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The map label for this gene is yciC [H]

Identifier: 158422727

GI number: 158422727

Start: 1230644

End: 1231894

Strand: Reverse

Name: yciC [H]

Synonym: AZC_1103

Alternate gene names: 158422727

Gene position: 1231894-1230644 (Counterclockwise)

Preceding gene: 158422730

Following gene: 158422725

Centisome position: 22.94

GC content: 67.39

Gene sequence:

>1251_bases
TTGTATCATTCAAAGGACCGCCCCATGCCGACCGCCGACAATCGCCTGCCAGTCACCGTGCTTTCAGGCTTTCTGGGCGC
CGGGAAGACCACCCTGCTCAACCACGTCCTCGCCAACCGCGAGGGCCTGAGGGTCGCGGTGATCGTCAACGATATGTCCG
AAGTGAACATCGATGCGGAACTGATCCGGGCCGGCGGCGGCGATCTTTCCCGCACGCAGGAAACGCTGGTGGAGATGACC
AACGGCTGCATCTGCTGCACCCTGCGCGACGACCTGCTGGCGGAAGTCACCCGCCTCGCCCGCGAAGGCCGCTTCGACGC
GCTGGTCATCGAGAGCACCGGCATCGCCGAGCCGCTGCCGGTGGCCGCGACCTTCGAGTTCCGGGACGAGGAGGGCTTCT
CCCTCTCCGACCTCGCCCGCCTCGACACCATGGTGACGGTGGTGGACGCGGCGAACCTCCTGAAGGACTACGCCTCCACC
GACTTCCTGCGCGACCGGGGCGAGAGCCTCGGGGAAGAGGACCAGCGGACCATCGTCGATCTGATGGTGGACCAGATCGA
GTTCGCCGACGTGATCGTGCTGAACAAGGTCGGCGCCACCGATCCGGAAAAGCTCCGGCTCGCCCGCGCCGTCATCAAGG
GGCTCAACCCGGACGCCCGCATCCTCGAGACGAACCACAGTCAGGTGCCGCTCGCCGAGGTGATGAACACCGGCCGCTTC
GATTTCGAGGCCGCCCATCGCCATCCGCTGTGGTTCAAGGAGCTGAACGGCTTTGCGGACCATGTGCCGGAGACCGAGGA
ATACGGCGTCGCGAGCTTCGTCTATCGCGCCCGCCGGCCCTTCCATCCGCAGAAGTTCTCCGCCTTCCTGCGCCGCACCT
GGCCGGGCCTGATCCGCGCCAAGGGGCTGTTCTGGCTGGCGACCCGCGATGCCTATGTGGGCGAGATGAGCCTTGCCGGT
TCGCTCTGCCGCACCGAGAAGCTGGGCCTGTGGTGGGCCGCCGTGCCGAAGGAGCACTGGCCGCAGGACCCCGCCTTCCG
CACCGAACTGAAGCGCTATTGGGCGCCCTTCTATGGCGACCGGCGGCAGGAGCTGGTGTTCATCGGCATGGGCCTGGATG
AAGCCGCCATCCGGGCGGCGCTGGATGACTGCCTGACGGGCCCCACCGATCCGGCGCAGCTCGACTTCGCCGCCTTGTCT
CACCTGCCGGACCCGTTCCCCTCGTGGAGCCGGCAGCCGGCCGTCGCCTGA

Upstream 100 bases:

>100_bases
GCTGCGCGGACAACGCGGACCCTTTCCGGAACGGCATCATCAGGCAGGCGAACGGTCCGGCACTTGCGCCAAAAAGACGG
GCATGCCATGAAATGATATA

Downstream 100 bases:

>100_bases
CCGGCGCGGCCGGAACCGGCGCCCGGCCTTTTCGCGCCCCCGGCCGGGCGCCGGTGTGATGTCCCTCAGTCCGGGGCGTC
CGTCGCCTCGTTGACGGCGG

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MYHSKDRPMPTADNRLPVTVLSGFLGAGKTTLLNHVLANREGLRVAVIVNDMSEVNIDAELIRAGGGDLSRTQETLVEMT
NGCICCTLRDDLLAEVTRLAREGRFDALVIESTGIAEPLPVAATFEFRDEEGFSLSDLARLDTMVTVVDAANLLKDYAST
DFLRDRGESLGEEDQRTIVDLMVDQIEFADVIVLNKVGATDPEKLRLARAVIKGLNPDARILETNHSQVPLAEVMNTGRF
DFEAAHRHPLWFKELNGFADHVPETEEYGVASFVYRARRPFHPQKFSAFLRRTWPGLIRAKGLFWLATRDAYVGEMSLAG
SLCRTEKLGLWWAAVPKEHWPQDPAFRTELKRYWAPFYGDRRQELVFIGMGLDEAAIRAALDDCLTGPTDPAQLDFAALS
HLPDPFPSWSRQPAVA

Sequences:

>Translated_416_residues
MYHSKDRPMPTADNRLPVTVLSGFLGAGKTTLLNHVLANREGLRVAVIVNDMSEVNIDAELIRAGGGDLSRTQETLVEMT
NGCICCTLRDDLLAEVTRLAREGRFDALVIESTGIAEPLPVAATFEFRDEEGFSLSDLARLDTMVTVVDAANLLKDYAST
DFLRDRGESLGEEDQRTIVDLMVDQIEFADVIVLNKVGATDPEKLRLARAVIKGLNPDARILETNHSQVPLAEVMNTGRF
DFEAAHRHPLWFKELNGFADHVPETEEYGVASFVYRARRPFHPQKFSAFLRRTWPGLIRAKGLFWLATRDAYVGEMSLAG
SLCRTEKLGLWWAAVPKEHWPQDPAFRTELKRYWAPFYGDRRQELVFIGMGLDEAAIRAALDDCLTGPTDPAQLDFAALS
HLPDPFPSWSRQPAVA
>Mature_416_residues
MYHSKDRPMPTADNRLPVTVLSGFLGAGKTTLLNHVLANREGLRVAVIVNDMSEVNIDAELIRAGGGDLSRTQETLVEMT
NGCICCTLRDDLLAEVTRLAREGRFDALVIESTGIAEPLPVAATFEFRDEEGFSLSDLARLDTMVTVVDAANLLKDYAST
DFLRDRGESLGEEDQRTIVDLMVDQIEFADVIVLNKVGATDPEKLRLARAVIKGLNPDARILETNHSQVPLAEVMNTGRF
DFEAAHRHPLWFKELNGFADHVPETEEYGVASFVYRARRPFHPQKFSAFLRRTWPGLIRAKGLFWLATRDAYVGEMSLAG
SLCRTEKLGLWWAAVPKEHWPQDPAFRTELKRYWAPFYGDRRQELVFIGMGLDEAAIRAALDDCLTGPTDPAQLDFAALS
HLPDPFPSWSRQPAVA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=293, Percent_Identity=31.3993174061433, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI148727351, Length=293, Percent_Identity=31.0580204778157, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI126722884, Length=293, Percent_Identity=31.0580204778157, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI146231952, Length=293, Percent_Identity=30.7167235494881, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI223941779, Length=217, Percent_Identity=35.0230414746544, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223941776, Length=282, Percent_Identity=30.4964539007092, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI119120938, Length=143, Percent_Identity=39.8601398601399, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082430, Length=387, Percent_Identity=29.4573643410853, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788499, Length=236, Percent_Identity=27.1186440677966, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=236, Percent_Identity=29.2372881355932, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 46470; Mature: 46470

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHSKDRPMPTADNRLPVTVLSGFLGAGKTTLLNHVLANREGLRVAVIVNDMSEVNIDAE
CCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCHHHCCCCHH
LIRAGGGDLSRTQETLVEMTNGCICCTLRDDLLAEVTRLAREGRFDALVIESTGIAEPLP
HHCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
VAATFEFRDEEGFSLSDLARLDTMVTVVDAANLLKDYASTDFLRDRGESLGEEDQRTIVD
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LMVDQIEFADVIVLNKVGATDPEKLRLARAVIKGLNPDARILETNHSQVPLAEVMNTGRF
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHCCCCC
DFEAAHRHPLWFKELNGFADHVPETEEYGVASFVYRARRPFHPQKFSAFLRRTWPGLIRA
CCHHCCCCCCHHHHHCCHHHCCCCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
KGLFWLATRDAYVGEMSLAGSLCRTEKLGLWWAAVPKEHWPQDPAFRTELKRYWAPFYGD
CCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEECCHHHCCCCCHHHHHHHHHHCCCCCC
RRQELVFIGMGLDEAAIRAALDDCLTGPTDPAQLDFAALSHLPDPFPSWSRQPAVA
CCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYHSKDRPMPTADNRLPVTVLSGFLGAGKTTLLNHVLANREGLRVAVIVNDMSEVNIDAE
CCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCHHHCCCCHH
LIRAGGGDLSRTQETLVEMTNGCICCTLRDDLLAEVTRLAREGRFDALVIESTGIAEPLP
HHCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
VAATFEFRDEEGFSLSDLARLDTMVTVVDAANLLKDYASTDFLRDRGESLGEEDQRTIVD
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LMVDQIEFADVIVLNKVGATDPEKLRLARAVIKGLNPDARILETNHSQVPLAEVMNTGRF
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHCCCCC
DFEAAHRHPLWFKELNGFADHVPETEEYGVASFVYRARRPFHPQKFSAFLRRTWPGLIRA
CCHHCCCCCCHHHHHCCHHHCCCCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
KGLFWLATRDAYVGEMSLAGSLCRTEKLGLWWAAVPKEHWPQDPAFRTELKRYWAPFYGD
CCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEECCHHHCCCCCHHHHHHHHHHCCCCCC
RRQELVFIGMGLDEAAIRAALDDCLTGPTDPAQLDFAALSHLPDPFPSWSRQPAVA
CCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]