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The map label for this gene is rnhA [H]

Identifier: 158423153

GI number: 158423153

Start: 1742778

End: 1743338

Strand: Direct

Name: rnhA [H]

Synonym: AZC_1529

Alternate gene names: 158423153

Gene position: 1742778-1743338 (Clockwise)

Preceding gene: 158423152

Following gene: 158423154

Centisome position: 32.46

GC content: 64.35

Gene sequence:

>561_bases
ATGGAAGGACATCTTCAACCAACGCCATCCCCCTCCTCGAAGTTGCTCGGAGAGAAGCCGCAAGCTGACGCCTTCGTGGT
GTACGCGGACGGCTCGTCGCTCCAAAACCCTGGCCCTGCGGGTTGGGCGGTTCTCGTCATCCCGCCTCATGGAGGCCCGC
AGACCTTCGCGGGATCGGAGCCATGGGCCACCAACAACCAGATGGAACTGCGGGCTGCCATCGAGGCCCTCAATGTGCTC
CCGATGGATGCGGCGGGCGTGATCCGCTGCGACAGTGAGTATGTCGTCAAAGGCGTGTCCGATTGGCGTTCTGGATGGGA
GCGCAGAGGCTGGCGCAACAGCAAAGGCCAGCCGGTTGCCAATGCAGACCTCTGGCGGACGTTGTACCGGCTATCCGATG
ACAGGCCCGGCGTTCGCTTCGCGTGGGTTCGGGGACATGCGGGGGACCCCGGAAATGAGCTTGCCGACATGCTCGCGAGA
GCGGAGGCGTCCAAAGCGGCTGCCCGTGTTGCCCCTGTCTCGCTGCCCCACACGCTGCTGTGCGCAGGTGAAGCATCGTG
A

Upstream 100 bases:

>100_bases
TGCGTGTGAATCTGTTGCACGCGCAAATCCCACCCACAATCACCAACACCCAGCGGGTCGCGACCAACGCGCGAACCCGC
CCATTGTCATGGACCATCAC

Downstream 100 bases:

>100_bases
CCGGCGGCAGCCACGTGAGGGTCGCGCTGGATGACCTCATCCTCGACCGAGAGTACCAGACGCGCCTTGCGCTCGATCAC
GGTGCTATCCGGCGATATGC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MEGHLQPTPSPSSKLLGEKPQADAFVVYADGSSLQNPGPAGWAVLVIPPHGGPQTFAGSEPWATNNQMELRAAIEALNVL
PMDAAGVIRCDSEYVVKGVSDWRSGWERRGWRNSKGQPVANADLWRTLYRLSDDRPGVRFAWVRGHAGDPGNELADMLAR
AEASKAAARVAPVSLPHTLLCAGEAS

Sequences:

>Translated_186_residues
MEGHLQPTPSPSSKLLGEKPQADAFVVYADGSSLQNPGPAGWAVLVIPPHGGPQTFAGSEPWATNNQMELRAAIEALNVL
PMDAAGVIRCDSEYVVKGVSDWRSGWERRGWRNSKGQPVANADLWRTLYRLSDDRPGVRFAWVRGHAGDPGNELADMLAR
AEASKAAARVAPVSLPHTLLCAGEAS
>Mature_186_residues
MEGHLQPTPSPSSKLLGEKPQADAFVVYADGSSLQNPGPAGWAVLVIPPHGGPQTFAGSEPWATNNQMELRAAIEALNVL
PMDAAGVIRCDSEYVVKGVSDWRSGWERRGWRNSKGQPVANADLWRTLYRLSDDRPGVRFAWVRGHAGDPGNELADMLAR
AEASKAAARVAPVSLPHTLLCAGEAS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=173, Percent_Identity=31.2138728323699, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=40.8759124087591, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI115532542, Length=162, Percent_Identity=35.1851851851852, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137476, Length=143, Percent_Identity=33.5664335664336, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45552509, Length=143, Percent_Identity=33.5664335664336, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 19905; Mature: 19905

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGHLQPTPSPSSKLLGEKPQADAFVVYADGSSLQNPGPAGWAVLVIPPHGGPQTFAGSE
CCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCC
PWATNNQMELRAAIEALNVLPMDAAGVIRCDSEYVVKGVSDWRSGWERRGWRNSKGQPVA
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCC
NADLWRTLYRLSDDRPGVRFAWVRGHAGDPGNELADMLARAEASKAAARVAPVSLPHTLL
CHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
CAGEAS
ECCCCC
>Mature Secondary Structure
MEGHLQPTPSPSSKLLGEKPQADAFVVYADGSSLQNPGPAGWAVLVIPPHGGPQTFAGSE
CCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCC
PWATNNQMELRAAIEALNVLPMDAAGVIRCDSEYVVKGVSDWRSGWERRGWRNSKGQPVA
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCC
NADLWRTLYRLSDDRPGVRFAWVRGHAGDPGNELADMLARAEASKAAARVAPVSLPHTLL
CHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
CAGEAS
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA