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The map label for this gene is merR [H]

Identifier: 158423081

GI number: 158423081

Start: 1658836

End: 1659366

Strand: Direct

Name: merR [H]

Synonym: AZC_1457

Alternate gene names: 158423081

Gene position: 1658836-1659366 (Clockwise)

Preceding gene: 158423079

Following gene: 158423083

Centisome position: 30.89

GC content: 65.35

Gene sequence:

>531_bases
GTGTTACGTCCTCTAGTCACTAGAGGAGCAAGACCCCATCTGTGGAAAAATGCAGCGGGCGGGAGCGGAGGCGAGATGGC
GGGACGAGCGCGAGGCGGGCAGAGCGAACAGGATGAGGTCGCCATTGGCGAGGCAGCCCGGCGCAGCGGCGTGAAGGTGC
CGACCATCCGTTATTATGAGCAGATCGGCCTTCTGGCCGCGCCGGTGCGCACCGAGGGCAATCGCCGGACCTATCGAAGC
GAGGACCTGAGCCGCCTTGCCTTCATTCGCCATGCCCGCGAACTCGGGTTCGAGGTGGAGGAGATCCGCGCGCTTCTGAC
GCTCCAGCAGGATCCCTCGCAATCCTGCGAGGCCGCCGACAGGATCGCGCGGGGCCATCTGGCGGATGTGGAGCGGCGGA
TTGCCAGCCTCATGGCCCTAAAGGCGGAGCTGGAGCGCATGATCGAGGGGTGCAGCCATGGTCGGCTCGCCGACTGCAAG
GTGATCGAGGTGCTGGCCGATCACGGCAAATGCACCCATCACCAGCACTGA

Upstream 100 bases:

>100_bases
CGATCTTGGCGGCACAGGAGGCGCAATCCATCTCCTCGACGCGAAAGCGGCTGCGGGATAGGGCGCTCGACATGACTCGT
CCTCCGATCTTTCCAACGCC

Downstream 100 bases:

>100_bases
ACCCGAAGGATCAGGCGGCCGGAGCCGCCAGGAGATCCTGCCATTCCGGGTGTCGACGGAACTGCGCCGCCACGTAGGAG
CAGAGGGGCACGATGGTGAA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MLRPLVTRGARPHLWKNAAGGSGGEMAGRARGGQSEQDEVAIGEAARRSGVKVPTIRYYEQIGLLAAPVRTEGNRRTYRS
EDLSRLAFIRHARELGFEVEEIRALLTLQQDPSQSCEAADRIARGHLADVERRIASLMALKAELERMIEGCSHGRLADCK
VIEVLADHGKCTHHQH

Sequences:

>Translated_176_residues
MLRPLVTRGARPHLWKNAAGGSGGEMAGRARGGQSEQDEVAIGEAARRSGVKVPTIRYYEQIGLLAAPVRTEGNRRTYRS
EDLSRLAFIRHARELGFEVEEIRALLTLQQDPSQSCEAADRIARGHLADVERRIASLMALKAELERMIEGCSHGRLADCK
VIEVLADHGKCTHHQH
>Mature_176_residues
MLRPLVTRGARPHLWKNAAGGSGGEMAGRARGGQSEQDEVAIGEAARRSGVKVPTIRYYEQIGLLAAPVRTEGNRRTYRS
EDLSRLAFIRHARELGFEVEEIRALLTLQQDPSQSCEAADRIARGHLADVERRIASLMALKAELERMIEGCSHGRLADCK
VIEVLADHGKCTHHQH

Specific function: Transcriptional regulator involved in acid tolerance. Binds copper [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=42.1875, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1786695, Length=135, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 19469; Mature: 19469

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRPLVTRGARPHLWKNAAGGSGGEMAGRARGGQSEQDEVAIGEAARRSGVKVPTIRYYE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
QIGLLAAPVRTEGNRRTYRSEDLSRLAFIRHARELGFEVEEIRALLTLQQDPSQSCEAAD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHH
RIARGHLADVERRIASLMALKAELERMIEGCSHGRLADCKVIEVLADHGKCTHHQH
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLRPLVTRGARPHLWKNAAGGSGGEMAGRARGGQSEQDEVAIGEAARRSGVKVPTIRYYE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
QIGLLAAPVRTEGNRRTYRSEDLSRLAFIRHARELGFEVEEIRALLTLQQDPSQSCEAAD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHH
RIARGHLADVERRIASLMALKAELERMIEGCSHGRLADCKVIEVLADHGKCTHHQH
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]