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The map label for this gene is lldD

Identifier: 158422446

GI number: 158422446

Start: 928219

End: 929361

Strand: Reverse

Name: lldD

Synonym: AZC_0822

Alternate gene names: 158422446

Gene position: 929361-928219 (Counterclockwise)

Preceding gene: 158422447

Following gene: 158422438

Centisome position: 17.31

GC content: 67.63

Gene sequence:

>1143_bases
ATGATCATCTCGTCACCGAACGACTATCGCGCCGCCGCCAAGAGCCGGCTGCCGCCCTTCCTCTTCCATTATGTGGATGG
CGGTGCCTATGCCGAATACACGCTGCGGCGGAACGTGGAGGATCTCAGCCACATCGCCCTGCGCCAGCAGGTGCTGCGCA
ATGTGGCGGACCTCAGCCTCGAGACCGAGCTGTTCGGCCAGAAGCTCACCATGCCGGTGGCGCTCGCGCCCGTGGGGCTG
ACGGGCATGCTGGCACGGCGCGGCGAGGTGCAGGCGGCGAAGGCGGCACAGGCCAAGGGCGTGCCCTTCACCCTCTCCAC
CGTTTCCGTCTGCCCCATCGAGGAGGTGCAGAGCCAGTGCGCCAAGCCCATCTGGTTCCAGCTCTATGTGCTGAAGGACC
GGGGCTTCATGCGGAACGCGCTGGAGCGGGCGCAGGCGGCGGGTATCAATACGCTGATCTTCACCGTGGACATGCCGGTG
CCCGGCGCGCGCTATCGCGATGCCCATTCGGGCATGTCCGGCCGCAGCGGGCCGACCCGCCGCGTCCTTCAGGCCATGGT
GCATCCACGCTGGGCGCTGGACGTGGGTCTGCTCGGCAAGCCGCACGATCTCGGCAACATCTCCACCTATCGCGGCAAGC
CCACGAACCTGGCCGATTACATCGGCTGGCTGGCGGCCAATTTCGATCCCTCCATCAGTTGGAAGGATCTCGAATGGATC
CGCTCCTTCTGGAAGGGGCCCATGATCATCAAGGGCATCCTTGATCCGGTGGATGCGCGCGATGCGGTGGCCTTCGGCGC
CGACGGCATCGTGGTGTCGAACCATGGCGGACGCCAGCTCGACGGCGTGCTCTCCTCGGCCCGCGCCCTGCCCGCCATCG
CGGATGCGGTGGGCGATGATCTGACGGTGCTGGCGGATTCCGGCATTCGCACCGGCCTCGACGTGGTGCGCATGCTGGCG
CTGGGGGCCAAGGGCGTGCTGCTGGGCCGGGCGTTCGCCTATGCCCTCGCCACGCATGGGCAGGCGGGCGTCGCCAACCT
GCTGGACCTCATCGAGAAGGAAATGCGGGTGGCCATGGCGCTCACCGGCGCCCGGTCCATCGCGGAAATCACGCGGGACA
GCCTCGTCGGCCTGCCGCGCTGA

Upstream 100 bases:

>100_bases
AGCATCTCGACTTCGTCGAACAGACGCTCCGCCAGATCGAAGAGGACGCCGCGCGCCTGCGGCGGGCCTCCATGCCCTTA
CGCCAAAAAGGAAACGCCCG

Downstream 100 bases:

>100_bases
AATAGCAATGGCGCCGGGCGGTGTCCCCGTCCGGCGCCATCGTGTCCTGCCGGAAGGCTCAGGCGGCCGCCACCGAGCGC
AGGAAGCCGTCGATCTCCGA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MIISSPNDYRAAAKSRLPPFLFHYVDGGAYAEYTLRRNVEDLSHIALRQQVLRNVADLSLETELFGQKLTMPVALAPVGL
TGMLARRGEVQAAKAAQAKGVPFTLSTVSVCPIEEVQSQCAKPIWFQLYVLKDRGFMRNALERAQAAGINTLIFTVDMPV
PGARYRDAHSGMSGRSGPTRRVLQAMVHPRWALDVGLLGKPHDLGNISTYRGKPTNLADYIGWLAANFDPSISWKDLEWI
RSFWKGPMIIKGILDPVDARDAVAFGADGIVVSNHGGRQLDGVLSSARALPAIADAVGDDLTVLADSGIRTGLDVVRMLA
LGAKGVLLGRAFAYALATHGQAGVANLLDLIEKEMRVAMALTGARSIAEITRDSLVGLPR

Sequences:

