCCGCCTCGTGC
CGGCCAGCTGGAGCCAGGCCTTCGATGCCATCGCCGCCAAGGTGAAGGCGACCCCGGCGGCCCGTCTCGGCGCCATCGCC
GGCGACCTCGCCACGACGGAAGAGCTGTTCGCTTTGAAGCAGCTCATGGGCAAGCTGGGAACGGCCAACGTCGACGCGCG
CCAGGATGGCGCCGCCCTCGATCCGGCGCTCGGCCGCGCGTCCTACGTCTTCAATCCCGCCATCGTCGGGATCGAGGAAG
CGGATGCCATCCTGCTGGTGGGCACCGATCCCCGCCACGAGGCCTCCGTCCTCAACGCCCGCATCCGCAAGCGCTGGCGC
CAGGGCGGCCTCAAGGTCGCGCTCATCGGCGAGCGGGTCGATCTGACCTATCCCTATGAGTATCTCGGCGCCGGCCCGGA
CACGCTCGCGGACCTCACCGGCGGCGGCACCTTTGCCGACGTTCTGAAGGGCGCGCAGCGTCCGCTGGTGATCGTTGGGC
AGGGCGCCATCGCCCGCGCCGACGGCGCCGCCATCCTGTCGCTGGCCGCACGCCTCGCGGTGTCTGTGGGCGCGGTGAAG
GACGGCTGGAACGGCTTTGCGGTGCTGCACACGGCGGCGAGCCGCGTCGGCGCGCTCGACATCGGCTTCGTGCCGGGGCA
GGGCGGTCTCACCGCCAAGGCCATGGCCGAGGGCGGCGTGGACACGCTGTTCCTGCTCGGTGCGGATGAGATCGAGGTCG
CTCCCGGCGCCTTCGTCGTCTACATCGGCACCCATGGCGACAAGGGCGCGCACCGCGCCGACGTCATCCTGCCCGGTGCC
GCTTATTCCGAGAAGTCCGGCCTCTATGTGAACACGGAAGGCCGTCCGCAGTTCGCCAACCGCGCGGCCTTCCCGCCCGG
TGAGGCGCGCGAGGACTGGGCCGTGCTCCGCGCCCTCTCCGAAGTGCTCGGCCAGAAGCTGCCCTACGACACGCTGTTCG
CTTTGCGCGCGGCGCTGGTGTCGGCTCATCCGCACCTCGGCCGCCTCGACGAGATCGAGCCGACGGATGTCTCGGTGGTG
GCCAAGGTGGCCGGCCTCGGCGGCACGCCGGACAAGGCTCCGTTCGCGCTGGCCGTGCGCGACTTCTATCTGACCAATCC
CATCGCGCGGTCTTCCGCCGTGATGGCCGAATGCTCCGCGCTCCGCCTCGGCGGAACCGCCGTGGCGGCGGAGTGA

Upstream 100 bases:

>100_bases
TGGGCAGCCGTCTCGACGGCATGACCATCGACGGCGTTGCGGTGACGGATCTCTTGGCTGCGTGGAACGCGGCTCAAGCG
GGCGGTAAGGCGGACGAATA

Downstream 100 bases:

>100_bases
GTGATGCGCGCGCAGGATCAATCTGACCGCGGGTGCCGGGCGACTGCCCGCACCGGCCGGAACTGAGGGCGAGTAGAACC
CATGAGTTGGCAGGACACCC

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 691; Mature: 690

Protein sequence:

>691_residues
MSKIIVDGTEVDVPAEYTLLQACEVAGVEIPRFCFHERLSIAGNCRMCLVEVKGGPPKPTASCAMAVKDLRPGPNGEPPV
VLTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDSSRFAENKRAVEDKYIGPLVRTSMNRCIHCTR
CVRFSTEVAGVPDLGAIGRGEDMEITTYLEHAMRSEMQGNVADLCPVGALTHKPYAFHARPWELAKTESIDVMDAVGSNI
RIDTRGREVMRILPRVHEGVNEEWISDKTRYVWDGLKTQRLDRPYVRQNGRLVPASWSQAFDAIAAKVKATPAARLGAIA
GDLATTEELFALKQLMGKLGTANVDARQDGAALDPALGRASYVFNPAIVGIEEADAILLVGTDPRHEASVLNARIRKRWR
QGGLKVALIGERVDLTYPYEYLGAGPDTLADLTGGGTFADVLKGAQRPLVIVGQGAIARADGAAILSLAARLAVSVGAVK
DGWNGFAVLHTAASRVGALDIGFVPGQGGLTAKAMAEGGVDTLFLLGADEIEVAPGAFVVYIGTHGDKGAHRADVILPGA
AYSEKSGLYVNTEGRPQFANRAAFPPGEAREDWAVLRALSEVLGQKLPYDTLFALRAALVSAHPHLGRLDEIEPTDVSVV
AKVAGLGGTPDKAPFALAVRDFYLTNPIARSSAVMAECSALRLGGTAVAAE

Sequences:

>Translated_691_residues
MSKIIVDGTEVDVPAEYTLLQACEVAGVEIPRFCFHERLSIAGNCRMCLVEVKGGPPKPTASCAMAVKDLRPGPNGEPPV
VLTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDSSRFAENKRAVEDKYIGPLVRTSMNRCIHCTR
CVRFSTEVAGVPDLGAIGRGEDMEITTYLEHAMRSEMQGNVADLCPVGALTHKPYAFHARPWELAKTESIDVMDAVGSNI
RIDTRGREVMRILPRVHEGVNEEWISDKTRYVWDGLKTQRLDRPYVRQNGRLVPASWSQAFDAIAAKVKATPAARLGAIA
GDLATTEELFALKQLMGKLGTANVDARQDGAALDPALGRASYVFNPAIVGIEEADAILLVGTDPRHEASVLNARIRKRWR
QGGLKVALIGERVDLTYPYEYLGAGPDTLADLTGGGTFADVLKGAQRPLVIVGQGAIARADGAAILSLAARLAVSVGAVK
DGWNGFAVLHTAASRVGALDIGFVPGQGGLTAKAMAEGGVDTLFLLGADEIEVAPGAFVVYIGTHGDKGAHRADVILPGA
AYSEKSGLYVNTEGRPQFANRAAFPPGEAREDWAVLRALSEVLGQKLPYDTLFALRAALVSAHPHLGRLDEIEPTDVSVV
AKVAGLGGTPDKAPFALAVRDFYLTNPIARSSAVMAECSALRLGGTAVAAE
>Mature_690_residues
SKIIVDGTEVDVPAEYTLLQACEVAGVEIPRFCFHERLSIAGNCRMCLVEVKGGPPKPTASCAMAVKDLRPGPNGEPPVV
LTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDSSRFAENKRAVEDKYIGPLVRTSMNRCIHCTRC
VRFSTEVAGVPDLGAIGRGEDMEITTYLEHAMRSEMQGNVADLCPVGALTHKPYAFHARPWELAKTESIDVMDAVGSNIR
IDTRGREVMRILPRVHEGVNEEWISDKTRYVWDGLKTQRLDRPYVRQNGRLVPASWSQAFDAIAAKVKATPAARLGAIAG
DLATTEELFALKQLMGKLGTANVDARQDGAALDPALGRASYVFNPAIVGIEEADAILLVGTDPRHEASVLNARIRKRWRQ
GGLKVALIGERVDLTYPYEYLGAGPDTLADLTGGGTFADVLKGAQRPLVIVGQGAIARADGAAILSLAARLAVSVGAVKD
GWNGFAVLHTAASRVGALDIGFVPGQGGLTAKAMAEGGVDTLFLLGADEIEVAPGAFVVYIGTHGDKGAHRADVILPGAA
YSEKSGLYVNTEGRPQFANRAAFPPGEAREDWAVLRALSEVLGQKLPYDTLFALRAALVSAHPHLGRLDEIEPTDVSVVA
KVAGLGGTPDKAPFALAVRDFYLTNPIARSSAVMAECSALRLGGTAVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=707, Percent_Identity=52.3338048090523, Blast_Score=696, Evalue=0.0,
Organism=Escherichia coli, GI145693161, Length=387, Percent_Identity=30.4909560723514, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17565758, Length=695, Percent_Identity=50.2158273381295, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32566231, Length=592, Percent_Identity=52.1959459459459, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI193209088, Length=260, Percent_Identity=60.7692307692308, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24640559, Length=695, Percent_Identity=52.0863309352518, Blast_Score=659, Evalue=0.0,
Organism=Drosophila melanogaster, GI24640557, Length=695, Percent_Identity=52.0863309352518, Blast_Score=659, Evalue=0.0,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73645; Mature: 73514

