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The map label for this gene is mmlH [H]

Identifier: 158422731

GI number: 158422731

Start: 1235890

End: 1237176

Strand: Reverse

Name: mmlH [H]

Synonym: AZC_1107

Alternate gene names: 158422731

Gene position: 1237176-1235890 (Counterclockwise)

Preceding gene: 158422732

Following gene: 158422730

Centisome position: 23.04

GC content: 69.62

Gene sequence:

>1287_bases
ATGTTCAGTTGGTTCCGCGAGATCGACGCCACCGAGCGCAAGACATTCTGGGCCTGCTTCGGCGGCTGGGCGCTCGATGC
GCTCGACGTCCAGCTCTTCTCCCTCGTCATCCCGACGCTGCTTGCCCTCTGGCACATCAGCAAGGCCGATGCGGGCATGA
TCACCAGCGTGACGCTCATCGCCTCGGCGCTGGGCGGCTGGGTCGGCGGGGCCATTTCGGACCGCATCGGCCGCGTGCGC
GCCCTGCAGGTGATGATCCTGTGGTTCGCGCTCGCGACCTTCGCCTCCGCCTTCGCGCAGGATTACAACCAGCTCCTCGT
GCTGAAAGCCTTGCAGGGCCTCGGCTTCGGCGGCGAATGGGCGGCCGGTGTCGCGCTCATGAGCGAGGCCATCCGCCCGA
GCCACCGCGGCAAGGCGCTGGGCACCGTGCAGAGCGCCTGGGCCGTGGGCTGGGGCGCCTCGGTGCTGATCCAGACCAGC
ATCTATTCCTTCGTGCCGCCGGAAATCGCCTGGCGCCTGCTGTTCGGCCTCGGCCTCATCCCGGCGATCCTCGTCATCTT
CGTGCGCCGCCATGTGCCCGAGCCCGAGGCCTCGCCGGCCCGCGCGCCCAAGGCGCAGCAGGCGCGCACGCCGCTGCTCG
GCATCTTCTCGCCGGACGTGCTGCGCGTCACGCTGGTGGGCCTTCTGCTCGGCACCGGCGCCCACGGCGGCTATTACGCG
GTGACGAGCTGGCTGCCCACGTATCTCAAGACCGAGCGCCATCTCTCCACGCTGGGCACCGGCGCCTATCTGGCGGTCAT
CATCGTCGCCTTCTTCTTCGGCTGCATCGCCGCCGCGCATCTGCTGGACCGCATCGGCCGCCGGCGCACGGTGGGCCTGT
TCGCGCTCTCCTGCGTCATCGTCGTGCTGGCCTATGTGTTCCTGCCCATCGGCGACACCGCCATGCTGATCCTCGGCTTC
CCGCTGGGCTTCTGCTCGGCCGGCATTCCGGCCAGCATGGGCGCGCTGTTCTCCGAGCTGTATCCGGGCGGCATCCGCGG
CACCGGCGTCGGCTTCTGCTACAATGCCGGGCGCATCGTTTCCGCCATCTTCCCCTTCCTCGTCGGCCATCTGTCCGAGC
AGATGTCGCTCGGCGCCGCCATCGGCATCGATGCAGCGGTGGCCTATGGCCTCGTGGTGGTGGCGGTGCTCATGCTACCC
GAGACCAAGGCGGTGAAGCTCGACGCGGTGGACGCGCCCGGCGCGCCGGCCGGTGCGGGCGTGCGCTCGTCCGCCCCGGC
GCAATGA

Upstream 100 bases:

>100_bases
CGAGATCCGCTGAGCGGTCCGCCGCTCATTTTCGTTCGCAACCGTTCACGCAAGGCGCCAGCCGGCCGCAAGAGCCGCGC
GGGCCTGCCGGAGGACACCC

Downstream 100 bases:

>100_bases
GCCGCCGCGCATCCGGTCCCGCAACATGAACGAACCCCTCGACGGCCGGCGGCGTTCCGCCGGCCTGATGGCCATCGACA
GCCACGCCCACATCTTCCGG

Product: major facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MFSWFREIDATERKTFWACFGGWALDALDVQLFSLVIPTLLALWHISKADAGMITSVTLIASALGGWVGGAISDRIGRVR
ALQVMILWFALATFASAFAQDYNQLLVLKALQGLGFGGEWAAGVALMSEAIRPSHRGKALGTVQSAWAVGWGASVLIQTS
IYSFVPPEIAWRLLFGLGLIPAILVIFVRRHVPEPEASPARAPKAQQARTPLLGIFSPDVLRVTLVGLLLGTGAHGGYYA
VTSWLPTYLKTERHLSTLGTGAYLAVIIVAFFFGCIAAAHLLDRIGRRRTVGLFALSCVIVVLAYVFLPIGDTAMLILGF
PLGFCSAGIPASMGALFSELYPGGIRGTGVGFCYNAGRIVSAIFPFLVGHLSEQMSLGAAIGIDAAVAYGLVVVAVLMLP
ETKAVKLDAVDAPGAPAGAGVRSSAPAQ

Sequences:

>Translated_428_residues
MFSWFREIDATERKTFWACFGGWALDALDVQLFSLVIPTLLALWHISKADAGMITSVTLIASALGGWVGGAISDRIGRVR
ALQVMILWFALATFASAFAQDYNQLLVLKALQGLGFGGEWAAGVALMSEAIRPSHRGKALGTVQSAWAVGWGASVLIQTS
IYSFVPPEIAWRLLFGLGLIPAILVIFVRRHVPEPEASPARAPKAQQARTPLLGIFSPDVLRVTLVGLLLGTGAHGGYYA
VTSWLPTYLKTERHLSTLGTGAYLAVIIVAFFFGCIAAAHLLDRIGRRRTVGLFALSCVIVVLAYVFLPIGDTAMLILGF
PLGFCSAGIPASMGALFSELYPGGIRGTGVGFCYNAGRIVSAIFPFLVGHLSEQMSLGAAIGIDAAVAYGLVVVAVLMLP
ETKAVKLDAVDAPGAPAGAGVRSSAPAQ
>Mature_428_residues
MFSWFREIDATERKTFWACFGGWALDALDVQLFSLVIPTLLALWHISKADAGMITSVTLIASALGGWVGGAISDRIGRVR
ALQVMILWFALATFASAFAQDYNQLLVLKALQGLGFGGEWAAGVALMSEAIRPSHRGKALGTVQSAWAVGWGASVLIQTS
IYSFVPPEIAWRLLFGLGLIPAILVIFVRRHVPEPEASPARAPKAQQARTPLLGIFSPDVLRVTLVGLLLGTGAHGGYYA
VTSWLPTYLKTERHLSTLGTGAYLAVIIVAFFFGCIAAAHLLDRIGRRRTVGLFALSCVIVVLAYVFLPIGDTAMLILGF
PLGFCSAGIPASMGALFSELYPGGIRGTGVGFCYNAGRIVSAIFPFLVGHLSEQMSLGAAIGIDAAVAYGLVVVAVLMLP
ETKAVKLDAVDAPGAPAGAGVRSSAPAQ

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=443, Percent_Identity=24.6049661399549, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI213021148, Length=446, Percent_Identity=22.4215246636771, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082404, Length=399, Percent_Identity=24.3107769423559, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082231, Length=207, Percent_Identity=28.5024154589372, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87081723, Length=398, Percent_Identity=27.1356783919598, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI87082159, Length=397, Percent_Identity=28.9672544080605, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786229, Length=396, Percent_Identity=23.7373737373737, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790550, Length=348, Percent_Identity=23.5632183908046, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788942, Length=355, Percent_Identity=24.2253521126761, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=433, Percent_Identity=24.0184757505774, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922874, Length=412, Percent_Identity=23.3009708737864, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45145; Mature: 45145

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSWFREIDATERKTFWACFGGWALDALDVQLFSLVIPTLLALWHISKADAGMITSVTLI
CCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ASALGGWVGGAISDRIGRVRALQVMILWFALATFASAFAQDYNQLLVLKALQGLGFGGEW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AAGVALMSEAIRPSHRGKALGTVQSAWAVGWGASVLIQTSIYSFVPPEIAWRLLFGLGLI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
PAILVIFVRRHVPEPEASPARAPKAQQARTPLLGIFSPDVLRVTLVGLLLGTGAHGGYYA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHH
VTSWLPTYLKTERHLSTLGTGAYLAVIIVAFFFGCIAAAHLLDRIGRRRTVGLFALSCVI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VVLAYVFLPIGDTAMLILGFPLGFCSAGIPASMGALFSELYPGGIRGTGVGFCYNAGRIV
HHHHHHHHCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECHHHHH
SAIFPFLVGHLSEQMSLGAAIGIDAAVAYGLVVVAVLMLPETKAVKLDAVDAPGAPAGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
VRSSAPAQ
CCCCCCCC
>Mature Secondary Structure
MFSWFREIDATERKTFWACFGGWALDALDVQLFSLVIPTLLALWHISKADAGMITSVTLI
CCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ASALGGWVGGAISDRIGRVRALQVMILWFALATFASAFAQDYNQLLVLKALQGLGFGGEW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AAGVALMSEAIRPSHRGKALGTVQSAWAVGWGASVLIQTSIYSFVPPEIAWRLLFGLGLI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
PAILVIFVRRHVPEPEASPARAPKAQQARTPLLGIFSPDVLRVTLVGLLLGTGAHGGYYA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHH
VTSWLPTYLKTERHLSTLGTGAYLAVIIVAFFFGCIAAAHLLDRIGRRRTVGLFALSCVI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VVLAYVFLPIGDTAMLILGFPLGFCSAGIPASMGALFSELYPGGIRGTGVGFCYNAGRIV
HHHHHHHHCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECHHHHH
SAIFPFLVGHLSEQMSLGAAIGIDAAVAYGLVVVAVLMLPETKAVKLDAVDAPGAPAGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
VRSSAPAQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]