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The map label for this gene is ywrD [H]

Identifier: 158422395

GI number: 158422395

Start: 871761

End: 873347

Strand: Reverse

Name: ywrD [H]

Synonym: AZC_0771

Alternate gene names: 158422395

Gene position: 873347-871761 (Counterclockwise)

Preceding gene: 158422396

Following gene: 158422393

Centisome position: 16.26

GC content: 67.17

Gene sequence:

>1587_bases
GTGCGTAATTTCTTCAAGACCGGCCGCTCCACCGTGTTCGCGCGCAATGCGGCGGTGGCCACCTCCCATCCGCTCTCCAG
CCTTGCCGCGCTCGACATGCTGCGCGCCGGCGGCAATGCGGTGGATGCCGCCATCACGGCCGTGGCCGTGCAGTGTGTGG
TCGACCCGCACATGACCGGCATCGGCGGCGACTGCTTCGTGCTCTACACGCCGAAGGGCGCGAGCGCGCCCATTGCCCTC
AACGGCTCGGGCAAGGCGCCGGCGGCGGCGAACGTGGACTGGTTCATCGAGCAGGGCATCACCGAGATCCCGCTCGATTC
GCCCCATGCCGTCACCATTCCCGGCGCGATCGCCGCCTGGACGAAGCTGCTGGCGGACCACGGCACGCGCTCGCTCGCCG
ACGTGCTCGCCCCCGCCATTCGCCTCGCGGAAGAGGGCTATGTGGTGCAGCCCCGCGTGGCGCGCGACTGGGCGCAGTAT
GCCCATCGCCTCCAGCGCGACGCGGTGAGCGTCGAGATCTTCCTGCCGGGCGGCAAGGCGCCGGGCCAGGGCGACGTCCA
CCGCCAGCCCAAGCTCGCCGCCACGCTGCGCAAGATCGCGGAAGGCGGGCGCGATGCCTTCTACACGGGCGAGGTGGCTG
AGGATGCGGTGGCCCGGCTGAAGGAACTGGGCGGGCTCCACACGCTGGAGGATTTCGCTGCGGCCGAAGCGGAATATGTG
ACGCCCGTCACCACCAACTATCGCGGCTATGACGTCTATGAGTGCCCGCCCAATGGCCAGGGCCTCGGCGTGCTGATGAT
GCTGAACGCGCTGGAGGGCTATGACCTCTCGCCCGACGCCCTTGGGGAGGCGGATCGCATCCACCTCTTCGCGGAGATCA
ACAAGCAGGTCTATCACCACCGCGACCATCTGTTCGCAGATCCGGTTCAGGCCTCCGTGCCGGTCGCCGAACTGCTGTCG
CCGGAATGGGCGGCCTTTGCCCGCTCGCGCGTGGACATGGCCAAGGCGGCCGATCCCATCGTGTGGCCGAAGGTGGCACA
CACAGACACCGTCTATCTCTGCGTGGTGGACAAGGACGGCAACGCCATCTCGCTCATCAACTCCATCTTCCACCAGTTCG
GCAGTTGCATCACGGCACCGAAGTCCGGCTTCCTGCTGCACAATCGCGGCGCGCAGTTCCGCCTCATCAAGGGCCACCCG
AATGCCATCGGCCCTTCCAAGCGGCCGCTGCACACCATCATTCCAGGCATGGTGATGAAGGACGGCAAGACCGTCGCGCC
CTTCGGTGTCATGGGCGGGCAGTACCAGACCATGGGCCATGTGGAACTGCTGACCAACATTATCGATCGCGGGATGGACG
TGCAGCAGGCCATGGAGGCGCCGCGCAGCTTTGCCTACAACGGTGCGCTGGAACTGGAGCCGGAATATGAACCCGGCCTG
CTCGACGAGATGCTGAAGCGCGGCCACGCGGCCAAGTGGTCGGCGGACCCGCTGGGCGGCGCGCAGATGATCTGGATCGA
CCAGGAGACCGGCATCCTCGCCGCCGGTTCGGAACCCCGCAAGGACGGCATGGCGCTCGGCTACTGA

Upstream 100 bases:

>100_bases
CGACGAGGCGAGCCACGCGCTCGTGGAAGCCGCGCCCGGGCATTTCGTCGCCCAGGCCGCCATCGGCTGACGGCCAGCAG
AACCCCAAGGAAACGTCCCC

Downstream 100 bases:

