Click here to switch to the map view.

The map label for this gene is cya [H]

Identifier: 158422624

GI number: 158422624

Start: 1118337

End: 1119476

Strand: Direct

Name: cya [H]

Synonym: AZC_1000

Alternate gene names: 158422624

Gene position: 1118337-1119476 (Clockwise)

Preceding gene: 158422623

Following gene: 158422628

Centisome position: 20.83

GC content: 66.49

Gene sequence:

>1140_bases
ATGCCGGACATCATCGGAAGTGAAGATCGCGATATCCTCTGGGGCGTTGTCGGATCGAAGAATATTCTTCTCGGCCTCGG
TGGGGACGACGTCCTCCACGGCCAGAACCTGGCCGACCATCTGGAAGGCGCGCGCGGCGACGACTGGCTTTACGGCGCCG
GCGGCAACGACACGCTGATCGGCGGTGAGGGCAACGATGTCCTGAACGGCGGCGCAGGCGCCGACCTGCTCATCGGTGGC
ACCGGCATCGACACGGTGGACTATTCCGCCAGTGGCGGCGCCGCGCAGGTGGGCGTCACTGTCGACCTCTCAGCCGGCGA
AGGCAGCGGCGGCGAGGCCGAGGGCGATCTCTATTTCGGCATCGAGAACATCATCGGCACCAGCGCCGCCGATACGCTCC
TCGGCAATGCAGGTGCCAACGTCATCGATGCCGGCGCATCCGCCATCGCGGGCGACGTGATCCTGGCCGGTGGCGGCGAC
GATACGGTCCTGATCGGCGCCAATGCGGCGACGGCGGATGGCGGCGACGGCTTCGACCGTCTGGTGCTGAACCTCGGCAC
GGAAGGATCGACCACCGGCGCCACCTTCGTCTTCGACAGCGGTGCCACCAGCCTTGGCGCCACCTTCACCAATTTCGAGA
CGGTGACCGTCACCGGCACGGCGGCCACAGACACGGTGTTCGGCGGCGCGGGCGATGATGTGCTCGATGGCGGGGCGGGC
CGCGATTATCTGCGCGGCGGCGCCGGAGGCGACGTGCTTATCGGCGGTGTCGGCCACGATTCCCTGCGCGGCGGCGATGG
CGACGACCGGCTGGAAGGCGGCTGGGGCAACGACTTCCTCGTCGGCGGCAAGGGGTCGGACACCTTCGTCTATGACGACC
TGAATTCCAGCCGCGACCGCATCATCGACTTTCAAGCCGGAGATGGCGGCGACAAGCTGGAACTGTCCCTGCTGCGGCAG
GACGTGTCGCACATCCACTCGTTCGACGATCTTCTGGCCCACGCCACCGATACGGCGCAAGGCGTCTATATCGACCTCTC
AGGCGACCTGCACTGGCCCATCGGTATCATCCTGCAAGGCGTGCATGTGGCGGATCTCACCGCCGACAACCTCTCCTTGC
CGGATCACGGCATCGGCTGA

Upstream 100 bases:

>100_bases
ATCGCGCGCATTTCCGCTGAAAAAAGAACGAATATTAAAATATTCGACGCTAACGCCGAAATCGACATGATGCCACTGCC
ACGCTGGCGGGAGTGGGATC

Downstream 100 bases:

>100_bases
GCGGTCAGCGCATGCCAGAGAGGCCGGGCGGGGCGAGGGGGTTGTCCGTCATCGCCGCCCGGTCCGGCGTGTCCACCGAG
GGCACACCAAGGAAGGCCTC

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MPDIIGSEDRDILWGVVGSKNILLGLGGDDVLHGQNLADHLEGARGDDWLYGAGGNDTLIGGEGNDVLNGGAGADLLIGG
TGIDTVDYSASGGAAQVGVTVDLSAGEGSGGEAEGDLYFGIENIIGTSAADTLLGNAGANVIDAGASAIAGDVILAGGGD
DTVLIGANAATADGGDGFDRLVLNLGTEGSTTGATFVFDSGATSLGATFTNFETVTVTGTAATDTVFGGAGDDVLDGGAG
RDYLRGGAGGDVLIGGVGHDSLRGGDGDDRLEGGWGNDFLVGGKGSDTFVYDDLNSSRDRIIDFQAGDGGDKLELSLLRQ
DVSHIHSFDDLLAHATDTAQGVYIDLSGDLHWPIGIILQGVHVADLTADNLSLPDHGIG

Sequences:

>Translated_379_residues
MPDIIGSEDRDILWGVVGSKNILLGLGGDDVLHGQNLADHLEGARGDDWLYGAGGNDTLIGGEGNDVLNGGAGADLLIGG
TGIDTVDYSASGGAAQVGVTVDLSAGEGSGGEAEGDLYFGIENIIGTSAADTLLGNAGANVIDAGASAIAGDVILAGGGD
DTVLIGANAATADGGDGFDRLVLNLGTEGSTTGATFVFDSGATSLGATFTNFETVTVTGTAATDTVFGGAGDDVLDGGAG
RDYLRGGAGGDVLIGGVGHDSLRGGDGDDRLEGGWGNDFLVGGKGSDTFVYDDLNSSRDRIIDFQAGDGGDKLELSLLRQ
DVSHIHSFDDLLAHATDTAQGVYIDLSGDLHWPIGIILQGVHVADLTADNLSLPDHGIG
>Mature_378_residues
PDIIGSEDRDILWGVVGSKNILLGLGGDDVLHGQNLADHLEGARGDDWLYGAGGNDTLIGGEGNDVLNGGAGADLLIGGT
GIDTVDYSASGGAAQVGVTVDLSAGEGSGGEAEGDLYFGIENIIGTSAADTLLGNAGANVIDAGASAIAGDVILAGGGDD
TVLIGANAATADGGDGFDRLVLNLGTEGSTTGATFVFDSGATSLGATFTNFETVTVTGTAATDTVFGGAGDDVLDGGAGR
DYLRGGAGGDVLIGGVGHDSLRGGDGDDRLEGGWGNDFLVGGKGSDTFVYDDLNSSRDRIIDFQAGDGGDKLELSLLRQD
VSHIHSFDDLLAHATDTAQGVYIDLSGDLHWPIGIILQGVHVADLTADNLSLPDHGIG

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 37747; Mature: 37616

Theoretical pI: Translated: 3.69; Mature: 3.69

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIIGSEDRDILWGVVGSKNILLGLGGDDVLHGQNLADHLEGARGDDWLYGAGGNDTLI
CCCCCCCCCCEEEEEEECCCEEEEECCCCCEECCCCHHHHHCCCCCCCEEEECCCCCEEE
GGEGNDVLNGGAGADLLIGGTGIDTVDYSASGGAAQVGVTVDLSAGEGSGGEAEGDLYFG
CCCCCCEECCCCCCEEEEECCCCCCEEECCCCCCEEEEEEEEEECCCCCCCCCCCEEEEE
IENIIGTSAADTLLGNAGANVIDAGASAIAGDVILAGGGDDTVLIGANAATADGGDGFDR
HHHHHCCCHHHHHHCCCCCCEEECCCCCEECCEEEECCCCCEEEEECCCCCCCCCCCCEE
LVLNLGTEGSTTGATFVFDSGATSLGATFTNFETVTVTGTAATDTVFGGAGDDVLDGGAG
EEEEECCCCCCCCEEEEECCCCCCCCCEEECEEEEEEECCCCCCEEECCCCCHHCCCCCC
RDYLRGGAGGDVLIGGVGHDSLRGGDGDDRLEGGWGNDFLVGGKGSDTFVYDDLNSSRDR
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCCCCE
IIDFQAGDGGDKLELSLLRQDVSHIHSFDDLLAHATDTAQGVYIDLSGDLHWPIGIILQG
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHEEEC
VHVADLTADNLSLPDHGIG
CEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PDIIGSEDRDILWGVVGSKNILLGLGGDDVLHGQNLADHLEGARGDDWLYGAGGNDTLI
CCCCCCCCCEEEEEEECCCEEEEECCCCCEECCCCHHHHHCCCCCCCEEEECCCCCEEE
GGEGNDVLNGGAGADLLIGGTGIDTVDYSASGGAAQVGVTVDLSAGEGSGGEAEGDLYFG
CCCCCCEECCCCCCEEEEECCCCCCEEECCCCCCEEEEEEEEEECCCCCCCCCCCEEEEE
IENIIGTSAADTLLGNAGANVIDAGASAIAGDVILAGGGDDTVLIGANAATADGGDGFDR
HHHHHCCCHHHHHHCCCCCCEEECCCCCEECCEEEECCCCCEEEEECCCCCCCCCCCCEE
LVLNLGTEGSTTGATFVFDSGATSLGATFTNFETVTVTGTAATDTVFGGAGDDVLDGGAG
EEEEECCCCCCCCEEEEECCCCCCCCCEEECEEEEEEECCCCCCEEECCCCCHHCCCCCC
RDYLRGGAGGDVLIGGVGHDSLRGGDGDDRLEGGWGNDFLVGGKGSDTFVYDDLNSSRDR
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCCCCE
IIDFQAGDGGDKLELSLLRQDVSHIHSFDDLLAHATDTAQGVYIDLSGDLHWPIGIILQG
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHEEEC
VHVADLTADNLSLPDHGIG
CEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]