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The map label for this gene is lysR [H]

Identifier: 158422932

GI number: 158422932

Start: 1463727

End: 1464653

Strand: Reverse

Name: lysR [H]

Synonym: AZC_1308

Alternate gene names: 158422932

Gene position: 1464653-1463727 (Counterclockwise)

Preceding gene: 158422935

Following gene: 158422931

Centisome position: 27.28

GC content: 63.65

Gene sequence:

>927_bases
TTGTCGGCGCAAAATCGTTCGCTAATATCGAACGTTATGTCCTCGCTGAATTACAACCATCTGCGCTATTTCTGGGCGGT
GGCGCATGACGGCAACCTGACCCGCACTGCGGAGCGACTGAACCTCACGCAGTCCGCCCTGTCGGTGCAGATCCGCAAAC
TTGAAGACCGACTGGGCCATGCGCTGTTTGAACGCCGGGGCCGGCAGCTTCATCTGACTGAGGCTGGAAAGATCGTTCTC
GATCATGCCGACGCGATCTTCGCCACGGGCGATGAGTTGCTGGGTACGCTTCGGCAGACCGGAGCGGCCCGGCAGGCGCT
GCGCGTCGGTTCGCTCGCCACGCTGTCGCGCAACTTCCAGATGGAGTTCCTGCGTCCGGTGCTTGGCCGCACGGATATCG
ACCTCGTTCTGCGATCGGGCAGCGTCGGTGAGCTGCTGCGGGCGCTTGAGGCGCTCAACCTCGACGTCGTTCTGCTGAAC
CAGGCACCGCCCGGCGACGCCCTGACCCCCTTCGTCACGCATCGGCTTGCGGAGCGTCCCGTCAGCCTGGTGGGAACTCC
CGAGCGGCTGCGCCATGCCGCGAGCTTCGCGGATCGGCTTCGAAGCCACCCCATAATCCTGCCGACGGTGGACAGCAGCG
TGCGCATCGGGTTCGACGCGCTCGCCGATCGCCTCGGCGTCAGGCCACAGATCGTGGCGGAAGTCGAGGACATGGCGATG
ATGCGTCTTCTCGCCCGGGAGGACATCGGGCTGGCCGTTCTCCCGTCCATCGTCGTGAAGGATGAGATTGCCGCAGGCGT
GCTGGTGGAAGGCGATCAGTTGTCAGACATCGTGGAGACGTTCCACGCGGTCACCATGTCGCGACGGTTCCCCAATCCCC
TGGTCAAGCTTCTCCTTCAACCCACGGGCACATCGGGAGATAACTGA

Upstream 100 bases:

>100_bases
TGCGCAAAGTGGAAGCAGGTAAGGTGACAAGGCGGTTCCCCTGTAGTCGTGACAGTCGGGAAGCCTTGGATATCGATCGC
AGGAAGCGAATTAAAATTCA

Downstream 100 bases:

>100_bases
CGCTGGTGCGGACCCCGGTCGCACCGTGACCGGTCAGCCATATGAGCCGGTCTCGCATGCACCCCAGGAGCGACAACCGA
GGTCGGTGCGCGAGACCACG

Product: transcriptional regulator

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSAQNRSLISNVMSSLNYNHLRYFWAVAHDGNLTRTAERLNLTQSALSVQIRKLEDRLGHALFERRGRQLHLTEAGKIVL
DHADAIFATGDELLGTLRQTGAARQALRVGSLATLSRNFQMEFLRPVLGRTDIDLVLRSGSVGELLRALEALNLDVVLLN
QAPPGDALTPFVTHRLAERPVSLVGTPERLRHAASFADRLRSHPIILPTVDSSVRIGFDALADRLGVRPQIVAEVEDMAM
MRLLAREDIGLAVLPSIVVKDEIAAGVLVEGDQLSDIVETFHAVTMSRRFPNPLVKLLLQPTGTSGDN

Sequences:

>Translated_308_residues
MSAQNRSLISNVMSSLNYNHLRYFWAVAHDGNLTRTAERLNLTQSALSVQIRKLEDRLGHALFERRGRQLHLTEAGKIVL
DHADAIFATGDELLGTLRQTGAARQALRVGSLATLSRNFQMEFLRPVLGRTDIDLVLRSGSVGELLRALEALNLDVVLLN
QAPPGDALTPFVTHRLAERPVSLVGTPERLRHAASFADRLRSHPIILPTVDSSVRIGFDALADRLGVRPQIVAEVEDMAM
MRLLAREDIGLAVLPSIVVKDEIAAGVLVEGDQLSDIVETFHAVTMSRRFPNPLVKLLLQPTGTSGDN
>Mature_307_residues
SAQNRSLISNVMSSLNYNHLRYFWAVAHDGNLTRTAERLNLTQSALSVQIRKLEDRLGHALFERRGRQLHLTEAGKIVLD
HADAIFATGDELLGTLRQTGAARQALRVGSLATLSRNFQMEFLRPVLGRTDIDLVLRSGSVGELLRALEALNLDVVLLNQ
APPGDALTPFVTHRLAERPVSLVGTPERLRHAASFADRLRSHPIILPTVDSSVRIGFDALADRLGVRPQIVAEVEDMAMM
RLLAREDIGLAVLPSIVVKDEIAAGVLVEGDQLSDIVETFHAVTMSRRFPNPLVKLLLQPTGTSGDN

Specific function: Plays a role in the positive regulation of nhaA (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786202, Length=288, Percent_Identity=27.7777777777778, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=29.718875502008, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI157672245, Length=255, Percent_Identity=27.843137254902, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788297, Length=243, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081904, Length=261, Percent_Identity=29.5019157088123, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1790399, Length=147, Percent_Identity=30.6122448979592, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33818; Mature: 33687

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQNRSLISNVMSSLNYNHLRYFWAVAHDGNLTRTAERLNLTQSALSVQIRKLEDRLGH
CCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFERRGRQLHLTEAGKIVLDHADAIFATGDELLGTLRQTGAARQALRVGSLATLSRNFQ
HHHHHCCCEEEEECCCEEEEECCCHHEECCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCH
MEFLRPVLGRTDIDLVLRSGSVGELLRALEALNLDVVLLNQAPPGDALTPFVTHRLAERP
HHHHHHHHCCCCHHEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCC
VSLVGTPERLRHAASFADRLRSHPIILPTVDSSVRIGFDALADRLGVRPQIVAEVEDMAM
HHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHCCCHHHHHHHHHHHH
MRLLAREDIGLAVLPSIVVKDEIAAGVLVEGDQLSDIVETFHAVTMSRRFPNPLVKLLLQ
HHHHHHCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
PTGTSGDN
CCCCCCCC
>Mature Secondary Structure 
SAQNRSLISNVMSSLNYNHLRYFWAVAHDGNLTRTAERLNLTQSALSVQIRKLEDRLGH
CCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFERRGRQLHLTEAGKIVLDHADAIFATGDELLGTLRQTGAARQALRVGSLATLSRNFQ
HHHHHCCCEEEEECCCEEEEECCCHHEECCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCH
MEFLRPVLGRTDIDLVLRSGSVGELLRALEALNLDVVLLNQAPPGDALTPFVTHRLAERP
HHHHHHHHCCCCHHEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCC
VSLVGTPERLRHAASFADRLRSHPIILPTVDSSVRIGFDALADRLGVRPQIVAEVEDMAM
HHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHCCCHHHHHHHHHHHH
MRLLAREDIGLAVLPSIVVKDEIAAGVLVEGDQLSDIVETFHAVTMSRRFPNPLVKLLLQ
HHHHHHCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
PTGTSGDN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]