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The map label for this gene is garR [H]

Identifier: 158423037

GI number: 158423037

Start: 1608027

End: 1608944

Strand: Direct

Name: garR [H]

Synonym: AZC_1413

Alternate gene names: 158423037

Gene position: 1608027-1608944 (Clockwise)

Preceding gene: 158423036

Following gene: 158423038

Centisome position: 29.95

GC content: 67.65

Gene sequence:

>918_bases
ATGACGGAAACGCTCACACTTGGCTGGATCGGGCTCGGGAAGATGGGCCTTCCCATCTCCACCCGCCTTGCCGCCGCAGG
CTACGACATCGCGGGCACGGACCGGGATCAGGAGCGCATCTCCGAGGCGGCCGCCAGCGGCGTGAAGCCCGCCGCGACGC
TCGCGGATGCCGCAACGCGCGACATCGTCTTCACATCCCTGCCGGACGACAAGGCGCTGCGGGCGGTCGCTCTCGATGGC
CCGCTGTTCCAGAGCATGCGCAAGGGTACGATCCTGGTGGAGACCTCGACCGTCAGCCCCGGCATCTCGGCCGAAGTGGC
GCAGGCGGCAGACGCGCGCGGCATCGCCTATCTGCGGGCGCCGGTCTCCGGCAATGCGGCGATCGCCCATACCGGCAATC
TCACCTGCTTCGTGTCCGGCCCGAAAGCCGCCTTTGACACCTTCCTGCCGGTCGCCCAGGCCTTCACGCGGGCGCAGAAA
TATCTCGGGACGGCGGAAGAGGCCCGCTACGCCAAGCTGGCGGTCAATCTCATGATTGCCGTCTCCGCCGCCATGATGGG
TGAGAGCATCGTCCTGGCCCGCAAGGGCAACCTGGCCTGGCAGGACATCCTCGACGTGCTGACCAACAGCGCGGTGGGCT
CGCCCATGGTGCACTACAAGGCCAAGAGCCTGGAGACGCGCGACTTCAACTCCACCTTCTCCTGCCGCCAGATGGCCAAG
GACCTCGACCTGATCGTCGGCGCCGGGCACGCGGCGGACATGGCCATGCCGCTCGCGACCCTGACGCGCGAGGTCTATGG
CGCGCTCATCGGGCGGGGCGAGGGCGAAGCGGATTTCATCTCCACCGTACGCCTTGCGGAATGGCTGGCCGGCCTCGGCG
AGCCGGACCTTGAACAGAATGAAGGGAGGCTCGCATGA

Upstream 100 bases:

>100_bases
GCCGCAGCGCTCGACGACACGCTCGCCCGTCTCGCCCGCTCCGGCGCGCGCATCGTGGACGAGCTCGGTCTCAAGCGGAC
GGCGGCGTGAGGAGACGGGG

Downstream 100 bases:

>100_bases
GGAACTTCGATCAGTTCACCATCACGCAGGCCGTGCTGGAGCGGGTCGCCAACACGCCGGACGCCCGCACCCGGCAGATC
AGCGAGGCGCTGGTTCGCCA

Product: dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTETLTLGWIGLGKMGLPISTRLAAAGYDIAGTDRDQERISEAAASGVKPAATLADAATRDIVFTSLPDDKALRAVALDG
PLFQSMRKGTILVETSTVSPGISAEVAQAADARGIAYLRAPVSGNAAIAHTGNLTCFVSGPKAAFDTFLPVAQAFTRAQK
YLGTAEEARYAKLAVNLMIAVSAAMMGESIVLARKGNLAWQDILDVLTNSAVGSPMVHYKAKSLETRDFNSTFSCRQMAK
DLDLIVGAGHAADMAMPLATLTREVYGALIGRGEGEADFISTVRLAEWLAGLGEPDLEQNEGRLA

Sequences:

>Translated_305_residues
MTETLTLGWIGLGKMGLPISTRLAAAGYDIAGTDRDQERISEAAASGVKPAATLADAATRDIVFTSLPDDKALRAVALDG
PLFQSMRKGTILVETSTVSPGISAEVAQAADARGIAYLRAPVSGNAAIAHTGNLTCFVSGPKAAFDTFLPVAQAFTRAQK
YLGTAEEARYAKLAVNLMIAVSAAMMGESIVLARKGNLAWQDILDVLTNSAVGSPMVHYKAKSLETRDFNSTFSCRQMAK
DLDLIVGAGHAADMAMPLATLTREVYGALIGRGEGEADFISTVRLAEWLAGLGEPDLEQNEGRLA
>Mature_304_residues
TETLTLGWIGLGKMGLPISTRLAAAGYDIAGTDRDQERISEAAASGVKPAATLADAATRDIVFTSLPDDKALRAVALDGP
LFQSMRKGTILVETSTVSPGISAEVAQAADARGIAYLRAPVSGNAAIAHTGNLTCFVSGPKAAFDTFLPVAQAFTRAQKY
LGTAEEARYAKLAVNLMIAVSAAMMGESIVLARKGNLAWQDILDVLTNSAVGSPMVHYKAKSLETRDFNSTFSCRQMAKD
LDLIVGAGHAADMAMPLATLTREVYGALIGRGEGEADFISTVRLAEWLAGLGEPDLEQNEGRLA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=266, Percent_Identity=30.0751879699248, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=25.3472222222222, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI145693186, Length=288, Percent_Identity=31.5972222222222, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786719, Length=290, Percent_Identity=25.8620689655172, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=24.0549828178694, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=26.2237762237762, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557316, Length=270, Percent_Identity=25.5555555555556, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24655230, Length=283, Percent_Identity=27.9151943462898, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI19922568, Length=283, Percent_Identity=27.9151943462898, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574115, Length=276, Percent_Identity=25, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 32036; Mature: 31905

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETLTLGWIGLGKMGLPISTRLAAAGYDIAGTDRDQERISEAAASGVKPAATLADAATR
CCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
DIVFTSLPDDKALRAVALDGPLFQSMRKGTILVETSTVSPGISAEVAQAADARGIAYLRA
CEEEEECCCCHHEEEEEECCHHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEC
PVSGNAAIAHTGNLTCFVSGPKAAFDTFLPVAQAFTRAQKYLGTAEEARYAKLAVNLMIA
CCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VSAAMMGESIVLARKGNLAWQDILDVLTNSAVGSPMVHYKAKSLETRDFNSTFSCRQMAK
HHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHH
DLDLIVGAGHAADMAMPLATLTREVYGALIGRGEGEADFISTVRLAEWLAGLGEPDLEQN
HHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
EGRLA
CCCCC
>Mature Secondary Structure 
TETLTLGWIGLGKMGLPISTRLAAAGYDIAGTDRDQERISEAAASGVKPAATLADAATR
CCEEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
DIVFTSLPDDKALRAVALDGPLFQSMRKGTILVETSTVSPGISAEVAQAADARGIAYLRA
CEEEEECCCCHHEEEEEECCHHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEC
PVSGNAAIAHTGNLTCFVSGPKAAFDTFLPVAQAFTRAQKYLGTAEEARYAKLAVNLMIA
CCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VSAAMMGESIVLARKGNLAWQDILDVLTNSAVGSPMVHYKAKSLETRDFNSTFSCRQMAK
HHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHH
DLDLIVGAGHAADMAMPLATLTREVYGALIGRGEGEADFISTVRLAEWLAGLGEPDLEQN
HHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
EGRLA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]