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The map label for this gene is fhuB [H]

Identifier: 158423247

GI number: 158423247

Start: 1852657

End: 1854609

Strand: Reverse

Name: fhuB [H]

Synonym: AZC_1623

Alternate gene names: 158423247

Gene position: 1854609-1852657 (Counterclockwise)

Preceding gene: 158423248

Following gene: 158423246

Centisome position: 34.54

GC content: 73.37

Gene sequence:

>1953_bases
TTGCCTCGCGCACCACTGGCGGTGGCCGGGCTCGCCCTTCTGGCGCTGACCCTGTGCGTCATGGGCCTGCTGCGGCAGCC
GGTCCTGCCCGGCGATCCGGCCACGGCGCGCGCGCTGGAACAGGTCGTGCTCTGGCACAGCCTGCTGCCACGCGCCGTGG
TGGCGCTGCTGGCGGGTGCGGCGCTGGGCCTGTCGGGCGCGCTGTTGCAACGGGTGCTGCGCAACCCCATCGCCGATCCC
TCGACGCTGGGCATCGCCTCCGGCGCGCAATTGGCCCTCACCGCCTCCGCCTTGCTCATTCCAGCCCTCGCCGAATGGCC
CCGCGAGGTCGTGGCGCTCATGGGCGGCGTTACCGCCGTCGGCCTCTTGCTGATGCTGAGCTGGAAGCGCGGGCTGGAGC
CGATCACGGTCGTGCTCTCGGGCATGACCCTCTCGCTCATCTGCGCCGCCTTGAGTTCGGCCCTCGTGCTGGCGCGCGGC
GAATATGTGCTCTCGCTTTTCGTCTGGGGCGCCGGCTCGCTGCACCAGCAGAGCTGGGGGCCTGCGCTGGGGCTGGCGTG
GCGCTTCGCCTTCGGCCTTGCGGCAGCCGTGCTCCTGCTCCGCCCGCTCTCGGTTCTGACGCTGGACGACTCCAGCGCCC
GCAGCCTTGGCATGGCCGTGAACGGCGCCCGGCTCGCCATCATCGCCCTCGCCGTGTGGCTGGCGGCGAGCGTCGTGGCG
CTGGTGGGCATCATCGGCTTCGTCGGCCTTGCCGCGCCGGCCTTCGCGAGGCTCGCGGGCGCGCGCACGCCCCGCGCCCA
ATTGCTGCTGGCGCCGCTCCTCGGCGCGCTGCTGCTGTGGCTCACGGACGGGCTCGTGCAGGTCTTGGGCGCCGACGTCC
TGCCCACGGGCGCCGCCACGGGCCTCATCGGTGGGCCGCTGCTGCTATGGCTGCTGCCGCGCCTCAAGCACGTCCAGCGC
CCGCAAGCCGCAGCACCGACAGGCCGGCGCCTCTCCCATCCCCTGCGCGGTCTCCTGTTTCTCGCCGGCGGGCTGGCGCT
TCTCATCCTCGCCGCTCTGCTGATCGGGCGCTCCTATGAGGGCTGGCGGCTGGCGACGGGCGCGCTGTTCGAGGCCCTCG
CCCCTTTCCGCGTGCCGCGCGTGGTCGCCGCCGCAGCGGCGGGCGCGCTCCTGGGGGCGGCGGGCACGCTGATGCAGCGC
CTCACGGGTAATCCTTTGGCGGGGCCGGAGGTGCTAGGCGTCAGTGCCGGGGCGGGCGTCGGGCTCTCGGTGGTTCTGCT
GCTCCTGCCCGCGCCCACGGTTGCCGTCATGATGGGCGGCAGCGCAGCGGGCGCGCTCGTGGCGCTGCTTGGCATTCTCG
CCTTCGCGCTCGCCACCGGCTTCGGGCCTGAGCGGCTGCTGCTTGGCGGCATCGCGCTCGGCGCCGCGAGCCTTGCCTTC
ATCTCCGCCGTTCTGGCCTCGGGAGATGCCCGCGCCTTCCTGCTGCTGGGCTGGATGGCCGGCACCACGGATCGCGTGGG
CAGCGTGGAGGCGGGCGCGGCGGTGGGCCTCGTGCTCCTGCTTGTCCCGCCGCTGCTGCTGGCCTCCCGCTGGCTCGACA
TATTGCCGCTCGGCAGCACCATGGCCCGCGCGCTGGGCGTGCCTTTGCTCGCAAGCCGCCTGCTCCTTGCGCTTGCCGCC
GCGCTGATGACGGCCTGCGCTGCCTTCATCGTCGGCCCGCTGAGCCTCGTCGGCCTCATCGGCCCGCATCTGGCGCGCCT
CTCGGGCTTCGCGCGCGGCGCCCACCAGTTGCTCGCCGCCGCGCTCATCGGCGCGGGCCTGATGGTGTTAGCGGACTGGC
TAGGGCGCACGCTCGCCTTCCCCTACCAGATCCCGGTGGGCCTCTTCGCCGCGCTGGTGGGCGGGCACTATCTCATCTGG
CTGCTGCGACGCAGCCCCGGCACAGGAGCCTGA

