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The map label for this gene is gabT [H]

Identifier: 158423269

GI number: 158423269

Start: 1884310

End: 1885728

Strand: Direct

Name: gabT [H]

Synonym: AZC_1645

Alternate gene names: 158423269

Gene position: 1884310-1885728 (Clockwise)

Preceding gene: 158423268

Following gene: 158423270

Centisome position: 35.09

GC content: 63.92

Gene sequence:

>1419_bases
ATGCTTGATCGCAGCCTGCTGACCGGCACCGCCACCACCGCCGAGGCGGAGCGCGAGCGCCTTCTCACCCTTGAGAATGC
CTATTGCTCCCATGGCGATACGGTTCACTACACGGAATTTCCGAAGATCTTCGAGCGCTGCGAAGGCTCGTTCATGTATG
ACGACGAGGACCGGCCGTTCCTCGATCTCCAGATGTGGTACTCGGCGGTCAATTTCGGCTACGGCAATCAGCGGCTCAAC
GACGCCATGCGCCGCCAGCTGGAGCGCCTGCCGCAGGTGGCCAGCCAGTATCTCCACCGCGAGAAGATCGAGCTGGCCGC
CGAGATCGCCATCGGCGCGCAGGAGCGCTTCGGCCGCAAGGGGCGCGTGCATTTCAACGTCGGTGGTGCGCAGGCCATTG
AAGACTCGCTCAAGATCGTGCGCAACGCCTGCGGCGGCAAGAGCCTGATGTTCGCCTTCGAAGGCGGCTATCACGGACGC
ACGCTGGGCGCCTCCGCCATCACCTCGTCCTACCGCTATCGCCGCCGCTACGGCCATTTCGGCGAGCGGGCGCAGTTTGT
CGAATTTCCCTATCATTTCCGCGGCCCCCGCGGCATGTCGAAGGAGGAATACGGCCTCCACTGCGTGCGCAAGTTCGAGC
GCCTGTTCGAGAGCGAATACAACGGCGTCTGGGACCCTAAGGTGGGCCAGAGCGAATATGCCGCCTTCTATGTGGAGCCC
ATCCAGGGCACCGGCGGCTATGTGATCCCGCCCGCCAATTTCTTCCCCGAGCTGAAGCGCGTGCTGGACAAGCATGGCAT
CCTGCTGGTGGTGGACGAGATCCAGATGGGCTTCTTCCGCACGGGCAAGCTCTGGTCCATCGAGCATTTTGGCGTTCAGC
CGGACGTGCTGGTGTTCGGCAAGGCGCTGACCAACGGCCTCAACCCGCTCTCCGGCGTGTGGGCGCGCGAGGAACTGATC
AATCCGCAGATCTTCCCCGCCGGCTCCACCCACTCCACCTTCAACGCCAATCCGCTCGGCACGGCCGTCGCGCTCGAAGC
GATGCGGATGATGCAGGAGGAGGATTTCGGCGCCAGCGTGATGGAGAAGGGTGCCCACTTCCTCGAAGGCATCAAGGAGC
TGAAGAAGAAGCACGCCATCGTCGGCGATGTGGACGGCCTCGGCCTCGCGCTCCGCATCGAGATCTGCGAGCCGCACGAC
AGCTACACGCCGTCCAAGAAGCTGGTGGACCTGATGGCCGACGAGGCCATGAAGGGCGACCTTGTCTATGGCGGCGAGCG
CTACGGTCTCGTGCTCGACATCGGCGGCTACCACAAGAACGTCATCACGCTTGCGCCCGCCCTCACCATCTCCCATGCGG
AGATCGACATGGCGCTGGCGCTGCTCGACCAGCTCTTCACCCGCGTCACGCCCCGGTGA

Upstream 100 bases:

>100_bases
CAGCGCGTCAGCGGCTTTGCCGATGCGTTGGACTATCTCCTCCAGAACGCCTCCACCCCCCGCACGGCCGCCTTCGGCGG
TCTTGAGCTTGAGGACATCC

Downstream 100 bases:

>100_bases
CGGCCATGCGCGCGCGCATCCTCGATCTCGACGGCGCCATCATGCTCCAGCCGGAAATGATGGACGCGTGCGCGCGCAGC
GGCGGCATCCGGACCGCCGC

Product: aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MLDRSLLTGTATTAEAERERLLTLENAYCSHGDTVHYTEFPKIFERCEGSFMYDDEDRPFLDLQMWYSAVNFGYGNQRLN
DAMRRQLERLPQVASQYLHREKIELAAEIAIGAQERFGRKGRVHFNVGGAQAIEDSLKIVRNACGGKSLMFAFEGGYHGR
TLGASAITSSYRYRRRYGHFGERAQFVEFPYHFRGPRGMSKEEYGLHCVRKFERLFESEYNGVWDPKVGQSEYAAFYVEP
IQGTGGYVIPPANFFPELKRVLDKHGILLVVDEIQMGFFRTGKLWSIEHFGVQPDVLVFGKALTNGLNPLSGVWAREELI
NPQIFPAGSTHSTFNANPLGTAVALEAMRMMQEEDFGASVMEKGAHFLEGIKELKKKHAIVGDVDGLGLALRIEICEPHD
SYTPSKKLVDLMADEAMKGDLVYGGERYGLVLDIGGYHKNVITLAPALTISHAEIDMALALLDQLFTRVTPR

Sequences:

>Translated_472_residues
MLDRSLLTGTATTAEAERERLLTLENAYCSHGDTVHYTEFPKIFERCEGSFMYDDEDRPFLDLQMWYSAVNFGYGNQRLN
DAMRRQLERLPQVASQYLHREKIELAAEIAIGAQERFGRKGRVHFNVGGAQAIEDSLKIVRNACGGKSLMFAFEGGYHGR
TLGASAITSSYRYRRRYGHFGERAQFVEFPYHFRGPRGMSKEEYGLHCVRKFERLFESEYNGVWDPKVGQSEYAAFYVEP
IQGTGGYVIPPANFFPELKRVLDKHGILLVVDEIQMGFFRTGKLWSIEHFGVQPDVLVFGKALTNGLNPLSGVWAREELI
NPQIFPAGSTHSTFNANPLGTAVALEAMRMMQEEDFGASVMEKGAHFLEGIKELKKKHAIVGDVDGLGLALRIEICEPHD
SYTPSKKLVDLMADEAMKGDLVYGGERYGLVLDIGGYHKNVITLAPALTISHAEIDMALALLDQLFTRVTPR
>Mature_472_residues
MLDRSLLTGTATTAEAERERLLTLENAYCSHGDTVHYTEFPKIFERCEGSFMYDDEDRPFLDLQMWYSAVNFGYGNQRLN
DAMRRQLERLPQVASQYLHREKIELAAEIAIGAQERFGRKGRVHFNVGGAQAIEDSLKIVRNACGGKSLMFAFEGGYHGR
TLGASAITSSYRYRRRYGHFGERAQFVEFPYHFRGPRGMSKEEYGLHCVRKFERLFESEYNGVWDPKVGQSEYAAFYVEP
IQGTGGYVIPPANFFPELKRVLDKHGILLVVDEIQMGFFRTGKLWSIEHFGVQPDVLVFGKALTNGLNPLSGVWAREELI
NPQIFPAGSTHSTFNANPLGTAVALEAMRMMQEEDFGASVMEKGAHFLEGIKELKKKHAIVGDVDGLGLALRIEICEPHD
SYTPSKKLVDLMADEAMKGDLVYGGERYGLVLDIGGYHKNVITLAPALTISHAEIDMALALLDQLFTRVTPR