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIIVDGTEVDVPAEYTLLQACEVAGVEIPRFCFHERLSIAGNCRMCLVEVKGGPPKPT
CCCEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCH
ASCAMAVKDLRPGPNGEPPVVLTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAYGVDSSRFAENKRAVEDKYIGPLVRTSMNRCIHCTRCVRFSTEVAGVPDLGAIGRG
CHHEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EDMEITTYLEHAMRSEMQGNVADLCPVGALTHKPYAFHARPWELAKTESIDVMDAVGSNI
CCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHCCCCE
RIDTRGREVMRILPRVHEGVNEEWISDKTRYVWDGLKTQRLDRPYVRQNGRLVPASWSQA
EEECCHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCHHHHHCCCCHHHCCCEEECCCHHHH
FDAIAAKVKATPAARLGAIAGDLATTEELFALKQLMGKLGTANVDARQDGAALDPALGRA
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC
SYVFNPAIVGIEEADAILLVGTDPRHEASVLNARIRKRWRQGGLKVALIGERVDLTYPYE
EEEECCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECEEEEECCHH
YLGAGPDTLADLTGGGTFADVLKGAQRPLVIVGQGAIARADGAAILSLAARLAVSVGAVK
HHCCCCHHHHHCCCCCHHHHHHCCCCCCEEEEECCCEECCCCHHHHHHHHHHHHHHCCCC
DGWNGFAVLHTAASRVGALDIGFVPGQGGLTAKAMAEGGVDTLFLLGADEIEVAPGAFVV
CCCCCEEHEEHHHHHCCEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCEEECCCEEEE
YIGTHGDKGAHRADVILPGAAYSEKSGLYVNTEGRPQFANRAAFPPGEAREDWAVLRALS
EEECCCCCCCCCCEEEECCCCCCCCCCEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHH
EVLGQKLPYDTLFALRAALVSAHPHLGRLDEIEPTDVSVVAKVAGLGGTPDKAPFALAVR
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEE
DFYLTNPIARSSAVMAECSALRLGGTAVAAE
HHHHCCCHHHHHHHHHHHHHEEECCEEECCC
>Mature Secondary Structure 
SKIIVDGTEVDVPAEYTLLQACEVAGVEIPRFCFHERLSIAGNCRMCLVEVKGGPPKPT
CCEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCH
ASCAMAVKDLRPGPNGEPPVVLTKSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAYGVDSSRFAENKRAVEDKYIGPLVRTSMNRCIHCTRCVRFSTEVAGVPDLGAIGRG
CHHEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EDMEITTYLEHAMRSEMQGNVADLCPVGALTHKPYAFHARPWELAKTESIDVMDAVGSNI
CCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHCCCCE
RIDTRGREVMRILPRVHEGVNEEWISDKTRYVWDGLKTQRLDRPYVRQNGRLVPASWSQA
EEECCHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCHHHHHCCCCHHHCCCEEECCCHHHH
FDAIAAKVKATPAARLGAIAGDLATTEELFALKQLMGKLGTANVDARQDGAALDPALGRA
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC
SYVFNPAIVGIEEADAILLVGTDPRHEASVLNARIRKRWRQGGLKVALIGERVDLTYPYE
EEEECCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECEEEEECCHH
YLGAGPDTLADLTGGGTFADVLKGAQRPLVIVGQGAIARADGAAILSLAARLAVSVGAVK
HHCCCCHHHHHCCCCCHHHHHHCCCCCCEEEEECCCEECCCCHHHHHHHHHHHHHHCCCC
DGWNGFAVLHTAASRVGALDIGFVPGQGGLTAKAMAEGGVDTLFLLGADEIEVAPGAFVV
CCCCCEEHEEHHHHHCCEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCEEECCCEEEE
YIGTHGDKGAHRADVILPGAAYSEKSGLYVNTEGRPQFANRAAFPPGEAREDWAVLRALS
EEECCCCCCCCCCEEEECCCCCCCCCCEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHH
EVLGQKLPYDTLFALRAALVSAHPHLGRLDEIEPTDVSVVAKVAGLGGTPDKAPFALAVR
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEE
DFYLTNPIARSSAVMAECSALRLGGTAVAAE
HHHHCCCHHHHHHHHHHHHHEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]