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The map label for this gene is ahpC [C]

Identifier: 158422675

GI number: 158422675

Start: 1180735

End: 1181289

Strand: Reverse

Name: ahpC [C]

Synonym: AZC_1051

Alternate gene names: 158422675

Gene position: 1181289-1180735 (Counterclockwise)

Preceding gene: 158422678

Following gene: 158422674

Centisome position: 22.0

GC content: 64.14

Gene sequence:

>555_bases
ATGCTCGGCATCGGCAGCACCCTTCCCGCCTTCTCGGTCACCGGCGTGAAGCCCGGCTTCAACCTCCACGAGGAGAACGG
GCAGTCCGCCTTCGAGACGGTCACGGAAGCGAGCTTCCCCGGTAAGTGGAAGATCATTTTCTTCTATCCGAAGGACTTCA
CCTTCGTCTGCCCGACCGAAATCGCGGAATTCGCGCGCCTTGCGGGCGATTTCGCCGACCGCGACGCCGTGGTGCTCGGC
GGCTCGACGGACAATGAGTTCGTGAAGCTCGCCTGGCGGCGCGACCACAAGGACCTCAACCGCCTGCCCATCTGGTCGTT
CGCCGACACCAACGGCTCGCTGGTGGATGGACTCGGCGTGCGCTCACCCGATGGCGTCGCCTATCGCTACACCTTCATCG
TCGATCCCGACAATGTGGTGCAGCACGTCTATGCGACCAACCTCAATGTCGGCCGCAATCCGAAGGACACGCTGCGCGTG
CTCGACGCCCTGCAGACGGACGAACTGTGCCCCTGCAACCGCGAGGTCGGCGGCGACGTGCTGAAGGTGGCCTGA

Upstream 100 bases:

>100_bases
GCAACGCAACAGCCGTGGCATACGCCTTGCTTGACAGACGTCGACAGCGGCGCGGCCCGACGACGATGGCCCGCCTGCGT
GAGCGATCACGGAGACAGAT

Downstream 100 bases:

>100_bases
GCGGATGAGCATCGAGGCGCTCAAGACCCAGCTTCCCGCTTTTGCGAAGGACGTGAAGCTCAACCTTTCCGCCCTGCCGC
GGGAGGACAGCCTGACCGAA

Product: alkyl hydroperoxide reductase

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MLGIGSTLPAFSVTGVKPGFNLHEENGQSAFETVTEASFPGKWKIIFFYPKDFTFVCPTEIAEFARLAGDFADRDAVVLG
GSTDNEFVKLAWRRDHKDLNRLPIWSFADTNGSLVDGLGVRSPDGVAYRYTFIVDPDNVVQHVYATNLNVGRNPKDTLRV
LDALQTDELCPCNREVGGDVLKVA

Sequences:

>Translated_184_residues
MLGIGSTLPAFSVTGVKPGFNLHEENGQSAFETVTEASFPGKWKIIFFYPKDFTFVCPTEIAEFARLAGDFADRDAVVLG
GSTDNEFVKLAWRRDHKDLNRLPIWSFADTNGSLVDGLGVRSPDGVAYRYTFIVDPDNVVQHVYATNLNVGRNPKDTLRV
LDALQTDELCPCNREVGGDVLKVA
>Mature_184_residues
MLGIGSTLPAFSVTGVKPGFNLHEENGQSAFETVTEASFPGKWKIIFFYPKDFTFVCPTEIAEFARLAGDFADRDAVVLG
GSTDNEFVKLAWRRDHKDLNRLPIWSFADTNGSLVDGLGVRSPDGVAYRYTFIVDPDNVVQHVYATNLNVGRNPKDTLRV
LDALQTDELCPCNREVGGDVLKVA

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=187, Percent_Identity=38.5026737967914, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI4505591, Length=187, Percent_Identity=34.7593582887701, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI32455266, Length=187, Percent_Identity=34.7593582887701, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI32455264, Length=187, Percent_Identity=34.7593582887701, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI5802974, Length=156, Percent_Identity=37.8205128205128, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI32483377, Length=156, Percent_Identity=37.8205128205128, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI33188454, Length=89, Percent_Identity=43.8202247191011, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4758638, Length=163, Percent_Identity=31.2883435582822, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786822, Length=174, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193204376, Length=187, Percent_Identity=37.4331550802139, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565831, Length=187, Percent_Identity=37.4331550802139, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17554494, Length=180, Percent_Identity=37.7777777777778, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25153706, Length=179, Percent_Identity=27.3743016759777, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323613, Length=160, Percent_Identity=40.625, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320661, Length=160, Percent_Identity=37.5, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319407, Length=155, Percent_Identity=31.6129032258064, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17157991, Length=189, Percent_Identity=33.8624338624339, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24641739, Length=189, Percent_Identity=33.8624338624339, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=31.0526315789474, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17738015, Length=153, Percent_Identity=33.9869281045752, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656348, Length=153, Percent_Identity=34.640522875817, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17864676, Length=153, Percent_Identity=34.640522875817, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17975518, Length=197, Percent_Identity=29.4416243654822, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652434, Length=197, Percent_Identity=29.4416243654822, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652436, Length=197, Percent_Identity=29.4416243654822, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20273; Mature: 20273

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIGSTLPAFSVTGVKPGFNLHEENGQSAFETVTEASFPGKWKIIFFYPKDFTFVCPTE
CCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IAEFARLAGDFADRDAVVLGGSTDNEFVKLAWRRDHKDLNRLPIWSFADTNGSLVDGLGV
HHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCEECCCCC
RSPDGVAYRYTFIVDPDNVVQHVYATNLNVGRNPKDTLRVLDALQTDELCPCNREVGGDV
CCCCCEEEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCE
LKVA
EEEC
>Mature Secondary Structure
MLGIGSTLPAFSVTGVKPGFNLHEENGQSAFETVTEASFPGKWKIIFFYPKDFTFVCPTE
CCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IAEFARLAGDFADRDAVVLGGSTDNEFVKLAWRRDHKDLNRLPIWSFADTNGSLVDGLGV
HHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCEECCCCC
RSPDGVAYRYTFIVDPDNVVQHVYATNLNVGRNPKDTLRVLDALQTDELCPCNREVGGDV
CCCCCEEEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCE
LKVA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA