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The map label for this gene is iclR [H]

Identifier: 158422617

GI number: 158422617

Start: 1110617

End: 1111372

Strand: Reverse

Name: iclR [H]

Synonym: AZC_0993

Alternate gene names: 158422617

Gene position: 1111372-1110617 (Counterclockwise)

Preceding gene: 158422622

Following gene: 158422616

Centisome position: 20.7

GC content: 67.59

Gene sequence:

>756_bases
ATGAAGCAGACGGATTTCATCGGCGGTTTGGCCAAGGGGCTGAAGGTGATGGAGGCCTTCGGCTCCGGGCAGCCGGGCAT
GACCATCGCCCAGATGTCGGAAGCGACCGGCCTCGATCGGGCCACCGCCCGGCGCTGCTTGCTGACGCTCGTGGAACTGG
GCTACGCCCGCACCGACGGCAAGCATTTCGAGCTCACCCCCAAGGTGCTGCGGCTCGGCACCGCCTATCTGTCTGCGACG
CCCCTGCCGCAACTGCTCCAGCCGCATCTGGAAGCCCTGTCCAAGGACGTGGGGCAGAGCGCATCGGCGAGCGTGCTGGA
AGGCACGGAGATCGTTTACATCGCCCGCGCCTCCCAGCGACGGGTCATGTCCATCAACCTCATGCCCGGCTCACGCCTGC
CGGCCTGGTGCGCCTCCATGGGCCGCGTGCTTCTGGCGGCACTGCCGCCGGACCAAGCCATCGCCCTGCTGGACCGTTCC
GACATCCGCCCCCTCACGCCCCACACCAAGGTCGCGCGGAATGACCTGCTCGAGGAGCTCGCCCGCGTGCGGACGCAGGG
CTATGCGATCATCGATCAGGAACTGGAACTCGGGCTGTGCTCCATCGCCGTTCCCCTGAAGGATTCTCGCGGCCGGACTG
TCGCCGCGCTCAATATCGGCGCGCCCGCGGCGGCCGTCACGGTGAGCGACATGCCCTCCGATTATCTGCCCGCCATGTTG
CGCGTGCAGGAGGAGTTGCGGGTGCTCCTGAGCTGA

Upstream 100 bases:

>100_bases
TCTGGCCCTGAGGAACGGATAGGCCCGGTCCCTATCGACAGCAAGGCATTTGTGCGATATTCGATTTTTGTTCAAATATC
GCACACCTCACGAGCGCGCC

Downstream 100 bases:

>100_bases
ACCCGTCACCCAAAGACCGGCACCCCGGGCTCCTGCGGCAATGCGGCACAGTGCTCCGCGTCCCGCTTTCGCCCCTGCCC
TACGCCTAAAATCGGCATCG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKQTDFIGGLAKGLKVMEAFGSGQPGMTIAQMSEATGLDRATARRCLLTLVELGYARTDGKHFELTPKVLRLGTAYLSAT
PLPQLLQPHLEALSKDVGQSASASVLEGTEIVYIARASQRRVMSINLMPGSRLPAWCASMGRVLLAALPPDQAIALLDRS
DIRPLTPHTKVARNDLLEELARVRTQGYAIIDQELELGLCSIAVPLKDSRGRTVAALNIGAPAAAVTVSDMPSDYLPAML
RVQEELRVLLS

Sequences:

>Translated_251_residues
MKQTDFIGGLAKGLKVMEAFGSGQPGMTIAQMSEATGLDRATARRCLLTLVELGYARTDGKHFELTPKVLRLGTAYLSAT
PLPQLLQPHLEALSKDVGQSASASVLEGTEIVYIARASQRRVMSINLMPGSRLPAWCASMGRVLLAALPPDQAIALLDRS
DIRPLTPHTKVARNDLLEELARVRTQGYAIIDQELELGLCSIAVPLKDSRGRTVAALNIGAPAAAVTVSDMPSDYLPAML
RVQEELRVLLS
>Mature_251_residues
MKQTDFIGGLAKGLKVMEAFGSGQPGMTIAQMSEATGLDRATARRCLLTLVELGYARTDGKHFELTPKVLRLGTAYLSAT
PLPQLLQPHLEALSKDVGQSASASVLEGTEIVYIARASQRRVMSINLMPGSRLPAWCASMGRVLLAALPPDQAIALLDRS
DIRPLTPHTKVARNDLLEELARVRTQGYAIIDQELELGLCSIAVPLKDSRGRTVAALNIGAPAAAVTVSDMPSDYLPAML
RVQEELRVLLS

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1789999, Length=215, Percent_Identity=30.2325581395349, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87082359, Length=247, Percent_Identity=25.5060728744939, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786468, Length=231, Percent_Identity=28.1385281385281, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788131, Length=223, Percent_Identity=28.6995515695067, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693096, Length=258, Percent_Identity=31.0077519379845, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786715, Length=220, Percent_Identity=23.6363636363636, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 26983; Mature: 26983

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTDFIGGLAKGLKVMEAFGSGQPGMTIAQMSEATGLDRATARRCLLTLVELGYARTDG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
KHFELTPKVLRLGTAYLSATPLPQLLQPHLEALSKDVGQSASASVLEGTEIVYIARASQR
CEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEECCCC
RVMSINLMPGSRLPAWCASMGRVLLAALPPDQAIALLDRSDIRPLTPHTKVARNDLLEEL
EEEEEEECCCCCCHHHHHHHHHHEEEECCCCHHEEEECCCCCCCCCCCHHHHHHHHHHHH
ARVRTQGYAIIDQELELGLCSIAVPLKDSRGRTVAALNIGAPAAAVTVSDMPSDYLPAML
HHHHHCCCEEEECCHHCCEEEEEEECCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHH
RVQEELRVLLS
HHHHHHHHHCC
>Mature Secondary Structure
MKQTDFIGGLAKGLKVMEAFGSGQPGMTIAQMSEATGLDRATARRCLLTLVELGYARTDG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
KHFELTPKVLRLGTAYLSATPLPQLLQPHLEALSKDVGQSASASVLEGTEIVYIARASQR
CEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEECCCC
RVMSINLMPGSRLPAWCASMGRVLLAALPPDQAIALLDRSDIRPLTPHTKVARNDLLEEL
EEEEEEECCCCCCHHHHHHHHHHEEEECCCCHHEEEECCCCCCCCCCCHHHHHHHHHHHH
ARVRTQGYAIIDQELELGLCSIAVPLKDSRGRTVAALNIGAPAAAVTVSDMPSDYLPAML
HHHHHCCCEEEECCHHCCEEEEEEECCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHH
RVQEELRVLLS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]