Click here to switch to the map view.

The map label for this gene is sufS [H]

Identifier: 158422671

GI number: 158422671

Start: 1175718

End: 1176998

Strand: Direct

Name: sufS [H]

Synonym: AZC_1047

Alternate gene names: 158422671

Gene position: 1175718-1176998 (Clockwise)

Preceding gene: 158422670

Following gene: 158422676

Centisome position: 21.9

GC content: 66.28

Gene sequence:

>1281_bases
ATGAACATGCATCCTTCCGTCACGCCCCCGACCGTGCCCGCCCATCCGGCGGTGACCGGGGAGGCCTATGACGTGGCGCG
CGTGCGCGCGGATTTCCCCATCCTCGGCCTCAGCGTCTATGGCAAGCCGCTGATCTATCTGGACAATGCAGCGTCCGCCC
AGAAGCCGCAGCAGGTGCTGGACCGCATCACGCAGGTCTATGCGTCGGAATATTCCAACGTGCACCGGGGCCTGCATTAT
CTCGCCAATGCAGCGACCGAGGCTTATGAGGGCGCCCGCGAGAAGGTGCGCGCCTTCCTCAATGCGCCGAGCACGGAAGA
GATCATCTTCACCAAGGGTGCGACGGAGGCCATCAACCTCGTGGCCCACACTTTCGGCCGCACGCGCGTTGGCGCGGGCG
ATGAGATCGTGCTCTCCATCATGGAGCACCACGCCAATGTGGTGCCCTGGCATTTCCTGCGCGAGCGGCAGGGCGCGGTG
CTGAAATGGGCGCCGGTGGACGACGAGGGCAACTTCCTCCTCGACGAATTCGAGGCCCTGCTCACCGAGCGCACCAAGCT
TGTCGCCATCACCCAGATGTCCAACGTGCTCGGCACGGTGGTGCCGGTGAAGGAGGTGGTGCGCCGCGCCCATGCCCGGG
GCATCCCGGTGCTGGTGGATGGGTCGCAGGCCAGCGTCCATATGGACGTGGACGTGCAGGACATCGATTGCGATTTCTAT
ATCATCACCGGCCACAAGCTCTATGGGCCGACGGGCATTGGGGCACTCTACGGCAAGGCGGAGATGCTCGCCGGGCTGCC
GCCGTTCAATGGCGGCGGGGAGATGATCCGCGAGGTGTCGCGCGACACCGTCACCTATGGCGCGCCGCCCCATCGCTTTG
AGGCGGGCACTCCGCCCATCGTGCAGGCGGCGGGGCTCGGCGCGGCGCTGGATTACATGGCCTCCCTCGGCAAGGCGCGC
ATCCAGGCCCATGAGGCGGATCTCTTGGCCTATGCGCAGGAGCGCCTGTCGGAAATTTCCGGCCTCAAAGTCTATGGCAC
GGCGGCGGAGAAGGGGGCGCTCATCTCCTTCTCTCTGGAGAATACGCACGCCCATGACGTCGCGACGGTGATCGACCGCT
CCGGCGTGGCGGTGCGCGCCGGCACCCATTGCGCCATGCCGCTGCTGGAGCGCTTCGGTGTCGCCGCCACCTGCCGCGCC
TCCTTCGCCCTCTACAACACGCGCGGCGATGTGGATGCGCTGGCGGAGGCCCTGATCAAGGCGCGCAGTTTCTTCGCCTG
A

Upstream 100 bases:

>100_bases
TCCAGGCCTTCATCGGCGAGGTGCTGGACGGCATCGCGCACGAGGGCGTCCGCGAGGCGTTGACCGCCGCAACGGTGAGC
TGGCTGGAGGCGCGCGGCGC

Downstream 100 bases:

>100_bases
GGAAGCCACGCGTCGGCGCGGGACCGTGGGGGCGCGGCCCCGCGCCTCCCTTCTGGTGTCCGCCCATGTGCGCCGGCAAG
ACCGCCGGATGGCGGTACGA

Product: cysteine desulphurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNMHPSVTPPTVPAHPAVTGEAYDVARVRADFPILGLSVYGKPLIYLDNAASAQKPQQVLDRITQVYASEYSNVHRGLHY
LANAATEAYEGAREKVRAFLNAPSTEEIIFTKGATEAINLVAHTFGRTRVGAGDEIVLSIMEHHANVVPWHFLRERQGAV
LKWAPVDDEGNFLLDEFEALLTERTKLVAITQMSNVLGTVVPVKEVVRRAHARGIPVLVDGSQASVHMDVDVQDIDCDFY
IITGHKLYGPTGIGALYGKAEMLAGLPPFNGGGEMIREVSRDTVTYGAPPHRFEAGTPPIVQAAGLGAALDYMASLGKAR
IQAHEADLLAYAQERLSEISGLKVYGTAAEKGALISFSLENTHAHDVATVIDRSGVAVRAGTHCAMPLLERFGVAATCRA
SFALYNTRGDVDALAEALIKARSFFA

Sequences:

>Translated_426_residues
MNMHPSVTPPTVPAHPAVTGEAYDVARVRADFPILGLSVYGKPLIYLDNAASAQKPQQVLDRITQVYASEYSNVHRGLHY
LANAATEAYEGAREKVRAFLNAPSTEEIIFTKGATEAINLVAHTFGRTRVGAGDEIVLSIMEHHANVVPWHFLRERQGAV
LKWAPVDDEGNFLLDEFEALLTERTKLVAITQMSNVLGTVVPVKEVVRRAHARGIPVLVDGSQASVHMDVDVQDIDCDFY
IITGHKLYGPTGIGALYGKAEMLAGLPPFNGGGEMIREVSRDTVTYGAPPHRFEAGTPPIVQAAGLGAALDYMASLGKAR
IQAHEADLLAYAQERLSEISGLKVYGTAAEKGALISFSLENTHAHDVATVIDRSGVAVRAGTHCAMPLLERFGVAATCRA
SFALYNTRGDVDALAEALIKARSFFA
>Mature_426_residues
MNMHPSVTPPTVPAHPAVTGEAYDVARVRADFPILGLSVYGKPLIYLDNAASAQKPQQVLDRITQVYASEYSNVHRGLHY
LANAATEAYEGAREKVRAFLNAPSTEEIIFTKGATEAINLVAHTFGRTRVGAGDEIVLSIMEHHANVVPWHFLRERQGAV
LKWAPVDDEGNFLLDEFEALLTERTKLVAITQMSNVLGTVVPVKEVVRRAHARGIPVLVDGSQASVHMDVDVQDIDCDFY
IITGHKLYGPTGIGALYGKAEMLAGLPPFNGGGEMIREVSRDTVTYGAPPHRFEAGTPPIVQAAGLGAALDYMASLGKAR
IQAHEADLLAYAQERLSEISGLKVYGTAAEKGALISFSLENTHAHDVATVIDRSGVAVRAGTHCAMPLLERFGVAATCRA
SFALYNTRGDVDALAEALIKARSFFA

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=270, Percent_Identity=29.2592592592593, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI156713448, Length=329, Percent_Identity=29.7872340425532, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1787970, Length=397, Percent_Identity=49.6221662468514, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1789175, Length=399, Percent_Identity=41.6040100250627, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI48994898, Length=268, Percent_Identity=29.4776119402985, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=213, Percent_Identity=30.9859154929577, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=389, Percent_Identity=24.1645244215938, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=251, Percent_Identity=31.8725099601594, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129463, Length=302, Percent_Identity=31.4569536423841, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45896; Mature: 45896

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMHPSVTPPTVPAHPAVTGEAYDVARVRADFPILGLSVYGKPLIYLDNAASAQKPQQVL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCHHHHH
DRITQVYASEYSNVHRGLHYLANAATEAYEGAREKVRAFLNAPSTEEIIFTKGATEAINL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
VAHTFGRTRVGAGDEIVLSIMEHHANVVPWHFLRERQGAVLKWAPVDDEGNFLLDEFEAL
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
LTERTKLVAITQMSNVLGTVVPVKEVVRRAHARGIPVLVDGSQASVHMDVDVQDIDCDFY
HHCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEECCCEE
IITGHKLYGPTGIGALYGKAEMLAGLPPFNGGGEMIREVSRDTVTYGAPPHRFEAGTPPI
EEECCEEECCCCCHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCEECCCCCCCCCCCCCCH
VQAAGLGAALDYMASLGKARIQAHEADLLAYAQERLSEISGLKVYGTAAEKGALISFSLE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEC
NTHAHDVATVIDRSGVAVRAGTHCAMPLLERFGVAATCRASFALYNTRGDVDALAEALIK
CCCHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCHHHHHHEEEEEECCCCHHHHHHHHHH
ARSFFA
HHHHCC
>Mature Secondary Structure
MNMHPSVTPPTVPAHPAVTGEAYDVARVRADFPILGLSVYGKPLIYLDNAASAQKPQQVL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCHHHHH
DRITQVYASEYSNVHRGLHYLANAATEAYEGAREKVRAFLNAPSTEEIIFTKGATEAINL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
VAHTFGRTRVGAGDEIVLSIMEHHANVVPWHFLRERQGAVLKWAPVDDEGNFLLDEFEAL
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
LTERTKLVAITQMSNVLGTVVPVKEVVRRAHARGIPVLVDGSQASVHMDVDVQDIDCDFY
HHCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEECCCEE
IITGHKLYGPTGIGALYGKAEMLAGLPPFNGGGEMIREVSRDTVTYGAPPHRFEAGTPPI
EEECCEEECCCCCHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCEECCCCCCCCCCCCCCH
VQAAGLGAALDYMASLGKARIQAHEADLLAYAQERLSEISGLKVYGTAAEKGALISFSLE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEC
NTHAHDVATVIDRSGVAVRAGTHCAMPLLERFGVAATCRASFALYNTRGDVDALAEALIK
CCCHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCHHHHHHEEEEEECCCCHHHHHHHHHH
ARSFFA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11251816 [H]