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The map label for this gene is thrS [H]

Identifier: 158422571

GI number: 158422571

Start: 1056677

End: 1058587

Strand: Direct

Name: thrS [H]

Synonym: AZC_0947

Alternate gene names: 158422571

Gene position: 1056677-1058587 (Clockwise)

Preceding gene: 158422570

Following gene: 158422572

Centisome position: 19.68

GC content: 65.57

Gene sequence:

>1911_bases
GTGGCCGCAGCCATTTCCAAGTCGCTCCTCAAGAAGGCGGTTGCCGTGACCCTCGACGGGGCGCTGACCGACCTGTCCGA
GCCGATCACCAAGGACGCCCGCATCGAGATCGTGACGCGCGATGATCCGCGCGCGCTCGAACTCATCCGCCACGACGCCG
CCCATGTGCTGGCCGAGGCGGTGCAGGAGCTGTTTCCGGGCACGCAGGTGACCATCGGCCCGGTGATCGAGAACGGCTTC
TATTACGATTTCGCCCGTAACGAGCCCTTCACCACCGACGATCTGCCGAAGATCGAGGCGAAGATGAAGGAGATCATCGC
CCGCGACAAACCCTTCACCAAGGAAGTGTGGTCGCGTGACGAGGCCAAGCGCGTGTTCCGCGACAAGGGCGAGGCGTTCA
AGGTCGAGCTGGTGGATGCCATCCCCGAGGACCAGGACGTCAAGATCTACAAGCAGGGCGAGTGGTTCGACCTTTGCCGT
GGGCCGCACATGCCCTCCACGGGCAAGATCGGCACCGCCTTCAAGCTCATGAAGGTGGCCGGCGCCTATTGGCGCGGCGA
CAGCAACAACCCCATGCTCACCCGCATCTACGGCACGGCGTGGAAGGACCAGAGCGAGCTCGACGCCTATCTGCACCGTC
TGGAAGAGGCGGAGAAGCGCGACCATCGCCGCCTCGGCCGGGAGATGGACCTCTTCCACTTCCAGGAGGAAGGGCCGGGC
GTCGTCTTCTGGCACCCGAAGGGCTGGAGCCTGTTCCAGGGCCTCGTCTCCTACATGCGCCGCCGCCTCAAGGCCGATTA
CAATGAGGTCAATGCCCCGCAGGTGCTCGACAAGAGCCTGTGGGAGACCTCCGGCCACTGGGGCTGGTACAAGGAGAACA
TGTTCAAGGTGCAGTCGGCCGGCGAAGAGACCGGCGACGAGCGCGTGTTCGCCCTGAAGCCCATGAACTGCCCCGGCCAT
GTGCAGATCTTCAAGCATGGCCTGAAGTCCTATCGCGACCTGCCGCTGCGCCTCGCCGAGTTCGGCGCGGTGCACCGCTA
CGAGCCCTCGGGCGCGTTGCACGGCCTCATGCGCGTGCGCGGCTTCACGCAGGACGACGCCCATGTCTTCTGCACCGAGG
AGCAGATGGCGGCGGAGTGCCTGAAGATCAACGATCTGATCCTCTCCACCTATGCCGACTTCGGCTTCGAGGAGATCACG
GTGAAGCTGTCCACCCGCCCCGAGAAGCGCGTGGGGTCCGACGCGGTGTGGGATCATGCCGAGGACGTCATGTCCCGCGT
GCTCAAGCAGATCGAGGCGGAATCCGGCGGGCGCATCAAGACCGGCATCCTGCCGGGCGAGGGCGCCTTCTACGGTCCGA
AGTTCGAGTATACGCTCTCGGACGCCATCGGCCGTGAGTGGCAGTGCGGCACCACGCAGGTGGACTTCAACCTGCCGGAG
CGCTTCGGCGCCTTCTATGTGGATGCCGACGGCCAGAAGAAGACGCCGGTGATGATCCACCGCGCCATCTGCGGCTCCAT
GGAGCGCTTCACCGGCATCCTGATCGAGCACTTCGCCGGTCATTTCCCGCTGTGGCTCGCCCCCGTGCAGCTCGCGGTCT
GCACCATCACGCAGGAGGCGGACGACTATGCCGCCGAGGTGGCCTCCGCGGCGCGGGCGCTGGACCTGAAAGTGGAACTC
GACACGCGCAACGAGAAGATCTCCTACAAGGTTCGCGAGCACTCGCTGGCCAAGATCCCGGTGCAGTTCGCGCTGGGCAA
GAAGGAGGCCGCCGAGCGCACCGTCTCCATCCGCCGCCTCGGCAGCCAGGAGCAGAAGGTGCTTCCCCTGGAGGAAGCGC
TGAAGCTGCTGGCGGACGAAGCCGTGCCGCCGGACCTGAAGCGCCGCGCGGCGGTTACGAAGGCCGCCTGA

Upstream 100 bases:

>100_bases
GCGGGGTACGCAGGAGTGGGCAGGAGAAGAAGCCATGCTGACCTTGACCTTTCCCGATGGCGCGCAGCGCGAGTATGCCC
CCGGGACCCGCGGCGCCGAT

Downstream 100 bases:

>100_bases
GCGCTTCCGAAATCAGCGACGCGGGTATCATGATCCGCGTCGCCGCTTCTGGCTTGTCCCAGGCTGACTGACCCCCCTGG
CGATTTCCTGCCCCTTTTGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MAAAISKSLLKKAVAVTLDGALTDLSEPITKDARIEIVTRDDPRALELIRHDAAHVLAEAVQELFPGTQVTIGPVIENGF
YYDFARNEPFTTDDLPKIEAKMKEIIARDKPFTKEVWSRDEAKRVFRDKGEAFKVELVDAIPEDQDVKIYKQGEWFDLCR
GPHMPSTGKIGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWKDQSELDAYLHRLEEAEKRDHRRLGREMDLFHFQEEGPG
VVFWHPKGWSLFQGLVSYMRRRLKADYNEVNAPQVLDKSLWETSGHWGWYKENMFKVQSAGEETGDERVFALKPMNCPGH
VQIFKHGLKSYRDLPLRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHVFCTEEQMAAECLKINDLILSTYADFGFEEIT
VKLSTRPEKRVGSDAVWDHAEDVMSRVLKQIEAESGGRIKTGILPGEGAFYGPKFEYTLSDAIGREWQCGTTQVDFNLPE
RFGAFYVDADGQKKTPVMIHRAICGSMERFTGILIEHFAGHFPLWLAPVQLAVCTITQEADDYAAEVASAARALDLKVEL
DTRNEKISYKVREHSLAKIPVQFALGKKEAAERTVSIRRLGSQEQKVLPLEEALKLLADEAVPPDLKRRAAVTKAA

Sequences:

>Translated_636_residues
MAAAISKSLLKKAVAVTLDGALTDLSEPITKDARIEIVTRDDPRALELIRHDAAHVLAEAVQELFPGTQVTIGPVIENGF
YYDFARNEPFTTDDLPKIEAKMKEIIARDKPFTKEVWSRDEAKRVFRDKGEAFKVELVDAIPEDQDVKIYKQGEWFDLCR
GPHMPSTGKIGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWKDQSELDAYLHRLEEAEKRDHRRLGREMDLFHFQEEGPG
VVFWHPKGWSLFQGLVSYMRRRLKADYNEVNAPQVLDKSLWETSGHWGWYKENMFKVQSAGEETGDERVFALKPMNCPGH
VQIFKHGLKSYRDLPLRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHVFCTEEQMAAECLKINDLILSTYADFGFEEIT
VKLSTRPEKRVGSDAVWDHAEDVMSRVLKQIEAESGGRIKTGILPGEGAFYGPKFEYTLSDAIGREWQCGTTQVDFNLPE
RFGAFYVDADGQKKTPVMIHRAICGSMERFTGILIEHFAGHFPLWLAPVQLAVCTITQEADDYAAEVASAARALDLKVEL
DTRNEKISYKVREHSLAKIPVQFALGKKEAAERTVSIRRLGSQEQKVLPLEEALKLLADEAVPPDLKRRAAVTKAA
>Mature_635_residues
AAAISKSLLKKAVAVTLDGALTDLSEPITKDARIEIVTRDDPRALELIRHDAAHVLAEAVQELFPGTQVTIGPVIENGFY
YDFARNEPFTTDDLPKIEAKMKEIIARDKPFTKEVWSRDEAKRVFRDKGEAFKVELVDAIPEDQDVKIYKQGEWFDLCRG
PHMPSTGKIGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWKDQSELDAYLHRLEEAEKRDHRRLGREMDLFHFQEEGPGV
VFWHPKGWSLFQGLVSYMRRRLKADYNEVNAPQVLDKSLWETSGHWGWYKENMFKVQSAGEETGDERVFALKPMNCPGHV
QIFKHGLKSYRDLPLRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHVFCTEEQMAAECLKINDLILSTYADFGFEEITV
KLSTRPEKRVGSDAVWDHAEDVMSRVLKQIEAESGGRIKTGILPGEGAFYGPKFEYTLSDAIGREWQCGTTQVDFNLPER
FGAFYVDADGQKKTPVMIHRAICGSMERFTGILIEHFAGHFPLWLAPVQLAVCTITQEADDYAAEVASAARALDLKVELD
TRNEKISYKVREHSLAKIPVQFALGKKEAAERTVSIRRLGSQEQKVLPLEEALKLLADEAVPPDLKRRAAVTKAA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=602, Percent_Identity=38.8704318936877, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI38202255, Length=602, Percent_Identity=38.8704318936877, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI20070344, Length=634, Percent_Identity=37.8548895899054, Blast_Score=418, Evalue=1e-117,
Organism=Escherichia coli, GI1788013, Length=630, Percent_Identity=48.8888888888889, Blast_Score=637, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=602, Percent_Identity=39.5348837209302, Blast_Score=446, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71984184, Length=602, Percent_Identity=39.5348837209302, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322112, Length=643, Percent_Identity=38.8802488335925, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=405, Percent_Identity=38.5185185185185, Blast_Score=272, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24583842, Length=628, Percent_Identity=37.8980891719745, Blast_Score=427, Evalue=1e-119,
Organism=Drosophila melanogaster, GI28574141, Length=628, Percent_Identity=37.8980891719745, Blast_Score=427, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24583839, Length=628, Percent_Identity=37.8980891719745, Blast_Score=427, Evalue=1e-119,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 71864; Mature: 71732

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAISKSLLKKAVAVTLDGALTDLSEPITKDARIEIVTRDDPRALELIRHDAAHVLAEA
CCHHHHHHHHHHHHHHEECCHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VQELFPGTQVTIGPVIENGFYYDFARNEPFTTDDLPKIEAKMKEIIARDKPFTKEVWSRD
HHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCH
EAKRVFRDKGEAFKVELVDAIPEDQDVKIYKQGEWFDLCRGPHMPSTGKIGTAFKLMKVA
HHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHH
GAYWRGDSNNPMLTRIYGTAWKDQSELDAYLHRLEEAEKRDHRRLGREMDLFHFQEEGPG
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
VVFWHPKGWSLFQGLVSYMRRRLKADYNEVNAPQVLDKSLWETSGHWGWYKENMFKVQSA
EEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GEETGDERVFALKPMNCPGHVQIFKHGLKSYRDLPLRLAEFGAVHRYEPSGALHGLMRVR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCEEECCCHHHHHHHHHC
GFTQDDAHVFCTEEQMAAECLKINDLILSTYADFGFEEITVKLSTRPEKRVGSDAVWDHA
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHCCCCHHHHHH
EDVMSRVLKQIEAESGGRIKTGILPGEGAFYGPKFEYTLSDAIGREWQCGTTQVDFNLPE
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEHHHCCCCCCCCCEEEECCCHH
RFGAFYVDADGQKKTPVMIHRAICGSMERFTGILIEHFAGHFPLWLAPVQLAVCTITQEA
HHCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCH
DDYAAEVASAARALDLKVELDTRNEKISYKVREHSLAKIPVQFALGKKEAAERTVSIRRL
HHHHHHHHHHHHHEEEEEEECCCCCEEEEEEHHCCHHHCCHHHHCCCHHHHHHHHHHHHC
GSQEQKVLPLEEALKLLADEAVPPDLKRRAAVTKAA
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AAAISKSLLKKAVAVTLDGALTDLSEPITKDARIEIVTRDDPRALELIRHDAAHVLAEA
CHHHHHHHHHHHHHHEECCHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VQELFPGTQVTIGPVIENGFYYDFARNEPFTTDDLPKIEAKMKEIIARDKPFTKEVWSRD
HHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCH
EAKRVFRDKGEAFKVELVDAIPEDQDVKIYKQGEWFDLCRGPHMPSTGKIGTAFKLMKVA
HHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHH
GAYWRGDSNNPMLTRIYGTAWKDQSELDAYLHRLEEAEKRDHRRLGREMDLFHFQEEGPG
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
VVFWHPKGWSLFQGLVSYMRRRLKADYNEVNAPQVLDKSLWETSGHWGWYKENMFKVQSA
EEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GEETGDERVFALKPMNCPGHVQIFKHGLKSYRDLPLRLAEFGAVHRYEPSGALHGLMRVR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCEEECCCHHHHHHHHHC
GFTQDDAHVFCTEEQMAAECLKINDLILSTYADFGFEEITVKLSTRPEKRVGSDAVWDHA
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHCCCCHHHHHH
EDVMSRVLKQIEAESGGRIKTGILPGEGAFYGPKFEYTLSDAIGREWQCGTTQVDFNLPE
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEHHHCCCCCCCCCEEEECCCHH
RFGAFYVDADGQKKTPVMIHRAICGSMERFTGILIEHFAGHFPLWLAPVQLAVCTITQEA
HHCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCH
DDYAAEVASAARALDLKVELDTRNEKISYKVREHSLAKIPVQFALGKKEAAERTVSIRRL
HHHHHHHHHHHHHEEEEEEECCCCCEEEEEEHHCCHHHCCHHHHCCCHHHHHHHHHHHHC
GSQEQKVLPLEEALKLLADEAVPPDLKRRAAVTKAA
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA