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The map label for this gene is glcD [H]

Identifier: 158423039

GI number: 158423039

Start: 1609907

End: 1611421

Strand: Direct

Name: glcD [H]

Synonym: AZC_1415

Alternate gene names: 158423039

Gene position: 1609907-1611421 (Clockwise)

Preceding gene: 158423038

Following gene: 158423040

Centisome position: 29.98

GC content: 67.85

Gene sequence:

>1515_bases
TTGATGGCGCAAGCGGTTTCGAACATCCGCAGACCGAGAGCCCGGAAAACGGGCCCCTTGCGGAGGGAGGAAGACATGTC
TGCCCAAGCCCGCATCGATGGCGTGCCCATCGGTGCCCCCTCGCTCGACATCATCATGGCGCGGCTCGCGGCCATCGTCG
GCGATCGTGCCAGTGCCGCCCCCGGCGTGCGGGCCGATCACGGCCGCAGCGAGGCCTATCACGCCGCCCGCCCGCCAGAC
GTGGTGGTCTTTCCGGAGACCACGGCGGAAGTGCAGGCCATCGTGAACCTGTGCCGCGAGCTCGATCTGCCACTCGTGCC
TTTCGGCGCCGGCACCTCGCTCGAAGGCAATGCCGCCGCCCTCCATGGCGGCGTGTGCCTCGACATGGGGCGCATGAACC
AGATGCTGGAGATCCACGCGGAAGACATGGATGTGCGGGTGCAGCCCGGCATCACCCGCAAGCAGCTCAACGCCCAACTG
CGCGACACTGGGCTGTTCTTCCCCATCGATCCGGGCGCGGACGCCTCCATCGGCGGCATGACCTCCACCCGCGCCTCCGG
CACCATGGCGGTGCGCTACGGGACCATGAAGGACAATGTGCTGGCCCTGGAAGTGGTGCTGGCCGACGGACGCGCCATCC
GCACCGCGCGGCGGGCCAAGAAGTCCGCCGCCGGCTATGATCTCACCCGCCTCTTCGTGGGGGCCGAGGGGACGCTCGGC
GTCATCACCGAGATCACGCTGAAGCTGCATCCGCAGCCGGAGGCGATCTCCTCCGCCGTCTGTGCCTTTCCCGACCTGAA
GGCGGCCGTGGACACCGCCATCGGCGTCATCCAGTCGGGCGTGCCGGTCGCCCGTATCGAATTGCTCGACGCCGTAATGA
TGCGGGGCATGAACCTGCATTCGCGCCTCGGCCTGCCCGAGGTGCCGCACCTGTTCTTCGAGTTTCACGGCTCCAGCGCT
TACGTGACCGAGCAGGCGGAGACCGCGCAGGCCATCGCGGCGGACAACGGCGGCCAGGGCTTTCAGTGGGCGGTGACGCC
CGAGGAGCGCACCCGGCTCTGGCACGCCCGCGACAACACGCTTTATGCGGGCCTCGCCCTGCGTCCCGGCGCCAAGGCCA
TGATTACCGACGTGTGCGTGCCCATCTCGCGGCTCGCGGACTGTCTCGTCGACACCGCTGCCGATCTTGTCGAATGCGGC
CTCGTCGCGCCGGTGGTGGGCCATGTGGGTGATGGAAATTTTCACCTGCTGGTGCTCATCGACCCGCAGGACCCGGAAGA
GCTTGCCCGCGCCAAGGCCTTCAACGAGCGGCTGGTACGCCGGGCCATCGCGCTGGACGGCACCTGCACCGGCGAGCACG
GCATCGGCATGGGCAAGATGGACTTCCTCGCCCTCGAATTGGGCGAGGCGGTGGATGCCATGCGGCTGCTCAAGGGTGCG
CTCGATCCGCACGGCATTCTGAACCCCGGCAAGATCTTCAAGCCCCATCCTCCCACCCAAGGATCTGCGCCATGA

Upstream 100 bases:

>100_bases
CTCGCGTGCGGCCTAGGCTCGCCATTCGGCCGGCGCCTTGAGCCGGCCGGACGGTACGTCCCAGTAGCTTCAGTCTGTCC
GGAGACGCCATCTCCGGCCC

Downstream 100 bases:

>100_bases
GAGCGGTGATGGAAAAGATGCCCCGCCTCGAAGCCGCCCCGTCCGCCGAGACCCCCGGCACGCCACTTCTGGAACTGCGC
GGCATCTCGAAGGTGTTTCC

Product: FAD/FMN-containing dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MMAQAVSNIRRPRARKTGPLRREEDMSAQARIDGVPIGAPSLDIIMARLAAIVGDRASAAPGVRADHGRSEAYHAARPPD
VVVFPETTAEVQAIVNLCRELDLPLVPFGAGTSLEGNAAALHGGVCLDMGRMNQMLEIHAEDMDVRVQPGITRKQLNAQL
RDTGLFFPIDPGADASIGGMTSTRASGTMAVRYGTMKDNVLALEVVLADGRAIRTARRAKKSAAGYDLTRLFVGAEGTLG
VITEITLKLHPQPEAISSAVCAFPDLKAAVDTAIGVIQSGVPVARIELLDAVMMRGMNLHSRLGLPEVPHLFFEFHGSSA
YVTEQAETAQAIAADNGGQGFQWAVTPEERTRLWHARDNTLYAGLALRPGAKAMITDVCVPISRLADCLVDTAADLVECG
LVAPVVGHVGDGNFHLLVLIDPQDPEELARAKAFNERLVRRAIALDGTCTGEHGIGMGKMDFLALELGEAVDAMRLLKGA
LDPHGILNPGKIFKPHPPTQGSAP

Sequences:

>Translated_504_residues
MMAQAVSNIRRPRARKTGPLRREEDMSAQARIDGVPIGAPSLDIIMARLAAIVGDRASAAPGVRADHGRSEAYHAARPPD
VVVFPETTAEVQAIVNLCRELDLPLVPFGAGTSLEGNAAALHGGVCLDMGRMNQMLEIHAEDMDVRVQPGITRKQLNAQL
RDTGLFFPIDPGADASIGGMTSTRASGTMAVRYGTMKDNVLALEVVLADGRAIRTARRAKKSAAGYDLTRLFVGAEGTLG
VITEITLKLHPQPEAISSAVCAFPDLKAAVDTAIGVIQSGVPVARIELLDAVMMRGMNLHSRLGLPEVPHLFFEFHGSSA
YVTEQAETAQAIAADNGGQGFQWAVTPEERTRLWHARDNTLYAGLALRPGAKAMITDVCVPISRLADCLVDTAADLVECG
LVAPVVGHVGDGNFHLLVLIDPQDPEELARAKAFNERLVRRAIALDGTCTGEHGIGMGKMDFLALELGEAVDAMRLLKGA
LDPHGILNPGKIFKPHPPTQGSAP
>Mature_504_residues
MMAQAVSNIRRPRARKTGPLRREEDMSAQARIDGVPIGAPSLDIIMARLAAIVGDRASAAPGVRADHGRSEAYHAARPPD
VVVFPETTAEVQAIVNLCRELDLPLVPFGAGTSLEGNAAALHGGVCLDMGRMNQMLEIHAEDMDVRVQPGITRKQLNAQL
RDTGLFFPIDPGADASIGGMTSTRASGTMAVRYGTMKDNVLALEVVLADGRAIRTARRAKKSAAGYDLTRLFVGAEGTLG
VITEITLKLHPQPEAISSAVCAFPDLKAAVDTAIGVIQSGVPVARIELLDAVMMRGMNLHSRLGLPEVPHLFFEFHGSSA
YVTEQAETAQAIAADNGGQGFQWAVTPEERTRLWHARDNTLYAGLALRPGAKAMITDVCVPISRLADCLVDTAADLVECG
LVAPVVGHVGDGNFHLLVLIDPQDPEELARAKAFNERLVRRAIALDGTCTGEHGIGMGKMDFLALELGEAVDAMRLLKGA
LDPHGILNPGKIFKPHPPTQGSAP

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=455, Percent_Identity=55.1648351648352, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI37595754, Length=478, Percent_Identity=52.510460251046, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI119964728, Length=435, Percent_Identity=31.4942528735632, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4501993, Length=248, Percent_Identity=31.0483870967742, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789351, Length=418, Percent_Identity=32.2966507177034, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1787977, Length=501, Percent_Identity=28.9421157684631, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI48994907, Length=217, Percent_Identity=29.9539170506912, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI48994914, Length=103, Percent_Identity=36.8932038834951, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992373, Length=451, Percent_Identity=47.8935698447894, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71992381, Length=451, Percent_Identity=46.5631929046563, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71992392, Length=376, Percent_Identity=50, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17534361, Length=437, Percent_Identity=28.8329519450801, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17556096, Length=221, Percent_Identity=31.2217194570136, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320027, Length=475, Percent_Identity=39.1578947368421, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6320023, Length=436, Percent_Identity=27.5229357798165, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320764, Length=444, Percent_Identity=27.7027027027027, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18921117, Length=432, Percent_Identity=30.3240740740741, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24639277, Length=432, Percent_Identity=30.3240740740741, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24639275, Length=432, Percent_Identity=30.3240740740741, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24653753, Length=220, Percent_Identity=33.6363636363636, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 53563; Mature: 53563

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAQAVSNIRRPRARKTGPLRREEDMSAQARIDGVPIGAPSLDIIMARLAAIVGDRASAA
CCHHHHHHHHCCCCCCCCCCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
PGVRADHGRSEAYHAARPPDVVVFPETTAEVQAIVNLCRELDLPLVPFGAGTSLEGNAAA
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEE
LHGGVCLDMGRMNQMLEIHAEDMDVRVQPGITRKQLNAQLRDTGLFFPIDPGADASIGGM
EECCEEEEHHHHHHHHEEECCCCCEEECCCCCHHHHCCHHHHCCEEEECCCCCCCCCCCC
TSTRASGTMAVRYGTMKDNVLALEVVLADGRAIRTARRAKKSAAGYDLTRLFVGAEGTLG
CCCCCCCEEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
VITEITLKLHPQPEAISSAVCAFPDLKAAVDTAIGVIQSGVPVARIELLDAVMMRGMNLH
EEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHH
SRLGLPEVPHLFFEFHGSSAYVTEQAETAQAIAADNGGQGFQWAVTPEERTRLWHARDNT
HHCCCCCCCEEEEEECCCCEEEECHHHHHHHHHCCCCCCCCEEEECCHHHHHEEECCCCE
LYAGLALRPGAKAMITDVCVPISRLADCLVDTAADLVECGLVAPVVGHVGDGNFHLLVLI
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
DPQDPEELARAKAFNERLVRRAIALDGTCTGEHGIGMGKMDFLALELGEAVDAMRLLKGA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
LDPHGILNPGKIFKPHPPTQGSAP
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMAQAVSNIRRPRARKTGPLRREEDMSAQARIDGVPIGAPSLDIIMARLAAIVGDRASAA
CCHHHHHHHHCCCCCCCCCCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
PGVRADHGRSEAYHAARPPDVVVFPETTAEVQAIVNLCRELDLPLVPFGAGTSLEGNAAA
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEE
LHGGVCLDMGRMNQMLEIHAEDMDVRVQPGITRKQLNAQLRDTGLFFPIDPGADASIGGM
EECCEEEEHHHHHHHHEEECCCCCEEECCCCCHHHHCCHHHHCCEEEECCCCCCCCCCCC
TSTRASGTMAVRYGTMKDNVLALEVVLADGRAIRTARRAKKSAAGYDLTRLFVGAEGTLG
CCCCCCCEEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
VITEITLKLHPQPEAISSAVCAFPDLKAAVDTAIGVIQSGVPVARIELLDAVMMRGMNLH
EEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHH
SRLGLPEVPHLFFEFHGSSAYVTEQAETAQAIAADNGGQGFQWAVTPEERTRLWHARDNT
HHCCCCCCCEEEEEECCCCEEEECHHHHHHHHHCCCCCCCCEEEECCHHHHHEEECCCCE
LYAGLALRPGAKAMITDVCVPISRLADCLVDTAADLVECGLVAPVVGHVGDGNFHLLVLI
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
DPQDPEELARAKAFNERLVRRAIALDGTCTGEHGIGMGKMDFLALELGEAVDAMRLLKGA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
LDPHGILNPGKIFKPHPPTQGSAP
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]