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The map label for this gene is mazG [H]

Identifier: 158423280

GI number: 158423280

Start: 1895165

End: 1896016

Strand: Reverse

Name: mazG [H]

Synonym: AZC_1656

Alternate gene names: 158423280

Gene position: 1896016-1895165 (Counterclockwise)

Preceding gene: 158423283

Following gene: 158423279

Centisome position: 35.31

GC content: 68.31

Gene sequence:

>852_bases
ATGCAGCCGTCCCGCGACATCGCCCGCCTGGTGGAAATCATGGCTGCGCTGCGCACGCCCGAGACCGGCTGCCCATGGGA
CCTCGAACAGAACTTCTCCACCGTCGCGCCCTACACCATCGAGGAAGCCTATGAGGTGGTGGATGCCATCGAGCGCGGCG
ACCTTGCGGACCTGAAGGATGAACTGGGTGACCTCCTCCTCCAGGTGGTCTTCCATGCCCGCCTCGCGCAGGAGCAGGGC
CTGTTCGAAATGGGCGACGTTGTGGAGGCGATCACCACCAAGCTGATCCGCCGTCATCCGCATGTCTTCGGCACGGCCCG
CGACCTCAGCCCGCAGGAGGTCAAGGCCCTGTGGGGCAAGATCAAGGAAGCCGAGAAGGCCGAGCGGGCCGCCAGCCGCG
CCGCACTCGGCCTGCCGCCGGACACCAAGGGCGGCGCCCTCGATGGCGTGCCCGCCGTCCTGCCGGCCATGACCCGCGCC
CTGAAACTGCAAGAGAAGGCCGGCCGCGTCGGCTTCGACTGGAACGATGCCCGTGCGGTGCTGGCCAAGATCCGCGAGGA
GACGGAAGAGGTGTCGGAAGCGCTGGACGCCGGCGGCACGGAGGCCATCAAGGACGAGGTGGGTGACCTCCTGTTCGCGG
TGGTGAACCTCGCCCGCCATGCGGGGGTCGATCCAGAAGCGGCGTTGCGCGGCACCAACGAGAAATTCACCCGGCGCTTC
GGCTTCCTCGAAGGCGCGCTGGCTACGCGGGGCGTCAAGCCGCAGGAGGCGACGCTGGAAGAGATGGAATCGCTCTGGCA
GCAGGCCAAGCAGGCCGAACGGGCCCCCGCGACCACGACTGCCGCCTCCTGA

Upstream 100 bases:

>100_bases
GACAGGGACGCGGACATGGGGCTCTCCTCCCGCCCATCATATCCGGCGCGCCGCCTCGGGGTGAGTCCCGCCGCCCACCT
TCCCCAGAGGAGCCCCGCTC

Downstream 100 bases:

>100_bases
CATGGTGACCCTGCTGAATGTCGAGGACGCACGTCGCCTCGCCCGCCGCCGCCTGCCCCGCGGCCTGTTCGAATATCTCG
ATCGCGGCACGGAGGATGAA

Product: MazG protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MQPSRDIARLVEIMAALRTPETGCPWDLEQNFSTVAPYTIEEAYEVVDAIERGDLADLKDELGDLLLQVVFHARLAQEQG
LFEMGDVVEAITTKLIRRHPHVFGTARDLSPQEVKALWGKIKEAEKAERAASRAALGLPPDTKGGALDGVPAVLPAMTRA
LKLQEKAGRVGFDWNDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALRGTNEKFTRRF
GFLEGALATRGVKPQEATLEEMESLWQQAKQAERAPATTTAAS

Sequences:

>Translated_283_residues
MQPSRDIARLVEIMAALRTPETGCPWDLEQNFSTVAPYTIEEAYEVVDAIERGDLADLKDELGDLLLQVVFHARLAQEQG
LFEMGDVVEAITTKLIRRHPHVFGTARDLSPQEVKALWGKIKEAEKAERAASRAALGLPPDTKGGALDGVPAVLPAMTRA
LKLQEKAGRVGFDWNDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALRGTNEKFTRRF
GFLEGALATRGVKPQEATLEEMESLWQQAKQAERAPATTTAAS
>Mature_283_residues
MQPSRDIARLVEIMAALRTPETGCPWDLEQNFSTVAPYTIEEAYEVVDAIERGDLADLKDELGDLLLQVVFHARLAQEQG
LFEMGDVVEAITTKLIRRHPHVFGTARDLSPQEVKALWGKIKEAEKAERAASRAALGLPPDTKGGALDGVPAVLPAMTRA
LKLQEKAGRVGFDWNDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALRGTNEKFTRRF
GFLEGALATRGVKPQEATLEEMESLWQQAKQAERAPATTTAAS

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=269, Percent_Identity=49.814126394052, Blast_Score=252, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30807; Mature: 30807

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSRDIARLVEIMAALRTPETGCPWDLEQNFSTVAPYTIEEAYEVVDAIERGDLADLKD
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
ELGDLLLQVVFHARLAQEQGLFEMGDVVEAITTKLIRRHPHVFGTARDLSPQEVKALWGK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHH
IKEAEKAERAASRAALGLPPDTKGGALDGVPAVLPAMTRALKLQEKAGRVGFDWNDARAV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALRGTNEKFTRRF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHH
GFLEGALATRGVKPQEATLEEMESLWQQAKQAERAPATTTAAS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQPSRDIARLVEIMAALRTPETGCPWDLEQNFSTVAPYTIEEAYEVVDAIERGDLADLKD
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
ELGDLLLQVVFHARLAQEQGLFEMGDVVEAITTKLIRRHPHVFGTARDLSPQEVKALWGK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHH
IKEAEKAERAASRAALGLPPDTKGGALDGVPAVLPAMTRALKLQEKAGRVGFDWNDARAV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALRGTNEKFTRRF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHH
GFLEGALATRGVKPQEATLEEMESLWQQAKQAERAPATTTAAS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]