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The map label for this gene is serA [H]

Identifier: 158422382

GI number: 158422382

Start: 856697

End: 857611

Strand: Direct

Name: serA [H]

Synonym: AZC_0758

Alternate gene names: 158422382

Gene position: 856697-857611 (Clockwise)

Preceding gene: 158422378

Following gene: 158422384

Centisome position: 15.95

GC content: 67.76

Gene sequence:

>915_bases
ATGCGTGCCGTATTCGTGGATGCCAGCCCGACCCTCGCCGGCGTAGCCGAGCGGCTGCACCGTGCCGACGACATTCCCCT
CGGCATCCATCGCAATCCGGACGTGACGCCTGCCGAACTGCCCGCCGTGCTCGATGGCGCCGAGATCGCCATCATCGACC
ACACTGCCTTGCCCACCGACATCGCCCGCACCTGCAACGGGCTGAAGCATGTGGTCTTCCTCGGCACCGGCGCGCGCAGC
TACATGAACCCGGAGGAACTGGCGGCGCTCGGCATCTCCGTCCACATCATCAAGGGCTATGGTGACACGGCGGTGGCCGA
ATGCGCCTTCGCCTTGATGTGGGCCGCAGCCAAGGGCTTCGCTTACATGGACCGTGGCGTGCGGGCCGGAAAATGGCTGC
GGACCGACGGCGTGGAACTCACCGGCAAGACCATCGGCCTCATCGGCTATGGCGGTATCGGCGCCGAGATGGCGCGCCTC
GCCAAGGGCGCGGGCATGCGCGTCATCGCCTGGAACCGCACGCCGAAGGACGAGCCGGGCGTGACTTTCGTCCCGCTGGA
GACGCTGCTCGCCGAGAGCGACGTGGTGTCCCTGCATCTCCTGCTCAATGACGAGACGCGCGGCTTCCTCTCCCGCGAAC
GGCTCGCGCAGCTCAAGCCCGGCGTCATCCTCGTGAACACGGCGCGCGGCGCCCTGATCGACGAAGAGGCGCTGGTGGAG
GCGCTGAAGTTCGGCAACGTGCGCCATGCGGGGCTCGACGTCTTTGTGACCGAGCCGCTGCCCGCCGACCATCCCTTCAC
CGCGCTGGAGAATGTGACGCTCTCCGCCCATTCCGCCTTCCGCACGCCGGAGGCCAGCGACAACCTCATCGAAGCCGCGC
TCAACCACTGCCGACGGATCGCTGCCGGAGGGTGA

Upstream 100 bases:

>100_bases
ACACGAGGCGTCCGCATCGCTACCCAAGCGCAAGGCCTCGCTCTAGAACGGTTGACGGGCAGATGCCCGCCTTGAGGTTT
TCTTCGCCGAGGAGTTGCCG

Downstream 100 bases:

>100_bases
GCGTCCGCGGCCGTTTCAGGCGCCGGAGCGTGAGGCACGCCCCGGCGTGATCCCGAGCGTCTTCATGCGGGAGGCGAGGG
TCGTCGGCTTGAGGCCGAGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MRAVFVDASPTLAGVAERLHRADDIPLGIHRNPDVTPAELPAVLDGAEIAIIDHTALPTDIARTCNGLKHVVFLGTGARS
YMNPEELAALGISVHIIKGYGDTAVAECAFALMWAAAKGFAYMDRGVRAGKWLRTDGVELTGKTIGLIGYGGIGAEMARL
AKGAGMRVIAWNRTPKDEPGVTFVPLETLLAESDVVSLHLLLNDETRGFLSRERLAQLKPGVILVNTARGALIDEEALVE
ALKFGNVRHAGLDVFVTEPLPADHPFTALENVTLSAHSAFRTPEASDNLIEAALNHCRRIAAGG

Sequences:

>Translated_304_residues
MRAVFVDASPTLAGVAERLHRADDIPLGIHRNPDVTPAELPAVLDGAEIAIIDHTALPTDIARTCNGLKHVVFLGTGARS
YMNPEELAALGISVHIIKGYGDTAVAECAFALMWAAAKGFAYMDRGVRAGKWLRTDGVELTGKTIGLIGYGGIGAEMARL
AKGAGMRVIAWNRTPKDEPGVTFVPLETLLAESDVVSLHLLLNDETRGFLSRERLAQLKPGVILVNTARGALIDEEALVE
ALKFGNVRHAGLDVFVTEPLPADHPFTALENVTLSAHSAFRTPEASDNLIEAALNHCRRIAAGG
>Mature_304_residues
MRAVFVDASPTLAGVAERLHRADDIPLGIHRNPDVTPAELPAVLDGAEIAIIDHTALPTDIARTCNGLKHVVFLGTGARS
YMNPEELAALGISVHIIKGYGDTAVAECAFALMWAAAKGFAYMDRGVRAGKWLRTDGVELTGKTIGLIGYGGIGAEMARL
AKGAGMRVIAWNRTPKDEPGVTFVPLETLLAESDVVSLHLLLNDETRGFLSRERLAQLKPGVILVNTARGALIDEEALVE
ALKFGNVRHAGLDVFVTEPLPADHPFTALENVTLSAHSAFRTPEASDNLIEAALNHCRRIAAGG

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=276, Percent_Identity=31.5217391304348, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI145580578, Length=301, Percent_Identity=30.5647840531561, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4557499, Length=301, Percent_Identity=30.5647840531561, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI145580575, Length=301, Percent_Identity=30.5647840531561, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI61743967, Length=303, Percent_Identity=29.3729372937294, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557497, Length=303, Percent_Identity=29.3729372937294, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912396, Length=203, Percent_Identity=30.0492610837438, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=35.3448275862069, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082289, Length=206, Percent_Identity=34.9514563106796, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789279, Length=194, Percent_Identity=34.020618556701, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081824, Length=141, Percent_Identity=36.1702127659575, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=174, Percent_Identity=31.6091954022989, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25147481, Length=204, Percent_Identity=27.9411764705882, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=216, Percent_Identity=32.8703703703704, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=218, Percent_Identity=28.8990825688073, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=234, Percent_Identity=28.2051282051282, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=86, Percent_Identity=39.5348837209302, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=25.5555555555556, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=27.7456647398844, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646446, Length=281, Percent_Identity=32.7402135231317, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646448, Length=281, Percent_Identity=32.7402135231317, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646452, Length=281, Percent_Identity=32.7402135231317, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646450, Length=281, Percent_Identity=32.7402135231317, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI62472511, Length=280, Percent_Identity=32.8571428571429, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28574286, Length=226, Percent_Identity=31.4159292035398, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28571528, Length=154, Percent_Identity=37.012987012987, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921140, Length=215, Percent_Identity=30.6976744186047, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585514, Length=213, Percent_Identity=29.5774647887324, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574282, Length=213, Percent_Identity=29.5774647887324, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574284, Length=213, Percent_Identity=29.5774647887324, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585516, Length=211, Percent_Identity=31.2796208530806, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551003, Length=213, Percent_Identity=29.5774647887324, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45552429, Length=213, Percent_Identity=29.5774647887324, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32363; Mature: 32363

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVFVDASPTLAGVAERLHRADDIPLGIHRNPDVTPAELPAVLDGAEIAIIDHTALPTD
CEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHCCCCEEEEEECCCCCHH
IARTCNGLKHVVFLGTGARSYMNPEELAALGISVHIIKGYGDTAVAECAFALMWAAAKGF
HHHHHCCCEEEEEEECCCHHCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHCCH
AYMDRGVRAGKWLRTDGVELTGKTIGLIGYGGIGAEMARLAKGAGMRVIAWNRTPKDEPG
HHHHCCCCCCCEEECCCCEECCCEEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCC
VTFVPLETLLAESDVVSLHLLLNDETRGFLSRERLAQLKPGVILVNTARGALIDEEALVE
EEEEEHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEECHHHHHH
ALKFGNVRHAGLDVFVTEPLPADHPFTALENVTLSAHSAFRTPEASDNLIEAALNHCRRI
HHHHCCEEECCEEEEEECCCCCCCCCHHHHCCEEEHHHHCCCCCCCHHHHHHHHHHHHHH
AAGG
HCCC
>Mature Secondary Structure
MRAVFVDASPTLAGVAERLHRADDIPLGIHRNPDVTPAELPAVLDGAEIAIIDHTALPTD
CEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHCCCCEEEEEECCCCCHH
IARTCNGLKHVVFLGTGARSYMNPEELAALGISVHIIKGYGDTAVAECAFALMWAAAKGF
HHHHHCCCEEEEEEECCCHHCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHCCH
AYMDRGVRAGKWLRTDGVELTGKTIGLIGYGGIGAEMARLAKGAGMRVIAWNRTPKDEPG
HHHHCCCCCCCEEECCCCEECCCEEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCC
VTFVPLETLLAESDVVSLHLLLNDETRGFLSRERLAQLKPGVILVNTARGALIDEEALVE
EEEEEHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEECHHHHHH
ALKFGNVRHAGLDVFVTEPLPADHPFTALENVTLSAHSAFRTPEASDNLIEAALNHCRRI
HHHHCCEEECCEEEEEECCCCCCCCCHHHHCCEEEHHHHCCCCCCCHHHHHHHHHHHHHH
AAGG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]