>100_bases
AGACGCCGGCGGGGCGAGGCGCGGCAGACGCCTCTGCCCTGCTCGGAATCGCGAAGTGGCCGCCCCTGCGGCCGCTTCCG
CTCACGGCTCACCCGGCAGC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MRNFFKTGRSTVFARNAAVATSHPLSSLAALDMLRAGGNAVDAAITAVAVQCVVDPHMTGIGGDCFVLYTPKGASAPIAL
NGSGKAPAAANVDWFIEQGITEIPLDSPHAVTIPGAIAAWTKLLADHGTRSLADVLAPAIRLAEEGYVVQPRVARDWAQY
AHRLQRDAVSVEIFLPGGKAPGQGDVHRQPKLAATLRKIAEGGRDAFYTGEVAEDAVARLKELGGLHTLEDFAAAEAEYV
TPVTTNYRGYDVYECPPNGQGLGVLMMLNALEGYDLSPDALGEADRIHLFAEINKQVYHHRDHLFADPVQASVPVAELLS
PEWAAFARSRVDMAKAADPIVWPKVAHTDTVYLCVVDKDGNAISLINSIFHQFGSCITAPKSGFLLHNRGAQFRLIKGHP
NAIGPSKRPLHTIIPGMVMKDGKTVAPFGVMGGQYQTMGHVELLTNIIDRGMDVQQAMEAPRSFAYNGALELEPEYEPGL
LDEMLKRGHAAKWSADPLGGAQMIWIDQETGILAAGSEPRKDGMALGY

Sequences:

>Translated_528_residues
MRNFFKTGRSTVFARNAAVATSHPLSSLAALDMLRAGGNAVDAAITAVAVQCVVDPHMTGIGGDCFVLYTPKGASAPIAL
NGSGKAPAAANVDWFIEQGITEIPLDSPHAVTIPGAIAAWTKLLADHGTRSLADVLAPAIRLAEEGYVVQPRVARDWAQY
AHRLQRDAVSVEIFLPGGKAPGQGDVHRQPKLAATLRKIAEGGRDAFYTGEVAEDAVARLKELGGLHTLEDFAAAEAEYV
TPVTTNYRGYDVYECPPNGQGLGVLMMLNALEGYDLSPDALGEADRIHLFAEINKQVYHHRDHLFADPVQASVPVAELLS
PEWAAFARSRVDMAKAADPIVWPKVAHTDTVYLCVVDKDGNAISLINSIFHQFGSCITAPKSGFLLHNRGAQFRLIKGHP
NAIGPSKRPLHTIIPGMVMKDGKTVAPFGVMGGQYQTMGHVELLTNIIDRGMDVQQAMEAPRSFAYNGALELEPEYEPGL
LDEMLKRGHAAKWSADPLGGAQMIWIDQETGILAAGSEPRKDGMALGY
>Mature_528_residues
MRNFFKTGRSTVFARNAAVATSHPLSSLAALDMLRAGGNAVDAAITAVAVQCVVDPHMTGIGGDCFVLYTPKGASAPIAL
NGSGKAPAAANVDWFIEQGITEIPLDSPHAVTIPGAIAAWTKLLADHGTRSLADVLAPAIRLAEEGYVVQPRVARDWAQY
AHRLQRDAVSVEIFLPGGKAPGQGDVHRQPKLAATLRKIAEGGRDAFYTGEVAEDAVARLKELGGLHTLEDFAAAEAEYV
TPVTTNYRGYDVYECPPNGQGLGVLMMLNALEGYDLSPDALGEADRIHLFAEINKQVYHHRDHLFADPVQASVPVAELLS
PEWAAFARSRVDMAKAADPIVWPKVAHTDTVYLCVVDKDGNAISLINSIFHQFGSCITAPKSGFLLHNRGAQFRLIKGHP
NAIGPSKRPLHTIIPGMVMKDGKTVAPFGVMGGQYQTMGHVELLTNIIDRGMDVQQAMEAPRSFAYNGALELEPEYEPGL
LDEMLKRGHAAKWSADPLGGAQMIWIDQETGILAAGSEPRKDGMALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=545, Percent_Identity=28.256880733945, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI73915090, Length=545, Percent_Identity=28.256880733945, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI73915096, Length=545, Percent_Identity=28.256880733945, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI73915094, Length=545, Percent_Identity=28.256880733945, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI113429324, Length=525, Percent_Identity=28, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI113429326, Length=529, Percent_Identity=27.5992438563327, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI153266885, Length=537, Percent_Identity=23.8361266294227, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI153266901, Length=538, Percent_Identity=23.7918215613383, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI153266907, Length=536, Percent_Identity=22.9477611940299, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI109148539, Length=520, Percent_Identity=25.7692307692308, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1789856, Length=541, Percent_Identity=33.456561922366, Blast_Score=251, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17506189, Length=520, Percent_Identity=26.3461538461538, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=448, Percent_Identity=26.1160714285714, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI212646519, Length=448, Percent_Identity=26.1160714285714, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=518, Percent_Identity=24.7104247104247, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193208247, Length=526, Percent_Identity=23.384030418251, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI193208245, Length=526, Percent_Identity=23.384030418251, Blast_Score=92, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323330, Length=468, Percent_Identity=22.2222222222222, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24642670, Length=548, Percent_Identity=27.3722627737226, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24642666, Length=548, Percent_Identity=27.3722627737226, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI161077878, Length=548, Percent_Identity=27.3722627737226, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI45551474, Length=548, Percent_Identity=27.3722627737226, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI161077880, Length=548, Percent_Identity=27.3722627737226, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI18859893, Length=532, Percent_Identity=24.812030075188, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI161077496, Length=428, Percent_Identity=24.7663551401869, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI18859741, Length=545, Percent_Identity=22.9357798165138, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56635; Mature: 56635