Upstream 100 bases:

>100_bases
GCCCTGCCCGCGGCCCTGCGTTTCGCACGCCTCCTCACCGATGCGCTCCCCTTTGCGAAGGCGGCCGCCCGTGGCTGATG
TCGCCCGCCTCCCCCGCCCC

Downstream 100 bases:

>100_bases
TCCATGGCCGCCCCCGCGCTTCTGCACGCCGCGACCCGTGTTCCCCTGCCCGATCCGGCCACCATGCTGGAGAAGCTCGC
CGCGCATTTCGAGACCCACG

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MPRAPLAVAGLALLALTLCVMGLLRQPVLPGDPATARALEQVVLWHSLLPRAVVALLAGAALGLSGALLQRVLRNPIADP
STLGIASGAQLALTASALLIPALAEWPREVVALMGGVTAVGLLLMLSWKRGLEPITVVLSGMTLSLICAALSSALVLARG
EYVLSLFVWGAGSLHQQSWGPALGLAWRFAFGLAAAVLLLRPLSVLTLDDSSARSLGMAVNGARLAIIALAVWLAASVVA
LVGIIGFVGLAAPAFARLAGARTPRAQLLLAPLLGALLLWLTDGLVQVLGADVLPTGAATGLIGGPLLLWLLPRLKHVQR
PQAAAPTGRRLSHPLRGLLFLAGGLALLILAALLIGRSYEGWRLATGALFEALAPFRVPRVVAAAAAGALLGAAGTLMQR
LTGNPLAGPEVLGVSAGAGVGLSVVLLLLPAPTVAVMMGGSAAGALVALLGILAFALATGFGPERLLLGGIALGAASLAF
ISAVLASGDARAFLLLGWMAGTTDRVGSVEAGAAVGLVLLLVPPLLLASRWLDILPLGSTMARALGVPLLASRLLLALAA
ALMTACAAFIVGPLSLVGLIGPHLARLSGFARGAHQLLAAALIGAGLMVLADWLGRTLAFPYQIPVGLFAALVGGHYLIW
LLRRSPGTGA

Sequences:

>Translated_650_residues
MPRAPLAVAGLALLALTLCVMGLLRQPVLPGDPATARALEQVVLWHSLLPRAVVALLAGAALGLSGALLQRVLRNPIADP
STLGIASGAQLALTASALLIPALAEWPREVVALMGGVTAVGLLLMLSWKRGLEPITVVLSGMTLSLICAALSSALVLARG
EYVLSLFVWGAGSLHQQSWGPALGLAWRFAFGLAAAVLLLRPLSVLTLDDSSARSLGMAVNGARLAIIALAVWLAASVVA
LVGIIGFVGLAAPAFARLAGARTPRAQLLLAPLLGALLLWLTDGLVQVLGADVLPTGAATGLIGGPLLLWLLPRLKHVQR
PQAAAPTGRRLSHPLRGLLFLAGGLALLILAALLIGRSYEGWRLATGALFEALAPFRVPRVVAAAAAGALLGAAGTLMQR
LTGNPLAGPEVLGVSAGAGVGLSVVLLLLPAPTVAVMMGGSAAGALVALLGILAFALATGFGPERLLLGGIALGAASLAF
ISAVLASGDARAFLLLGWMAGTTDRVGSVEAGAAVGLVLLLVPPLLLASRWLDILPLGSTMARALGVPLLASRLLLALAA
ALMTACAAFIVGPLSLVGLIGPHLARLSGFARGAHQLLAAALIGAGLMVLADWLGRTLAFPYQIPVGLFAALVGGHYLIW
LLRRSPGTGA
>Mature_649_residues
PRAPLAVAGLALLALTLCVMGLLRQPVLPGDPATARALEQVVLWHSLLPRAVVALLAGAALGLSGALLQRVLRNPIADPS
TLGIASGAQLALTASALLIPALAEWPREVVALMGGVTAVGLLLMLSWKRGLEPITVVLSGMTLSLICAALSSALVLARGE
YVLSLFVWGAGSLHQQSWGPALGLAWRFAFGLAAAVLLLRPLSVLTLDDSSARSLGMAVNGARLAIIALAVWLAASVVAL
VGIIGFVGLAAPAFARLAGARTPRAQLLLAPLLGALLLWLTDGLVQVLGADVLPTGAATGLIGGPLLLWLLPRLKHVQRP
QAAAPTGRRLSHPLRGLLFLAGGLALLILAALLIGRSYEGWRLATGALFEALAPFRVPRVVAAAAAGALLGAAGTLMQRL
TGNPLAGPEVLGVSAGAGVGLSVVLLLLPAPTVAVMMGGSAAGALVALLGILAFALATGFGPERLLLGGIALGAASLAFI
SAVLASGDARAFLLLGWMAGTTDRVGSVEAGAAVGLVLLLVPPLLLASRWLDILPLGSTMARALGVPLLASRLLLALAAA
LMTACAAFIVGPLSLVGLIGPHLARLSGFARGAHQLLAAALIGAGLMVLADWLGRTLAFPYQIPVGLFAALVGGHYLIWL
LRRSPGTGA

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=617, Percent_Identity=43.9222042139384, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1790741, Length=295, Percent_Identity=33.5593220338983, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790740, Length=312, Percent_Identity=33.974358974359, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788004, Length=298, Percent_Identity=33.5570469798658, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786804, Length=273, Percent_Identity=32.967032967033, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786805, Length=284, Percent_Identity=36.9718309859155, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 65711; Mature: 65580

Theoretical pI: Translated: 12.02; Mature: 12.02

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRAPLAVAGLALLALTLCVMGLLRQPVLPGDPATARALEQVVLWHSLLPRAVVALLAGA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGLSGALLQRVLRNPIADPSTLGIASGAQLALTASALLIPALAEWPREVVALMGGVTAV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLLLMLSWKRGLEPITVVLSGMTLSLICAALSSALVLARGEYVLSLFVWGAGSLHQQSWG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHCCC
PALGLAWRFAFGLAAAVLLLRPLSVLTLDDSSARSLGMAVNGARLAIIALAVWLAASVVA
CHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LVGIIGFVGLAAPAFARLAGARTPRAQLLLAPLLGALLLWLTDGLVQVLGADVLPTGAAT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
GLIGGPLLLWLLPRLKHVQRPQAAAPTGRRLSHPLRGLLFLAGGLALLILAALLIGRSYE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GWRLATGALFEALAPFRVPRVVAAAAAGALLGAAGTLMQRLTGNPLAGPEVLGVSAGAGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCH
GLSVVLLLLPAPTVAVMMGGSAAGALVALLGILAFALATGFGPERLLLGGIALGAASLAF
HHHHHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ISAVLASGDARAFLLLGWMAGTTDRVGSVEAGAAVGLVLLLVPPLLLASRWLDILPLGST
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
MARALGVPLLASRLLLALAAALMTACAAFIVGPLSLVGLIGPHLARLSGFARGAHQLLAA
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIGAGLMVLADWLGRTLAFPYQIPVGLFAALVGGHYLIWLLRRSPGTGA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHEEEEEECCCCCCC
>Mature Secondary Structure 
PRAPLAVAGLALLALTLCVMGLLRQPVLPGDPATARALEQVVLWHSLLPRAVVALLAGA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGLSGALLQRVLRNPIADPSTLGIASGAQLALTASALLIPALAEWPREVVALMGGVTAV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLLLMLSWKRGLEPITVVLSGMTLSLICAALSSALVLARGEYVLSLFVWGAGSLHQQSWG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHCCC
PALGLAWRFAFGLAAAVLLLRPLSVLTLDDSSARSLGMAVNGARLAIIALAVWLAASVVA
CHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LVGIIGFVGLAAPAFARLAGARTPRAQLLLAPLLGALLLWLTDGLVQVLGADVLPTGAAT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
GLIGGPLLLWLLPRLKHVQRPQAAAPTGRRLSHPLRGLLFLAGGLALLILAALLIGRSYE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GWRLATGALFEALAPFRVPRVVAAAAAGALLGAAGTLMQRLTGNPLAGPEVLGVSAGAGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCH
GLSVVLLLLPAPTVAVMMGGSAAGALVALLGILAFALATGFGPERLLLGGIALGAASLAF
HHHHHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ISAVLASGDARAFLLLGWMAGTTDRVGSVEAGAAVGLVLLLVPPLLLASRWLDILPLGST
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
MARALGVPLLASRLLLALAAALMTACAAFIVGPLSLVGLIGPHLARLSGFARGAHQLLAA
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIGAGLMVLADWLGRTLAFPYQIPVGLFAALVGGHYLIWLLRRSPGTGA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]