>Translated_380_residues
MIISSPNDYRAAAKSRLPPFLFHYVDGGAYAEYTLRRNVEDLSHIALRQQVLRNVADLSLETELFGQKLTMPVALAPVGL
TGMLARRGEVQAAKAAQAKGVPFTLSTVSVCPIEEVQSQCAKPIWFQLYVLKDRGFMRNALERAQAAGINTLIFTVDMPV
PGARYRDAHSGMSGRSGPTRRVLQAMVHPRWALDVGLLGKPHDLGNISTYRGKPTNLADYIGWLAANFDPSISWKDLEWI
RSFWKGPMIIKGILDPVDARDAVAFGADGIVVSNHGGRQLDGVLSSARALPAIADAVGDDLTVLADSGIRTGLDVVRMLA
LGAKGVLLGRAFAYALATHGQAGVANLLDLIEKEMRVAMALTGARSIAEITRDSLVGLPR
>Mature_380_residues
MIISSPNDYRAAAKSRLPPFLFHYVDGGAYAEYTLRRNVEDLSHIALRQQVLRNVADLSLETELFGQKLTMPVALAPVGL
TGMLARRGEVQAAKAAQAKGVPFTLSTVSVCPIEEVQSQCAKPIWFQLYVLKDRGFMRNALERAQAAGINTLIFTVDMPV
PGARYRDAHSGMSGRSGPTRRVLQAMVHPRWALDVGLLGKPHDLGNISTYRGKPTNLADYIGWLAANFDPSISWKDLEWI
RSFWKGPMIIKGILDPVDARDAVAFGADGIVVSNHGGRQLDGVLSSARALPAIADAVGDDLTVLADSGIRTGLDVVRMLA
LGAKGVLLGRAFAYALATHGQAGVANLLDLIEKEMRVAMALTGARSIAEITRDSLVGLPR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=371, Percent_Identity=36.3881401617251, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI54234014, Length=381, Percent_Identity=34.1207349081365, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI7705393, Length=381, Percent_Identity=34.1207349081365, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1790033, Length=376, Percent_Identity=79.5212765957447, Blast_Score=617, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=32.8840970350404, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=30.2816901408451, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323587, Length=380, Percent_Identity=30.2631578947368, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI78707188, Length=377, Percent_Identity=34.4827586206897, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI281363140, Length=377, Percent_Identity=34.4827586206897, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI78707190, Length=377, Percent_Identity=34.4827586206897, Blast_Score=214, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_AZOC5 (A8HTC9)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001523738.1
- ProteinModelPortal:   A8HTC9
- SMR:   A8HTC9
- GeneID:   5689797
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_0822
- HOGENOM:   HBG517781
- OMA:   WIREFWE
- BioCyc:   ACAU438753:AZC_0822-MONOMER
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 41006; Mature: 41006

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISSPNDYRAAAKSRLPPFLFHYVDGGAYAEYTLRRNVEDLSHIALRQQVLRNVADLSL
CCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETELFGQKLTMPVALAPVGLTGMLARRGEVQAAKAAQAKGVPFTLSTVSVCPIEEVQSQC
HHHHHCCCCCCCEEECCCCHHHHHHHCCCHHHHHHHHCCCCCEEECCEECCCHHHHHHHH
AKPIWFQLYVLKDRGFMRNALERAQAAGINTLIFTVDMPVPGARYRDAHSGMSGRSGPTR
CCCEEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCCCHHH
RVLQAMVHPRWALDVGLLGKPHDLGNISTYRGKPTNLADYIGWLAANFDPSISWKDLEWI
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
RSFWKGPMIIKGILDPVDARDAVAFGADGIVVSNHGGRQLDGVLSSARALPAIADAVGDD
HHHCCCCEEEHHHCCCCCCCHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
LTVLADSGIRTGLDVVRMLALGAKGVLLGRAFAYALATHGQAGVANLLDLIEKEMRVAMA
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LTGARSIAEITRDSLVGLPR
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIISSPNDYRAAAKSRLPPFLFHYVDGGAYAEYTLRRNVEDLSHIALRQQVLRNVADLSL
CCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETELFGQKLTMPVALAPVGLTGMLARRGEVQAAKAAQAKGVPFTLSTVSVCPIEEVQSQC
HHHHHCCCCCCCEEECCCCHHHHHHHCCCHHHHHHHHCCCCCEEECCEECCCHHHHHHHH
AKPIWFQLYVLKDRGFMRNALERAQAAGINTLIFTVDMPVPGARYRDAHSGMSGRSGPTR
CCCEEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCCCHHH
RVLQAMVHPRWALDVGLLGKPHDLGNISTYRGKPTNLADYIGWLAANFDPSISWKDLEWI
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
RSFWKGPMIIKGILDPVDARDAVAFGADGIVVSNHGGRQLDGVLSSARALPAIADAVGDD
HHHCCCCEEEHHHCCCCCCCHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
LTVLADSGIRTGLDVVRMLALGAKGVLLGRAFAYALATHGQAGVANLLDLIEKEMRVAMA
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LTGARSIAEITRDSLVGLPR
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA