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The map label for this gene is lysR [H]

Identifier: 158422919

GI number: 158422919

Start: 1444604

End: 1445494

Strand: Reverse

Name: lysR [H]

Synonym: AZC_1295

Alternate gene names: 158422919

Gene position: 1445494-1444604 (Counterclockwise)

Preceding gene: 158422922

Following gene: 158422915

Centisome position: 26.92

GC content: 64.09

Gene sequence:

>891_bases
ATGATGCAGGGCAGCCTGACCGAATTGGACGCCGTTCTCATGGTGGCCCGTCATGGCAAGTTCCGGACGGCTGCCCTTGA
GCTGGGGCTCTCGACGACCGCGCTCAGCAACGCGGTCGGAAAGCTGGAACGCACGCTCGGCGTCCGCCTCTTCAACCGCA
CGACGCGAAGCGTATCCTTGACGGAGGCAGGCCAGCAGTTCGTCGCTCAAGTGGCTCCTGCCCTGCGGGACATCCATGAG
GCGATGGAGGTTGTGCGCTCTCAAAAGGCCACGCCGTCCGGCACACTGCGCATCAACGCCTTTCCGACGGCGGCACGGGA
GATTTTCTCCTGGCTCGTCCTACCGTTTCTCCGGATGTATCCGAAGGTCCACATCGACATCGTCACAGAAGGTCGGCTGG
TGGATATTGTCGCGGGCGGCTTTGACCTTGGCGTCCGGAGCGCCGACCTTGTGCCGGTCGACATGATCGCGCTCCCCTTG
GGCGGCGGGCGGCGAAATGTTGTGGTGGCCACCCCGCGCTATTTGAAAGCGCACGGAATACCCGTGATGCCTCAGGATCT
CGCCGGCCATTCCTGTTTGCGCGTCCGGCTTCCCAATGGCACAATCTACCGATGGCCGTTCGAAAAGGACGGACAATCGG
TCCATATCGCGGTGGAGGGCCCCATCACCCTTGACGAAGCGAGCCTCGCACGCGCCGCGGCCCTCGCCTCCATCGGTCTC
ACACTGGCGATGGAATCCGACGTGCGGGACGACATCGAAGCCGGCCGCCTTGTCCGCGTGCTTGAAGACTGGACCCCGGC
TCTGCCGCCCTTGAGCCTCTACTATCCGAGCCGCCGCAATCCGACCGCGGCGTTCAAGGCCTTCGTCGATTTCGCGCGGA
GGCAGGCCTGA

Upstream 100 bases:

>100_bases
GCTGCAACCGCGGCGGCTGCCCCTGCACGCCAAGCTAGCGATAGACAACTGGCGCGATAACCAGGACAATTCGGGACGGC
TCATCACGAAAATCGGGATA

Downstream 100 bases:

>100_bases
TGGGGGCGATGAGGCTTGCAGCGATAGCTCAAGGAGTCCGCTCATGGGCTGCGCAGGCACACATCGGATGGACACCCGCC
ACAGACCACATCGACAGGTT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MMQGSLTELDAVLMVARHGKFRTAALELGLSTTALSNAVGKLERTLGVRLFNRTTRSVSLTEAGQQFVAQVAPALRDIHE
AMEVVRSQKATPSGTLRINAFPTAAREIFSWLVLPFLRMYPKVHIDIVTEGRLVDIVAGGFDLGVRSADLVPVDMIALPL
GGGRRNVVVATPRYLKAHGIPVMPQDLAGHSCLRVRLPNGTIYRWPFEKDGQSVHIAVEGPITLDEASLARAAALASIGL
TLAMESDVRDDIEAGRLVRVLEDWTPALPPLSLYYPSRRNPTAAFKAFVDFARRQA

Sequences:

>Translated_296_residues
MMQGSLTELDAVLMVARHGKFRTAALELGLSTTALSNAVGKLERTLGVRLFNRTTRSVSLTEAGQQFVAQVAPALRDIHE
AMEVVRSQKATPSGTLRINAFPTAAREIFSWLVLPFLRMYPKVHIDIVTEGRLVDIVAGGFDLGVRSADLVPVDMIALPL
GGGRRNVVVATPRYLKAHGIPVMPQDLAGHSCLRVRLPNGTIYRWPFEKDGQSVHIAVEGPITLDEASLARAAALASIGL
TLAMESDVRDDIEAGRLVRVLEDWTPALPPLSLYYPSRRNPTAAFKAFVDFARRQA
>Mature_296_residues
MMQGSLTELDAVLMVARHGKFRTAALELGLSTTALSNAVGKLERTLGVRLFNRTTRSVSLTEAGQQFVAQVAPALRDIHE
AMEVVRSQKATPSGTLRINAFPTAAREIFSWLVLPFLRMYPKVHIDIVTEGRLVDIVAGGFDLGVRSADLVPVDMIALPL
GGGRRNVVVATPRYLKAHGIPVMPQDLAGHSCLRVRLPNGTIYRWPFEKDGQSVHIAVEGPITLDEASLARAAALASIGL
TLAMESDVRDDIEAGRLVRVLEDWTPALPPLSLYYPSRRNPTAAFKAFVDFARRQA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787128, Length=292, Percent_Identity=38.6986301369863, Blast_Score=221, Evalue=3e-59,
Organism=Escherichia coli, GI1787589, Length=291, Percent_Identity=35.0515463917526, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1786401, Length=291, Percent_Identity=29.8969072164948, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081978, Length=290, Percent_Identity=30.3448275862069, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1789440, Length=267, Percent_Identity=26.9662921348315, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI145693193, Length=283, Percent_Identity=30.0353356890459, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1789639, Length=188, Percent_Identity=34.5744680851064, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788706, Length=301, Percent_Identity=26.9102990033223, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786448, Length=294, Percent_Identity=24.1496598639456, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789173, Length=263, Percent_Identity=28.8973384030418, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693105, Length=204, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=157, Percent_Identity=28.0254777070064, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI157672245, Length=174, Percent_Identity=28.735632183908, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790399, Length=141, Percent_Identity=30.4964539007092, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788748, Length=147, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787879, Length=150, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32271; Mature: 32271

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQGSLTELDAVLMVARHGKFRTAALELGLSTTALSNAVGKLERTLGVRLFNRTTRSVSL
CCCCCHHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEH
TEAGQQFVAQVAPALRDIHEAMEVVRSQKATPSGTLRINAFPTAAREIFSWLVLPFLRMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
PKVHIDIVTEGRLVDIVAGGFDLGVRSADLVPVDMIALPLGGGRRNVVVATPRYLKAHGI
CEEEEEEEECCEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCHHHHHCCC
PVMPQDLAGHSCLRVRLPNGTIYRWPFEKDGQSVHIAVEGPITLDEASLARAAALASIGL
CCCCHHHCCCCEEEEECCCCCEEECCCCCCCCEEEEEEECCEEECHHHHHHHHHHHHHCE
TLAMESDVRDDIEAGRLVRVLEDWTPALPPLSLYYPSRRNPTAAFKAFVDFARRQA
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMQGSLTELDAVLMVARHGKFRTAALELGLSTTALSNAVGKLERTLGVRLFNRTTRSVSL
CCCCCHHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEH
TEAGQQFVAQVAPALRDIHEAMEVVRSQKATPSGTLRINAFPTAAREIFSWLVLPFLRMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
PKVHIDIVTEGRLVDIVAGGFDLGVRSADLVPVDMIALPLGGGRRNVVVATPRYLKAHGI
CEEEEEEEECCEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCHHHHHCCC
PVMPQDLAGHSCLRVRLPNGTIYRWPFEKDGQSVHIAVEGPITLDEASLARAAALASIGL
CCCCHHHCCCCEEEEECCCCCEEECCCCCCCCEEEEEEECCEEECHHHHHHHHHHHHHCE
TLAMESDVRDDIEAGRLVRVLEDWTPALPPLSLYYPSRRNPTAAFKAFVDFARRQA
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]