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=436, Percent_Identity=23.6238532110092, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=23.8532110091743, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=24.0601503759398, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI13994255, Length=463, Percent_Identity=24.622030237581, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI24119277, Length=449, Percent_Identity=24.0534521158129, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4557809, Length=472, Percent_Identity=25.8474576271186, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=28.0373831775701, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI188536080, Length=450, Percent_Identity=22.2222222222222, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI38679950, Length=450, Percent_Identity=22.2222222222222, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI38679946, Length=450, Percent_Identity=22.2222222222222, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789016, Length=428, Percent_Identity=28.9719626168224, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1787560, Length=425, Percent_Identity=28, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI145693181, Length=356, Percent_Identity=26.9662921348315, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1788044, Length=430, Percent_Identity=26.9767441860465, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789759, Length=417, Percent_Identity=26.1390887290168, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1786991, Length=369, Percent_Identity=26.5582655826558, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786349, Length=346, Percent_Identity=21.6763005780347, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992977, Length=474, Percent_Identity=23.8396624472574, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=443, Percent_Identity=25.7336343115124, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=24.6666666666667, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=240, Percent_Identity=30.8333333333333, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=475, Percent_Identity=23.3684210526316, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=454, Percent_Identity=30.1762114537445, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324432, Length=418, Percent_Identity=24.6411483253589, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6324386, Length=351, Percent_Identity=23.3618233618234, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161085790, Length=462, Percent_Identity=24.8917748917749, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574759, Length=467, Percent_Identity=24.6252676659529, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357415, Length=461, Percent_Identity=25.1626898047722, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356575, Length=478, Percent_Identity=22.8033472803347, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281366494, Length=396, Percent_Identity=25.2525252525253, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667139, Length=396, Percent_Identity=25.2525252525253, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667143, Length=396, Percent_Identity=25.2525252525253, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 53073; Mature: 53073

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS01159 WW_DOMAIN_1 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRSLLTGTATTAEAERERLLTLENAYCSHGDTVHYTEFPKIFERCEGSFMYDDEDRPF
CCCCCCCCCCCCHHHHHHHHHEEEHHHHCCCCCEEEECHHHHHHHHCCCCEEECCCCCCE
LDLQMWYSAVNFGYGNQRLNDAMRRQLERLPQVASQYLHREKIELAAEIAIGAQERFGRK
EHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
GRVHFNVGGAQAIEDSLKIVRNACGGKSLMFAFEGGYHGRTLGASAITSSYRYRRRYGHF
CEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
GERAQFVEFPYHFRGPRGMSKEEYGLHCVRKFERLFESEYNGVWDPKVGQSEYAAFYVEP
CCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEE
IQGTGGYVIPPANFFPELKRVLDKHGILLVVDEIQMGFFRTGKLWSIEHFGVQPDVLVFG
CCCCCCEEECCHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCEEEECCCCCCCCHHEEE
KALTNGLNPLSGVWAREELINPQIFPAGSTHSTFNANPLGTAVALEAMRMMQEEDFGASV
HHHHCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
MEKGAHFLEGIKELKKKHAIVGDVDGLGLALRIEICEPHDSYTPSKKLVDLMADEAMKGD
HHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCC
LVYGGERYGLVLDIGGYHKNVITLAPALTISHAEIDMALALLDQLFTRVTPR
EEECCCEEEEEEEECCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDRSLLTGTATTAEAERERLLTLENAYCSHGDTVHYTEFPKIFERCEGSFMYDDEDRPF
CCCCCCCCCCCCHHHHHHHHHEEEHHHHCCCCCEEEECHHHHHHHHCCCCEEECCCCCCE
LDLQMWYSAVNFGYGNQRLNDAMRRQLERLPQVASQYLHREKIELAAEIAIGAQERFGRK
EHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
GRVHFNVGGAQAIEDSLKIVRNACGGKSLMFAFEGGYHGRTLGASAITSSYRYRRRYGHF
CEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
GERAQFVEFPYHFRGPRGMSKEEYGLHCVRKFERLFESEYNGVWDPKVGQSEYAAFYVEP
CCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEE
IQGTGGYVIPPANFFPELKRVLDKHGILLVVDEIQMGFFRTGKLWSIEHFGVQPDVLVFG
CCCCCCEEECCHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCEEEECCCCCCCCHHEEE
KALTNGLNPLSGVWAREELINPQIFPAGSTHSTFNANPLGTAVALEAMRMMQEEDFGASV
HHHHCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
MEKGAHFLEGIKELKKKHAIVGDVDGLGLALRIEICEPHDSYTPSKKLVDLMADEAMKGD
HHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCC
LVYGGERYGLVLDIGGYHKNVITLAPALTISHAEIDMALALLDQLFTRVTPR
EEECCCEEEEEEEECCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]