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The map label for this gene is argE [C]

Identifier: 158422431

GI number: 158422431

Start: 910557

End: 911966

Strand: Reverse

Name: argE [C]

Synonym: AZC_0807

Alternate gene names: 158422431

Gene position: 911966-910557 (Counterclockwise)

Preceding gene: 158422432

Following gene: 158422430

Centisome position: 16.98

GC content: 68.79

Gene sequence:

>1410_bases
ATGAGCCGCCAAGATGCCGTCGCCCGCGCTGCGGAGTATTTCGACCGCGGAGACTTTCGCTCGGACCTCGCCCGCCGCGT
CGCCATGGCCACCGAGAGCCAGACAGGCGAAAGCCTCGAGGCGCTGCGCGCCTATCTCACCGACGAGATGATTCCGACGC
TGGAGAAGCTCGGCTTCTCCTCCCGCATCGTCGAGAATCCCGTGCCCGGCTATGGCCCGTTCCTGATCGCCGAGCGGCAT
GAGGCCGATGGCCTGCCCACCGTGCTTACCTATGGCCATGGCGATGTGATCTTCGGCCAGGAAGGCAGCTGGCGCGAGGG
GCTTGCCCCCTGGACGCTGGTGGAGCAGGGCGACCGCTGGTACGGCCGCGGGACCGCCGACAACAAGGGCCAGCACTCCA
TCAACATCGCCGCGCTGGAGCAGGTGATGGCGGCGCGCGGCGGCAAGCTCGGCTTCAACTGCAAGATGCTCATCGAGATG
GGCGAGGAAGCCGGCTCGCCGGGCCTGCGCGACATCGCAAGGATCGAGCGCGAGGCGCTCTCCGCCGACCTCCTCATCGG
CTCGGACGGCCCGCGCCTCTCCGCCGTGCGCCCCACCGTCTTCCTCGGATCGCGCGGCGCCTTCAACTTCGAGCTGGAGG
TGAACCTGCGCGAGAGCGGGCATCACTCCGGCAACTGGGGCGGCGTGCTCGCCAATGCCGGTACGCTCCTCGCCCACGCG
ATCACGAGGCTCGTGGACCAGAAGGGCCGCATCCTCGTCGACGGCCTGACCCCGAAGGAGATTCCCGCCTCCGTCCGTGC
GGCCCTCACCGACATCCAGCTCGAACAGGGCATGGGTGACCCGGAGATCGATCCCGACTGGGGCGAGCCGGGCCTGACGC
AGGCGGAGAAGATCTTCGCCTGGAACACGCTGGAAGTGCTGGCCTTCAAGACCGGCGCGCCGGAAGCCCCCGCCAATGCC
GTGCCGCCCTCGGCGCGTGCGACCATGCAGTTGCGCTTCGTCGTGGGCACCGATCCCAACACCATCATCCCGCTGGTGCA
GGCGCATCTGGACGCCGCCGGCCTCTCGCAAGTGCGGGCGCGGCCCTCGCGCATGGCGACCTTCGAGGCCACCCGGGTCG
ATCCGGAGGATGCGTGGGTGAAGTGGGCGCTCGCCTCCATCGAGACCACCACCGCCAAGAAGCCCGCCCTGCTGCCGAAC
CTCGGCGGCTCGCTGCCGAACGACGTGTTTGCGCTCATCCTCGGCATGCCCACCGTGTGGGTGCCGCACTCCTATCCCGC
GTGCTCCCAGCACGCGCCAAACGAGCATCTGCTCGCCTCCGTCGCGCGGGAGGCTCTTCAACTCATGGCCGGCCTGTTCT
ACGACCTCGGCGAAGATGGTTCCTCGATCCTGAAGGCGCGCGCCGCATGA

Upstream 100 bases:

>100_bases
GGGCAGGGAGGGGGGTAAGACCCTCTCCGCCTAGACACTATCCGACCCCGACGCGCCGCCCGCGCGCGCCAGAACCCTCC
CCACAGAAGAAGCTGATCCC

Downstream 100 bases:

>100_bases
GCACCCTGCCCACCCCCACCGGCCTTGATGCCGCGCTGGCCGAAAAGGTCGTCGCCTGGCTCGCACCCCGGTTCGACGAG
ATGGAGGCGCTGCTGAAGCG

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: Peptidase; M20/M25/M40 Family Peptidase; Peptidase Family; ArgE/DapE/Acy1 Family Protein; Deacylase; Succinyl-Diaminopimelate Desuccinylase; Beta-Ala-His Dipeptidase; Peptidase Dimerisation Domain Protein; Peptidase Dimerisation Domain-Containing Protein; Zinc Metallopeptidase; Peptidase Dimerization Domain Protein; N-Acyl-L-Amino Acid Amidohydrolase; Acetylornithine Deacetylase ArgE; Metallopeptidase; N-Succinyl-Diaminopimelate Deacylase; ArgE/DapE/Acy1 Family Peptidase; Nonspecific Dipeptidase

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSRQDAVARAAEYFDRGDFRSDLARRVAMATESQTGESLEALRAYLTDEMIPTLEKLGFSSRIVENPVPGYGPFLIAERH
EADGLPTVLTYGHGDVIFGQEGSWREGLAPWTLVEQGDRWYGRGTADNKGQHSINIAALEQVMAARGGKLGFNCKMLIEM
GEEAGSPGLRDIARIEREALSADLLIGSDGPRLSAVRPTVFLGSRGAFNFELEVNLRESGHHSGNWGGVLANAGTLLAHA
ITRLVDQKGRILVDGLTPKEIPASVRAALTDIQLEQGMGDPEIDPDWGEPGLTQAEKIFAWNTLEVLAFKTGAPEAPANA
VPPSARATMQLRFVVGTDPNTIIPLVQAHLDAAGLSQVRARPSRMATFEATRVDPEDAWVKWALASIETTTAKKPALLPN
LGGSLPNDVFALILGMPTVWVPHSYPACSQHAPNEHLLASVAREALQLMAGLFYDLGEDGSSILKARAA

Sequences:

>Translated_469_residues
MSRQDAVARAAEYFDRGDFRSDLARRVAMATESQTGESLEALRAYLTDEMIPTLEKLGFSSRIVENPVPGYGPFLIAERH
EADGLPTVLTYGHGDVIFGQEGSWREGLAPWTLVEQGDRWYGRGTADNKGQHSINIAALEQVMAARGGKLGFNCKMLIEM
GEEAGSPGLRDIARIEREALSADLLIGSDGPRLSAVRPTVFLGSRGAFNFELEVNLRESGHHSGNWGGVLANAGTLLAHA
ITRLVDQKGRILVDGLTPKEIPASVRAALTDIQLEQGMGDPEIDPDWGEPGLTQAEKIFAWNTLEVLAFKTGAPEAPANA
VPPSARATMQLRFVVGTDPNTIIPLVQAHLDAAGLSQVRARPSRMATFEATRVDPEDAWVKWALASIETTTAKKPALLPN
LGGSLPNDVFALILGMPTVWVPHSYPACSQHAPNEHLLASVAREALQLMAGLFYDLGEDGSSILKARAA
>Mature_468_residues
SRQDAVARAAEYFDRGDFRSDLARRVAMATESQTGESLEALRAYLTDEMIPTLEKLGFSSRIVENPVPGYGPFLIAERHE
ADGLPTVLTYGHGDVIFGQEGSWREGLAPWTLVEQGDRWYGRGTADNKGQHSINIAALEQVMAARGGKLGFNCKMLIEMG
EEAGSPGLRDIARIEREALSADLLIGSDGPRLSAVRPTVFLGSRGAFNFELEVNLRESGHHSGNWGGVLANAGTLLAHAI
TRLVDQKGRILVDGLTPKEIPASVRAALTDIQLEQGMGDPEIDPDWGEPGLTQAEKIFAWNTLEVLAFKTGAPEAPANAV
PPSARATMQLRFVVGTDPNTIIPLVQAHLDAAGLSQVRARPSRMATFEATRVDPEDAWVKWALASIETTTAKKPALLPNL
GGSLPNDVFALILGMPTVWVPHSYPACSQHAPNEHLLASVAREALQLMAGLFYDLGEDGSSILKARAA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI21071039, Length=457, Percent_Identity=24.2888402625821, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI271398239, Length=197, Percent_Identity=34.010152284264, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17563146, Length=196, Percent_Identity=30.6122448979592, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193211059, Length=392, Percent_Identity=25.5102040816327, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321159, Length=296, Percent_Identity=27.3648648648649, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585880, Length=389, Percent_Identity=26.2210796915167, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 50496; Mature: 50365

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQDAVARAAEYFDRGDFRSDLARRVAMATESQTGESLEALRAYLTDEMIPTLEKLGFS
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
SRIVENPVPGYGPFLIAERHEADGLPTVLTYGHGDVIFGQEGSWREGLAPWTLVEQGDRW
HHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCEEECCCCCCCCCCCCEEEEECCCCE
YGRGTADNKGQHSINIAALEQVMAARGGKLGFNCKMLIEMGEEAGSPGLRDIARIEREAL
ECCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCEEEEEECHHCCCCCHHHHHHHHHHHH
SADLLIGSDGPRLSAVRPTVFLGSRGAFNFELEVNLRESGHHSGNWGGVLANAGTLLAHA
CCEEEECCCCCCCEEECCEEEECCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ITRLVDQKGRILVDGLTPKEIPASVRAALTDIQLEQGMGDPEIDPDWGEPGLTQAEKIFA
HHHHHCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEE
WNTLEVLAFKTGAPEAPANAVPPSARATMQLRFVVGTDPNTIIPLVQAHLDAAGLSQVRA
CCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCHHHHHHHHC
RPSRMATFEATRVDPEDAWVKWALASIETTTAKKPALLPNLGGSLPNDVFALILGMPTVW
CCHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
VPHSYPACSQHAPNEHLLASVAREALQLMAGLFYDLGEDGSSILKARAA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure 
SRQDAVARAAEYFDRGDFRSDLARRVAMATESQTGESLEALRAYLTDEMIPTLEKLGFS
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
SRIVENPVPGYGPFLIAERHEADGLPTVLTYGHGDVIFGQEGSWREGLAPWTLVEQGDRW
HHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCEEECCCCCCCCCCCCEEEEECCCCE
YGRGTADNKGQHSINIAALEQVMAARGGKLGFNCKMLIEMGEEAGSPGLRDIARIEREAL
ECCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCEEEEEECHHCCCCCHHHHHHHHHHHH
SADLLIGSDGPRLSAVRPTVFLGSRGAFNFELEVNLRESGHHSGNWGGVLANAGTLLAHA
CCEEEECCCCCCCEEECCEEEECCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ITRLVDQKGRILVDGLTPKEIPASVRAALTDIQLEQGMGDPEIDPDWGEPGLTQAEKIFA
HHHHHCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEE
WNTLEVLAFKTGAPEAPANAVPPSARATMQLRFVVGTDPNTIIPLVQAHLDAAGLSQVRA
CCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCHHHHHHHHC
RPSRMATFEATRVDPEDAWVKWALASIETTTAKKPALLPNLGGSLPNDVFALILGMPTVW
CCHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
VPHSYPACSQHAPNEHLLASVAREALQLMAGLFYDLGEDGSSILKARAA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA