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The map label for this gene is uao [H]

Identifier: 158422412

GI number: 158422412

Start: 889689

End: 891128

Strand: Reverse

Name: uao [H]

Synonym: AZC_0788

Alternate gene names: 158422412

Gene position: 891128-889689 (Counterclockwise)

Preceding gene: 158422413

Following gene: 158422411

Centisome position: 16.6

GC content: 68.33

Gene sequence:

>1440_bases
ATGCCCGCTCCCGCCTCCGATTATCCCCGCGACCTCATCGGCTATGGCCGCAACCCGCCGCATCCGCGCTGGCCGGGGGA
GGCGCGAATCTGCGTGCAGTTCGTGATCAATTACGAGGAAGGCGCCGAGCGCTGCCTGCTGCACGGGGACACGGAATCGG
AAGCGTTCCTGTCCGACATCTCCAGCGCCCAGCCCTGGCCCGGCCAACGGCACATGAACATGGAGTCCATCTATGAATAC
GGCGCCCGCGCCGGCTTCTGGCGGCTCCATCGCCTGTTCACGGCGCGCAACATGCCGGTCACTGTCTTCGGCGTCGCCAA
GGCATTGGAGCGCAATCCGGAGGCGGTCGCGGCGATGAATGAGGCCGGCTGGGAGATCGCCAGCCACGGCCTGCGCTGGA
TCGACTATCGCAACCTCTCCGCCGAGACCGAGCGCGCGCACATCGCGGAAGCGGTGCGCATCCAGAACGAAGTGGCGGGC
GAGCGGCCGCTCGGCCTCTATCAGGGCCGCACCAGCGAGAACACGCTGCCCCTGACCATCGCCGAGGGCGGCTTTCTCTA
TTCCGCCGACACCTATGCGGATGAGCTGCCCTACTGGATCGAGAGCGAGCGCGGCCCCTTCCTGATGGTGCCCTATACGC
TCGAAGCCAATGACATGCGCTTCGCCATTCCCGAGGGCTATGCCTCGGGCGACGACTTCTTTGCCTATCTGCGCGACAGC
TTCGACCTGCTCTATGCGGAAGGCGAGACCGCCCCGCGCATGATGTCGGTGGGCCTGCACTGCCGCCTTGTGGGGCGGCC
CGGCCGGGCGCAGGGGCTGGCCCGCTTCCTCGATTACATCGCTGGGCATGAGCGGGTGTGGGTGGCGCGGCGCCTCGACA
TCGCCCGCCACTGGGTGGCCCACCATCCGCCCAAGGGCGGCTATGTGCCCTCGCGTCTCTCCCGCCCGCTGTTCGTGGAG
CGCTTCGGCAGCATCATCGAGCATTCGCCCTGGATCGCGGAAACGGTTTATGACACCGGCCTCACGCCCGCGCACGATAC
GGCGGAGGGCTTACAGGCCGCGCTCGTCGCCGTGCTGCGCGCGGCATCGCCCGACCGACAGCTCGCCGTCATCAATGCAC
ATCCGGACCTCGCCGGCCGCCTCGCCGCCGCCAAGCTGCTCACGCCGGATTCCACGGACGAGCAGGCCTCCGCCGGCCTC
GATGCCCTGACCGCCGAGGAGAAGGCCCGCTTCACGGCGCTGAATGACGCTTACCGGCAGAAGTTCGGCATCGTCTTCAT
CATGGCGGTGCGCGGGCGCTCCAAGGCGGAGATCCTGGACGCCTTCGAGCGGCGCCTGGCCCATGACGTTGCCGCCGAGC
ATGCGGAAGCCCTCGCCCAGATCGAGCGCATCTGCCTGCTGCGCCTCCAGCAGATCCTGCCGTCGCGGGGCGCCGCGTGA

Upstream 100 bases:

>100_bases
GTGCCGCTGCGCGTCACGCTGAGCGAGGACGGGCATTACCACGTGCCCCTGCTCTGCTCCCCCTGGGCCTATTCCACCTA
TCGCGGCTCCTGAGGTTCCG

Downstream 100 bases:

>100_bases
TGTCCGTGGCCACCGAAAGCAGTGCCACCGATGTTCTAGAGGGCAGCCGGCTCCTAGCGCGCCTTGAAGCGCTCGCGCGT
TTCACAGACGTGCCGGGCGA

Product: hypothetical protein

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MPAPASDYPRDLIGYGRNPPHPRWPGEARICVQFVINYEEGAERCLLHGDTESEAFLSDISSAQPWPGQRHMNMESIYEY
GARAGFWRLHRLFTARNMPVTVFGVAKALERNPEAVAAMNEAGWEIASHGLRWIDYRNLSAETERAHIAEAVRIQNEVAG
ERPLGLYQGRTSENTLPLTIAEGGFLYSADTYADELPYWIESERGPFLMVPYTLEANDMRFAIPEGYASGDDFFAYLRDS
FDLLYAEGETAPRMMSVGLHCRLVGRPGRAQGLARFLDYIAGHERVWVARRLDIARHWVAHHPPKGGYVPSRLSRPLFVE
RFGSIIEHSPWIAETVYDTGLTPAHDTAEGLQAALVAVLRAASPDRQLAVINAHPDLAGRLAAAKLLTPDSTDEQASAGL
DALTAEEKARFTALNDAYRQKFGIVFIMAVRGRSKAEILDAFERRLAHDVAAEHAEALAQIERICLLRLQQILPSRGAA

Sequences:

>Translated_479_residues
MPAPASDYPRDLIGYGRNPPHPRWPGEARICVQFVINYEEGAERCLLHGDTESEAFLSDISSAQPWPGQRHMNMESIYEY
GARAGFWRLHRLFTARNMPVTVFGVAKALERNPEAVAAMNEAGWEIASHGLRWIDYRNLSAETERAHIAEAVRIQNEVAG
ERPLGLYQGRTSENTLPLTIAEGGFLYSADTYADELPYWIESERGPFLMVPYTLEANDMRFAIPEGYASGDDFFAYLRDS
FDLLYAEGETAPRMMSVGLHCRLVGRPGRAQGLARFLDYIAGHERVWVARRLDIARHWVAHHPPKGGYVPSRLSRPLFVE
RFGSIIEHSPWIAETVYDTGLTPAHDTAEGLQAALVAVLRAASPDRQLAVINAHPDLAGRLAAAKLLTPDSTDEQASAGL
DALTAEEKARFTALNDAYRQKFGIVFIMAVRGRSKAEILDAFERRLAHDVAAEHAEALAQIERICLLRLQQILPSRGAA
>Mature_478_residues
PAPASDYPRDLIGYGRNPPHPRWPGEARICVQFVINYEEGAERCLLHGDTESEAFLSDISSAQPWPGQRHMNMESIYEYG
ARAGFWRLHRLFTARNMPVTVFGVAKALERNPEAVAAMNEAGWEIASHGLRWIDYRNLSAETERAHIAEAVRIQNEVAGE
RPLGLYQGRTSENTLPLTIAEGGFLYSADTYADELPYWIESERGPFLMVPYTLEANDMRFAIPEGYASGDDFFAYLRDSF
DLLYAEGETAPRMMSVGLHCRLVGRPGRAQGLARFLDYIAGHERVWVARRLDIARHWVAHHPPKGGYVPSRLSRPLFVER
FGSIIEHSPWIAETVYDTGLTPAHDTAEGLQAALVAVLRAASPDRQLAVINAHPDLAGRLAAAKLLTPDSTDEQASAGLD
ALTAEEKARFTALNDAYRQKFGIVFIMAVRGRSKAEILDAFERRLAHDVAAEHAEALAQIERICLLRLQQILPSRGAA

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG0726

COG function: function code G; Predicted xylanase/chitin deacetylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Homo sapiens, GI157743280, Length=156, Percent_Identity=35.2564102564103, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 53344; Mature: 53213

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPASDYPRDLIGYGRNPPHPRWPGEARICVQFVINYEEGAERCLLHGDTESEAFLSDI
CCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEEEEHHHCCCEEEEECCCCHHHHHHHH
SSAQPWPGQRHMNMESIYEYGARAGFWRLHRLFTARNMPVTVFGVAKALERNPEAVAAMN
HCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHH
EAGWEIASHGLRWIDYRNLSAETERAHIAEAVRIQNEVAGERPLGLYQGRTSENTLPLTI
HHCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEE
AEGGFLYSADTYADELPYWIESERGPFLMVPYTLEANDMRFAIPEGYASGDDFFAYLRDS
ECCCEEEECCCHHHHCCCCEECCCCCEEEEEEEECCCCEEEECCCCCCCCHHHHHHHHCC
FDLLYAEGETAPRMMSVGLHCRLVGRPGRAQGLARFLDYIAGHERVWVARRLDIARHWVA
CEEEEECCCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
HHPPKGGYVPSRLSRPLFVERFGSIIEHSPWIAETVYDTGLTPAHDTAEGLQAALVAVLR
CCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AASPDRQLAVINAHPDLAGRLAAAKLLTPDSTDEQASAGLDALTAEEKARFTALNDAYRQ
HCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
KFGIVFIMAVRGRSKAEILDAFERRLAHDVAAEHAEALAQIERICLLRLQQILPSRGAA
HCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PAPASDYPRDLIGYGRNPPHPRWPGEARICVQFVINYEEGAERCLLHGDTESEAFLSDI
CCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEEEEHHHCCCEEEEECCCCHHHHHHHH
SSAQPWPGQRHMNMESIYEYGARAGFWRLHRLFTARNMPVTVFGVAKALERNPEAVAAMN
HCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHH
EAGWEIASHGLRWIDYRNLSAETERAHIAEAVRIQNEVAGERPLGLYQGRTSENTLPLTI
HHCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEE
AEGGFLYSADTYADELPYWIESERGPFLMVPYTLEANDMRFAIPEGYASGDDFFAYLRDS
ECCCEEEECCCHHHHCCCCEECCCCCEEEEEEEECCCCEEEECCCCCCCCHHHHHHHHCC
FDLLYAEGETAPRMMSVGLHCRLVGRPGRAQGLARFLDYIAGHERVWVARRLDIARHWVA
CEEEEECCCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
HHPPKGGYVPSRLSRPLFVERFGSIIEHSPWIAETVYDTGLTPAHDTAEGLQAALVAVLR
CCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AASPDRQLAVINAHPDLAGRLAAAKLLTPDSTDEQASAGLDALTAEEKARFTALNDAYRQ
HCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
KFGIVFIMAVRGRSKAEILDAFERRLAHDVAAEHAEALAQIERICLLRLQQILPSRGAA
HCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]