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNFFKTGRSTVFARNAAVATSHPLSSLAALDMLRAGGNAVDAAITAVAVQCVVDPHMTG
CCCHHHCCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCC
IGGDCFVLYTPKGASAPIALNGSGKAPAAANVDWFIEQGITEIPLDSPHAVTIPGAIAAW
CCCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEECCHHHHHH
TKLLADHGTRSLADVLAPAIRLAEEGYVVQPRVARDWAQYAHRLQRDAVSVEIFLPGGKA
HHHHHHCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCEEEEEEECCCCC
PGQGDVHRQPKLAATLRKIAEGGRDAFYTGEVAEDAVARLKELGGLHTLEDFAAAEAEYV
CCCCCCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
TPVTTNYRGYDVYECPPNGQGLGVLMMLNALEGYDLSPDALGEADRIHLFAEINKQVYHH
CCEECCCCCEEEEECCCCCCCCCHHEEEHHHCCCCCCHHHCCCCHHEEEHHHHHHHHHHH
RDHLFADPVQASVPVAELLSPEWAAFARSRVDMAKAADPIVWPKVAHTDTVYLCVVDKDG
HCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NAISLINSIFHQFGSCITAPKSGFLLHNRGAQFRLIKGHPNAIGPSKRPLHTIIPGMVMK
CHHHHHHHHHHHHCCEECCCCCCCEEECCCCEEEEEECCCCCCCCCCCCHHHHCCCEEEC
DGKTVAPFGVMGGQYQTMGHVELLTNIIDRGMDVQQAMEAPRSFAYNGALELEPEYEPGL
CCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHHCCCCEEEECCCCCCCH
LDEMLKRGHAAKWSADPLGGAQMIWIDQETGILAAGSEPRKDGMALGY
HHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MRNFFKTGRSTVFARNAAVATSHPLSSLAALDMLRAGGNAVDAAITAVAVQCVVDPHMTG
CCCHHHCCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCC
IGGDCFVLYTPKGASAPIALNGSGKAPAAANVDWFIEQGITEIPLDSPHAVTIPGAIAAW
CCCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEECCHHHHHH
TKLLADHGTRSLADVLAPAIRLAEEGYVVQPRVARDWAQYAHRLQRDAVSVEIFLPGGKA
HHHHHHCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCEEEEEEECCCCC
PGQGDVHRQPKLAATLRKIAEGGRDAFYTGEVAEDAVARLKELGGLHTLEDFAAAEAEYV
CCCCCCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
TPVTTNYRGYDVYECPPNGQGLGVLMMLNALEGYDLSPDALGEADRIHLFAEINKQVYHH
CCEECCCCCEEEEECCCCCCCCCHHEEEHHHCCCCCCHHHCCCCHHEEEHHHHHHHHHHH
RDHLFADPVQASVPVAELLSPEWAAFARSRVDMAKAADPIVWPKVAHTDTVYLCVVDKDG
HCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NAISLINSIFHQFGSCITAPKSGFLLHNRGAQFRLIKGHPNAIGPSKRPLHTIIPGMVMK
CHHHHHHHHHHHHCCEECCCCCCCEEECCCCEEEEEECCCCCCCCCCCCHHHHCCCEEEC
DGKTVAPFGVMGGQYQTMGHVELLTNIIDRGMDVQQAMEAPRSFAYNGALELEPEYEPGL
CCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHHCCCCEEEECCCCCCCH
LDEMLKRGHAAKWSADPLGGAQMIWIDQETGILAAGSEPRKDGMALGY
HHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]